Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4ICB1_LEIIN

TriTrypDb:

LINF_360076900

Length:

681

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4ICB1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ICB1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	355	359	PF00656	0.699
CLV_C14_Caspase3-7	496	500	PF00656	0.573
CLV_NRD_NRD_1	513	515	PF00675	0.602
CLV_NRD_NRD_1	561	563	PF00675	0.551
CLV_NRD_NRD_1	668	670	PF00675	0.654
CLV_PCSK_KEX2_1	259	261	PF00082	0.518
CLV_PCSK_KEX2_1	513	515	PF00082	0.570
CLV_PCSK_KEX2_1	561	563	PF00082	0.551
CLV_PCSK_KEX2_1	609	611	PF00082	0.630
CLV_PCSK_KEX2_1	668	670	PF00082	0.493
CLV_PCSK_PC1ET2_1	259	261	PF00082	0.571
CLV_PCSK_PC1ET2_1	609	611	PF00082	0.630
CLV_PCSK_SKI1_1	246	250	PF00082	0.589
CLV_PCSK_SKI1_1	260	264	PF00082	0.355
CLV_PCSK_SKI1_1	501	505	PF00082	0.594
CLV_PCSK_SKI1_1	525	529	PF00082	0.522
DEG_APCC_DBOX_1	500	508	PF00400	0.621
DEG_Nend_Nbox_1	1	3	PF02207	0.396
DEG_SPOP_SBC_1	32	36	PF00917	0.442
DEG_SPOP_SBC_1	423	427	PF00917	0.410
DOC_CDC14_PxL_1	476	484	PF14671	0.546
DOC_CKS1_1	621	626	PF01111	0.765
DOC_CYCLIN_yCln2_LP_2	303	309	PF00134	0.405
DOC_CYCLIN_yCln2_LP_2	622	628	PF00134	0.632
DOC_MAPK_DCC_7	592	602	PF00069	0.642
DOC_MAPK_gen_1	609	615	PF00069	0.588
DOC_MAPK_gen_1	668	675	PF00069	0.503
DOC_MAPK_MEF2A_6	41	49	PF00069	0.428
DOC_MAPK_MEF2A_6	80	88	PF00069	0.446
DOC_PP1_RVXF_1	244	250	PF00149	0.593
DOC_PP2B_LxvP_1	24	27	PF13499	0.419
DOC_PP2B_LxvP_1	303	306	PF13499	0.460
DOC_PP2B_LxvP_1	373	376	PF13499	0.402
DOC_PP2B_LxvP_1	47	50	PF13499	0.431
DOC_PP2B_LxvP_1	622	625	PF13499	0.622
DOC_PP2B_LxvP_1	86	89	PF13499	0.434
DOC_PP4_FxxP_1	202	205	PF00568	0.545
DOC_PP4_FxxP_1	327	330	PF00568	0.578
DOC_PP4_FxxP_1	448	451	PF00568	0.597
DOC_SPAK_OSR1_1	447	451	PF12202	0.530
DOC_USP7_MATH_1	203	207	PF00917	0.631
DOC_USP7_MATH_1	352	356	PF00917	0.698
DOC_USP7_MATH_1	423	427	PF00917	0.410
DOC_USP7_MATH_1	627	631	PF00917	0.686
DOC_WW_Pin1_4	201	206	PF00397	0.610
DOC_WW_Pin1_4	209	214	PF00397	0.732
DOC_WW_Pin1_4	241	246	PF00397	0.611
DOC_WW_Pin1_4	27	32	PF00397	0.421
DOC_WW_Pin1_4	350	355	PF00397	0.602
DOC_WW_Pin1_4	404	409	PF00397	0.479
DOC_WW_Pin1_4	620	625	PF00397	0.636
DOC_WW_Pin1_4	638	643	PF00397	0.716
LIG_14-3-3_CanoR_1	124	129	PF00244	0.550
LIG_14-3-3_CanoR_1	142	150	PF00244	0.401
LIG_14-3-3_CanoR_1	260	268	PF00244	0.484
LIG_14-3-3_CanoR_1	295	304	PF00244	0.584
LIG_14-3-3_CanoR_1	389	394	PF00244	0.693
LIG_14-3-3_CanoR_1	485	489	PF00244	0.622
LIG_14-3-3_CanoR_1	5	11	PF00244	0.378
LIG_14-3-3_CanoR_1	513	517	PF00244	0.684
LIG_14-3-3_CanoR_1	519	525	PF00244	0.635
LIG_14-3-3_CanoR_1	610	614	PF00244	0.742
LIG_BRCT_BRCA1_1	13	17	PF00533	0.408
LIG_BRCT_BRCA1_1	233	237	PF00533	0.622
LIG_BRCT_BRCA1_1	33	37	PF00533	0.445
LIG_BRCT_BRCA1_1	444	448	PF00533	0.486
LIG_deltaCOP1_diTrp_1	443	448	PF00928	0.537
LIG_DLG_GKlike_1	124	132	PF00625	0.440
LIG_EVH1_1	24	28	PF00568	0.420
LIG_FHA_1	124	130	PF00498	0.526
LIG_FHA_1	2	8	PF00498	0.410
LIG_FHA_1	222	228	PF00498	0.693
LIG_FHA_1	396	402	PF00498	0.527
LIG_FHA_1	423	429	PF00498	0.404
LIG_FHA_1	621	627	PF00498	0.739
LIG_FHA_1	633	639	PF00498	0.589
LIG_FHA_1	649	655	PF00498	0.668
LIG_FHA_1	91	97	PF00498	0.652
LIG_FHA_2	134	140	PF00498	0.475
LIG_FHA_2	261	267	PF00498	0.483
LIG_FHA_2	521	527	PF00498	0.580
LIG_FHA_2	530	536	PF00498	0.434
LIG_FHA_2	544	550	PF00498	0.413
LIG_LIR_Apic_2	199	205	PF02991	0.547
LIG_LIR_Apic_2	324	330	PF02991	0.651
LIG_LIR_Apic_2	445	451	PF02991	0.522
LIG_LIR_Apic_2	69	74	PF02991	0.533
LIG_LIR_Gen_1	263	273	PF02991	0.419
LIG_LIR_Gen_1	319	330	PF02991	0.517
LIG_LIR_Gen_1	434	442	PF02991	0.406
LIG_LIR_Nem_3	14	20	PF02991	0.434
LIG_LIR_Nem_3	263	268	PF02991	0.459
LIG_LIR_Nem_3	271	276	PF02991	0.378
LIG_LIR_Nem_3	319	325	PF02991	0.553
LIG_NRBOX	145	151	PF00104	0.535
LIG_PCNA_PIPBox_1	521	530	PF02747	0.554
LIG_Pex14_1	444	448	PF04695	0.542
LIG_SH2_CRK	22	26	PF00017	0.432
LIG_SH2_SRC	71	74	PF00017	0.431
LIG_SH2_STAP1	437	441	PF00017	0.522
LIG_SH2_STAT5	121	124	PF00017	0.537
LIG_SH2_STAT5	229	232	PF00017	0.572
LIG_SH2_STAT5	322	325	PF00017	0.540
LIG_SH2_STAT5	449	452	PF00017	0.696
LIG_SH2_STAT5	71	74	PF00017	0.445
LIG_SH3_1	22	28	PF00018	0.427
LIG_SH3_1	514	520	PF00018	0.576
LIG_SH3_3	22	28	PF00018	0.427
LIG_SH3_3	239	245	PF00018	0.619
LIG_SH3_3	405	411	PF00018	0.424
LIG_SH3_3	514	520	PF00018	0.576
LIG_SH3_3	59	65	PF00018	0.453
LIG_SH3_3	592	598	PF00018	0.676
LIG_SH3_3	618	624	PF00018	0.754
LIG_SH3_3	643	649	PF00018	0.648
LIG_SH3_CIN85_PxpxPR_1	241	246	PF14604	0.497
LIG_SUMO_SIM_anti_2	397	403	PF11976	0.396
LIG_SUMO_SIM_anti_2	657	663	PF11976	0.506
LIG_SUMO_SIM_par_1	480	487	PF11976	0.554
LIG_TRAF2_1	156	159	PF00917	0.421
LIG_TRAF2_1	605	608	PF00917	0.545
LIG_WRC_WIRS_1	173	178	PF05994	0.597
LIG_WRC_WIRS_1	428	433	PF05994	0.424
MOD_CDK_SPK_2	241	246	PF00069	0.551
MOD_CDK_SPxxK_3	201	208	PF00069	0.537
MOD_CK1_1	113	119	PF00069	0.602
MOD_CK1_1	123	129	PF00069	0.537
MOD_CK1_1	177	183	PF00069	0.635
MOD_CK1_1	201	207	PF00069	0.718
MOD_CK1_1	233	239	PF00069	0.615
MOD_CK1_1	359	365	PF00069	0.602
MOD_CK1_1	492	498	PF00069	0.696
MOD_CK1_1	580	586	PF00069	0.647
MOD_CK1_1	67	73	PF00069	0.434
MOD_CK2_1	100	106	PF00069	0.552
MOD_CK2_1	296	302	PF00069	0.567
MOD_CK2_1	432	438	PF00069	0.369
MOD_CK2_1	529	535	PF00069	0.484
MOD_CK2_1	537	543	PF00069	0.469
MOD_CK2_1	675	681	PF00069	0.551
MOD_GlcNHglycan	17	20	PF01048	0.428
MOD_GlcNHglycan	213	216	PF01048	0.626
MOD_GlcNHglycan	268	271	PF01048	0.392
MOD_GlcNHglycan	318	321	PF01048	0.528
MOD_GlcNHglycan	354	357	PF01048	0.591
MOD_GlcNHglycan	491	494	PF01048	0.665
MOD_GlcNHglycan	495	498	PF01048	0.612
MOD_GlcNHglycan	514	517	PF01048	0.689
MOD_GlcNHglycan	539	542	PF01048	0.588
MOD_GlcNHglycan	578	582	PF01048	0.690
MOD_GSK3_1	11	18	PF00069	0.406
MOD_GSK3_1	120	127	PF00069	0.459
MOD_GSK3_1	129	136	PF00069	0.469
MOD_GSK3_1	172	179	PF00069	0.746
MOD_GSK3_1	231	238	PF00069	0.538
MOD_GSK3_1	27	34	PF00069	0.464
MOD_GSK3_1	312	319	PF00069	0.619
MOD_GSK3_1	321	328	PF00069	0.598
MOD_GSK3_1	348	355	PF00069	0.710
MOD_GSK3_1	385	392	PF00069	0.711
MOD_GSK3_1	423	430	PF00069	0.383
MOD_GSK3_1	432	439	PF00069	0.359
MOD_GSK3_1	450	457	PF00069	0.419
MOD_GSK3_1	489	496	PF00069	0.599
MOD_GSK3_1	529	536	PF00069	0.540
MOD_GSK3_1	573	580	PF00069	0.565
MOD_GSK3_1	60	67	PF00069	0.430
MOD_GSK3_1	627	634	PF00069	0.598
MOD_GSK3_1	96	103	PF00069	0.587
MOD_N-GLC_1	296	301	PF02516	0.629
MOD_N-GLC_1	489	494	PF02516	0.669
MOD_NEK2_1	1	6	PF00069	0.387
MOD_NEK2_1	122	127	PF00069	0.509
MOD_NEK2_1	129	134	PF00069	0.516
MOD_NEK2_1	176	181	PF00069	0.731
MOD_NEK2_1	221	226	PF00069	0.695
MOD_NEK2_1	232	237	PF00069	0.515
MOD_NEK2_1	249	254	PF00069	0.467
MOD_NEK2_1	275	280	PF00069	0.377
MOD_NEK2_1	316	321	PF00069	0.473
MOD_NEK2_1	33	38	PF00069	0.487
MOD_NEK2_1	348	353	PF00069	0.722
MOD_NEK2_1	365	370	PF00069	0.463
MOD_NEK2_1	431	436	PF00069	0.435
MOD_NEK2_1	454	459	PF00069	0.491
MOD_NEK2_1	483	488	PF00069	0.710
MOD_NEK2_1	96	101	PF00069	0.576
MOD_NEK2_2	520	525	PF00069	0.577
MOD_NEK2_2	6	11	PF00069	0.380
MOD_PIKK_1	141	147	PF00454	0.495
MOD_PIKK_1	505	511	PF00454	0.523
MOD_PKA_1	609	615	PF00069	0.634
MOD_PKA_2	123	129	PF00069	0.558
MOD_PKA_2	141	147	PF00069	0.437
MOD_PKA_2	388	394	PF00069	0.699
MOD_PKA_2	484	490	PF00069	0.716
MOD_PKA_2	512	518	PF00069	0.636
MOD_PKA_2	576	582	PF00069	0.702
MOD_PKA_2	585	591	PF00069	0.692
MOD_PKA_2	609	615	PF00069	0.744
MOD_Plk_1	311	317	PF00069	0.528
MOD_Plk_1	325	331	PF00069	0.432
MOD_Plk_1	548	554	PF00069	0.520
MOD_Plk_1	675	681	PF00069	0.617
MOD_Plk_4	11	17	PF00069	0.404
MOD_Plk_4	124	130	PF00069	0.487
MOD_Plk_4	268	274	PF00069	0.363
MOD_Plk_4	356	362	PF00069	0.549
MOD_Plk_4	424	430	PF00069	0.376
MOD_Plk_4	432	438	PF00069	0.352
MOD_Plk_4	67	73	PF00069	0.440
MOD_Plk_4	675	681	PF00069	0.570
MOD_Plk_4	91	97	PF00069	0.476
MOD_ProDKin_1	201	207	PF00069	0.605
MOD_ProDKin_1	209	215	PF00069	0.732
MOD_ProDKin_1	241	247	PF00069	0.613
MOD_ProDKin_1	27	33	PF00069	0.424
MOD_ProDKin_1	350	356	PF00069	0.597
MOD_ProDKin_1	404	410	PF00069	0.484
MOD_ProDKin_1	620	626	PF00069	0.639
MOD_ProDKin_1	638	644	PF00069	0.716
MOD_SUMO_rev_2	465	473	PF00179	0.636
MOD_SUMO_rev_2	585	594	PF00179	0.639
TRG_DiLeu_BaEn_1	159	164	PF01217	0.462
TRG_DiLeu_BaEn_4	159	165	PF01217	0.570
TRG_DiLeu_BaLyEn_6	477	482	PF01217	0.651
TRG_ENDOCYTIC_2	229	232	PF00928	0.687
TRG_ENDOCYTIC_2	273	276	PF00928	0.354
TRG_ENDOCYTIC_2	322	325	PF00928	0.558
TRG_ENDOCYTIC_2	437	440	PF00928	0.412
TRG_ER_diArg_1	292	295	PF00400	0.501
TRG_ER_diArg_1	560	562	PF00400	0.550
TRG_ER_diArg_1	667	669	PF00400	0.512
TRG_Pf-PMV_PEXEL_1	246	250	PF00026	0.456
TRG_Pf-PMV_PEXEL_1	562	566	PF00026	0.560
TRG_Pf-PMV_PEXEL_1	668	672	PF00026	0.586

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2K6	Leptomonas seymouri	53%	100%
A0A1X0NLK5	Trypanosomatidae	35%	100%
A0A3R7NFJ5	Trypanosoma rangeli	35%	100%
A0A3S7XCD6	Leishmania donovani	100%	100%
A4HQH5	Leishmania braziliensis	77%	100%
D0A3M4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9AU88	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4Q0A3	Leishmania major	93%	100%
V5DDT5	Trypanosoma cruzi	34%	100%