Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4ICB2_LEIIN

TriTrypDb:

LINF_360077000

Length:

397

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0000126	transcription factor TFIIIB complex	4	1
GO:0005667	transcription regulator complex	2	1
GO:0032991	protein-containing complex	1	1
GO:0090576	RNA polymerase III transcription regulator complex	3	1

Expansion

Sequence features

A4ICB2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ICB2

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0043933	protein-containing complex organization	4	1
GO:0065003	protein-containing complex assembly	5	1
GO:0065004	protein-DNA complex assembly	6	1
GO:0070897	transcription preinitiation complex assembly	7	1
GO:0070898	RNA polymerase III preinitiation complex assembly	8	1
GO:0071824	protein-DNA complex subunit organization	5	1
GO:0071840	cellular component organization or biogenesis	2	1

Molecular functions
Term	Name	Level	Count
GO:0001025	RNA polymerase III general transcription initiation factor binding	5	1
GO:0001156	TFIIIC-class transcription factor complex binding	6	1
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0008134	transcription factor binding	3	1
GO:0140296	general transcription initiation factor binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	169	171	PF00675	0.628
CLV_NRD_NRD_1	211	213	PF00675	0.326
CLV_NRD_NRD_1	319	321	PF00675	0.623
CLV_PCSK_FUR_1	167	171	PF00082	0.623
CLV_PCSK_FUR_1	209	213	PF00082	0.388
CLV_PCSK_KEX2_1	169	171	PF00082	0.628
CLV_PCSK_KEX2_1	211	213	PF00082	0.326
CLV_PCSK_KEX2_1	215	217	PF00082	0.329
CLV_PCSK_KEX2_1	317	319	PF00082	0.621
CLV_PCSK_KEX2_1	334	336	PF00082	0.491
CLV_PCSK_PC1ET2_1	215	217	PF00082	0.312
CLV_PCSK_PC1ET2_1	317	319	PF00082	0.621
CLV_PCSK_PC1ET2_1	334	336	PF00082	0.491
CLV_PCSK_PC7_1	211	217	PF00082	0.312
CLV_PCSK_PC7_1	314	320	PF00082	0.629
CLV_PCSK_SKI1_1	212	216	PF00082	0.388
CLV_PCSK_SKI1_1	334	338	PF00082	0.746
CLV_PCSK_SKI1_1	74	78	PF00082	0.524
DEG_Nend_UBRbox_2	1	3	PF02207	0.593
DEG_SIAH_1	93	101	PF03145	0.585
DEG_SPOP_SBC_1	76	80	PF00917	0.620
DOC_CKS1_1	32	37	PF01111	0.607
DOC_CYCLIN_yCln2_LP_2	292	298	PF00134	0.657
DOC_CYCLIN_yCln2_LP_2	32	38	PF00134	0.602
DOC_MAPK_FxFP_2	36	39	PF00069	0.554
DOC_MAPK_FxFP_2	6	9	PF00069	0.551
DOC_MAPK_MEF2A_6	288	296	PF00069	0.614
DOC_PP1_RVXF_1	175	181	PF00149	0.352
DOC_PP2B_LxvP_1	292	295	PF13499	0.653
DOC_PP4_FxxP_1	36	39	PF00568	0.554
DOC_PP4_FxxP_1	374	377	PF00568	0.537
DOC_PP4_FxxP_1	6	9	PF00568	0.551
DOC_USP7_MATH_1	124	128	PF00917	0.637
DOC_USP7_MATH_1	207	211	PF00917	0.279
DOC_USP7_MATH_1	86	90	PF00917	0.621
DOC_USP7_MATH_1	92	96	PF00917	0.632
DOC_USP7_UBL2_3	334	338	PF12436	0.616
DOC_WW_Pin1_4	108	113	PF00397	0.660
DOC_WW_Pin1_4	19	24	PF00397	0.597
DOC_WW_Pin1_4	27	32	PF00397	0.555
LIG_14-3-3_CanoR_1	74	82	PF00244	0.736
LIG_14-3-3_CanoR_1	93	99	PF00244	0.586
LIG_CtBP_PxDLS_1	238	242	PF00389	0.388
LIG_FHA_1	241	247	PF00498	0.424
LIG_FHA_1	335	341	PF00498	0.677
LIG_FHA_1	38	44	PF00498	0.457
LIG_FHA_2	298	304	PF00498	0.606
LIG_LIR_Apic_2	3	9	PF02991	0.565
LIG_LIR_Apic_2	34	39	PF02991	0.647
LIG_LIR_Apic_2	371	377	PF02991	0.534
LIG_LIR_Gen_1	187	195	PF02991	0.334
LIG_LIR_Gen_1	197	207	PF02991	0.379
LIG_LIR_Gen_1	353	360	PF02991	0.643
LIG_LIR_Nem_3	187	192	PF02991	0.334
LIG_LIR_Nem_3	197	202	PF02991	0.379
LIG_LIR_Nem_3	353	359	PF02991	0.571
LIG_PCNA_yPIPBox_3	352	361	PF02747	0.515
LIG_PCNA_yPIPBox_3	62	73	PF02747	0.602
LIG_SH2_CRK	189	193	PF00017	0.388
LIG_SH3_2	312	317	PF14604	0.622
LIG_SH3_3	120	126	PF00018	0.626
LIG_SH3_3	201	207	PF00018	0.312
LIG_SH3_3	291	297	PF00018	0.610
LIG_SH3_3	309	315	PF00018	0.530
LIG_SH3_3	55	61	PF00018	0.552
LIG_SUMO_SIM_anti_2	200	206	PF11976	0.312
LIG_TRAF2_1	130	133	PF00917	0.610
LIG_TRAF2_2	10	15	PF00917	0.564
LIG_WRC_WIRS_1	185	190	PF05994	0.312
LIG_WRC_WIRS_1	241	246	PF05994	0.255
LIG_WW_2	123	126	PF00397	0.617
MOD_CDC14_SPxK_1	30	33	PF00782	0.616
MOD_CDK_SPxK_1	27	33	PF00069	0.612
MOD_CK1_1	127	133	PF00069	0.653
MOD_CK1_1	19	25	PF00069	0.543
MOD_CK1_1	281	287	PF00069	0.576
MOD_CK2_1	126	132	PF00069	0.613
MOD_CK2_1	178	184	PF00069	0.342
MOD_GlcNHglycan	118	121	PF01048	0.598
MOD_GlcNHglycan	126	129	PF01048	0.642
MOD_GlcNHglycan	156	159	PF01048	0.568
MOD_GlcNHglycan	198	202	PF01048	0.345
MOD_GlcNHglycan	94	97	PF01048	0.674
MOD_GSK3_1	108	115	PF00069	0.618
MOD_GSK3_1	19	26	PF00069	0.653
MOD_GSK3_1	190	197	PF00069	0.312
MOD_GSK3_1	27	34	PF00069	0.626
MOD_GSK3_1	330	337	PF00069	0.718
MOD_N-GLC_1	65	70	PF02516	0.600
MOD_NEK2_1	77	82	PF00069	0.676
MOD_PIKK_1	101	107	PF00454	0.678
MOD_PIKK_1	190	196	PF00454	0.312
MOD_PIKK_1	56	62	PF00454	0.539
MOD_PKA_1	319	325	PF00069	0.640
MOD_PKA_1	334	340	PF00069	0.565
MOD_PKA_2	319	325	PF00069	0.770
MOD_PKA_2	334	340	PF00069	0.574
MOD_PKA_2	92	98	PF00069	0.639
MOD_Plk_1	197	203	PF00069	0.312
MOD_Plk_1	281	287	PF00069	0.535
MOD_Plk_1	65	71	PF00069	0.597
MOD_Plk_2-3	240	246	PF00069	0.255
MOD_Plk_2-3	351	357	PF00069	0.509
MOD_Plk_4	351	357	PF00069	0.570
MOD_Plk_4	43	49	PF00069	0.473
MOD_ProDKin_1	108	114	PF00069	0.663
MOD_ProDKin_1	19	25	PF00069	0.600
MOD_ProDKin_1	27	33	PF00069	0.558
MOD_SUMO_for_1	287	290	PF00179	0.592
MOD_SUMO_rev_2	210	217	PF00179	0.276
MOD_SUMO_rev_2	326	336	PF00179	0.694
TRG_DiLeu_BaEn_2	266	272	PF01217	0.579
TRG_DiLeu_BaEn_4	267	273	PF01217	0.578
TRG_ENDOCYTIC_2	189	192	PF00928	0.317
TRG_ER_diArg_1	166	169	PF00400	0.630
TRG_ER_diArg_1	209	212	PF00400	0.343
TRG_ER_diArg_1	318	320	PF00400	0.680
TRG_NLS_Bipartite_1	251	265	PF00514	0.478
TRG_NLS_MonoExtN_4	258	265	PF00514	0.509

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZV5	Leptomonas seymouri	54%	100%
A0A3Q8IM42	Leishmania donovani	100%	100%
A4HQH6	Leishmania braziliensis	79%	99%
E9AU89	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q0A2	Leishmania major	92%	100%