LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4ICA7_LEIIN
TriTrypDb:
LINF_360076500
Length:
652

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 7
NetGPI no yes: 0, no: 7
Cellular components
Term Name Level Count
GO:0016020 membrane 2 6
GO:0110165 cellular anatomical entity 1 6

Expansion

Sequence features

A4ICA7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ICA7

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 338 342 PF00656 0.559
CLV_NRD_NRD_1 172 174 PF00675 0.584
CLV_NRD_NRD_1 297 299 PF00675 0.425
CLV_NRD_NRD_1 36 38 PF00675 0.434
CLV_NRD_NRD_1 42 44 PF00675 0.408
CLV_NRD_NRD_1 448 450 PF00675 0.453
CLV_NRD_NRD_1 554 556 PF00675 0.571
CLV_NRD_NRD_1 582 584 PF00675 0.576
CLV_NRD_NRD_1 640 642 PF00675 0.536
CLV_NRD_NRD_1 90 92 PF00675 0.517
CLV_PCSK_FUR_1 580 584 PF00082 0.554
CLV_PCSK_KEX2_1 172 174 PF00082 0.476
CLV_PCSK_KEX2_1 272 274 PF00082 0.373
CLV_PCSK_KEX2_1 35 37 PF00082 0.435
CLV_PCSK_KEX2_1 42 44 PF00082 0.409
CLV_PCSK_KEX2_1 448 450 PF00082 0.430
CLV_PCSK_KEX2_1 554 556 PF00082 0.571
CLV_PCSK_KEX2_1 582 584 PF00082 0.533
CLV_PCSK_KEX2_1 640 642 PF00082 0.560
CLV_PCSK_KEX2_1 90 92 PF00082 0.557
CLV_PCSK_PC1ET2_1 272 274 PF00082 0.373
CLV_PCSK_PC1ET2_1 35 37 PF00082 0.405
CLV_PCSK_SKI1_1 141 145 PF00082 0.504
CLV_PCSK_SKI1_1 299 303 PF00082 0.444
CLV_PCSK_SKI1_1 38 42 PF00082 0.404
CLV_PCSK_SKI1_1 494 498 PF00082 0.631
CLV_PCSK_SKI1_1 70 74 PF00082 0.380
CLV_Separin_Metazoa 237 241 PF03568 0.561
CLV_Separin_Metazoa 39 43 PF03568 0.548
DEG_APCC_DBOX_1 69 77 PF00400 0.604
DEG_Nend_UBRbox_2 1 3 PF02207 0.461
DEG_SCF_FBW7_1 204 209 PF00400 0.574
DEG_SCF_FBW7_1 413 420 PF00400 0.589
DEG_SCF_FBW7_1 98 104 PF00400 0.670
DEG_SPOP_SBC_1 149 153 PF00917 0.675
DEG_SPOP_SBC_1 78 82 PF00917 0.671
DOC_CKS1_1 414 419 PF01111 0.589
DOC_CKS1_1 575 580 PF01111 0.362
DOC_CKS1_1 98 103 PF01111 0.706
DOC_CYCLIN_yCln2_LP_2 484 490 PF00134 0.410
DOC_MAPK_gen_1 448 455 PF00069 0.608
DOC_MAPK_MEF2A_6 388 396 PF00069 0.464
DOC_PP2B_LxvP_1 484 487 PF13499 0.429
DOC_PP2B_LxvP_1 517 520 PF13499 0.357
DOC_PP4_FxxP_1 575 578 PF00568 0.362
DOC_USP7_MATH_1 168 172 PF00917 0.716
DOC_USP7_MATH_1 258 262 PF00917 0.593
DOC_USP7_MATH_1 408 412 PF00917 0.650
DOC_USP7_MATH_1 417 421 PF00917 0.685
DOC_USP7_MATH_1 531 535 PF00917 0.399
DOC_USP7_MATH_1 581 585 PF00917 0.385
DOC_USP7_MATH_1 72 76 PF00917 0.628
DOC_USP7_MATH_1 78 82 PF00917 0.699
DOC_USP7_UBL2_3 286 290 PF12436 0.607
DOC_WW_Pin1_4 171 176 PF00397 0.675
DOC_WW_Pin1_4 182 187 PF00397 0.727
DOC_WW_Pin1_4 202 207 PF00397 0.645
DOC_WW_Pin1_4 27 32 PF00397 0.623
DOC_WW_Pin1_4 313 318 PF00397 0.616
DOC_WW_Pin1_4 413 418 PF00397 0.574
DOC_WW_Pin1_4 46 51 PF00397 0.596
DOC_WW_Pin1_4 477 482 PF00397 0.490
DOC_WW_Pin1_4 56 61 PF00397 0.540
DOC_WW_Pin1_4 574 579 PF00397 0.356
DOC_WW_Pin1_4 598 603 PF00397 0.386
DOC_WW_Pin1_4 85 90 PF00397 0.780
DOC_WW_Pin1_4 94 99 PF00397 0.827
LIG_14-3-3_CanoR_1 129 134 PF00244 0.805
LIG_14-3-3_CanoR_1 150 155 PF00244 0.704
LIG_14-3-3_CanoR_1 199 205 PF00244 0.710
LIG_14-3-3_CanoR_1 298 308 PF00244 0.666
LIG_14-3-3_CanoR_1 580 586 PF00244 0.354
LIG_Clathr_ClatBox_1 548 552 PF01394 0.328
LIG_deltaCOP1_diTrp_1 616 624 PF00928 0.341
LIG_deltaCOP1_diTrp_1 8 11 PF00928 0.390
LIG_DLG_GKlike_1 129 137 PF00625 0.719
LIG_EVH1_2 519 523 PF00568 0.364
LIG_FHA_1 150 156 PF00498 0.706
LIG_FHA_1 207 213 PF00498 0.682
LIG_FHA_1 264 270 PF00498 0.587
LIG_FHA_1 331 337 PF00498 0.530
LIG_FHA_1 429 435 PF00498 0.552
LIG_FHA_1 512 518 PF00498 0.340
LIG_FHA_1 535 541 PF00498 0.411
LIG_FHA_1 571 577 PF00498 0.368
LIG_FHA_1 604 610 PF00498 0.336
LIG_FHA_2 114 120 PF00498 0.659
LIG_FHA_2 301 307 PF00498 0.626
LIG_FHA_2 336 342 PF00498 0.579
LIG_FHA_2 495 501 PF00498 0.404
LIG_FHA_2 542 548 PF00498 0.378
LIG_HCF-1_HBM_1 529 532 PF13415 0.418
LIG_LIR_Apic_2 229 235 PF02991 0.595
LIG_LIR_Apic_2 572 578 PF02991 0.354
LIG_LIR_Gen_1 306 315 PF02991 0.596
LIG_LIR_Gen_1 521 531 PF02991 0.387
LIG_LIR_Gen_1 565 576 PF02991 0.333
LIG_LIR_Gen_1 616 627 PF02991 0.341
LIG_LIR_Gen_1 8 19 PF02991 0.257
LIG_LIR_LC3C_4 108 112 PF02991 0.617
LIG_LIR_Nem_3 104 110 PF02991 0.651
LIG_LIR_Nem_3 287 291 PF02991 0.539
LIG_LIR_Nem_3 306 311 PF02991 0.568
LIG_LIR_Nem_3 521 526 PF02991 0.415
LIG_LIR_Nem_3 565 571 PF02991 0.340
LIG_LIR_Nem_3 616 622 PF02991 0.287
LIG_LIR_Nem_3 8 14 PF02991 0.300
LIG_MYND_1 482 486 PF01753 0.448
LIG_NRBOX 346 352 PF00104 0.562
LIG_PTAP_UEV_1 402 407 PF05743 0.577
LIG_SH2_CRK 312 316 PF00017 0.619
LIG_SH2_GRB2like 308 311 PF00017 0.627
LIG_SH2_PTP2 308 311 PF00017 0.627
LIG_SH2_SRC 308 311 PF00017 0.627
LIG_SH2_STAP1 332 336 PF00017 0.552
LIG_SH2_STAP1 343 347 PF00017 0.587
LIG_SH2_STAP1 532 536 PF00017 0.390
LIG_SH2_STAT3 332 335 PF00017 0.509
LIG_SH2_STAT3 352 355 PF00017 0.463
LIG_SH2_STAT3 379 382 PF00017 0.532
LIG_SH2_STAT3 610 613 PF00017 0.332
LIG_SH2_STAT5 23 26 PF00017 0.397
LIG_SH2_STAT5 270 273 PF00017 0.568
LIG_SH2_STAT5 288 291 PF00017 0.494
LIG_SH2_STAT5 308 311 PF00017 0.498
LIG_SH2_STAT5 324 327 PF00017 0.523
LIG_SH2_STAT5 332 335 PF00017 0.524
LIG_SH2_STAT5 352 355 PF00017 0.463
LIG_SH2_STAT5 390 393 PF00017 0.536
LIG_SH2_STAT5 468 471 PF00017 0.271
LIG_SH2_STAT5 570 573 PF00017 0.363
LIG_SH3_2 578 583 PF14604 0.359
LIG_SH3_3 389 395 PF00018 0.546
LIG_SH3_3 397 403 PF00018 0.526
LIG_SH3_3 479 485 PF00018 0.520
LIG_SH3_3 575 581 PF00018 0.356
LIG_SH3_3 95 101 PF00018 0.742
LIG_SUMO_SIM_anti_2 247 255 PF11976 0.511
LIG_SUMO_SIM_anti_2 49 55 PF11976 0.601
LIG_SUMO_SIM_par_1 108 114 PF11976 0.679
LIG_TRAF2_1 342 345 PF00917 0.582
LIG_UBA3_1 51 55 PF00899 0.526
LIG_WW_2 482 485 PF00397 0.444
MOD_CDC14_SPxK_1 174 177 PF00782 0.635
MOD_CDC14_SPxK_1 601 604 PF00782 0.376
MOD_CDK_SPK_2 85 90 PF00069 0.709
MOD_CDK_SPxK_1 171 177 PF00069 0.635
MOD_CDK_SPxK_1 413 419 PF00069 0.541
MOD_CDK_SPxK_1 574 580 PF00069 0.358
MOD_CDK_SPxK_1 598 604 PF00069 0.358
MOD_CDK_SPxK_1 85 91 PF00069 0.711
MOD_CK1_1 132 138 PF00069 0.808
MOD_CK1_1 156 162 PF00069 0.707
MOD_CK1_1 171 177 PF00069 0.724
MOD_CK1_1 226 232 PF00069 0.570
MOD_CK1_1 247 253 PF00069 0.545
MOD_CK1_1 534 540 PF00069 0.345
MOD_CK1_1 542 548 PF00069 0.337
MOD_CK1_1 82 88 PF00069 0.715
MOD_CK1_1 97 103 PF00069 0.735
MOD_CK2_1 300 306 PF00069 0.615
MOD_CK2_1 541 547 PF00069 0.430
MOD_CK2_1 56 62 PF00069 0.588
MOD_CK2_1 566 572 PF00069 0.352
MOD_CK2_1 626 632 PF00069 0.380
MOD_GlcNHglycan 155 158 PF01048 0.425
MOD_GlcNHglycan 162 165 PF01048 0.415
MOD_GlcNHglycan 200 203 PF01048 0.558
MOD_GlcNHglycan 217 220 PF01048 0.272
MOD_GlcNHglycan 225 228 PF01048 0.378
MOD_GlcNHglycan 254 259 PF01048 0.362
MOD_GlcNHglycan 355 358 PF01048 0.365
MOD_GlcNHglycan 364 368 PF01048 0.470
MOD_GlcNHglycan 419 422 PF01048 0.435
MOD_GlcNHglycan 503 506 PF01048 0.589
MOD_GlcNHglycan 509 512 PF01048 0.640
MOD_GlcNHglycan 544 547 PF01048 0.649
MOD_GlcNHglycan 628 631 PF01048 0.575
MOD_GSK3_1 127 134 PF00069 0.791
MOD_GSK3_1 141 148 PF00069 0.668
MOD_GSK3_1 149 156 PF00069 0.671
MOD_GSK3_1 198 205 PF00069 0.681
MOD_GSK3_1 23 30 PF00069 0.572
MOD_GSK3_1 254 261 PF00069 0.576
MOD_GSK3_1 300 307 PF00069 0.636
MOD_GSK3_1 413 420 PF00069 0.649
MOD_GSK3_1 503 510 PF00069 0.365
MOD_GSK3_1 534 541 PF00069 0.365
MOD_GSK3_1 566 573 PF00069 0.384
MOD_GSK3_1 598 605 PF00069 0.391
MOD_GSK3_1 78 85 PF00069 0.713
MOD_GSK3_1 97 104 PF00069 0.643
MOD_N-GLC_1 168 173 PF02516 0.461
MOD_N-GLC_1 428 433 PF02516 0.333
MOD_NEK2_1 133 138 PF00069 0.717
MOD_NEK2_1 217 222 PF00069 0.515
MOD_NEK2_1 350 355 PF00069 0.564
MOD_NEK2_1 503 508 PF00069 0.369
MOD_NEK2_1 538 543 PF00069 0.356
MOD_NEK2_1 643 648 PF00069 0.349
MOD_NEK2_2 113 118 PF00069 0.653
MOD_NEK2_2 206 211 PF00069 0.585
MOD_NEK2_2 23 28 PF00069 0.376
MOD_NEK2_2 570 575 PF00069 0.332
MOD_NEK2_2 72 77 PF00069 0.611
MOD_PIKK_1 83 89 PF00454 0.681
MOD_PKA_1 554 560 PF00069 0.356
MOD_PKA_2 149 155 PF00069 0.694
MOD_PKA_2 198 204 PF00069 0.745
MOD_PKA_2 247 253 PF00069 0.545
MOD_PKA_2 554 560 PF00069 0.403
MOD_PKA_2 581 587 PF00069 0.389
MOD_PKB_1 129 137 PF00069 0.694
MOD_PKB_1 94 102 PF00069 0.680
MOD_Plk_1 254 260 PF00069 0.590
MOD_Plk_1 428 434 PF00069 0.498
MOD_Plk_1 511 517 PF00069 0.380
MOD_Plk_1 532 538 PF00069 0.378
MOD_Plk_1 560 566 PF00069 0.376
MOD_Plk_2-3 193 199 PF00069 0.658
MOD_Plk_4 150 156 PF00069 0.703
MOD_Plk_4 247 253 PF00069 0.545
MOD_Plk_4 284 290 PF00069 0.600
MOD_Plk_4 300 306 PF00069 0.645
MOD_Plk_4 503 509 PF00069 0.334
MOD_Plk_4 511 517 PF00069 0.332
MOD_Plk_4 522 528 PF00069 0.310
MOD_Plk_4 534 540 PF00069 0.364
MOD_Plk_4 570 576 PF00069 0.361
MOD_Plk_4 603 609 PF00069 0.342
MOD_Plk_4 643 649 PF00069 0.356
MOD_Plk_4 79 85 PF00069 0.676
MOD_ProDKin_1 171 177 PF00069 0.677
MOD_ProDKin_1 182 188 PF00069 0.727
MOD_ProDKin_1 202 208 PF00069 0.639
MOD_ProDKin_1 27 33 PF00069 0.621
MOD_ProDKin_1 313 319 PF00069 0.606
MOD_ProDKin_1 413 419 PF00069 0.583
MOD_ProDKin_1 46 52 PF00069 0.597
MOD_ProDKin_1 477 483 PF00069 0.487
MOD_ProDKin_1 56 62 PF00069 0.539
MOD_ProDKin_1 574 580 PF00069 0.358
MOD_ProDKin_1 598 604 PF00069 0.390
MOD_ProDKin_1 85 91 PF00069 0.782
MOD_ProDKin_1 94 100 PF00069 0.826
MOD_SUMO_rev_2 283 287 PF00179 0.546
TRG_DiLeu_BaEn_1 616 621 PF01217 0.319
TRG_DiLeu_BaEn_1 8 13 PF01217 0.288
TRG_DiLeu_BaEn_2 236 242 PF01217 0.569
TRG_DiLeu_BaLyEn_6 451 456 PF01217 0.548
TRG_ENDOCYTIC_2 107 110 PF00928 0.644
TRG_ENDOCYTIC_2 288 291 PF00928 0.553
TRG_ENDOCYTIC_2 308 311 PF00928 0.498
TRG_ER_diArg_1 128 131 PF00400 0.678
TRG_ER_diArg_1 210 213 PF00400 0.570
TRG_ER_diArg_1 41 43 PF00400 0.627
TRG_ER_diArg_1 553 555 PF00400 0.350
TRG_ER_diArg_1 580 583 PF00400 0.355
TRG_ER_diArg_1 639 641 PF00400 0.323
TRG_ER_diArg_1 89 91 PF00400 0.717
TRG_ER_FFAT_1 185 196 PF00635 0.657
TRG_Pf-PMV_PEXEL_1 240 244 PF00026 0.362
TRG_Pf-PMV_PEXEL_1 42 46 PF00026 0.430

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IHH7 Leptomonas seymouri 42% 100%
A0A3S7XCG4 Leishmania donovani 100% 100%
A0A422NKE7 Trypanosoma rangeli 28% 100%
A4HQH1 Leishmania braziliensis 69% 100%
E9AU84 Leishmania mexicana (strain MHOM/GT/2001/U1103) 84% 100%
Q4Q0A7 Leishmania major 91% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS