NUC153 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4ICA9_LEIIN

TriTrypDb:

LINF_360076700

Length:

629

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4ICA9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ICA9

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006364	rRNA processing	8	12
GO:0006396	RNA processing	6	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0016072	rRNA metabolic process	7	12
GO:0034470	ncRNA processing	7	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0034660	ncRNA metabolic process	6	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	278	282	PF00656	0.426
CLV_C14_Caspase3-7	303	307	PF00656	0.677
CLV_C14_Caspase3-7	600	604	PF00656	0.581
CLV_NRD_NRD_1	182	184	PF00675	0.360
CLV_NRD_NRD_1	320	322	PF00675	0.438
CLV_NRD_NRD_1	324	326	PF00675	0.458
CLV_NRD_NRD_1	451	453	PF00675	0.449
CLV_NRD_NRD_1	503	505	PF00675	0.479
CLV_NRD_NRD_1	54	56	PF00675	0.374
CLV_NRD_NRD_1	541	543	PF00675	0.540
CLV_PCSK_FUR_1	317	321	PF00082	0.611
CLV_PCSK_KEX2_1	182	184	PF00082	0.451
CLV_PCSK_KEX2_1	319	321	PF00082	0.507
CLV_PCSK_KEX2_1	323	325	PF00082	0.505
CLV_PCSK_KEX2_1	451	453	PF00082	0.449
CLV_PCSK_KEX2_1	503	505	PF00082	0.479
CLV_PCSK_KEX2_1	53	55	PF00082	0.370
CLV_PCSK_KEX2_1	541	543	PF00082	0.536
CLV_PCSK_KEX2_1	576	578	PF00082	0.486
CLV_PCSK_KEX2_1	596	598	PF00082	0.530
CLV_PCSK_KEX2_1	97	99	PF00082	0.464
CLV_PCSK_PC1ET2_1	319	321	PF00082	0.535
CLV_PCSK_PC1ET2_1	576	578	PF00082	0.505
CLV_PCSK_PC1ET2_1	596	598	PF00082	0.569
CLV_PCSK_PC1ET2_1	97	99	PF00082	0.464
CLV_PCSK_PC7_1	320	326	PF00082	0.590
CLV_PCSK_SKI1_1	164	168	PF00082	0.505
CLV_PCSK_SKI1_1	453	457	PF00082	0.477
CLV_PCSK_SKI1_1	460	464	PF00082	0.462
CLV_PCSK_SKI1_1	509	513	PF00082	0.480
CLV_PCSK_SKI1_1	519	523	PF00082	0.476
CLV_PCSK_SKI1_1	625	629	PF00082	0.490
CLV_PCSK_SKI1_1	97	101	PF00082	0.399
DEG_APCC_DBOX_1	481	489	PF00400	0.622
DEG_SCF_TRCP1_1	372	378	PF00400	0.490
DOC_ANK_TNKS_1	598	605	PF00023	0.595
DOC_MAPK_gen_1	522	533	PF00069	0.469
DOC_MAPK_MEF2A_6	104	112	PF00069	0.440
DOC_PP1_RVXF_1	263	269	PF00149	0.397
DOC_PP4_FxxP_1	234	237	PF00568	0.421
DOC_USP7_MATH_1	298	302	PF00917	0.550
DOC_USP7_MATH_1	609	613	PF00917	0.627
DOC_USP7_UBL2_3	315	319	PF12436	0.608
DOC_USP7_UBL2_3	449	453	PF12436	0.479
DOC_USP7_UBL2_3	456	460	PF12436	0.476
DOC_USP7_UBL2_3	501	505	PF12436	0.492
DOC_USP7_UBL2_3	625	629	PF12436	0.503
DOC_WW_Pin1_4	233	238	PF00397	0.498
LIG_14-3-3_CanoR_1	265	269	PF00244	0.433
LIG_14-3-3_CanoR_1	275	280	PF00244	0.436
LIG_14-3-3_CanoR_1	381	387	PF00244	0.552
LIG_14-3-3_CanoR_1	597	606	PF00244	0.653
LIG_BIR_II_1	1	5	PF00653	0.559
LIG_CaM_IQ_9	422	438	PF13499	0.592
LIG_CaM_IQ_9	534	550	PF13499	0.588
LIG_CSL_BTD_1	41	44	PF09270	0.617
LIG_FHA_1	493	499	PF00498	0.465
LIG_FHA_1	532	538	PF00498	0.630
LIG_FHA_1	557	563	PF00498	0.406
LIG_FHA_2	14	20	PF00498	0.628
LIG_FHA_2	284	290	PF00498	0.470
LIG_FHA_2	538	544	PF00498	0.547
LIG_LIR_Apic_2	231	237	PF02991	0.427
LIG_LIR_Gen_1	62	71	PF02991	0.340
LIG_LIR_Nem_3	178	184	PF02991	0.495
LIG_LIR_Nem_3	62	66	PF02991	0.347
LIG_LIR_Nem_3	70	75	PF02991	0.369
LIG_Pex14_2	264	268	PF04695	0.378
LIG_REV1ctd_RIR_1	617	628	PF16727	0.606
LIG_SH2_CRK	326	330	PF00017	0.470
LIG_SH2_CRK	72	76	PF00017	0.383
LIG_SH2_NCK_1	193	197	PF00017	0.317
LIG_SH2_NCK_1	606	610	PF00017	0.495
LIG_SH2_STAP1	326	330	PF00017	0.436
LIG_SH2_STAP1	72	76	PF00017	0.383
LIG_SH2_STAT5	227	230	PF00017	0.375
LIG_SH2_STAT5	295	298	PF00017	0.497
LIG_SH2_STAT5	606	609	PF00017	0.570
LIG_SH3_3	147	153	PF00018	0.748
LIG_SUMO_SIM_par_1	84	89	PF11976	0.472
LIG_TRAF2_1	28	31	PF00917	0.673
LIG_TRAF2_1	286	289	PF00917	0.656
LIG_WRC_WIRS_1	195	200	PF05994	0.323
MOD_CDK_SPxxK_3	233	240	PF00069	0.493
MOD_CK1_1	2	8	PF00069	0.664
MOD_CK1_1	200	206	PF00069	0.355
MOD_CK1_1	236	242	PF00069	0.610
MOD_CK1_1	257	263	PF00069	0.483
MOD_CK1_1	9	15	PF00069	0.608
MOD_CK2_1	122	128	PF00069	0.652
MOD_CK2_1	13	19	PF00069	0.586
MOD_CK2_1	283	289	PF00069	0.605
MOD_CK2_1	298	304	PF00069	0.487
MOD_CK2_1	380	386	PF00069	0.591
MOD_CK2_1	496	502	PF00069	0.508
MOD_CK2_1	537	543	PF00069	0.551
MOD_Cter_Amidation	594	597	PF01082	0.551
MOD_Cter_Amidation	95	98	PF01082	0.378
MOD_GlcNHglycan	124	127	PF01048	0.768
MOD_GlcNHglycan	199	202	PF01048	0.360
MOD_GlcNHglycan	217	221	PF01048	0.373
MOD_GlcNHglycan	256	259	PF01048	0.446
MOD_GlcNHglycan	356	359	PF01048	0.717
MOD_GlcNHglycan	371	375	PF01048	0.492
MOD_GlcNHglycan	498	501	PF01048	0.501
MOD_GlcNHglycan	6	9	PF01048	0.700
MOD_GSK3_1	148	155	PF00069	0.702
MOD_GSK3_1	2	9	PF00069	0.632
MOD_GSK3_1	275	282	PF00069	0.424
MOD_GSK3_1	417	424	PF00069	0.663
MOD_GSK3_1	488	495	PF00069	0.464
MOD_GSK3_1	556	563	PF00069	0.501
MOD_GSK3_1	609	616	PF00069	0.596
MOD_GSK3_1	86	93	PF00069	0.497
MOD_N-GLC_1	9	14	PF02516	0.527
MOD_NEK2_1	254	259	PF00069	0.377
MOD_NEK2_1	279	284	PF00069	0.517
MOD_NEK2_1	455	460	PF00069	0.601
MOD_NEK2_1	531	536	PF00069	0.554
MOD_NEK2_1	569	574	PF00069	0.596
MOD_NEK2_1	585	590	PF00069	0.305
MOD_NEK2_1	86	91	PF00069	0.523
MOD_PIKK_1	257	263	PF00454	0.385
MOD_PIKK_1	531	537	PF00454	0.684
MOD_PIKK_1	569	575	PF00454	0.547
MOD_PKA_2	264	270	PF00069	0.394
MOD_PKA_2	380	386	PF00069	0.539
MOD_PKA_2	496	502	PF00069	0.665
MOD_Plk_1	375	381	PF00069	0.573
MOD_Plk_1	410	416	PF00069	0.556
MOD_Plk_1	613	619	PF00069	0.577
MOD_Plk_1	86	92	PF00069	0.483
MOD_Plk_2-3	143	149	PF00069	0.684
MOD_Plk_4	402	408	PF00069	0.650
MOD_Plk_4	86	92	PF00069	0.486
MOD_ProDKin_1	233	239	PF00069	0.494
MOD_SUMO_rev_2	116	125	PF00179	0.573
MOD_SUMO_rev_2	307	316	PF00179	0.639
MOD_SUMO_rev_2	415	423	PF00179	0.509
MOD_SUMO_rev_2	600	607	PF00179	0.635
TRG_DiLeu_BaEn_4	30	36	PF01217	0.613
TRG_ENDOCYTIC_2	192	195	PF00928	0.333
TRG_ENDOCYTIC_2	208	211	PF00928	0.350
TRG_ENDOCYTIC_2	326	329	PF00928	0.433
TRG_ENDOCYTIC_2	72	75	PF00928	0.374
TRG_ER_diArg_1	181	183	PF00400	0.455
TRG_ER_diArg_1	320	323	PF00400	0.456
TRG_ER_diArg_1	324	326	PF00400	0.478
TRG_ER_diArg_1	450	452	PF00400	0.454
TRG_ER_diArg_1	53	55	PF00400	0.390
TRG_ER_diLys_1	624	629	PF00400	0.511
TRG_NES_CRM1_1	377	391	PF08389	0.711
TRG_NES_CRM1_1	70	84	PF08389	0.347
TRG_NLS_Bipartite_1	504	526	PF00514	0.488
TRG_NLS_MonoCore_2	622	627	PF00514	0.458
TRG_NLS_MonoExtC_3	455	460	PF00514	0.472
TRG_NLS_MonoExtC_3	521	526	PF00514	0.509
TRG_NLS_MonoExtC_3	595	601	PF00514	0.586
TRG_NLS_MonoExtN_4	453	460	PF00514	0.490
TRG_NLS_MonoExtN_4	519	526	PF00514	0.474
TRG_NLS_MonoExtN_4	593	600	PF00514	0.564
TRG_NLS_MonoExtN_4	623	628	PF00514	0.464
TRG_Pf-PMV_PEXEL_1	15	19	PF00026	0.614
TRG_Pf-PMV_PEXEL_1	98	103	PF00026	0.427

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2Z4	Leptomonas seymouri	71%	86%
A0A0S4IQI8	Bodo saltans	48%	85%
A0A1X0NN45	Trypanosomatidae	54%	85%
A0A3S5IRC1	Trypanosoma rangeli	53%	92%
A0A3S7XCB2	Leishmania donovani	98%	100%
A4HQH3	Leishmania braziliensis	81%	100%
D0A3M2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	88%
E9AU86	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q0A5	Leishmania major	92%	100%
V5AXL9	Trypanosoma cruzi	54%	92%