LeishMANIAdb
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CPSF_A domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
CPSF_A domain-containing protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4ICD4_LEIIN
TriTrypDb:
LINF_360081400
Length:
135

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4ICD4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ICD4

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_PCSK_SKI1_1 34 38 PF00082 0.537
CLV_PCSK_SKI1_1 46 50 PF00082 0.326
CLV_PCSK_SKI1_1 5 9 PF00082 0.666
DEG_Nend_UBRbox_1 1 4 PF02207 0.611
DOC_CYCLIN_RxL_1 2 11 PF00134 0.664
DOC_USP7_MATH_1 12 16 PF00917 0.620
DOC_USP7_MATH_1 64 68 PF00917 0.532
DOC_USP7_UBL2_3 99 103 PF12436 0.421
LIG_14-3-3_CanoR_1 63 73 PF00244 0.529
LIG_EH1_1 94 102 PF00400 0.500
LIG_FHA_1 114 120 PF00498 0.411
LIG_FHA_2 113 119 PF00498 0.439
LIG_SH2_PTP2 106 109 PF00017 0.487
LIG_SH2_SRC 106 109 PF00017 0.532
LIG_SH2_STAT5 106 109 PF00017 0.441
LIG_SH2_STAT5 113 116 PF00017 0.390
LIG_SH2_STAT5 83 86 PF00017 0.417
LIG_SH3_3 98 104 PF00018 0.458
MOD_CK1_1 124 130 PF00069 0.501
MOD_CK2_1 112 118 PF00069 0.449
MOD_CK2_1 13 19 PF00069 0.624
MOD_GlcNHglycan 10 13 PF01048 0.629
MOD_GSK3_1 109 116 PF00069 0.588
MOD_GSK3_1 8 15 PF00069 0.652
MOD_NEK2_1 1 6 PF00069 0.701
MOD_NEK2_1 8 13 PF00069 0.512
MOD_NEK2_2 18 23 PF00069 0.607
MOD_NEK2_2 41 46 PF00069 0.399
MOD_PIKK_1 64 70 PF00454 0.480
MOD_PKA_2 1 7 PF00069 0.616
MOD_Plk_1 18 24 PF00069 0.602
MOD_Plk_4 109 115 PF00069 0.508
MOD_Plk_4 124 130 PF00069 0.365
TRG_ENDOCYTIC_2 106 109 PF00928 0.506
TRG_ER_diArg_1 73 76 PF00400 0.468
TRG_Pf-PMV_PEXEL_1 5 9 PF00026 0.619

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PEU6 Leptomonas seymouri 75% 99%
A0A0S4KL81 Bodo saltans 33% 100%
A0A1X0NL52 Trypanosomatidae 45% 100%
A0A3S5IS15 Trypanosoma rangeli 50% 100%
A0A3S7XCF1 Leishmania donovani 100% 100%
A4HQL5 Leishmania braziliensis 85% 100%
D0A3R9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 51% 78%
E9AUD0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
Q4Q060 Leishmania major 95% 100%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS