LeishMANIAdb
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Prolyl endopeptidase

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Prolyl endopeptidase
Gene product:
serine peptidase clan SC - family S9A - putative
Species:
Leishmania infantum
UniProt:
A4ICB5_LEIIN
TriTrypDb:
LINF_360079300
Length:
697

Annotations

Annotations by Jardim et al.

Proteases, prolyl oligopeptidase

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) yes yes: 2
Forrest at al. (procyclic) yes yes: 2
Silverman et al. no yes: 0
Pissara et al. yes yes: 15
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 6
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 10
GO:0110165 cellular anatomical entity 1 10
GO:0005829 cytosol 2 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4ICB5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ICB5

Function

Biological processes
Term Name Level Count
GO:0006508 proteolysis 4 11
GO:0006807 nitrogen compound metabolic process 2 11
GO:0008152 metabolic process 1 11
GO:0019538 protein metabolic process 3 11
GO:0043170 macromolecule metabolic process 3 11
GO:0044238 primary metabolic process 2 11
GO:0071704 organic substance metabolic process 2 11
GO:1901564 organonitrogen compound metabolic process 3 11
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 11
GO:0004175 endopeptidase activity 4 11
GO:0004252 serine-type endopeptidase activity 5 11
GO:0008233 peptidase activity 3 11
GO:0008236 serine-type peptidase activity 4 11
GO:0016787 hydrolase activity 2 11
GO:0017171 serine hydrolase activity 3 11
GO:0140096 catalytic activity, acting on a protein 2 11
GO:0070012 oligopeptidase activity 5 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 309 311 PF00675 0.281
CLV_NRD_NRD_1 358 360 PF00675 0.347
CLV_NRD_NRD_1 9 11 PF00675 0.280
CLV_PCSK_KEX2_1 274 276 PF00082 0.218
CLV_PCSK_KEX2_1 9 11 PF00082 0.280
CLV_PCSK_PC1ET2_1 274 276 PF00082 0.218
CLV_PCSK_SKI1_1 10 14 PF00082 0.319
CLV_PCSK_SKI1_1 336 340 PF00082 0.338
CLV_PCSK_SKI1_1 482 486 PF00082 0.297
DEG_Kelch_Keap1_1 157 162 PF01344 0.515
DEG_Nend_UBRbox_1 1 4 PF02207 0.520
DEG_SCF_FBW7_1 472 479 PF00400 0.336
DOC_CDC14_PxL_1 186 194 PF14671 0.498
DOC_CYCLIN_yClb5_NLxxxL_5 484 493 PF00134 0.368
DOC_CYCLIN_yCln2_LP_2 273 279 PF00134 0.547
DOC_CYCLIN_yCln2_LP_2 653 659 PF00134 0.400
DOC_MAPK_gen_1 274 282 PF00069 0.418
DOC_MAPK_gen_1 310 318 PF00069 0.456
DOC_MAPK_gen_1 368 374 PF00069 0.506
DOC_MAPK_gen_1 385 391 PF00069 0.434
DOC_MAPK_MEF2A_6 106 114 PF00069 0.571
DOC_MAPK_MEF2A_6 310 318 PF00069 0.520
DOC_MAPK_MEF2A_6 341 349 PF00069 0.498
DOC_PP1_RVXF_1 165 171 PF00149 0.520
DOC_PP1_RVXF_1 273 280 PF00149 0.580
DOC_PP1_RVXF_1 480 486 PF00149 0.317
DOC_PP2B_LxvP_1 226 229 PF13499 0.481
DOC_PP2B_LxvP_1 370 373 PF13499 0.499
DOC_PP2B_LxvP_1 493 496 PF13499 0.340
DOC_PP2B_PxIxI_1 620 626 PF00149 0.340
DOC_PP4_FxxP_1 113 116 PF00568 0.468
DOC_PP4_FxxP_1 396 399 PF00568 0.468
DOC_PP4_FxxP_1 669 672 PF00568 0.432
DOC_USP7_MATH_1 399 403 PF00917 0.491
DOC_USP7_MATH_1 410 414 PF00917 0.481
DOC_USP7_MATH_1 636 640 PF00917 0.321
DOC_USP7_MATH_1 678 682 PF00917 0.290
DOC_USP7_MATH_1 73 77 PF00917 0.498
DOC_USP7_UBL2_3 671 675 PF12436 0.321
DOC_WW_Pin1_4 454 459 PF00397 0.416
DOC_WW_Pin1_4 472 477 PF00397 0.346
DOC_WW_Pin1_4 535 540 PF00397 0.321
DOC_WW_Pin1_4 606 611 PF00397 0.321
LIG_14-3-3_CanoR_1 65 72 PF00244 0.507
LIG_14-3-3_CanoR_1 9 17 PF00244 0.487
LIG_APCC_ABBA_1 345 350 PF00400 0.498
LIG_APCC_ABBA_1 414 419 PF00400 0.407
LIG_FHA_1 109 115 PF00498 0.498
LIG_FHA_1 12 18 PF00498 0.547
LIG_FHA_1 122 128 PF00498 0.434
LIG_FHA_1 341 347 PF00498 0.493
LIG_FHA_1 520 526 PF00498 0.291
LIG_FHA_1 539 545 PF00498 0.391
LIG_FHA_1 65 71 PF00498 0.521
LIG_FHA_1 671 677 PF00498 0.317
LIG_FHA_2 19 25 PF00498 0.498
LIG_FHA_2 266 272 PF00498 0.536
LIG_FHA_2 318 324 PF00498 0.516
LIG_FHA_2 647 653 PF00498 0.420
LIG_HCF-1_HBM_1 243 246 PF13415 0.538
LIG_LIR_Apic_2 111 116 PF02991 0.481
LIG_LIR_Apic_2 394 399 PF02991 0.468
LIG_LIR_Apic_2 591 596 PF02991 0.320
LIG_LIR_Gen_1 148 158 PF02991 0.481
LIG_LIR_Gen_1 24 32 PF02991 0.482
LIG_LIR_Gen_1 243 252 PF02991 0.486
LIG_LIR_Gen_1 268 277 PF02991 0.557
LIG_LIR_Gen_1 278 287 PF02991 0.470
LIG_LIR_Gen_1 387 396 PF02991 0.547
LIG_LIR_Gen_1 428 437 PF02991 0.451
LIG_LIR_Gen_1 563 572 PF02991 0.432
LIG_LIR_Gen_1 681 691 PF02991 0.324
LIG_LIR_Nem_3 148 153 PF02991 0.455
LIG_LIR_Nem_3 24 29 PF02991 0.499
LIG_LIR_Nem_3 243 249 PF02991 0.471
LIG_LIR_Nem_3 268 273 PF02991 0.536
LIG_LIR_Nem_3 278 282 PF02991 0.458
LIG_LIR_Nem_3 3 8 PF02991 0.478
LIG_LIR_Nem_3 378 384 PF02991 0.532
LIG_LIR_Nem_3 387 391 PF02991 0.500
LIG_LIR_Nem_3 428 433 PF02991 0.455
LIG_LIR_Nem_3 46 51 PF02991 0.513
LIG_LIR_Nem_3 503 507 PF02991 0.458
LIG_LIR_Nem_3 563 568 PF02991 0.340
LIG_LIR_Nem_3 599 605 PF02991 0.304
LIG_LIR_Nem_3 606 611 PF02991 0.305
LIG_LYPXL_S_1 4 8 PF13949 0.388
LIG_LYPXL_yS_3 189 192 PF13949 0.498
LIG_LYPXL_yS_3 5 8 PF13949 0.374
LIG_LYPXL_yS_3 620 623 PF13949 0.321
LIG_PAM2_1 76 88 PF00658 0.547
LIG_PCNA_yPIPBox_3 571 582 PF02747 0.335
LIG_Pex14_1 589 593 PF04695 0.321
LIG_REV1ctd_RIR_1 182 189 PF16727 0.468
LIG_SH2_CRK 358 362 PF00017 0.571
LIG_SH2_CRK 608 612 PF00017 0.297
LIG_SH2_PTP2 152 155 PF00017 0.547
LIG_SH2_PTP2 290 293 PF00017 0.418
LIG_SH2_PTP2 430 433 PF00017 0.446
LIG_SH2_SRC 290 293 PF00017 0.418
LIG_SH2_SRC 530 533 PF00017 0.419
LIG_SH2_STAP1 684 688 PF00017 0.340
LIG_SH2_STAT3 85 88 PF00017 0.515
LIG_SH2_STAT5 152 155 PF00017 0.522
LIG_SH2_STAT5 209 212 PF00017 0.550
LIG_SH2_STAT5 246 249 PF00017 0.498
LIG_SH2_STAT5 28 31 PF00017 0.518
LIG_SH2_STAT5 290 293 PF00017 0.469
LIG_SH2_STAT5 348 351 PF00017 0.467
LIG_SH2_STAT5 403 406 PF00017 0.520
LIG_SH2_STAT5 430 433 PF00017 0.392
LIG_SH2_STAT5 530 533 PF00017 0.341
LIG_SH2_STAT5 642 645 PF00017 0.313
LIG_SH3_3 226 232 PF00018 0.479
LIG_SH3_3 455 461 PF00018 0.440
LIG_SH3_3 615 621 PF00018 0.379
LIG_SH3_4 671 678 PF00018 0.321
LIG_SUMO_SIM_anti_2 220 227 PF11976 0.498
LIG_SUMO_SIM_anti_2 342 348 PF11976 0.455
LIG_SUMO_SIM_par_1 622 627 PF11976 0.321
LIG_TRAF2_1 269 272 PF00917 0.515
LIG_TRAF2_1 320 323 PF00917 0.520
LIG_TRAF2_1 328 331 PF00917 0.520
LIG_TRAF2_1 596 599 PF00917 0.388
LIG_TYR_ITIM 618 623 PF00017 0.340
LIG_UBA3_1 260 265 PF00899 0.520
LIG_UBA3_1 299 306 PF00899 0.496
LIG_WRC_WIRS_1 283 288 PF05994 0.554
LIG_WRC_WIRS_1 388 393 PF05994 0.487
MOD_CDC14_SPxK_1 479 482 PF00782 0.374
MOD_CDK_SPxK_1 476 482 PF00069 0.374
MOD_CK1_1 174 180 PF00069 0.546
MOD_CK1_1 379 385 PF00069 0.479
MOD_CK1_1 457 463 PF00069 0.486
MOD_CK1_1 538 544 PF00069 0.328
MOD_CK1_1 76 82 PF00069 0.520
MOD_CK2_1 130 136 PF00069 0.473
MOD_CK2_1 18 24 PF00069 0.498
MOD_CK2_1 265 271 PF00069 0.540
MOD_CK2_1 317 323 PF00069 0.460
MOD_CK2_1 51 57 PF00069 0.571
MOD_CK2_1 646 652 PF00069 0.389
MOD_GlcNHglycan 119 122 PF01048 0.338
MOD_GlcNHglycan 173 176 PF01048 0.306
MOD_GlcNHglycan 203 206 PF01048 0.338
MOD_GlcNHglycan 438 441 PF01048 0.450
MOD_GlcNHglycan 525 528 PF01048 0.426
MOD_GSK3_1 117 124 PF00069 0.527
MOD_GSK3_1 141 148 PF00069 0.521
MOD_GSK3_1 302 309 PF00069 0.524
MOD_GSK3_1 375 382 PF00069 0.477
MOD_GSK3_1 387 394 PF00069 0.451
MOD_GSK3_1 436 443 PF00069 0.403
MOD_GSK3_1 470 477 PF00069 0.358
MOD_GSK3_1 519 526 PF00069 0.402
MOD_GSK3_1 535 542 PF00069 0.241
MOD_GSK3_1 642 649 PF00069 0.329
MOD_GSK3_1 687 694 PF00069 0.268
MOD_GSK3_1 72 79 PF00069 0.520
MOD_N-GLC_1 94 99 PF02516 0.293
MOD_N-GLC_2 253 255 PF02516 0.288
MOD_NEK2_1 100 105 PF00069 0.501
MOD_NEK2_1 139 144 PF00069 0.524
MOD_NEK2_1 300 305 PF00069 0.543
MOD_NEK2_1 391 396 PF00069 0.482
MOD_NEK2_1 470 475 PF00069 0.359
MOD_NEK2_1 545 550 PF00069 0.312
MOD_NEK2_1 646 651 PF00069 0.329
MOD_NEK2_1 687 692 PF00069 0.329
MOD_NEK2_2 412 417 PF00069 0.572
MOD_NEK2_2 636 641 PF00069 0.340
MOD_PK_1 312 318 PF00069 0.497
MOD_PKA_1 452 458 PF00069 0.486
MOD_PKA_2 512 518 PF00069 0.432
MOD_PKA_2 64 70 PF00069 0.508
MOD_PKA_2 73 79 PF00069 0.460
MOD_Plk_1 563 569 PF00069 0.367
MOD_Plk_1 94 100 PF00069 0.493
MOD_Plk_4 108 114 PF00069 0.427
MOD_Plk_4 282 288 PF00069 0.504
MOD_Plk_4 329 335 PF00069 0.471
MOD_Plk_4 340 346 PF00069 0.461
MOD_Plk_4 376 382 PF00069 0.494
MOD_Plk_4 392 398 PF00069 0.414
MOD_Plk_4 412 418 PF00069 0.396
MOD_Plk_4 94 100 PF00069 0.488
MOD_ProDKin_1 454 460 PF00069 0.408
MOD_ProDKin_1 472 478 PF00069 0.345
MOD_ProDKin_1 535 541 PF00069 0.321
MOD_ProDKin_1 606 612 PF00069 0.321
MOD_SUMO_rev_2 271 276 PF00179 0.578
MOD_SUMO_rev_2 30 40 PF00179 0.498
MOD_SUMO_rev_2 319 326 PF00179 0.544
MOD_SUMO_rev_2 350 355 PF00179 0.468
TRG_DiLeu_BaEn_2 35 41 PF01217 0.498
TRG_ENDOCYTIC_2 152 155 PF00928 0.547
TRG_ENDOCYTIC_2 189 192 PF00928 0.471
TRG_ENDOCYTIC_2 209 212 PF00928 0.335
TRG_ENDOCYTIC_2 246 249 PF00928 0.481
TRG_ENDOCYTIC_2 26 29 PF00928 0.481
TRG_ENDOCYTIC_2 270 273 PF00928 0.548
TRG_ENDOCYTIC_2 290 293 PF00928 0.475
TRG_ENDOCYTIC_2 358 361 PF00928 0.481
TRG_ENDOCYTIC_2 430 433 PF00928 0.513
TRG_ENDOCYTIC_2 467 470 PF00928 0.345
TRG_ENDOCYTIC_2 5 8 PF00928 0.374
TRG_ENDOCYTIC_2 504 507 PF00928 0.251
TRG_ENDOCYTIC_2 608 611 PF00928 0.307
TRG_ENDOCYTIC_2 620 623 PF00928 0.347
TRG_ENDOCYTIC_2 684 687 PF00928 0.305
TRG_ER_diArg_1 8 10 PF00400 0.509
TRG_Pf-PMV_PEXEL_1 20 24 PF00026 0.338

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P7J4 Leptomonas seymouri 26% 95%
A0A0N0P803 Leptomonas seymouri 78% 100%
A0A0N1PDP3 Leptomonas seymouri 21% 80%
A0A0S4IIS9 Bodo saltans 59% 100%
A0A1X0NKN5 Trypanosomatidae 24% 76%
A0A1X0NLB6 Trypanosomatidae 62% 100%
A0A3Q8IGZ3 Leishmania donovani 25% 95%
A0A3Q8IJI4 Leishmania donovani 100% 100%
A0A3S5H5P5 Leishmania donovani 22% 77%
A0A422N761 Trypanosoma rangeli 24% 98%
A4H4J9 Leishmania braziliensis 21% 100%
A4H5Q8 Leishmania braziliensis 24% 100%
A4HQJ7 Leishmania braziliensis 82% 100%
A4HSS5 Leishmania infantum 22% 77%
A4HTZ8 Leishmania infantum 25% 100%
C9ZTC4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 21% 77%
D0A3P6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 64% 100%
E2JFG1 Amanita bisporigera 39% 92%
E2JFG2 Amanita bisporigera 37% 95%
E9AKR2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 22% 100%
E9AUB0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 90% 100%
H2E7Q7 Galerina marginata (strain CBS 339.88) 37% 94%
H2E7Q8 Galerina marginata (strain CBS 339.88) 36% 95%
O07834 Pseudoxanthomonas mexicana 28% 96%
O70196 Rattus norvegicus 43% 98%
P23687 Sus scrofa 44% 98%
P24555 Escherichia coli (strain K12) 25% 100%
P27028 Elizabethkingia meningoseptica 37% 99%
P27195 Elizabethkingia miricola 37% 99%
P48147 Homo sapiens 44% 98%
P55627 Sinorhizobium fredii (strain NBRC 101917 / NGR234) 22% 92%
P55656 Sinorhizobium fredii (strain NBRC 101917 / NGR234) 22% 99%
Q06903 Aeromonas hydrophila 38% 100%
Q4Q080 Leishmania major 96% 100%
Q4QHU7 Leishmania major 25% 100%
Q4QJ45 Leishmania major 22% 100%
Q59536 Moraxella lacunata 25% 100%
Q86AS5 Dictyostelium discoideum 36% 92%
Q9QUR6 Mus musculus 44% 98%
Q9XTA2 Bos taurus 43% 98%
V5B5S3 Trypanosoma cruzi 24% 81%
V5B860 Trypanosoma cruzi 25% 97%
V5BM62 Trypanosoma cruzi 65% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS