LeishMANIAdb
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AP complex subunit beta

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
AP complex subunit beta
Gene product:
adaptin complex 1 subunit - putative
Species:
Leishmania infantum
UniProt:
A4ICB7_LEIIN
TriTrypDb:
LINF_360079500
Length:
746

Annotations

Annotations by Jardim et al.

Intracellular protein trafficking, AP complex subunit beta

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0030117 membrane coat 3 10
GO:0032991 protein-containing complex 1 12
GO:0098796 membrane protein complex 2 12
GO:0016020 membrane 2 1
GO:0110165 cellular anatomical entity 1 1
GO:0030119 AP-type membrane coat adaptor complex 3 2
GO:0030131 clathrin adaptor complex 4 2

Expansion

Sequence features

A4ICB7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ICB7

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 12
GO:0006886 intracellular protein transport 4 12
GO:0008104 protein localization 4 12
GO:0009987 cellular process 1 12
GO:0015031 protein transport 4 12
GO:0016192 vesicle-mediated transport 4 12
GO:0033036 macromolecule localization 2 12
GO:0045184 establishment of protein localization 3 12
GO:0046907 intracellular transport 3 12
GO:0051179 localization 1 12
GO:0051234 establishment of localization 2 12
GO:0051641 cellular localization 2 12
GO:0051649 establishment of localization in cell 3 12
GO:0070727 cellular macromolecule localization 3 12
GO:0071702 organic substance transport 4 12
GO:0071705 nitrogen compound transport 4 12
Molecular functions
Term Name Level Count
GO:0005488 binding 1 8
GO:0005515 protein binding 2 8
GO:0030276 clathrin binding 3 8

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 334 338 PF00656 0.293
CLV_C14_Caspase3-7 569 573 PF00656 0.397
CLV_C14_Caspase3-7 634 638 PF00656 0.653
CLV_NRD_NRD_1 13 15 PF00675 0.459
CLV_NRD_NRD_1 146 148 PF00675 0.248
CLV_NRD_NRD_1 156 158 PF00675 0.229
CLV_NRD_NRD_1 30 32 PF00675 0.355
CLV_NRD_NRD_1 416 418 PF00675 0.304
CLV_NRD_NRD_1 432 434 PF00675 0.162
CLV_NRD_NRD_1 47 49 PF00675 0.274
CLV_NRD_NRD_1 5 7 PF00675 0.429
CLV_PCSK_KEX2_1 146 148 PF00082 0.274
CLV_PCSK_KEX2_1 30 32 PF00082 0.514
CLV_PCSK_KEX2_1 308 310 PF00082 0.386
CLV_PCSK_KEX2_1 416 418 PF00082 0.232
CLV_PCSK_KEX2_1 54 56 PF00082 0.240
CLV_PCSK_PC1ET2_1 308 310 PF00082 0.366
CLV_PCSK_PC1ET2_1 54 56 PF00082 0.240
CLV_PCSK_SKI1_1 102 106 PF00082 0.386
CLV_PCSK_SKI1_1 355 359 PF00082 0.240
CLV_PCSK_SKI1_1 504 508 PF00082 0.255
CLV_PCSK_SKI1_1 546 550 PF00082 0.504
CLV_Separin_Metazoa 143 147 PF03568 0.255
CLV_Separin_Metazoa 387 391 PF03568 0.323
DEG_APCC_DBOX_1 492 500 PF00400 0.386
DEG_Nend_UBRbox_2 1 3 PF02207 0.457
DOC_CKS1_1 360 365 PF01111 0.256
DOC_CKS1_1 622 627 PF01111 0.666
DOC_CYCLIN_RxL_1 350 362 PF00134 0.255
DOC_CYCLIN_RxL_1 97 109 PF00134 0.302
DOC_MAPK_DCC_7 342 351 PF00069 0.240
DOC_MAPK_gen_1 157 164 PF00069 0.265
DOC_MAPK_gen_1 181 187 PF00069 0.386
DOC_MAPK_gen_1 350 360 PF00069 0.240
DOC_MAPK_gen_1 433 441 PF00069 0.240
DOC_MAPK_gen_1 85 92 PF00069 0.240
DOC_MAPK_HePTP_8 316 328 PF00069 0.240
DOC_MAPK_MEF2A_6 127 134 PF00069 0.279
DOC_MAPK_MEF2A_6 319 328 PF00069 0.240
DOC_MAPK_MEF2A_6 342 351 PF00069 0.240
DOC_MAPK_MEF2A_6 353 360 PF00069 0.240
DOC_MAPK_MEF2A_6 390 399 PF00069 0.244
DOC_MAPK_MEF2A_6 433 440 PF00069 0.274
DOC_MAPK_MEF2A_6 64 73 PF00069 0.289
DOC_MAPK_MEF2A_6 85 92 PF00069 0.274
DOC_MAPK_NFAT4_5 353 361 PF00069 0.240
DOC_MAPK_RevD_3 71 86 PF00069 0.240
DOC_PP4_FxxP_1 590 593 PF00568 0.351
DOC_PP4_FxxP_1 597 600 PF00568 0.401
DOC_USP7_MATH_1 361 365 PF00917 0.368
DOC_USP7_MATH_1 391 395 PF00917 0.366
DOC_USP7_MATH_1 458 462 PF00917 0.240
DOC_USP7_MATH_1 593 597 PF00917 0.356
DOC_USP7_MATH_1 623 627 PF00917 0.683
DOC_USP7_MATH_1 658 662 PF00917 0.613
DOC_USP7_MATH_1 678 682 PF00917 0.428
DOC_USP7_MATH_1 693 697 PF00917 0.556
DOC_USP7_UBL2_3 20 24 PF12436 0.546
DOC_USP7_UBL2_3 50 54 PF12436 0.243
DOC_WW_Pin1_4 115 120 PF00397 0.240
DOC_WW_Pin1_4 359 364 PF00397 0.256
DOC_WW_Pin1_4 621 626 PF00397 0.597
DOC_WW_Pin1_4 676 681 PF00397 0.609
DOC_WW_Pin1_4 684 689 PF00397 0.653
DOC_WW_Pin1_4 698 703 PF00397 0.646
LIG_14-3-3_CanoR_1 133 138 PF00244 0.447
LIG_14-3-3_CanoR_1 157 164 PF00244 0.265
LIG_14-3-3_CanoR_1 286 292 PF00244 0.284
LIG_14-3-3_CanoR_1 294 298 PF00244 0.253
LIG_14-3-3_CanoR_1 342 346 PF00244 0.253
LIG_14-3-3_CanoR_1 390 396 PF00244 0.293
LIG_14-3-3_CanoR_1 592 598 PF00244 0.444
LIG_Actin_WH2_2 130 148 PF00022 0.255
LIG_Actin_WH2_2 344 361 PF00022 0.302
LIG_Actin_WH2_2 567 582 PF00022 0.407
LIG_AP2alpha_1 672 676 PF02296 0.633
LIG_AP2alpha_2 670 672 PF02296 0.638
LIG_BRCT_BRCA1_1 22 26 PF00533 0.427
LIG_BRCT_BRCA1_1 66 70 PF00533 0.255
LIG_BRCT_BRCA1_1 686 690 PF00533 0.630
LIG_Clathr_ClatBox_1 438 442 PF01394 0.334
LIG_FHA_1 257 263 PF00498 0.334
LIG_FHA_1 294 300 PF00498 0.360
LIG_FHA_1 311 317 PF00498 0.166
LIG_FHA_1 360 366 PF00498 0.443
LIG_FHA_1 583 589 PF00498 0.370
LIG_FHA_1 93 99 PF00498 0.386
LIG_FHA_2 332 338 PF00498 0.377
LIG_FHA_2 484 490 PF00498 0.365
LIG_FHA_2 524 530 PF00498 0.277
LIG_FHA_2 567 573 PF00498 0.462
LIG_FHA_2 611 617 PF00498 0.668
LIG_FHA_2 78 84 PF00498 0.334
LIG_LIR_Apic_2 596 600 PF02991 0.412
LIG_LIR_Gen_1 345 356 PF02991 0.309
LIG_LIR_Gen_1 468 473 PF02991 0.240
LIG_LIR_Gen_1 644 651 PF02991 0.667
LIG_LIR_Gen_1 65 76 PF02991 0.243
LIG_LIR_Nem_3 337 343 PF02991 0.292
LIG_LIR_Nem_3 345 351 PF02991 0.293
LIG_LIR_Nem_3 468 472 PF02991 0.246
LIG_LIR_Nem_3 644 649 PF02991 0.586
LIG_LIR_Nem_3 65 71 PF02991 0.262
LIG_LIR_Nem_3 670 675 PF02991 0.635
LIG_LYPXL_SIV_4 600 608 PF13949 0.581
LIG_LYPXL_yS_3 435 438 PF13949 0.243
LIG_MAD2 555 563 PF02301 0.497
LIG_MLH1_MIPbox_1 22 26 PF16413 0.427
LIG_MYND_1 418 422 PF01753 0.255
LIG_NRBOX 183 189 PF00104 0.255
LIG_NRBOX 353 359 PF00104 0.255
LIG_Pex14_1 234 238 PF04695 0.299
LIG_Pex14_2 672 676 PF04695 0.633
LIG_RPA_C_Fungi 26 38 PF08784 0.349
LIG_SH2_NCK_1 343 347 PF00017 0.302
LIG_SH2_SRC 89 92 PF00017 0.240
LIG_SH2_STAT3 25 28 PF00017 0.580
LIG_SH2_STAT5 140 143 PF00017 0.288
LIG_SH2_STAT5 155 158 PF00017 0.298
LIG_SH2_STAT5 238 241 PF00017 0.379
LIG_SH2_STAT5 25 28 PF00017 0.580
LIG_SH2_STAT5 315 318 PF00017 0.255
LIG_SH2_STAT5 340 343 PF00017 0.242
LIG_SH2_STAT5 469 472 PF00017 0.383
LIG_SH2_STAT5 68 71 PF00017 0.299
LIG_SH2_STAT5 89 92 PF00017 0.240
LIG_SH3_3 146 152 PF00018 0.301
LIG_SH3_3 323 329 PF00018 0.240
LIG_SH3_3 616 622 PF00018 0.619
LIG_SH3_3 696 702 PF00018 0.734
LIG_SH3_3 721 727 PF00018 0.542
LIG_SUMO_SIM_anti_2 183 190 PF11976 0.338
LIG_SUMO_SIM_par_1 103 109 PF11976 0.386
LIG_SUMO_SIM_par_1 437 442 PF11976 0.290
LIG_TRFH_1 140 144 PF08558 0.255
LIG_TYR_ITIM 66 71 PF00017 0.386
LIG_TYR_ITIM 87 92 PF00017 0.240
LIG_UBA3_1 303 308 PF00899 0.309
LIG_WRC_WIRS_1 107 112 PF05994 0.240
LIG_WRC_WIRS_1 594 599 PF05994 0.367
MOD_CDK_SPxxK_3 115 122 PF00069 0.240
MOD_CK1_1 253 259 PF00069 0.330
MOD_CK1_1 285 291 PF00069 0.345
MOD_CK1_1 582 588 PF00069 0.396
MOD_CK1_1 626 632 PF00069 0.602
MOD_CK1_1 679 685 PF00069 0.651
MOD_CK1_1 701 707 PF00069 0.656
MOD_CK2_1 133 139 PF00069 0.313
MOD_CK2_1 213 219 PF00069 0.386
MOD_CK2_1 246 252 PF00069 0.314
MOD_CK2_1 483 489 PF00069 0.338
MOD_CK2_1 704 710 PF00069 0.596
MOD_CK2_1 77 83 PF00069 0.334
MOD_GlcNHglycan 252 255 PF01048 0.334
MOD_GlcNHglycan 377 380 PF01048 0.392
MOD_GlcNHglycan 499 502 PF01048 0.240
MOD_GlcNHglycan 633 636 PF01048 0.663
MOD_GlcNHglycan 660 663 PF01048 0.628
MOD_GlcNHglycan 676 679 PF01048 0.526
MOD_GlcNHglycan 693 696 PF01048 0.608
MOD_GlcNHglycan 706 709 PF01048 0.593
MOD_GlcNHglycan 718 721 PF01048 0.580
MOD_GlcNHglycan 728 731 PF01048 0.703
MOD_GlcNHglycan 733 736 PF01048 0.684
MOD_GSK3_1 111 118 PF00069 0.255
MOD_GSK3_1 16 23 PF00069 0.465
MOD_GSK3_1 246 253 PF00069 0.346
MOD_GSK3_1 298 305 PF00069 0.252
MOD_GSK3_1 542 549 PF00069 0.386
MOD_GSK3_1 568 575 PF00069 0.439
MOD_GSK3_1 674 681 PF00069 0.655
MOD_GSK3_1 716 723 PF00069 0.682
MOD_N-GLC_1 115 120 PF02516 0.262
MOD_N-GLC_1 41 46 PF02516 0.334
MOD_N-GLC_1 58 63 PF02516 0.334
MOD_NEK2_1 111 116 PF00069 0.255
MOD_NEK2_1 16 21 PF00069 0.480
MOD_NEK2_1 26 31 PF00069 0.423
MOD_NEK2_1 331 336 PF00069 0.323
MOD_NEK2_1 483 488 PF00069 0.392
MOD_NEK2_1 579 584 PF00069 0.337
MOD_PIKK_1 285 291 PF00454 0.366
MOD_PIKK_1 310 316 PF00454 0.274
MOD_PIKK_1 626 632 PF00454 0.723
MOD_PIKK_1 693 699 PF00454 0.751
MOD_PIKK_1 718 724 PF00454 0.682
MOD_PIKK_1 736 742 PF00454 0.597
MOD_PK_1 133 139 PF00069 0.301
MOD_PKA_2 132 138 PF00069 0.359
MOD_PKA_2 156 162 PF00069 0.255
MOD_PKA_2 246 252 PF00069 0.341
MOD_PKA_2 285 291 PF00069 0.325
MOD_PKA_2 293 299 PF00069 0.346
MOD_PKA_2 341 347 PF00069 0.253
MOD_PKA_2 736 742 PF00069 0.597
MOD_Plk_1 138 144 PF00069 0.240
MOD_Plk_1 566 572 PF00069 0.426
MOD_Plk_1 58 64 PF00069 0.272
MOD_Plk_2-3 509 515 PF00069 0.323
MOD_Plk_2-3 572 578 PF00069 0.392
MOD_Plk_2-3 610 616 PF00069 0.575
MOD_Plk_4 106 112 PF00069 0.240
MOD_Plk_4 133 139 PF00069 0.386
MOD_Plk_4 253 259 PF00069 0.308
MOD_Plk_4 458 464 PF00069 0.312
MOD_Plk_4 483 489 PF00069 0.371
MOD_Plk_4 593 599 PF00069 0.396
MOD_Plk_4 64 70 PF00069 0.299
MOD_ProDKin_1 115 121 PF00069 0.240
MOD_ProDKin_1 359 365 PF00069 0.256
MOD_ProDKin_1 621 627 PF00069 0.597
MOD_ProDKin_1 676 682 PF00069 0.610
MOD_ProDKin_1 684 690 PF00069 0.656
MOD_ProDKin_1 698 704 PF00069 0.647
MOD_SUMO_for_1 349 352 PF00179 0.240
MOD_SUMO_rev_2 17 21 PF00179 0.608
MOD_SUMO_rev_2 451 461 PF00179 0.281
MOD_SUMO_rev_2 572 582 PF00179 0.392
MOD_SUMO_rev_2 79 87 PF00179 0.386
TRG_AP2beta_CARGO_1 345 355 PF09066 0.302
TRG_DiLeu_BaEn_1 352 357 PF01217 0.240
TRG_DiLeu_BaEn_1 83 88 PF01217 0.240
TRG_DiLeu_BaEn_2 467 473 PF01217 0.240
TRG_DiLeu_BaLyEn_6 539 544 PF01217 0.240
TRG_DiLeu_LyEn_5 352 357 PF01217 0.255
TRG_ENDOCYTIC_2 435 438 PF00928 0.243
TRG_ENDOCYTIC_2 469 472 PF00928 0.386
TRG_ENDOCYTIC_2 540 543 PF00928 0.288
TRG_ENDOCYTIC_2 594 597 PF00928 0.363
TRG_ENDOCYTIC_2 643 646 PF00928 0.698
TRG_ENDOCYTIC_2 68 71 PF00928 0.299
TRG_ENDOCYTIC_2 89 92 PF00928 0.240
TRG_ER_diArg_1 145 147 PF00400 0.274
TRG_ER_diArg_1 416 418 PF00400 0.309
TRG_ER_diArg_1 640 643 PF00400 0.444
TRG_NES_CRM1_1 495 509 PF08389 0.348
TRG_NLS_Bipartite_1 30 52 PF00514 0.386
TRG_Pf-PMV_PEXEL_1 14 18 PF00026 0.544
TRG_Pf-PMV_PEXEL_1 182 186 PF00026 0.357
TRG_Pf-PMV_PEXEL_1 371 375 PF00026 0.189

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I7B0 Leptomonas seymouri 82% 100%
A0A0N1IC81 Leptomonas seymouri 27% 96%
A0A0S4IS43 Bodo saltans 32% 79%
A0A0S4J8G3 Bodo saltans 27% 100%
A0A0S4JSJ9 Bodo saltans 56% 76%
A0A0S4KGY6 Bodo saltans 25% 87%
A0A1X0NL72 Trypanosomatidae 60% 77%
A0A1X0NUY1 Trypanosomatidae 31% 81%
A0A1X0P0E5 Trypanosomatidae 27% 95%
A0A3Q8I939 Leishmania donovani 30% 75%
A0A3Q8IK57 Leishmania donovani 100% 100%
A0A3R7L5L0 Trypanosoma rangeli 30% 82%
A0A3S5IS14 Trypanosoma rangeli 59% 78%
A0A422NKG4 Trypanosoma rangeli 27% 96%
A4HQJ9 Leishmania braziliensis 86% 100%
A4HV08 Leishmania infantum 30% 75%
D0A3P8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 55% 100%
D0A442 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 27% 97%
E9ANP3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 30% 75%
E9AUB2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 95% 100%
O00203 Homo sapiens 25% 68%
O13939 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 24% 100%
O35643 Mus musculus 38% 79%
O43005 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 33% 100%
O43079 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 32% 100%
O81742 Arabidopsis thaliana 37% 84%
P27351 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 27% 100%
P36000 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 35% 100%
P46682 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 24% 92%
P52303 Rattus norvegicus 38% 79%
P62944 Rattus norvegicus 36% 80%
P63009 Bos taurus 37% 80%
P63010 Homo sapiens 36% 80%
Q08DS7 Bos taurus 37% 78%
Q10567 Homo sapiens 36% 79%
Q13367 Homo sapiens 27% 69%
Q32PG1 Bos taurus 25% 69%
Q4Q078 Leishmania major 96% 100%
Q4QGY0 Leishmania major 30% 75%
Q54R84 Dictyostelium discoideum 27% 89%
Q54X82 Dictyostelium discoideum 38% 79%
Q759E2 Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) 24% 96%
Q7YRF1 Canis lupus familiaris 25% 68%
Q9DBG3 Mus musculus 36% 80%
Q9JME5 Mus musculus 27% 69%
Q9LDK9 Arabidopsis thaliana 28% 89%
Q9SUS3 Arabidopsis thaliana 38% 83%
Q9WV76 Mus musculus 29% 100%
Q9Y6B7 Homo sapiens 28% 100%
Q9Z1T1 Mus musculus 25% 68%
V5BRU9 Trypanosoma cruzi 31% 82%
V5BTB0 Trypanosoma cruzi 26% 96%
V5DDV1 Trypanosoma cruzi 63% 78%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS