LeishMANIAdb
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Putative histidine secretory acid phosphatase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative histidine secretory acid phosphatase
Gene product:
tartrate-sensitive acid phosphatase acp-3.2 - putative
Species:
Leishmania infantum
UniProt:
A4ICA5_LEIIN
TriTrypDb:
LINF_360076300 *
Length:
667

Annotations

LeishMANIAdb annotations

An extensively expanded family of exophosphatase enzymes presumed to be active at acidic pH

Annotations by Jardim et al.

Phosphatase, histidine secretory acid phosphatase

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 1
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 60
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 7
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 14
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 30, no: 2
NetGPI no yes: 0, no: 32
Cellular components
TermNameLevelCount
GO:0016020 membrane 2 24
GO:0110165 cellular anatomical entity 1 24
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Expansion

Sequence features

A4ICA5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ICA5

Function

Biological processes
TermNameLevelCount
GO:0006793 phosphorus metabolic process 3 4
GO:0006796 phosphate-containing compound metabolic process 4 4
GO:0008152 metabolic process 1 4
GO:0009987 cellular process 1 4
GO:0016311 dephosphorylation 5 4
GO:0044237 cellular metabolic process 2 4
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Molecular functions
TermNameLevelCount
GO:0003824 catalytic activity 1 5
GO:0003993 acid phosphatase activity 6 1
GO:0016787 hydrolase activity 2 5
GO:0016788 hydrolase activity, acting on ester bonds 3 5
GO:0016791 phosphatase activity 5 5
GO:0042578 phosphoric ester hydrolase activity 4 5
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Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_C14_Caspase3-7 154 158 PF00656 0.283
CLV_C14_Caspase3-7 320 324 PF00656 0.394
CLV_C14_Caspase3-7 406 410 PF00656 0.535
CLV_NRD_NRD_1 376 378 PF00675 0.515
CLV_NRD_NRD_1 655 657 PF00675 0.492
CLV_PCSK_KEX2_1 376 378 PF00082 0.500
CLV_PCSK_SKI1_1 119 123 PF00082 0.453
CLV_PCSK_SKI1_1 239 243 PF00082 0.433
CLV_PCSK_SKI1_1 39 43 PF00082 0.298
CLV_Separin_Metazoa 66 70 PF03568 0.242
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N0P5Y5 Leptomonas seymouri 33% 100%
A0A0N1PEH4 Leptomonas seymouri 61% 100%
A0A0S4IV77 Bodo saltans 32% 100%
A0A0S4IXN9 Bodo saltans 27% 100%
A0A0S4JEA9 Bodo saltans 26% 100%
A0A1X0NQL4 Trypanosomatidae 28% 100%
A0A3Q8IR23 Leishmania donovani 36% 100%
A0A3R7MHJ7 Trypanosoma rangeli 27% 100%
A0A3S5H827 Leishmania donovani 36% 100%
A0A3S7WXU0 Leishmania donovani 35% 100%
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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS