LeishMANIAdb
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CG7219 protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
CG7219 protein
Gene product:
CG1104 protein-like protein
Species:
Leishmania infantum
UniProt:
A4ICC0_LEIIN
TriTrypDb:
LINF_360079900
Length:
737

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0005789 endoplasmic reticulum membrane 4 1
GO:0016020 membrane 2 1
GO:0031090 organelle membrane 3 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4ICC0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ICC0

Function

Biological processes
Term Name Level Count
GO:0006807 nitrogen compound metabolic process 2 12
GO:0008152 metabolic process 1 12
GO:0019538 protein metabolic process 3 12
GO:0032446 protein modification by small protein conjugation 6 12
GO:0036211 protein modification process 4 12
GO:0043170 macromolecule metabolic process 3 12
GO:0043412 macromolecule modification 4 12
GO:0044238 primary metabolic process 2 12
GO:0070647 protein modification by small protein conjugation or removal 5 12
GO:0071569 protein ufmylation 7 12
GO:0071704 organic substance metabolic process 2 12
GO:1901564 organonitrogen compound metabolic process 3 12
GO:0006950 response to stress 2 1
GO:0009894 regulation of catabolic process 4 1
GO:0009987 cellular process 1 1
GO:0019222 regulation of metabolic process 3 1
GO:0030162 regulation of proteolysis 6 1
GO:0031323 regulation of cellular metabolic process 4 1
GO:0031329 regulation of cellular catabolic process 5 1
GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process 7 1
GO:0033554 cellular response to stress 3 1
GO:0034976 response to endoplasmic reticulum stress 4 1
GO:0042176 regulation of protein catabolic process 5 1
GO:0050789 regulation of biological process 2 1
GO:0050794 regulation of cellular process 3 1
GO:0050896 response to stimulus 1 1
GO:0051171 regulation of nitrogen compound metabolic process 4 1
GO:0051246 regulation of protein metabolic process 5 1
GO:0051716 cellular response to stimulus 2 1
GO:0060255 regulation of macromolecule metabolic process 4 1
GO:0061136 regulation of proteasomal protein catabolic process 6 1
GO:0065007 biological regulation 1 1
GO:0080090 regulation of primary metabolic process 4 1
GO:1903050 regulation of proteolysis involved in protein catabolic process 7 1
GO:1990564 protein polyufmylation 8 1
GO:1990592 protein K69-linked ufmylation 9 1
GO:2000058 regulation of ubiquitin-dependent protein catabolic process 6 1
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 12
GO:0016740 transferase activity 2 12
GO:0019787 ubiquitin-like protein transferase activity 3 12
GO:0061659 ubiquitin-like protein ligase activity 4 12
GO:0061666 UFM1 ligase activity 5 12
GO:0071568 UFM1 transferase activity 4 12
GO:0140096 catalytic activity, acting on a protein 2 12

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 520 524 PF00656 0.320
CLV_NRD_NRD_1 304 306 PF00675 0.603
CLV_NRD_NRD_1 308 310 PF00675 0.572
CLV_NRD_NRD_1 585 587 PF00675 0.408
CLV_PCSK_KEX2_1 11 13 PF00082 0.434
CLV_PCSK_KEX2_1 204 206 PF00082 0.362
CLV_PCSK_KEX2_1 242 244 PF00082 0.362
CLV_PCSK_KEX2_1 308 310 PF00082 0.519
CLV_PCSK_KEX2_1 585 587 PF00082 0.410
CLV_PCSK_KEX2_1 61 63 PF00082 0.306
CLV_PCSK_PC1ET2_1 11 13 PF00082 0.434
CLV_PCSK_PC1ET2_1 204 206 PF00082 0.232
CLV_PCSK_PC1ET2_1 242 244 PF00082 0.331
CLV_PCSK_PC1ET2_1 61 63 PF00082 0.411
CLV_PCSK_SKI1_1 152 156 PF00082 0.373
CLV_PCSK_SKI1_1 364 368 PF00082 0.333
CLV_PCSK_SKI1_1 420 424 PF00082 0.490
CLV_PCSK_SKI1_1 494 498 PF00082 0.566
CLV_PCSK_SKI1_1 576 580 PF00082 0.416
CLV_PCSK_SKI1_1 730 734 PF00082 0.403
CLV_Separin_Metazoa 195 199 PF03568 0.331
CLV_Separin_Metazoa 458 462 PF03568 0.497
DEG_APCC_DBOX_1 585 593 PF00400 0.357
DEG_Nend_UBRbox_2 1 3 PF02207 0.551
DOC_CDC14_PxL_1 352 360 PF14671 0.412
DOC_CYCLIN_RxL_1 573 583 PF00134 0.433
DOC_CYCLIN_yClb5_NLxxxL_5 37 46 PF00134 0.287
DOC_MAPK_gen_1 39 47 PF00069 0.340
DOC_MAPK_gen_1 431 437 PF00069 0.617
DOC_MAPK_gen_1 585 592 PF00069 0.495
DOC_MAPK_gen_1 627 637 PF00069 0.401
DOC_MAPK_MEF2A_6 321 329 PF00069 0.617
DOC_MAPK_MEF2A_6 364 371 PF00069 0.356
DOC_MAPK_MEF2A_6 39 47 PF00069 0.361
DOC_MAPK_MEF2A_6 628 637 PF00069 0.398
DOC_MAPK_NFAT4_5 40 48 PF00069 0.387
DOC_MIT_MIM_1 8 16 PF04212 0.411
DOC_PP1_RVXF_1 511 518 PF00149 0.338
DOC_PP2B_LxvP_1 208 211 PF13499 0.311
DOC_PP2B_LxvP_1 449 452 PF13499 0.485
DOC_PP2B_LxvP_1 552 555 PF13499 0.459
DOC_PP4_FxxP_1 622 625 PF00568 0.407
DOC_USP7_MATH_1 211 215 PF00917 0.426
DOC_USP7_MATH_1 292 296 PF00917 0.633
DOC_USP7_MATH_1 357 361 PF00917 0.435
DOC_USP7_MATH_1 430 434 PF00917 0.569
DOC_USP7_MATH_1 618 622 PF00917 0.408
DOC_USP7_MATH_1 648 652 PF00917 0.578
DOC_USP7_MATH_1 94 98 PF00917 0.265
DOC_USP7_UBL2_3 306 310 PF12436 0.642
LIG_14-3-3_CanoR_1 12 17 PF00244 0.373
LIG_14-3-3_CanoR_1 326 330 PF00244 0.568
LIG_14-3-3_CanoR_1 504 510 PF00244 0.439
LIG_14-3-3_CanoR_1 532 542 PF00244 0.366
LIG_14-3-3_CanoR_1 585 590 PF00244 0.436
LIG_14-3-3_CanoR_1 691 699 PF00244 0.457
LIG_14-3-3_CanoR_1 730 735 PF00244 0.407
LIG_APCC_ABBA_1 375 380 PF00400 0.486
LIG_BRCT_BRCA1_1 146 150 PF00533 0.360
LIG_BRCT_BRCA1_2 146 152 PF00533 0.331
LIG_eIF4E_1 203 209 PF01652 0.411
LIG_FHA_1 174 180 PF00498 0.271
LIG_FHA_1 242 248 PF00498 0.426
LIG_FHA_1 406 412 PF00498 0.498
LIG_FHA_1 665 671 PF00498 0.428
LIG_FHA_1 729 735 PF00498 0.551
LIG_FHA_1 86 92 PF00498 0.392
LIG_FHA_2 54 60 PF00498 0.411
LIG_FHA_2 578 584 PF00498 0.427
LIG_FHA_2 605 611 PF00498 0.492
LIG_FHA_2 723 729 PF00498 0.513
LIG_GBD_Chelix_1 470 478 PF00786 0.498
LIG_LIR_Apic_2 276 281 PF02991 0.473
LIG_LIR_Apic_2 621 625 PF02991 0.402
LIG_LIR_Gen_1 138 146 PF02991 0.309
LIG_LIR_Gen_1 175 186 PF02991 0.432
LIG_LIR_Gen_1 503 512 PF02991 0.416
LIG_LIR_Gen_1 56 65 PF02991 0.266
LIG_LIR_Gen_1 632 642 PF02991 0.467
LIG_LIR_Nem_3 175 181 PF02991 0.383
LIG_LIR_Nem_3 207 212 PF02991 0.440
LIG_LIR_Nem_3 231 237 PF02991 0.431
LIG_LIR_Nem_3 258 262 PF02991 0.282
LIG_LIR_Nem_3 382 388 PF02991 0.444
LIG_LIR_Nem_3 394 399 PF02991 0.382
LIG_LIR_Nem_3 454 459 PF02991 0.422
LIG_LIR_Nem_3 465 470 PF02991 0.360
LIG_LIR_Nem_3 503 508 PF02991 0.425
LIG_LIR_Nem_3 56 60 PF02991 0.266
LIG_LIR_Nem_3 632 637 PF02991 0.528
LIG_LYPXL_S_1 395 399 PF13949 0.503
LIG_LYPXL_yS_3 396 399 PF13949 0.502
LIG_NRBOX 41 47 PF00104 0.314
LIG_NRBOX 664 670 PF00104 0.386
LIG_PCNA_PIPBox_1 143 152 PF02747 0.287
LIG_SH2_CRK 259 263 PF00017 0.266
LIG_SH2_NCK_1 278 282 PF00017 0.559
LIG_SH2_PTP2 234 237 PF00017 0.331
LIG_SH2_PTP2 634 637 PF00017 0.390
LIG_SH2_SRC 117 120 PF00017 0.266
LIG_SH2_STAP1 174 178 PF00017 0.325
LIG_SH2_STAT3 174 177 PF00017 0.325
LIG_SH2_STAT5 117 120 PF00017 0.266
LIG_SH2_STAT5 174 177 PF00017 0.304
LIG_SH2_STAT5 234 237 PF00017 0.266
LIG_SH2_STAT5 273 276 PF00017 0.460
LIG_SH2_STAT5 351 354 PF00017 0.373
LIG_SH2_STAT5 54 57 PF00017 0.281
LIG_SH2_STAT5 634 637 PF00017 0.496
LIG_SH3_3 565 571 PF00018 0.493
LIG_SH3_3 675 681 PF00018 0.375
LIG_SH3_3 75 81 PF00018 0.281
LIG_SUMO_SIM_par_1 103 108 PF11976 0.434
LIG_SUMO_SIM_par_1 407 412 PF11976 0.519
LIG_SUMO_SIM_par_1 614 621 PF11976 0.530
LIG_SUMO_SIM_par_1 731 737 PF11976 0.372
LIG_SUMO_SIM_par_1 82 88 PF11976 0.353
LIG_TRAF2_1 192 195 PF00917 0.331
LIG_TRAF2_1 414 417 PF00917 0.432
LIG_TRAF2_1 496 499 PF00917 0.386
LIG_TRAF2_1 725 728 PF00917 0.436
LIG_TYR_ITIM 257 262 PF00017 0.266
LIG_UBA3_1 377 383 PF00899 0.539
LIG_UBA3_1 589 597 PF00899 0.560
LIG_WRC_WIRS_1 578 583 PF05994 0.304
LIG_WRC_WIRS_1 619 624 PF05994 0.410
LIG_WRC_WIRS_1 86 91 PF05994 0.427
MOD_CK1_1 172 178 PF00069 0.357
MOD_CK1_1 296 302 PF00069 0.705
MOD_CK1_1 664 670 PF00069 0.370
MOD_CK1_1 85 91 PF00069 0.381
MOD_CK2_1 53 59 PF00069 0.416
MOD_CK2_1 577 583 PF00069 0.419
MOD_CK2_1 604 610 PF00069 0.453
MOD_CK2_1 714 720 PF00069 0.473
MOD_CK2_1 722 728 PF00069 0.413
MOD_CK2_1 94 100 PF00069 0.296
MOD_Cter_Amidation 306 309 PF01082 0.596
MOD_GlcNHglycan 298 301 PF01048 0.710
MOD_GlcNHglycan 331 334 PF01048 0.546
MOD_GlcNHglycan 400 403 PF01048 0.567
MOD_GlcNHglycan 411 414 PF01048 0.441
MOD_GlcNHglycan 480 483 PF01048 0.592
MOD_GlcNHglycan 526 529 PF01048 0.470
MOD_GlcNHglycan 610 614 PF01048 0.420
MOD_GSK3_1 131 138 PF00069 0.308
MOD_GSK3_1 169 176 PF00069 0.300
MOD_GSK3_1 288 295 PF00069 0.561
MOD_GSK3_1 325 332 PF00069 0.495
MOD_GSK3_1 405 412 PF00069 0.403
MOD_GSK3_1 431 438 PF00069 0.587
MOD_GSK3_1 577 584 PF00069 0.450
MOD_GSK3_1 660 667 PF00069 0.443
MOD_GSK3_1 714 721 PF00069 0.409
MOD_GSK3_1 730 737 PF00069 0.495
MOD_N-GLC_1 548 553 PF02516 0.381
MOD_N-GLC_2 254 256 PF02516 0.265
MOD_NEK2_1 135 140 PF00069 0.348
MOD_NEK2_1 150 155 PF00069 0.193
MOD_NEK2_1 173 178 PF00069 0.248
MOD_NEK2_1 212 217 PF00069 0.349
MOD_NEK2_1 228 233 PF00069 0.283
MOD_NEK2_1 250 255 PF00069 0.323
MOD_NEK2_1 293 298 PF00069 0.563
MOD_NEK2_1 478 483 PF00069 0.552
MOD_NEK2_1 508 513 PF00069 0.381
MOD_NEK2_1 581 586 PF00069 0.500
MOD_NEK2_1 604 609 PF00069 0.374
MOD_NEK2_1 611 616 PF00069 0.345
MOD_NEK2_1 661 666 PF00069 0.337
MOD_NEK2_2 618 623 PF00069 0.411
MOD_NEK2_2 82 87 PF00069 0.337
MOD_PIKK_1 135 141 PF00454 0.393
MOD_PIKK_1 173 179 PF00454 0.246
MOD_PIKK_1 566 572 PF00454 0.530
MOD_PK_1 431 437 PF00069 0.385
MOD_PK_1 597 603 PF00069 0.433
MOD_PK_1 646 652 PF00069 0.434
MOD_PKA_1 431 437 PF00069 0.485
MOD_PKA_1 585 591 PF00069 0.443
MOD_PKA_2 325 331 PF00069 0.586
MOD_PKA_2 503 509 PF00069 0.448
MOD_PKA_2 585 591 PF00069 0.445
MOD_PKA_2 714 720 PF00069 0.532
MOD_Plk_1 169 175 PF00069 0.397
MOD_Plk_1 548 554 PF00069 0.391
MOD_Plk_1 597 603 PF00069 0.507
MOD_Plk_2-3 53 59 PF00069 0.266
MOD_Plk_2-3 722 728 PF00069 0.446
MOD_Plk_4 145 151 PF00069 0.286
MOD_Plk_4 169 175 PF00069 0.428
MOD_Plk_4 212 218 PF00069 0.339
MOD_Plk_4 229 235 PF00069 0.286
MOD_Plk_4 357 363 PF00069 0.416
MOD_Plk_4 400 406 PF00069 0.416
MOD_Plk_4 444 450 PF00069 0.453
MOD_Plk_4 585 591 PF00069 0.537
MOD_Plk_4 664 670 PF00069 0.316
MOD_Plk_4 94 100 PF00069 0.417
MOD_SUMO_for_1 60 63 PF00179 0.411
MOD_SUMO_for_1 692 695 PF00179 0.447
MOD_SUMO_rev_2 412 422 PF00179 0.393
MOD_SUMO_rev_2 639 648 PF00179 0.507
TRG_DiLeu_BaEn_1 108 113 PF01217 0.281
TRG_DiLeu_BaEn_1 400 405 PF01217 0.502
TRG_DiLeu_BaEn_1 5 10 PF01217 0.271
TRG_DiLeu_BaEn_4 100 106 PF01217 0.287
TRG_DiLeu_BaEn_4 194 200 PF01217 0.331
TRG_DiLeu_BaLyEn_6 383 388 PF01217 0.363
TRG_DiLeu_BaLyEn_6 588 593 PF01217 0.494
TRG_DiLeu_LyEn_5 258 263 PF01217 0.210
TRG_ENDOCYTIC_2 234 237 PF00928 0.425
TRG_ENDOCYTIC_2 259 262 PF00928 0.266
TRG_ENDOCYTIC_2 396 399 PF00928 0.502
TRG_ENDOCYTIC_2 456 459 PF00928 0.436
TRG_ENDOCYTIC_2 634 637 PF00928 0.514
TRG_ER_diArg_1 161 164 PF00400 0.331
TRG_NES_CRM1_1 365 380 PF08389 0.440
TRG_NLS_MonoExtC_3 304 309 PF00514 0.607
TRG_Pf-PMV_PEXEL_1 461 465 PF00026 0.477
TRG_Pf-PMV_PEXEL_1 62 66 PF00026 0.366

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IM39 Leptomonas seymouri 66% 100%
A0A0S4JTJ6 Bodo saltans 35% 95%
A0A1X0NLV8 Trypanosomatidae 41% 98%
A0A3S7XCH5 Leishmania donovani 99% 100%
A0A422NVV8 Trypanosoma rangeli 41% 99%
A4HQK2 Leishmania braziliensis 81% 100%
D0A3Q3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 42% 100%
E9AUB5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 89% 99%
Q4Q075 Leishmania major 91% 100%
V5AXN4 Trypanosoma cruzi 39% 99%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS