LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
Protein of unknown function (DUF2453) - putative
Species:
Leishmania infantum
UniProt:
A4ICC4_LEIIN
TriTrypDb:
LINF_360080300
Length:
350

Annotations

LeishMANIAdb annotations

These Kinetoplastid proteins share considerable homology with the animal TMEM65 proteins at their membrane domains, with a unique EF-hand at the N-terminus.. While the animal orthologs have a mitochondrial transit signal, it seems to be absent from the Kinetoplastid proteins. The latter have an alanine-rich segment of unclear function.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 12
NetGPI no yes: 0, no: 12
Cellular components
Term Name Level Count
GO:0016020 membrane 2 13
GO:0110165 cellular anatomical entity 1 13
GO:0005739 mitochondrion 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1

Expansion

Sequence features

A4ICC4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ICC4

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0005488 binding 1 11
GO:0005509 calcium ion binding 5 11
GO:0043167 ion binding 2 11
GO:0043169 cation binding 3 11
GO:0046872 metal ion binding 4 11

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 186 190 PF00656 0.249
CLV_C14_Caspase3-7 341 345 PF00656 0.354
CLV_C14_Caspase3-7 90 94 PF00656 0.592
CLV_NRD_NRD_1 115 117 PF00675 0.354
CLV_NRD_NRD_1 244 246 PF00675 0.250
CLV_NRD_NRD_1 68 70 PF00675 0.330
CLV_PCSK_KEX2_1 114 116 PF00082 0.342
CLV_PCSK_KEX2_1 122 124 PF00082 0.392
CLV_PCSK_KEX2_1 244 246 PF00082 0.261
CLV_PCSK_KEX2_1 67 69 PF00082 0.328
CLV_PCSK_PC1ET2_1 114 116 PF00082 0.383
CLV_PCSK_PC1ET2_1 122 124 PF00082 0.425
CLV_PCSK_SKI1_1 122 126 PF00082 0.491
CLV_PCSK_SKI1_1 128 132 PF00082 0.549
CLV_PCSK_SKI1_1 244 248 PF00082 0.275
CLV_PCSK_SKI1_1 346 350 PF00082 0.625
DEG_SPOP_SBC_1 30 34 PF00917 0.627
DOC_CDC14_PxL_1 264 272 PF14671 0.369
DOC_CKS1_1 231 236 PF01111 0.504
DOC_CYCLIN_RxL_1 303 314 PF00134 0.344
DOC_PP1_RVXF_1 226 232 PF00149 0.442
DOC_PP1_RVXF_1 327 333 PF00149 0.375
DOC_PP4_FxxP_1 231 234 PF00568 0.440
DOC_USP7_MATH_1 148 152 PF00917 0.708
DOC_USP7_MATH_1 24 28 PF00917 0.716
DOC_USP7_MATH_1 30 34 PF00917 0.727
DOC_USP7_UBL2_3 224 228 PF12436 0.452
DOC_WW_Pin1_4 142 147 PF00397 0.780
DOC_WW_Pin1_4 230 235 PF00397 0.470
DOC_WW_Pin1_4 98 103 PF00397 0.559
LIG_14-3-3_CanoR_1 123 130 PF00244 0.615
LIG_BIR_II_1 1 5 PF00653 0.657
LIG_BRCT_BRCA1_1 190 194 PF00533 0.348
LIG_Clathr_ClatBox_1 269 273 PF01394 0.335
LIG_FHA_1 151 157 PF00498 0.651
LIG_FHA_1 178 184 PF00498 0.263
LIG_FHA_1 231 237 PF00498 0.513
LIG_FHA_1 253 259 PF00498 0.291
LIG_FHA_2 129 135 PF00498 0.732
LIG_FHA_2 35 41 PF00498 0.590
LIG_LIR_Gen_1 280 290 PF02991 0.399
LIG_LIR_Gen_1 293 301 PF02991 0.374
LIG_LIR_Gen_1 331 340 PF02991 0.363
LIG_LIR_Nem_3 280 285 PF02991 0.400
LIG_LIR_Nem_3 293 298 PF02991 0.376
LIG_LIR_Nem_3 300 304 PF02991 0.363
LIG_LIR_Nem_3 331 335 PF02991 0.328
LIG_Pex14_2 105 109 PF04695 0.556
LIG_PTB_Apo_2 289 296 PF02174 0.379
LIG_SH2_GRB2like 195 198 PF00017 0.335
LIG_SH2_STAT5 195 198 PF00017 0.310
LIG_SH2_STAT5 282 285 PF00017 0.389
LIG_SH3_3 293 299 PF00018 0.326
LIG_SUMO_SIM_par_1 160 165 PF11976 0.363
LIG_TRAF2_1 85 88 PF00917 0.629
MOD_CDK_SPK_2 98 103 PF00069 0.559
MOD_CK1_1 135 141 PF00069 0.737
MOD_CK1_1 29 35 PF00069 0.702
MOD_CK2_1 128 134 PF00069 0.768
MOD_CK2_1 34 40 PF00069 0.606
MOD_GlcNHglycan 110 113 PF01048 0.387
MOD_GlcNHglycan 134 137 PF01048 0.580
MOD_GlcNHglycan 202 205 PF01048 0.303
MOD_GlcNHglycan 210 213 PF01048 0.245
MOD_GlcNHglycan 26 29 PF01048 0.517
MOD_GlcNHglycan 292 295 PF01048 0.555
MOD_GlcNHglycan 83 86 PF01048 0.402
MOD_GSK3_1 128 135 PF00069 0.712
MOD_GSK3_1 196 203 PF00069 0.380
MOD_GSK3_1 22 29 PF00069 0.692
MOD_GSK3_1 230 237 PF00069 0.487
MOD_GSK3_1 273 280 PF00069 0.394
MOD_GSK3_1 30 37 PF00069 0.622
MOD_N-GLC_1 177 182 PF02516 0.501
MOD_N-GLC_1 196 201 PF02516 0.170
MOD_N-GLC_1 290 295 PF02516 0.590
MOD_N-GLC_2 208 210 PF02516 0.417
MOD_NEK2_1 1 6 PF00069 0.745
MOD_NEK2_1 176 181 PF00069 0.339
MOD_NEK2_1 196 201 PF00069 0.272
MOD_NEK2_1 252 257 PF00069 0.374
MOD_NEK2_1 70 75 PF00069 0.637
MOD_PIKK_1 333 339 PF00454 0.361
MOD_PKA_1 122 128 PF00069 0.642
MOD_PKA_2 122 128 PF00069 0.711
MOD_Plk_1 176 182 PF00069 0.279
MOD_Plk_1 196 202 PF00069 0.141
MOD_Plk_4 177 183 PF00069 0.282
MOD_Plk_4 196 202 PF00069 0.170
MOD_Plk_4 31 37 PF00069 0.679
MOD_ProDKin_1 142 148 PF00069 0.776
MOD_ProDKin_1 230 236 PF00069 0.470
MOD_ProDKin_1 98 104 PF00069 0.554
MOD_SUMO_rev_2 341 348 PF00179 0.456
TRG_DiLeu_BaLyEn_6 265 270 PF01217 0.262
TRG_ENDOCYTIC_2 282 285 PF00928 0.378
TRG_ER_diArg_1 244 246 PF00400 0.461
TRG_ER_diArg_1 67 69 PF00400 0.527
TRG_NLS_MonoExtC_3 120 126 PF00514 0.691
TRG_Pf-PMV_PEXEL_1 303 307 PF00026 0.566
TRG_Pf-PMV_PEXEL_1 318 322 PF00026 0.572
TRG_Pf-PMV_PEXEL_1 5 9 PF00026 0.490
TRG_Pf-PMV_PEXEL_1 53 57 PF00026 0.437

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P806 Leptomonas seymouri 80% 99%
A0A0S4J8V3 Bodo saltans 34% 100%
A0A0S4JY67 Bodo saltans 55% 100%
A0A1X0NL71 Trypanosomatidae 56% 100%
A0A3R7NFF7 Trypanosoma rangeli 30% 90%
A0A3S7XCB7 Leishmania donovani 96% 100%
A4HQK4 Leishmania braziliensis 85% 100%
E9AUB9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
Q4Q071 Leishmania major 96% 100%
V5BGX0 Trypanosoma cruzi 34% 84%
V5BHN9 Trypanosoma cruzi 55% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS