LeishMANIAdb
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Elks delta-like protein

Quick info Annotations Function or PPIs Localization Phosphorylation Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Elks delta-like protein
Gene product:
elks delta-like protein
Species:
Leishmania infantum
UniProt:
A4ICD6_LEIIN
TriTrypDb:
LINF_360081700
Length:
368

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Could not find GO cellular_component term for this entry.

Phosphorylation

Amastigote: 214
Promastigote/Amastigote: 22

Expansion

Sequence features

A4ICD6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ICD6

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 103 105 PF00675 0.581
CLV_NRD_NRD_1 200 202 PF00675 0.488
CLV_NRD_NRD_1 205 207 PF00675 0.547
CLV_NRD_NRD_1 249 251 PF00675 0.592
CLV_NRD_NRD_1 304 306 PF00675 0.573
CLV_NRD_NRD_1 31 33 PF00675 0.594
CLV_NRD_NRD_1 332 334 PF00675 0.523
CLV_PCSK_KEX2_1 130 132 PF00082 0.511
CLV_PCSK_KEX2_1 200 202 PF00082 0.481
CLV_PCSK_KEX2_1 304 306 PF00082 0.537
CLV_PCSK_KEX2_1 33 35 PF00082 0.610
CLV_PCSK_PC1ET2_1 130 132 PF00082 0.578
CLV_PCSK_PC1ET2_1 33 35 PF00082 0.610
CLV_PCSK_SKI1_1 119 123 PF00082 0.557
CLV_PCSK_SKI1_1 130 134 PF00082 0.444
CLV_PCSK_SKI1_1 207 211 PF00082 0.603
CLV_PCSK_SKI1_1 222 226 PF00082 0.453
CLV_PCSK_SKI1_1 334 338 PF00082 0.518
CLV_PCSK_SKI1_1 351 355 PF00082 0.330
CLV_PCSK_SKI1_1 72 76 PF00082 0.615
DEG_APCC_DBOX_1 12 20 PF00400 0.562
DEG_APCC_KENBOX_2 347 351 PF00400 0.573
DOC_MAPK_gen_1 175 183 PF00069 0.586
DOC_MAPK_gen_1 328 338 PF00069 0.463
DOC_MAPK_RevD_3 109 125 PF00069 0.458
DOC_MAPK_RevD_3 135 151 PF00069 0.600
DOC_PP1_RVXF_1 332 339 PF00149 0.554
DOC_USP7_MATH_1 50 54 PF00917 0.560
LIG_14-3-3_CanoR_1 131 135 PF00244 0.490
LIG_14-3-3_CanoR_1 136 141 PF00244 0.468
LIG_14-3-3_CanoR_1 211 216 PF00244 0.591
LIG_APCC_ABBA_1 213 218 PF00400 0.497
LIG_FHA_1 178 184 PF00498 0.548
LIG_FHA_1 208 214 PF00498 0.566
LIG_FHA_1 277 283 PF00498 0.708
LIG_FHA_1 309 315 PF00498 0.471
LIG_FHA_2 167 173 PF00498 0.584
LIG_FHA_2 50 56 PF00498 0.627
LIG_LIR_Gen_1 193 202 PF02991 0.384
LIG_LIR_Nem_3 193 197 PF02991 0.388
LIG_NRBOX 143 149 PF00104 0.601
LIG_PCNA_yPIPBox_3 244 256 PF02747 0.547
LIG_SH2_SRC 216 219 PF00017 0.610
LIG_SH2_STAT3 93 96 PF00017 0.614
LIG_SH2_STAT5 261 264 PF00017 0.585
LIG_SH2_STAT5 307 310 PF00017 0.554
LIG_SH2_STAT5 48 51 PF00017 0.565
LIG_SH2_STAT5 93 96 PF00017 0.510
LIG_SH3_3 149 155 PF00018 0.661
LIG_SUMO_SIM_anti_2 180 185 PF11976 0.319
LIG_SUMO_SIM_par_1 178 185 PF11976 0.320
LIG_TRAF2_1 100 103 PF00917 0.540
LIG_TRAF2_1 169 172 PF00917 0.566
LIG_TRAF2_1 52 55 PF00917 0.534
LIG_TRAF2_1 8 11 PF00917 0.525
LIG_UBA3_1 140 149 PF00899 0.560
LIG_WRC_WIRS_1 191 196 PF05994 0.387
MOD_CK1_1 82 88 PF00069 0.727
MOD_CK2_1 153 159 PF00069 0.658
MOD_CK2_1 166 172 PF00069 0.434
MOD_CK2_1 182 188 PF00069 0.482
MOD_CK2_1 272 278 PF00069 0.723
MOD_CK2_1 314 320 PF00069 0.497
MOD_CK2_1 49 55 PF00069 0.539
MOD_CK2_1 5 11 PF00069 0.528
MOD_CK2_1 85 91 PF00069 0.655
MOD_GlcNHglycan 155 158 PF01048 0.713
MOD_GlcNHglycan 264 267 PF01048 0.613
MOD_GlcNHglycan 274 277 PF01048 0.628
MOD_GSK3_1 207 214 PF00069 0.614
MOD_GSK3_1 256 263 PF00069 0.546
MOD_GSK3_1 272 279 PF00069 0.694
MOD_GSK3_1 356 363 PF00069 0.473
MOD_GSK3_1 50 57 PF00069 0.589
MOD_GSK3_1 75 82 PF00069 0.644
MOD_N-GLC_1 211 216 PF02516 0.555
MOD_NEK2_1 166 171 PF00069 0.607
MOD_NEK2_1 19 24 PF00069 0.502
MOD_NEK2_1 256 261 PF00069 0.519
MOD_NEK2_1 280 285 PF00069 0.645
MOD_NEK2_1 324 329 PF00069 0.554
MOD_NEK2_1 356 361 PF00069 0.464
MOD_NEK2_1 49 54 PF00069 0.602
MOD_PIKK_1 50 56 PF00454 0.627
MOD_PIKK_1 77 83 PF00454 0.694
MOD_PIKK_1 92 98 PF00454 0.610
MOD_PKA_1 130 136 PF00069 0.541
MOD_PKA_2 130 136 PF00069 0.491
MOD_PKA_2 269 275 PF00069 0.716
MOD_PKA_2 327 333 PF00069 0.562
MOD_PKB_1 175 183 PF00069 0.551
MOD_PKB_1 32 40 PF00069 0.600
MOD_Plk_1 177 183 PF00069 0.552
MOD_Plk_1 19 25 PF00069 0.481
MOD_Plk_1 211 217 PF00069 0.503
MOD_Plk_1 319 325 PF00069 0.620
MOD_Plk_1 340 346 PF00069 0.563
MOD_Plk_2-3 190 196 PF00069 0.521
MOD_Plk_4 136 142 PF00069 0.511
MOD_Plk_4 143 149 PF00069 0.546
MOD_Plk_4 19 25 PF00069 0.531
MOD_Plk_4 190 196 PF00069 0.521
MOD_Plk_4 211 217 PF00069 0.523
MOD_Plk_4 319 325 PF00069 0.594
MOD_Plk_4 82 88 PF00069 0.747
MOD_SUMO_for_1 309 312 PF00179 0.616
MOD_SUMO_rev_2 101 107 PF00179 0.588
MOD_SUMO_rev_2 120 126 PF00179 0.474
MOD_SUMO_rev_2 254 262 PF00179 0.526
MOD_SUMO_rev_2 347 356 PF00179 0.574
TRG_DiLeu_BaEn_1 234 239 PF01217 0.578
TRG_DiLeu_BaEn_2 189 195 PF01217 0.386
TRG_ER_diArg_1 200 202 PF00400 0.536
TRG_ER_diArg_1 304 306 PF00400 0.582
TRG_NES_CRM1_1 15 28 PF08389 0.594
TRG_NES_CRM1_1 203 218 PF08389 0.566
TRG_Pf-PMV_PEXEL_1 119 123 PF00026 0.593
TRG_Pf-PMV_PEXEL_1 200 204 PF00026 0.529
TRG_Pf-PMV_PEXEL_1 250 254 PF00026 0.542

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IAJ8 Leptomonas seymouri 68% 100%
A0A0S4KNY7 Bodo saltans 24% 95%
A0A1X0NLT9 Trypanosomatidae 33% 98%
A0A3Q8IQ67 Leishmania donovani 99% 100%
A0A422NVX8 Trypanosoma rangeli 32% 98%
A4HQL8 Leishmania braziliensis 76% 100%
D0A3S1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 32% 98%
E9AUD3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 100%
Q4Q057 Leishmania major 92% 100%
V5BD37 Trypanosoma cruzi 31% 99%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS