Similarity to endo-1-like protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

similarity to endo-1-like protein

Species:

Leishmania infantum

UniProt:

A4ICB3_LEIIN

TriTrypDb:

LINF_360077100

Length:

240

Annotations

Annotations by Jardim et al.

Hydrolase, Similarity to endo-1-like

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 1
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4ICB3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ICB3

Function

Could not find GO biological_process term for this entry.

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	8
GO:0016787	hydrolase activity	2	8

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	197	199	PF00082	0.297
CLV_PCSK_KEX2_1	54	56	PF00082	0.308
CLV_PCSK_PC1ET2_1	197	199	PF00082	0.297
CLV_PCSK_PC1ET2_1	54	56	PF00082	0.278
CLV_PCSK_SKI1_1	162	166	PF00082	0.274
DOC_CYCLIN_RxL_1	222	233	PF00134	0.478
DOC_MAPK_gen_1	162	171	PF00069	0.474
DOC_MAPK_MEF2A_6	162	171	PF00069	0.478
DOC_PP2B_LxvP_1	169	172	PF13499	0.580
DOC_PP4_FxxP_1	72	75	PF00568	0.431

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P241	Leptomonas seymouri	62%	99%
A0A0S4KTD2	Bodo saltans	38%	100%
A0A2V5GSC6	Aspergillus violaceofuscus (strain CBS 115571)	31%	98%
A0A3S7XCB3	Leishmania donovani	100%	100%
A4HQH7	Leishmania braziliensis	74%	100%
B8M9K0	Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)	27%	94%
E9AU90	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
O14359	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	29%	96%
Q4Q0A1	Leishmania major	93%	100%
Q5RBU3	Pongo abelii	26%	98%

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