Uncharacterized protein

Quick info Annotations Localization Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

EVE domain containing protein - putative

Species:

Leishmania infantum

UniProt:

A4ICC8_LEIIN

TriTrypDb:

LINF_360080700

Length:

204

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4ICC8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ICC8

PDB structure(s): 2ar1_A

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	127	129	PF00675	0.320
CLV_NRD_NRD_1	162	164	PF00675	0.388
CLV_NRD_NRD_1	191	193	PF00675	0.459
CLV_NRD_NRD_1	2	4	PF00675	0.480
CLV_PCSK_FUR_1	189	193	PF00082	0.462
CLV_PCSK_KEX2_1	127	129	PF00082	0.320
CLV_PCSK_KEX2_1	188	190	PF00082	0.470
CLV_PCSK_KEX2_1	191	193	PF00082	0.447
CLV_PCSK_KEX2_1	197	199	PF00082	0.407
CLV_PCSK_KEX2_1	4	6	PF00082	0.406
CLV_PCSK_PC1ET2_1	188	190	PF00082	0.470
CLV_PCSK_PC1ET2_1	191	193	PF00082	0.447
CLV_PCSK_PC1ET2_1	197	199	PF00082	0.407
CLV_PCSK_PC1ET2_1	4	6	PF00082	0.406
CLV_PCSK_SKI1_1	132	136	PF00082	0.372
CLV_PCSK_SKI1_1	194	198	PF00082	0.447
CLV_PCSK_SKI1_1	56	60	PF00082	0.239
CLV_Separin_Metazoa	74	78	PF03568	0.320
DEG_APCC_DBOX_1	126	134	PF00400	0.320
DEG_MDM2_SWIB_1	111	119	PF02201	0.370
DOC_MAPK_gen_1	125	135	PF00069	0.289
DOC_MAPK_gen_1	191	201	PF00069	0.447
DOC_PP1_RVXF_1	54	60	PF00149	0.257
DOC_USP7_UBL2_3	101	105	PF12436	0.401
DOC_USP7_UBL2_3	110	114	PF12436	0.173
DOC_USP7_UBL2_3	193	197	PF12436	0.448
DOC_WW_Pin1_4	31	36	PF00397	0.231
LIG_14-3-3_CanoR_1	140	144	PF00244	0.232
LIG_14-3-3_CanoR_1	192	201	PF00244	0.445
LIG_BIR_II_1	1	5	PF00653	0.512
LIG_BRCT_BRCA1_1	89	93	PF00533	0.320
LIG_FHA_2	118	124	PF00498	0.354
LIG_FHA_2	82	88	PF00498	0.251
LIG_LIR_Apic_2	89	95	PF02991	0.370
LIG_LIR_Gen_1	149	157	PF02991	0.264
LIG_LIR_Gen_1	81	87	PF02991	0.370
LIG_LIR_Nem_3	10	16	PF02991	0.320
LIG_LIR_Nem_3	149	154	PF02991	0.264
LIG_LIR_Nem_3	33	39	PF02991	0.232
LIG_LIR_Nem_3	81	86	PF02991	0.370
LIG_MLH1_MIPbox_1	89	93	PF16413	0.320
LIG_Pex14_2	111	115	PF04695	0.229
LIG_SH2_CRK	151	155	PF00017	0.320
LIG_SH2_SRC	151	154	PF00017	0.289
LIG_SH2_STAP1	151	155	PF00017	0.264
LIG_SH2_STAT5	153	156	PF00017	0.320
LIG_SH2_STAT5	92	95	PF00017	0.400
LIG_SUMO_SIM_par_1	116	123	PF11976	0.209
LIG_TYR_ITIM	11	16	PF00017	0.320
MOD_CK1_1	139	145	PF00069	0.325
MOD_CK2_1	117	123	PF00069	0.310
MOD_CK2_1	144	150	PF00069	0.266
MOD_CK2_1	81	87	PF00069	0.172
MOD_GlcNHglycan	146	149	PF01048	0.266
MOD_N-GLC_2	47	49	PF02516	0.198
MOD_NEK2_1	136	141	PF00069	0.289
MOD_NEK2_1	59	64	PF00069	0.229
MOD_PIKK_1	134	140	PF00454	0.323
MOD_PKA_1	192	198	PF00069	0.449
MOD_PKA_2	139	145	PF00069	0.229
MOD_PKA_2	177	183	PF00069	0.417
MOD_PKA_2	197	203	PF00069	0.357
MOD_Plk_1	81	87	PF00069	0.264
MOD_Plk_4	114	120	PF00069	0.314
MOD_Plk_4	197	203	PF00069	0.438
MOD_ProDKin_1	31	37	PF00069	0.231
MOD_SUMO_for_1	16	19	PF00179	0.231
MOD_SUMO_rev_2	90	98	PF00179	0.237
TRG_ENDOCYTIC_2	13	16	PF00928	0.285
TRG_ENDOCYTIC_2	151	154	PF00928	0.264
TRG_ENDOCYTIC_2	80	83	PF00928	0.378
TRG_ER_diArg_1	3	6	PF00400	0.452
TRG_NLS_MonoCore_2	190	195	PF00514	0.456
TRG_NLS_MonoExtC_3	187	192	PF00514	0.468
TRG_NLS_MonoExtC_3	2	7	PF00514	0.451
TRG_NLS_MonoExtN_4	188	195	PF00514	0.461
TRG_NLS_MonoExtN_4	3	8	PF00514	0.438

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I255	Leptomonas seymouri	78%	100%
A0A0S4JQP8	Bodo saltans	59%	100%
A0A0S4KI49	Bodo saltans	59%	100%
A0A1X0NLS9	Trypanosomatidae	63%	100%
A0A3R7KTV7	Trypanosoma rangeli	65%	100%
A0A3S7XCF0	Leishmania donovani	100%	100%
A4HQK8	Leishmania braziliensis	89%	100%
D0A3R0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	100%
E9AUC3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
O94645	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	31%	85%
Q4Q067	Leishmania major	98%	100%
Q6P3E0	Rattus norvegicus	45%	90%
Q6PFL8	Danio rerio	43%	88%
Q90679	Gallus gallus	40%	84%
Q91YJ3	Mus musculus	43%	90%
Q9P016	Homo sapiens	46%	91%