Prolyl endopeptidase

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

serine peptidase clan SC - family S9A - putative

Species:

Leishmania infantum

UniProt:

A4ICB5_LEIIN

TriTrypDb:

LINF_360079300

Length:

697

Annotations

Annotations by Jardim et al.

Proteases, prolyl oligopeptidase

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	yes	yes: 2
Forrest at al. (procyclic)	yes	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	10
GO:0005829	cytosol	2	1
GO:0110165	cellular anatomical entity	1	10

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Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4ICB5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ICB5

Function

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Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0019538	protein metabolic process	3	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044238	primary metabolic process	2	11
GO:0071704	organic substance metabolic process	2	11
GO:1901564	organonitrogen compound metabolic process	3	11

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004175	endopeptidase activity	4	11
GO:0004252	serine-type endopeptidase activity	5	11
GO:0008233	peptidase activity	3	11
GO:0008236	serine-type peptidase activity	4	11
GO:0016787	hydrolase activity	2	11
GO:0017171	serine hydrolase activity	3	11
GO:0070012	oligopeptidase activity	5	1
GO:0140096	catalytic activity, acting on a protein	2	11

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	309	311	PF00675	0.281
CLV_NRD_NRD_1	358	360	PF00675	0.347
CLV_NRD_NRD_1	9	11	PF00675	0.280
CLV_PCSK_KEX2_1	274	276	PF00082	0.218
CLV_PCSK_KEX2_1	9	11	PF00082	0.280
CLV_PCSK_PC1ET2_1	274	276	PF00082	0.218
CLV_PCSK_SKI1_1	10	14	PF00082	0.319
CLV_PCSK_SKI1_1	336	340	PF00082	0.338
CLV_PCSK_SKI1_1	482	486	PF00082	0.297
DEG_Kelch_Keap1_1	157	162	PF01344	0.515

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7J4	Leptomonas seymouri	26%	95%
A0A0N0P803	Leptomonas seymouri	78%	100%
A0A0N1PDP3	Leptomonas seymouri	21%	80%
A0A0S4IIS9	Bodo saltans	59%	100%
A0A1X0NKN5	Trypanosomatidae	24%	76%
A0A1X0NLB6	Trypanosomatidae	62%	100%
A0A3Q8IGZ3	Leishmania donovani	25%	95%
A0A3Q8IJI4	Leishmania donovani	100%	100%
A0A3S5H5P5	Leishmania donovani	22%	77%
A0A422N761	Trypanosoma rangeli	24%	98%

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