LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
EVE domain containing protein - putative
Species:
Leishmania infantum
UniProt:
A4ICC8_LEIIN
TriTrypDb:
LINF_360080700
Length:
204

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4ICC8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ICC8

PDB structure(s): 2ar1_A

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 127 129 PF00675 0.320
CLV_NRD_NRD_1 162 164 PF00675 0.388
CLV_NRD_NRD_1 191 193 PF00675 0.459
CLV_NRD_NRD_1 2 4 PF00675 0.480
CLV_PCSK_FUR_1 189 193 PF00082 0.462
CLV_PCSK_KEX2_1 127 129 PF00082 0.320
CLV_PCSK_KEX2_1 188 190 PF00082 0.470
CLV_PCSK_KEX2_1 191 193 PF00082 0.447
CLV_PCSK_KEX2_1 197 199 PF00082 0.407
CLV_PCSK_KEX2_1 4 6 PF00082 0.406
CLV_PCSK_PC1ET2_1 188 190 PF00082 0.470
CLV_PCSK_PC1ET2_1 191 193 PF00082 0.447
CLV_PCSK_PC1ET2_1 197 199 PF00082 0.407
CLV_PCSK_PC1ET2_1 4 6 PF00082 0.406
CLV_PCSK_SKI1_1 132 136 PF00082 0.372
CLV_PCSK_SKI1_1 194 198 PF00082 0.447
CLV_PCSK_SKI1_1 56 60 PF00082 0.239
CLV_Separin_Metazoa 74 78 PF03568 0.320
DEG_APCC_DBOX_1 126 134 PF00400 0.320
DEG_MDM2_SWIB_1 111 119 PF02201 0.370
DOC_MAPK_gen_1 125 135 PF00069 0.289
DOC_MAPK_gen_1 191 201 PF00069 0.447
DOC_PP1_RVXF_1 54 60 PF00149 0.257
DOC_USP7_UBL2_3 101 105 PF12436 0.401
DOC_USP7_UBL2_3 110 114 PF12436 0.173
DOC_USP7_UBL2_3 193 197 PF12436 0.448
DOC_WW_Pin1_4 31 36 PF00397 0.231
LIG_14-3-3_CanoR_1 140 144 PF00244 0.232
LIG_14-3-3_CanoR_1 192 201 PF00244 0.445
LIG_BIR_II_1 1 5 PF00653 0.512
LIG_BRCT_BRCA1_1 89 93 PF00533 0.320
LIG_FHA_2 118 124 PF00498 0.354
LIG_FHA_2 82 88 PF00498 0.251
LIG_LIR_Apic_2 89 95 PF02991 0.370
LIG_LIR_Gen_1 149 157 PF02991 0.264
LIG_LIR_Gen_1 81 87 PF02991 0.370
LIG_LIR_Nem_3 10 16 PF02991 0.320
LIG_LIR_Nem_3 149 154 PF02991 0.264
LIG_LIR_Nem_3 33 39 PF02991 0.232
LIG_LIR_Nem_3 81 86 PF02991 0.370
LIG_MLH1_MIPbox_1 89 93 PF16413 0.320
LIG_Pex14_2 111 115 PF04695 0.229
LIG_SH2_CRK 151 155 PF00017 0.320
LIG_SH2_SRC 151 154 PF00017 0.289
LIG_SH2_STAP1 151 155 PF00017 0.264
LIG_SH2_STAT5 153 156 PF00017 0.320
LIG_SH2_STAT5 92 95 PF00017 0.400
LIG_SUMO_SIM_par_1 116 123 PF11976 0.209
LIG_TYR_ITIM 11 16 PF00017 0.320
MOD_CK1_1 139 145 PF00069 0.325
MOD_CK2_1 117 123 PF00069 0.310
MOD_CK2_1 144 150 PF00069 0.266
MOD_CK2_1 81 87 PF00069 0.172
MOD_GlcNHglycan 146 149 PF01048 0.266
MOD_N-GLC_2 47 49 PF02516 0.198
MOD_NEK2_1 136 141 PF00069 0.289
MOD_NEK2_1 59 64 PF00069 0.229
MOD_PIKK_1 134 140 PF00454 0.323
MOD_PKA_1 192 198 PF00069 0.449
MOD_PKA_2 139 145 PF00069 0.229
MOD_PKA_2 177 183 PF00069 0.417
MOD_PKA_2 197 203 PF00069 0.357
MOD_Plk_1 81 87 PF00069 0.264
MOD_Plk_4 114 120 PF00069 0.314
MOD_Plk_4 197 203 PF00069 0.438
MOD_ProDKin_1 31 37 PF00069 0.231
MOD_SUMO_for_1 16 19 PF00179 0.231
MOD_SUMO_rev_2 90 98 PF00179 0.237
TRG_ENDOCYTIC_2 13 16 PF00928 0.285
TRG_ENDOCYTIC_2 151 154 PF00928 0.264
TRG_ENDOCYTIC_2 80 83 PF00928 0.378
TRG_ER_diArg_1 3 6 PF00400 0.452
TRG_NLS_MonoCore_2 190 195 PF00514 0.456
TRG_NLS_MonoExtC_3 187 192 PF00514 0.468
TRG_NLS_MonoExtC_3 2 7 PF00514 0.451
TRG_NLS_MonoExtN_4 188 195 PF00514 0.461
TRG_NLS_MonoExtN_4 3 8 PF00514 0.438

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I255 Leptomonas seymouri 78% 100%
A0A0S4JQP8 Bodo saltans 59% 100%
A0A0S4KI49 Bodo saltans 59% 100%
A0A1X0NLS9 Trypanosomatidae 63% 100%
A0A3R7KTV7 Trypanosoma rangeli 65% 100%
A0A3S7XCF0 Leishmania donovani 100% 100%
A4HQK8 Leishmania braziliensis 89% 100%
D0A3R0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 60% 100%
E9AUC3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 97% 100%
O94645 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 31% 85%
Q4Q067 Leishmania major 98% 100%
Q6P3E0 Rattus norvegicus 45% 90%
Q6PFL8 Danio rerio 43% 88%
Q90679 Gallus gallus 40% 84%
Q91YJ3 Mus musculus 43% 90%
Q9P016 Homo sapiens 46% 91%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS