COP9 signalosome complex subunit 4

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cop9 signalosome complex subunit - putative

Species:

Leishmania infantum

UniProt:

A4ICA8_LEIIN

TriTrypDb:

LINF_360076600

Length:

399

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4ICA8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ICA8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	18	22	PF00656	0.464
CLV_C14_Caspase3-7	374	378	PF00656	0.658
CLV_PCSK_KEX2_1	380	382	PF00082	0.529
CLV_PCSK_PC1ET2_1	380	382	PF00082	0.570
CLV_PCSK_SKI1_1	230	234	PF00082	0.434
CLV_PCSK_SKI1_1	300	304	PF00082	0.450
CLV_PCSK_SKI1_1	330	334	PF00082	0.534
CLV_PCSK_SKI1_1	34	38	PF00082	0.541
DEG_APCC_DBOX_1	229	237	PF00400	0.434
DOC_CYCLIN_RxL_1	318	329	PF00134	0.509
DOC_MAPK_gen_1	391	399	PF00069	0.594
DOC_MAPK_JIP1_4	393	399	PF00069	0.626
DOC_MAPK_MEF2A_6	391	398	PF00069	0.648
DOC_PP1_RVXF_1	109	116	PF00149	0.468
DOC_PP2B_LxvP_1	261	264	PF13499	0.482
DOC_USP7_MATH_1	211	215	PF00917	0.447
DOC_USP7_MATH_1	4	8	PF00917	0.536
DOC_WW_Pin1_4	129	134	PF00397	0.528
LIG_14-3-3_CanoR_1	210	216	PF00244	0.420
LIG_14-3-3_CanoR_1	34	39	PF00244	0.519
LIG_14-3-3_CanoR_1	79	88	PF00244	0.634
LIG_APCC_ABBA_1	323	328	PF00400	0.487
LIG_BIR_II_1	1	5	PF00653	0.651
LIG_BRCT_BRCA1_1	121	125	PF00533	0.478
LIG_BRCT_BRCA1_1	4	8	PF00533	0.693
LIG_deltaCOP1_diTrp_1	70	78	PF00928	0.504
LIG_FHA_1	356	362	PF00498	0.511
LIG_FHA_2	102	108	PF00498	0.566
LIG_FHA_2	130	136	PF00498	0.460
LIG_FHA_2	16	22	PF00498	0.516
LIG_FHA_2	26	32	PF00498	0.475
LIG_FHA_2	331	337	PF00498	0.495
LIG_FHA_2	372	378	PF00498	0.695
LIG_Integrin_isoDGR_2	39	41	PF01839	0.450
LIG_Integrin_RGD_1	19	21	PF01839	0.464
LIG_LIR_Apic_2	70	76	PF02991	0.502
LIG_LIR_Gen_1	101	109	PF02991	0.402
LIG_LIR_Gen_1	132	141	PF02991	0.470
LIG_LIR_Gen_1	314	323	PF02991	0.473
LIG_LIR_Gen_1	336	345	PF02991	0.423
LIG_LIR_Gen_1	357	367	PF02991	0.530
LIG_LIR_Gen_1	42	53	PF02991	0.454
LIG_LIR_Gen_1	7	17	PF02991	0.498
LIG_LIR_Nem_3	101	106	PF02991	0.548
LIG_LIR_Nem_3	122	128	PF02991	0.482
LIG_LIR_Nem_3	132	137	PF02991	0.478
LIG_LIR_Nem_3	165	170	PF02991	0.444
LIG_LIR_Nem_3	214	218	PF02991	0.535
LIG_LIR_Nem_3	314	318	PF02991	0.497
LIG_LIR_Nem_3	336	341	PF02991	0.473
LIG_LIR_Nem_3	357	363	PF02991	0.500
LIG_LIR_Nem_3	377	382	PF02991	0.547
LIG_LIR_Nem_3	42	48	PF02991	0.459
LIG_LIR_Nem_3	7	13	PF02991	0.493
LIG_MLH1_MIPbox_1	122	126	PF16413	0.579
LIG_NRBOX	336	342	PF00104	0.477
LIG_PDZ_Class_2	394	399	PF00595	0.668
LIG_Pex14_2	212	216	PF04695	0.513
LIG_SH2_CRK	128	132	PF00017	0.444
LIG_SH2_CRK	167	171	PF00017	0.609
LIG_SH2_CRK	266	270	PF00017	0.462
LIG_SH2_CRK	338	342	PF00017	0.466
LIG_SH2_NCK_1	103	107	PF00017	0.566
LIG_SH2_PTP2	268	271	PF00017	0.473
LIG_SH2_STAP1	338	342	PF00017	0.466
LIG_SH2_STAT3	273	276	PF00017	0.509
LIG_SH2_STAT3	293	296	PF00017	0.549
LIG_SH2_STAT5	103	106	PF00017	0.454
LIG_SH2_STAT5	194	197	PF00017	0.388
LIG_SH2_STAT5	208	211	PF00017	0.224
LIG_SH2_STAT5	268	271	PF00017	0.390
LIG_SH2_STAT5	293	296	PF00017	0.411
LIG_SH3_3	289	295	PF00018	0.448
LIG_SUMO_SIM_par_1	93	98	PF11976	0.363
LIG_TRAF2_1	68	71	PF00917	0.360
LIG_TYR_ITSM	99	106	PF00017	0.544
LIG_UBA3_1	308	313	PF00899	0.445
LIG_WRC_WIRS_1	212	217	PF05994	0.538
MOD_CDK_SPxxK_3	129	136	PF00069	0.573
MOD_CK1_1	147	153	PF00069	0.509
MOD_CK1_1	2	8	PF00069	0.712
MOD_CK1_1	46	52	PF00069	0.463
MOD_CK1_1	80	86	PF00069	0.616
MOD_CK2_1	25	31	PF00069	0.532
MOD_CK2_1	330	336	PF00069	0.517
MOD_GlcNHglycan	122	125	PF01048	0.534
MOD_GlcNHglycan	157	160	PF01048	0.515
MOD_GlcNHglycan	177	180	PF01048	0.366
MOD_GlcNHglycan	256	259	PF01048	0.571
MOD_GlcNHglycan	278	281	PF01048	0.580
MOD_GlcNHglycan	3	7	PF01048	0.453
MOD_GlcNHglycan	49	52	PF01048	0.453
MOD_GlcNHglycan	83	86	PF01048	0.623
MOD_GSK3_1	120	127	PF00069	0.582
MOD_GSK3_1	2	9	PF00069	0.480
MOD_GSK3_1	250	257	PF00069	0.426
MOD_GSK3_1	340	347	PF00069	0.499
MOD_GSK3_1	43	50	PF00069	0.424
MOD_GSK3_1	77	84	PF00069	0.595
MOD_GSK3_1	98	105	PF00069	0.474
MOD_N-GLC_1	80	85	PF02516	0.717
MOD_NEK2_1	120	125	PF00069	0.571
MOD_NEK2_1	144	149	PF00069	0.468
MOD_NEK2_1	340	345	PF00069	0.561
MOD_NEK2_1	95	100	PF00069	0.307
MOD_NEK2_2	211	216	PF00069	0.509
MOD_PIKK_1	180	186	PF00454	0.575
MOD_PIKK_1	250	256	PF00454	0.418
MOD_PIKK_1	344	350	PF00454	0.414
MOD_PIKK_1	43	49	PF00454	0.480
MOD_PKA_2	144	150	PF00069	0.479
MOD_PKA_2	254	260	PF00069	0.469
MOD_PKB_1	173	181	PF00069	0.706
MOD_Plk_1	20	26	PF00069	0.363
MOD_Plk_4	162	168	PF00069	0.555
MOD_Plk_4	211	217	PF00069	0.433
MOD_Plk_4	340	346	PF00069	0.572
MOD_ProDKin_1	129	135	PF00069	0.523
MOD_SUMO_rev_2	322	332	PF00179	0.516
TRG_DiLeu_BaEn_1	336	341	PF01217	0.479
TRG_ENDOCYTIC_2	103	106	PF00928	0.395
TRG_ENDOCYTIC_2	128	131	PF00928	0.432
TRG_ENDOCYTIC_2	167	170	PF00928	0.441
TRG_ENDOCYTIC_2	266	269	PF00928	0.441
TRG_ENDOCYTIC_2	338	341	PF00928	0.469
TRG_ER_diArg_1	173	176	PF00400	0.621
TRG_NES_CRM1_1	207	220	PF08389	0.454

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2K5	Leptomonas seymouri	56%	100%
A0A3S7XCD5	Leishmania donovani	99%	100%
A4HQH2	Leishmania braziliensis	81%	100%
E9AU85	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4Q0A6	Leishmania major	91%	100%