RNA editing comple protein MP63

Quick info Localization Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA editing comple protein MP63

Species:

Leishmania infantum

UniProt:

A4ICD3_LEIIN

TriTrypDb:

LINF_360081300

Length:

626

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4ICD3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ICD3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	137	139	PF00675	0.592
CLV_NRD_NRD_1	21	23	PF00675	0.650
CLV_NRD_NRD_1	260	262	PF00675	0.572
CLV_NRD_NRD_1	482	484	PF00675	0.611
CLV_NRD_NRD_1	5	7	PF00675	0.558
CLV_NRD_NRD_1	61	63	PF00675	0.548
CLV_PCSK_KEX2_1	137	139	PF00082	0.592
CLV_PCSK_KEX2_1	171	173	PF00082	0.580
CLV_PCSK_KEX2_1	21	23	PF00082	0.598
CLV_PCSK_KEX2_1	4	6	PF00082	0.550
CLV_PCSK_KEX2_1	482	484	PF00082	0.604
CLV_PCSK_KEX2_1	486	488	PF00082	0.562
CLV_PCSK_KEX2_1	61	63	PF00082	0.489
CLV_PCSK_PC1ET2_1	171	173	PF00082	0.600
CLV_PCSK_PC1ET2_1	4	6	PF00082	0.528
CLV_PCSK_PC1ET2_1	486	488	PF00082	0.576
CLV_PCSK_PC7_1	17	23	PF00082	0.597
CLV_PCSK_PC7_1	482	488	PF00082	0.551
CLV_PCSK_SKI1_1	262	266	PF00082	0.674
DEG_APCC_DBOX_1	16	24	PF00400	0.577
DEG_SCF_FBW7_1	299	306	PF00400	0.632
DOC_CKS1_1	106	111	PF01111	0.647
DOC_CKS1_1	283	288	PF01111	0.487
DOC_CYCLIN_yCln2_LP_2	106	112	PF00134	0.481
DOC_MAPK_MEF2A_6	151	158	PF00069	0.531
DOC_MAPK_MEF2A_6	269	276	PF00069	0.730
DOC_MAPK_RevD_3	47	62	PF00069	0.512
DOC_PP2B_LxvP_1	553	556	PF13499	0.294
DOC_PP4_FxxP_1	371	374	PF00568	0.501
DOC_USP7_MATH_1	13	17	PF00917	0.710
DOC_USP7_MATH_1	189	193	PF00917	0.613
DOC_USP7_MATH_1	24	28	PF00917	0.461
DOC_USP7_MATH_1	303	307	PF00917	0.657
DOC_USP7_MATH_1	346	350	PF00917	0.633
DOC_USP7_MATH_1	36	40	PF00917	0.701
DOC_USP7_MATH_1	364	368	PF00917	0.580
DOC_USP7_MATH_1	507	511	PF00917	0.642
DOC_USP7_MATH_1	512	516	PF00917	0.643
DOC_USP7_MATH_1	556	560	PF00917	0.514
DOC_USP7_MATH_1	590	594	PF00917	0.383
DOC_USP7_UBL2_3	140	144	PF12436	0.671
DOC_USP7_UBL2_3	265	269	PF12436	0.592
DOC_USP7_UBL2_3	602	606	PF12436	0.440
DOC_WW_Pin1_4	105	110	PF00397	0.576
DOC_WW_Pin1_4	282	287	PF00397	0.489
DOC_WW_Pin1_4	293	298	PF00397	0.539
DOC_WW_Pin1_4	299	304	PF00397	0.478
DOC_WW_Pin1_4	317	322	PF00397	0.565
DOC_WW_Pin1_4	326	331	PF00397	0.554
DOC_WW_Pin1_4	342	347	PF00397	0.564
DOC_WW_Pin1_4	373	378	PF00397	0.515
DOC_WW_Pin1_4	383	388	PF00397	0.513
DOC_WW_Pin1_4	392	397	PF00397	0.555
DOC_WW_Pin1_4	495	500	PF00397	0.469
DOC_WW_Pin1_4	503	508	PF00397	0.469
LIG_14-3-3_CanoR_1	17	21	PF00244	0.529
LIG_14-3-3_CanoR_1	366	372	PF00244	0.524
LIG_14-3-3_CanoR_1	514	524	PF00244	0.602
LIG_14-3-3_CanoR_1	569	578	PF00244	0.481
LIG_14-3-3_CanoR_1	62	68	PF00244	0.414
LIG_APCC_ABBA_1	596	601	PF00400	0.409
LIG_APCC_ABBAyCdc20_2	580	586	PF00400	0.351
LIG_BIR_III_4	218	222	PF00653	0.519
LIG_BRCT_BRCA1_1	318	322	PF00533	0.617
LIG_BRCT_BRCA1_1	571	575	PF00533	0.516
LIG_CSK_EPIYA_1	196	200	PF00017	0.672
LIG_CtBP_PxDLS_1	499	503	PF00389	0.460
LIG_EH_1	207	211	PF12763	0.534
LIG_EH_1	256	260	PF12763	0.509
LIG_FHA_1	123	129	PF00498	0.554
LIG_FHA_1	279	285	PF00498	0.593
LIG_FHA_1	312	318	PF00498	0.583
LIG_FHA_1	617	623	PF00498	0.342
LIG_FHA_2	222	228	PF00498	0.667
LIG_FHA_2	516	522	PF00498	0.635
LIG_Integrin_isoDGR_2	480	482	PF01839	0.486
LIG_LIR_Apic_2	370	374	PF02991	0.514
LIG_LIR_Gen_1	515	525	PF02991	0.623
LIG_LIR_Nem_3	227	233	PF02991	0.544
LIG_LIR_Nem_3	245	250	PF02991	0.512
LIG_LIR_Nem_3	285	290	PF02991	0.529
LIG_LIR_Nem_3	345	350	PF02991	0.641
LIG_LIR_Nem_3	455	459	PF02991	0.328
LIG_LIR_Nem_3	515	520	PF02991	0.631
LIG_LIR_Nem_3	572	578	PF02991	0.417
LIG_LIR_Nem_3	581	587	PF02991	0.378
LIG_Pex14_2	426	430	PF04695	0.476
LIG_SH2_CRK	459	463	PF00017	0.265
LIG_SH2_STAP1	525	529	PF00017	0.585
LIG_SH2_STAP1	608	612	PF00017	0.390
LIG_SH3_1	487	493	PF00018	0.541
LIG_SH3_2	249	254	PF14604	0.577
LIG_SH3_3	115	121	PF00018	0.594
LIG_SH3_3	198	204	PF00018	0.678
LIG_SH3_3	211	217	PF00018	0.633
LIG_SH3_3	246	252	PF00018	0.549
LIG_SH3_3	280	286	PF00018	0.518
LIG_SH3_3	315	321	PF00018	0.541
LIG_SH3_3	371	377	PF00018	0.632
LIG_SH3_3	487	493	PF00018	0.516
LIG_SH3_3	612	618	PF00018	0.324
LIG_SH3_4	140	147	PF00018	0.556
LIG_SH3_4	352	359	PF00018	0.461
LIG_SH3_4	523	530	PF00018	0.465
LIG_SUMO_SIM_anti_2	312	320	PF11976	0.454
LIG_SUMO_SIM_par_1	159	168	PF11976	0.482
LIG_SUMO_SIM_par_1	312	320	PF11976	0.454
LIG_SUMO_SIM_par_1	498	503	PF11976	0.475
LIG_TRAF2_1	307	310	PF00917	0.691
LIG_TRAF2_2	98	103	PF00917	0.555
LIG_TYR_ITIM	582	587	PF00017	0.336
LIG_WRC_WIRS_1	427	432	PF05994	0.450
MOD_CK1_1	16	22	PF00069	0.597
MOD_CK1_1	298	304	PF00069	0.632
MOD_CK1_1	316	322	PF00069	0.555
MOD_CK1_1	367	373	PF00069	0.684
MOD_CK1_1	383	389	PF00069	0.482
MOD_CK1_1	395	401	PF00069	0.633
MOD_CK1_1	428	434	PF00069	0.601
MOD_CK1_1	455	461	PF00069	0.366
MOD_CK1_1	515	521	PF00069	0.600
MOD_CK1_1	530	536	PF00069	0.355
MOD_CK1_1	541	547	PF00069	0.371
MOD_CK1_1	558	564	PF00069	0.455
MOD_CK2_1	221	227	PF00069	0.696
MOD_CK2_1	303	309	PF00069	0.729
MOD_CK2_1	515	521	PF00069	0.493
MOD_CK2_1	556	562	PF00069	0.464
MOD_Cter_Amidation	480	483	PF01082	0.559
MOD_GlcNHglycan	305	308	PF01048	0.675
MOD_GlcNHglycan	33	36	PF01048	0.685
MOD_GlcNHglycan	366	369	PF01048	0.673
MOD_GlcNHglycan	38	41	PF01048	0.700
MOD_GlcNHglycan	382	385	PF01048	0.578
MOD_GlcNHglycan	401	404	PF01048	0.628
MOD_GlcNHglycan	430	433	PF01048	0.646
MOD_GlcNHglycan	510	513	PF01048	0.558
MOD_GlcNHglycan	514	517	PF01048	0.552
MOD_GlcNHglycan	55	58	PF01048	0.449
MOD_GlcNHglycan	571	574	PF01048	0.407
MOD_GlcNHglycan	609	612	PF01048	0.546
MOD_GlcNHglycan	86	89	PF01048	0.434
MOD_GSK3_1	278	285	PF00069	0.537
MOD_GSK3_1	295	302	PF00069	0.571
MOD_GSK3_1	309	316	PF00069	0.635
MOD_GSK3_1	342	349	PF00069	0.627
MOD_GSK3_1	395	402	PF00069	0.558
MOD_GSK3_1	426	433	PF00069	0.707
MOD_GSK3_1	443	450	PF00069	0.546
MOD_GSK3_1	503	510	PF00069	0.490
MOD_GSK3_1	538	545	PF00069	0.452
MOD_GSK3_1	556	563	PF00069	0.416
MOD_GSK3_1	574	581	PF00069	0.387
MOD_GSK3_1	597	604	PF00069	0.439
MOD_GSK3_1	84	91	PF00069	0.370
MOD_N-GLC_1	326	331	PF02516	0.698
MOD_N-GLC_1	53	58	PF02516	0.575
MOD_N-GLC_1	530	535	PF02516	0.350
MOD_NEK2_1	177	182	PF00069	0.494
MOD_NEK2_1	31	36	PF00069	0.662
MOD_NEK2_1	397	402	PF00069	0.705
MOD_NEK2_1	426	431	PF00069	0.655
MOD_NEK2_1	502	507	PF00069	0.464
MOD_NEK2_1	508	513	PF00069	0.484
MOD_NEK2_1	549	554	PF00069	0.394
MOD_NEK2_1	578	583	PF00069	0.456
MOD_NEK2_1	63	68	PF00069	0.356
MOD_NEK2_2	346	351	PF00069	0.545
MOD_NEK2_2	590	595	PF00069	0.432
MOD_NEK2_2	68	73	PF00069	0.421
MOD_PIKK_1	601	607	PF00454	0.436
MOD_PK_1	160	166	PF00069	0.563
MOD_PKA_2	16	22	PF00069	0.543
MOD_PKA_2	189	195	PF00069	0.657
MOD_PKA_2	568	574	PF00069	0.429
MOD_Plk_1	500	506	PF00069	0.585
MOD_Plk_1	53	59	PF00069	0.572
MOD_Plk_1	530	536	PF00069	0.343
MOD_Plk_4	119	125	PF00069	0.616
MOD_Plk_4	152	158	PF00069	0.551
MOD_Plk_4	160	166	PF00069	0.519
MOD_Plk_4	178	184	PF00069	0.378
MOD_Plk_4	549	555	PF00069	0.339
MOD_ProDKin_1	105	111	PF00069	0.577
MOD_ProDKin_1	282	288	PF00069	0.487
MOD_ProDKin_1	293	299	PF00069	0.538
MOD_ProDKin_1	317	323	PF00069	0.565
MOD_ProDKin_1	326	332	PF00069	0.556
MOD_ProDKin_1	342	348	PF00069	0.565
MOD_ProDKin_1	373	379	PF00069	0.515
MOD_ProDKin_1	383	389	PF00069	0.512
MOD_ProDKin_1	392	398	PF00069	0.556
MOD_ProDKin_1	495	501	PF00069	0.468
MOD_ProDKin_1	503	509	PF00069	0.472
MOD_SUMO_rev_2	515	524	PF00179	0.506
TRG_DiLeu_BaEn_1	152	157	PF01217	0.550
TRG_ENDOCYTIC_2	199	202	PF00928	0.564
TRG_ENDOCYTIC_2	459	462	PF00928	0.265
TRG_ENDOCYTIC_2	584	587	PF00928	0.338
TRG_ER_diArg_1	20	22	PF00400	0.630
TRG_ER_diArg_1	5	7	PF00400	0.564
TRG_ER_diArg_1	61	63	PF00400	0.454
TRG_Pf-PMV_PEXEL_1	21	25	PF00026	0.569
TRG_Pf-PMV_PEXEL_1	261	266	PF00026	0.678
TRG_Pf-PMV_PEXEL_1	537	542	PF00026	0.411

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8D6	Leptomonas seymouri	54%	100%
A0A0S4KI33	Bodo saltans	39%	97%
A0A1X0NLZ8	Trypanosomatidae	38%	100%
A0A3S7XCC6	Leishmania donovani	100%	100%
A0A422NVX1	Trypanosoma rangeli	39%	100%
A4HQL4	Leishmania braziliensis	74%	99%
D0A3R8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9AUC9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q6T448	Leishmania major	92%	99%
V5DDW7	Trypanosoma cruzi	40%	100%