Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4ICD1_LEIIN

TriTrypDb:

LINF_360081000

Length:

707

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	7
GO:0042995	cell projection	2	7
GO:0043226	organelle	2	7
GO:0043227	membrane-bounded organelle	3	7
GO:0110165	cellular anatomical entity	1	7
GO:0120025	plasma membrane bounded cell projection	3	7
GO:0000164	protein phosphatase type 1 complex	5	1
GO:0008287	protein serine/threonine phosphatase complex	4	1
GO:0032991	protein-containing complex	1	1
GO:1902494	catalytic complex	2	1
GO:1903293	phosphatase complex	3	1

Expansion

Sequence features

A4ICD1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ICD1

Function

Biological processes
Term	Name	Level	Count
GO:0009893	positive regulation of metabolic process	4	1
GO:0010562	positive regulation of phosphorus metabolic process	6	1
GO:0010604	positive regulation of macromolecule metabolic process	5	1
GO:0019220	regulation of phosphate metabolic process	6	1
GO:0019222	regulation of metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031325	positive regulation of cellular metabolic process	5	1
GO:0031399	regulation of protein modification process	6	1
GO:0031401	positive regulation of protein modification process	7	1
GO:0035303	regulation of dephosphorylation	7	1
GO:0035304	regulation of protein dephosphorylation	7	1
GO:0035306	positive regulation of dephosphorylation	8	1
GO:0035307	positive regulation of protein dephosphorylation	8	1
GO:0045937	positive regulation of phosphate metabolic process	7	1
GO:0048518	positive regulation of biological process	3	1
GO:0048522	positive regulation of cellular process	4	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051173	positive regulation of nitrogen compound metabolic process	5	1
GO:0051174	regulation of phosphorus metabolic process	5	1
GO:0051246	regulation of protein metabolic process	5	1
GO:0051247	positive regulation of protein metabolic process	6	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0080090	regulation of primary metabolic process	4	1

Molecular functions
Term	Name	Level	Count
GO:0004857	enzyme inhibitor activity	3	1
GO:0004864	protein phosphatase inhibitor activity	5	1
GO:0004865	protein serine/threonine phosphatase inhibitor activity	6	1
GO:0019208	phosphatase regulator activity	3	1
GO:0019212	phosphatase inhibitor activity	4	1
GO:0019888	protein phosphatase regulator activity	4	1
GO:0030234	enzyme regulator activity	2	1
GO:0098772	molecular function regulator activity	1	1
GO:0140678	molecular function inhibitor activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	100	104	PF00656	0.481
CLV_C14_Caspase3-7	435	439	PF00656	0.727
CLV_C14_Caspase3-7	681	685	PF00656	0.717
CLV_C14_Caspase3-7	701	705	PF00656	0.690
CLV_NRD_NRD_1	150	152	PF00675	0.531
CLV_NRD_NRD_1	153	155	PF00675	0.529
CLV_NRD_NRD_1	204	206	PF00675	0.539
CLV_NRD_NRD_1	21	23	PF00675	0.640
CLV_NRD_NRD_1	372	374	PF00675	0.696
CLV_NRD_NRD_1	468	470	PF00675	0.766
CLV_NRD_NRD_1	601	603	PF00675	0.768
CLV_NRD_NRD_1	652	654	PF00675	0.691
CLV_PCSK_FUR_1	151	155	PF00082	0.558
CLV_PCSK_KEX2_1	120	122	PF00082	0.467
CLV_PCSK_KEX2_1	150	152	PF00082	0.555
CLV_PCSK_KEX2_1	153	155	PF00082	0.543
CLV_PCSK_KEX2_1	158	160	PF00082	0.545
CLV_PCSK_KEX2_1	204	206	PF00082	0.539
CLV_PCSK_KEX2_1	371	373	PF00082	0.691
CLV_PCSK_KEX2_1	601	603	PF00082	0.618
CLV_PCSK_KEX2_1	652	654	PF00082	0.691
CLV_PCSK_PC1ET2_1	120	122	PF00082	0.467
CLV_PCSK_PC1ET2_1	158	160	PF00082	0.608
CLV_PCSK_PC7_1	154	160	PF00082	0.548
CLV_PCSK_SKI1_1	121	125	PF00082	0.402
CLV_PCSK_SKI1_1	169	173	PF00082	0.547
CLV_PCSK_SKI1_1	197	201	PF00082	0.532
CLV_PCSK_SKI1_1	314	318	PF00082	0.510
CLV_PCSK_SKI1_1	343	347	PF00082	0.470
CLV_PCSK_SKI1_1	376	380	PF00082	0.678
CLV_PCSK_SKI1_1	63	67	PF00082	0.424
CLV_PCSK_SKI1_1	695	699	PF00082	0.677
DEG_APCC_DBOX_1	296	304	PF00400	0.512
DEG_Nend_UBRbox_2	1	3	PF02207	0.537
DEG_SPOP_SBC_1	240	244	PF00917	0.705
DEG_SPOP_SBC_1	377	381	PF00917	0.590
DEG_SPOP_SBC_1	414	418	PF00917	0.730
DOC_CDC14_PxL_1	332	340	PF14671	0.473
DOC_CDC14_PxL_1	567	575	PF14671	0.685
DOC_CKS1_1	106	111	PF01111	0.402
DOC_CYCLIN_RxL_1	309	322	PF00134	0.508
DOC_CYCLIN_RxL_1	340	349	PF00134	0.445
DOC_CYCLIN_RxL_1	692	702	PF00134	0.724
DOC_CYCLIN_yCln2_LP_2	224	227	PF00134	0.784
DOC_MAPK_DCC_7	309	318	PF00069	0.496
DOC_MAPK_gen_1	120	126	PF00069	0.407
DOC_MAPK_gen_1	22	30	PF00069	0.600
DOC_MAPK_gen_1	297	305	PF00069	0.616
DOC_MAPK_gen_1	309	318	PF00069	0.320
DOC_MAPK_gen_1	652	663	PF00069	0.697
DOC_MAPK_MEF2A_6	23	32	PF00069	0.588
DOC_MAPK_MEF2A_6	297	305	PF00069	0.606
DOC_MAPK_MEF2A_6	351	358	PF00069	0.609
DOC_MAPK_MEF2A_6	88	97	PF00069	0.439
DOC_PP2B_LxvP_1	224	227	PF13499	0.784
DOC_PP2B_LxvP_1	591	594	PF13499	0.746
DOC_USP7_MATH_1	136	140	PF00917	0.536
DOC_USP7_MATH_1	215	219	PF00917	0.639
DOC_USP7_MATH_1	240	244	PF00917	0.553
DOC_USP7_MATH_1	377	381	PF00917	0.694
DOC_USP7_MATH_1	384	388	PF00917	0.773
DOC_USP7_MATH_1	406	410	PF00917	0.662
DOC_USP7_MATH_1	414	418	PF00917	0.784
DOC_USP7_MATH_1	448	452	PF00917	0.684
DOC_USP7_MATH_1	456	460	PF00917	0.731
DOC_USP7_MATH_1	493	497	PF00917	0.727
DOC_USP7_MATH_1	519	523	PF00917	0.754
DOC_USP7_MATH_1	605	609	PF00917	0.739
DOC_USP7_MATH_1	678	682	PF00917	0.778
DOC_USP7_UBL2_3	116	120	PF12436	0.499
DOC_USP7_UBL2_3	466	470	PF12436	0.733
DOC_WW_Pin1_4	105	110	PF00397	0.408
DOC_WW_Pin1_4	213	218	PF00397	0.569
DOC_WW_Pin1_4	371	376	PF00397	0.763
DOC_WW_Pin1_4	380	385	PF00397	0.670
DOC_WW_Pin1_4	416	421	PF00397	0.693
DOC_WW_Pin1_4	623	628	PF00397	0.669
LIG_14-3-3_CanoR_1	137	145	PF00244	0.435
LIG_14-3-3_CanoR_1	159	168	PF00244	0.599
LIG_14-3-3_CanoR_1	177	184	PF00244	0.570
LIG_14-3-3_CanoR_1	239	247	PF00244	0.558
LIG_14-3-3_CanoR_1	314	319	PF00244	0.450
LIG_14-3-3_CanoR_1	34	43	PF00244	0.470
LIG_14-3-3_CanoR_1	469	477	PF00244	0.702
LIG_14-3-3_CanoR_1	549	557	PF00244	0.728
LIG_14-3-3_CanoR_1	601	609	PF00244	0.716
LIG_14-3-3_CanoR_1	67	72	PF00244	0.559
LIG_14-3-3_CanoR_1	693	698	PF00244	0.777
LIG_Actin_WH2_2	248	264	PF00022	0.333
LIG_BIR_III_4	230	234	PF00653	0.792
LIG_BIR_III_4	322	326	PF00653	0.566
LIG_BRCT_BRCA1_1	243	247	PF00533	0.581
LIG_BRCT_BRCA1_1	38	42	PF00533	0.503
LIG_BRCT_BRCA1_1	386	390	PF00533	0.670
LIG_BRCT_BRCA1_1	490	494	PF00533	0.722
LIG_BRCT_BRCA1_1	526	530	PF00533	0.710
LIG_BRCT_BRCA1_1	536	540	PF00533	0.603
LIG_BRCT_BRCA1_1	645	649	PF00533	0.753
LIG_BRCT_BRCA1_1	659	663	PF00533	0.827
LIG_BRCT_BRCA1_1	690	694	PF00533	0.766
LIG_CaM_IQ_9	187	203	PF13499	0.668
LIG_DLG_GKlike_1	58	65	PF00625	0.551
LIG_DLG_GKlike_1	67	74	PF00625	0.452
LIG_eIF4E_1	3	9	PF01652	0.472
LIG_eIF4E_1	342	348	PF01652	0.490
LIG_eIF4E_1	87	93	PF01652	0.433
LIG_FHA_1	201	207	PF00498	0.581
LIG_FHA_1	325	331	PF00498	0.529
LIG_FHA_1	380	386	PF00498	0.651
LIG_FHA_1	484	490	PF00498	0.626
LIG_FHA_1	496	502	PF00498	0.681
LIG_FHA_1	604	610	PF00498	0.816
LIG_FHA_1	656	662	PF00498	0.602
LIG_FHA_2	106	112	PF00498	0.511
LIG_FHA_2	136	142	PF00498	0.501
LIG_FHA_2	184	190	PF00498	0.627
LIG_FHA_2	191	197	PF00498	0.504
LIG_FHA_2	358	364	PF00498	0.636
LIG_FHA_2	36	42	PF00498	0.570
LIG_FHA_2	399	405	PF00498	0.707
LIG_FHA_2	531	537	PF00498	0.649
LIG_LIR_Gen_1	139	149	PF02991	0.499
LIG_LIR_Gen_1	2	9	PF02991	0.480
LIG_LIR_Gen_1	24	32	PF02991	0.551
LIG_LIR_Gen_1	276	284	PF02991	0.600
LIG_LIR_Gen_1	329	338	PF02991	0.480
LIG_LIR_Gen_1	38	48	PF02991	0.373
LIG_LIR_Nem_3	127	131	PF02991	0.464
LIG_LIR_Nem_3	139	145	PF02991	0.495
LIG_LIR_Nem_3	14	19	PF02991	0.487
LIG_LIR_Nem_3	147	152	PF02991	0.508
LIG_LIR_Nem_3	2	6	PF02991	0.495
LIG_LIR_Nem_3	24	30	PF02991	0.517
LIG_LIR_Nem_3	276	280	PF02991	0.626
LIG_LIR_Nem_3	329	335	PF02991	0.490
LIG_LIR_Nem_3	340	345	PF02991	0.453
LIG_LIR_Nem_3	38	43	PF02991	0.366
LIG_LIR_Nem_3	60	65	PF02991	0.469
LIG_LIR_Nem_3	691	697	PF02991	0.805
LIG_MYND_1	223	227	PF01753	0.684
LIG_MYND_1	571	575	PF01753	0.723
LIG_NRBOX	88	94	PF00104	0.432
LIG_SH2_CRK	142	146	PF00017	0.481
LIG_SH2_CRK	342	346	PF00017	0.460
LIG_SH2_NCK_1	184	188	PF00017	0.512
LIG_SH2_NCK_1	56	60	PF00017	0.367
LIG_SH2_STAP1	142	146	PF00017	0.481
LIG_SH2_STAP1	463	467	PF00017	0.636
LIG_SH2_STAT5	48	51	PF00017	0.467
LIG_SH3_1	569	575	PF00018	0.725
LIG_SH3_3	103	109	PF00018	0.399
LIG_SH3_3	220	226	PF00018	0.626
LIG_SH3_3	349	355	PF00018	0.530
LIG_SH3_3	441	447	PF00018	0.658
LIG_SH3_3	565	571	PF00018	0.705
LIG_SH3_3	621	627	PF00018	0.693
LIG_SUMO_SIM_anti_2	250	256	PF11976	0.562
LIG_SUMO_SIM_par_1	354	360	PF11976	0.614
LIG_TRAF2_1	108	111	PF00917	0.498
LIG_TRAF2_1	550	553	PF00917	0.697
LIG_TYR_ITIM	126	131	PF00017	0.457
LIG_TYR_ITIM	54	59	PF00017	0.347
LIG_WRC_WIRS_1	13	18	PF05994	0.418
LIG_WRC_WIRS_1	37	42	PF05994	0.434
LIG_WRC_WIRS_1	385	390	PF05994	0.712
LIG_WRC_WIRS_1	59	64	PF05994	0.463
LIG_WRC_WIRS_1	632	637	PF05994	0.687
LIG_WW_2	444	447	PF00397	0.656
LIG_WW_3	593	597	PF00397	0.721
MOD_CDK_SPK_2	371	376	PF00069	0.686
MOD_CDK_SPxxK_3	105	112	PF00069	0.401
MOD_CK1_1	241	247	PF00069	0.615
MOD_CK1_1	293	299	PF00069	0.628
MOD_CK1_1	357	363	PF00069	0.596
MOD_CK1_1	380	386	PF00069	0.675
MOD_CK1_1	398	404	PF00069	0.568
MOD_CK1_1	461	467	PF00069	0.739
MOD_CK1_1	506	512	PF00069	0.699
MOD_CK1_1	534	540	PF00069	0.693
MOD_CK1_1	548	554	PF00069	0.750
MOD_CK1_1	604	610	PF00069	0.723
MOD_CK1_1	631	637	PF00069	0.718
MOD_CK1_1	642	648	PF00069	0.687
MOD_CK1_1	659	665	PF00069	0.751
MOD_CK1_1	70	76	PF00069	0.545
MOD_CK2_1	105	111	PF00069	0.516
MOD_CK2_1	135	141	PF00069	0.510
MOD_CK2_1	183	189	PF00069	0.689
MOD_CK2_1	190	196	PF00069	0.575
MOD_CK2_1	245	251	PF00069	0.559
MOD_CK2_1	35	41	PF00069	0.559
MOD_CK2_1	357	363	PF00069	0.663
MOD_CK2_1	398	404	PF00069	0.621
MOD_CK2_1	419	425	PF00069	0.740
MOD_CK2_1	530	536	PF00069	0.671
MOD_CK2_1	539	545	PF00069	0.604
MOD_Cter_Amidation	118	121	PF01082	0.506
MOD_Cter_Amidation	650	653	PF01082	0.702
MOD_GlcNHglycan	138	141	PF01048	0.529
MOD_GlcNHglycan	217	220	PF01048	0.714
MOD_GlcNHglycan	243	246	PF01048	0.615
MOD_GlcNHglycan	247	250	PF01048	0.582
MOD_GlcNHglycan	348	351	PF01048	0.469
MOD_GlcNHglycan	408	411	PF01048	0.661
MOD_GlcNHglycan	450	453	PF01048	0.712
MOD_GlcNHglycan	561	565	PF01048	0.705
MOD_GlcNHglycan	603	606	PF01048	0.744
MOD_GlcNHglycan	609	612	PF01048	0.603
MOD_GlcNHglycan	615	618	PF01048	0.778
MOD_GlcNHglycan	637	640	PF01048	0.565
MOD_GlcNHglycan	671	674	PF01048	0.718
MOD_GlcNHglycan	680	683	PF01048	0.745
MOD_GlcNHglycan	684	687	PF01048	0.548
MOD_GSK3_1	160	167	PF00069	0.607
MOD_GSK3_1	241	248	PF00069	0.567
MOD_GSK3_1	376	383	PF00069	0.731
MOD_GSK3_1	384	391	PF00069	0.670
MOD_GSK3_1	395	402	PF00069	0.536
MOD_GSK3_1	415	422	PF00069	0.669
MOD_GSK3_1	461	468	PF00069	0.616
MOD_GSK3_1	530	537	PF00069	0.657
MOD_GSK3_1	600	607	PF00069	0.746
MOD_GSK3_1	623	630	PF00069	0.764
MOD_GSK3_1	63	70	PF00069	0.487
MOD_GSK3_1	631	638	PF00069	0.705
MOD_GSK3_1	639	646	PF00069	0.580
MOD_GSK3_1	655	662	PF00069	0.562
MOD_GSK3_1	665	672	PF00069	0.690
MOD_GSK3_1	674	681	PF00069	0.684
MOD_GSK3_1	689	696	PF00069	0.697
MOD_GSK3_1	698	705	PF00069	0.628
MOD_LATS_1	312	318	PF00433	0.487
MOD_N-GLC_1	438	443	PF02516	0.717
MOD_NEK2_1	124	129	PF00069	0.437
MOD_NEK2_1	175	180	PF00069	0.674
MOD_NEK2_1	337	342	PF00069	0.422
MOD_NEK2_1	346	351	PF00069	0.532
MOD_NEK2_1	356	361	PF00069	0.723
MOD_NEK2_1	378	383	PF00069	0.720
MOD_NEK2_1	415	420	PF00069	0.647
MOD_NEK2_1	42	47	PF00069	0.525
MOD_NEK2_1	465	470	PF00069	0.639
MOD_NEK2_1	494	499	PF00069	0.716
MOD_NEK2_1	530	535	PF00069	0.657
MOD_NEK2_1	635	640	PF00069	0.673
MOD_NEK2_1	663	668	PF00069	0.689
MOD_PIKK_1	157	163	PF00454	0.697
MOD_PIKK_1	177	183	PF00454	0.661
MOD_PIKK_1	357	363	PF00454	0.608
MOD_PIKK_1	595	601	PF00454	0.719
MOD_PIKK_1	639	645	PF00454	0.723
MOD_PK_1	164	170	PF00069	0.522
MOD_PKA_1	601	607	PF00069	0.611
MOD_PKA_2	136	142	PF00069	0.438
MOD_PKA_2	200	206	PF00069	0.569
MOD_PKA_2	238	244	PF00069	0.609
MOD_PKA_2	35	41	PF00069	0.521
MOD_PKA_2	468	474	PF00069	0.790
MOD_PKA_2	548	554	PF00069	0.727
MOD_PKA_2	595	601	PF00069	0.710
MOD_PKA_2	678	684	PF00069	0.745
MOD_PKB_1	34	42	PF00069	0.434
MOD_Plk_1	195	201	PF00069	0.518
MOD_Plk_1	461	467	PF00069	0.652
MOD_Plk_4	256	262	PF00069	0.550
MOD_Plk_4	290	296	PF00069	0.526
MOD_Plk_4	337	343	PF00069	0.384
MOD_Plk_4	524	530	PF00069	0.738
MOD_Plk_4	534	540	PF00069	0.639
MOD_Plk_4	643	649	PF00069	0.746
MOD_ProDKin_1	105	111	PF00069	0.404
MOD_ProDKin_1	213	219	PF00069	0.575
MOD_ProDKin_1	371	377	PF00069	0.768
MOD_ProDKin_1	380	386	PF00069	0.670
MOD_ProDKin_1	416	422	PF00069	0.692
MOD_ProDKin_1	623	629	PF00069	0.669
MOD_SUMO_rev_2	155	160	PF00179	0.591
TRG_DiLeu_BaEn_1	524	529	PF01217	0.582
TRG_DiLeu_BaLyEn_6	220	225	PF01217	0.784
TRG_DiLeu_BaLyEn_6	333	338	PF01217	0.581
TRG_ENDOCYTIC_2	128	131	PF00928	0.465
TRG_ENDOCYTIC_2	142	145	PF00928	0.488
TRG_ENDOCYTIC_2	3	6	PF00928	0.485
TRG_ENDOCYTIC_2	342	345	PF00928	0.460
TRG_ENDOCYTIC_2	56	59	PF00928	0.358
TRG_ENDOCYTIC_2	86	89	PF00928	0.429
TRG_ER_diArg_1	149	151	PF00400	0.613
TRG_ER_diArg_1	152	154	PF00400	0.583
TRG_ER_diArg_1	204	206	PF00400	0.539
TRG_ER_diArg_1	308	311	PF00400	0.457
TRG_ER_diArg_1	34	37	PF00400	0.529
TRG_ER_diArg_1	370	373	PF00400	0.679
TRG_NES_CRM1_1	689	702	PF08389	0.588
TRG_Pf-PMV_PEXEL_1	150	155	PF00026	0.632
TRG_Pf-PMV_PEXEL_1	63	68	PF00026	0.478
TRG_Pf-PMV_PEXEL_1	695	700	PF00026	0.723
TRG_Pf-PMV_PEXEL_1	72	77	PF00026	0.469

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0K7	Leptomonas seymouri	45%	100%
A0A3S7XCG9	Leishmania donovani	99%	100%
A4HQL1	Leishmania braziliensis	59%	100%
E9AUC6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4Q064	Leishmania major	87%	100%