LeishMANIAdb
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Putative histidine secretory acid phosphatase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative histidine secretory acid phosphatase
Gene product:
tartrate-sensitive acid phosphatase acp-3.2 - putative
Species:
Leishmania infantum
UniProt:
A4ICA5_LEIIN
TriTrypDb:
LINF_360076300 *
Length:
667

Annotations

LeishMANIAdb annotations

An extensively expanded family of exophosphatase enzymes presumed to be active at acidic pH

Annotations by Jardim et al.

Phosphatase, histidine secretory acid phosphatase

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 1
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 60
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 7
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 14
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 30, no: 2
NetGPI no yes: 0, no: 32
Cellular components
Term Name Level Count
GO:0016020 membrane 2 24
GO:0110165 cellular anatomical entity 1 24

Expansion

Sequence features

A4ICA5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ICA5

Function

Biological processes
Term Name Level Count
GO:0006793 phosphorus metabolic process 3 4
GO:0006796 phosphate-containing compound metabolic process 4 4
GO:0008152 metabolic process 1 4
GO:0009987 cellular process 1 4
GO:0016311 dephosphorylation 5 4
GO:0044237 cellular metabolic process 2 4
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 5
GO:0003993 acid phosphatase activity 6 1
GO:0016787 hydrolase activity 2 5
GO:0016788 hydrolase activity, acting on ester bonds 3 5
GO:0016791 phosphatase activity 5 5
GO:0042578 phosphoric ester hydrolase activity 4 5

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 154 158 PF00656 0.283
CLV_C14_Caspase3-7 320 324 PF00656 0.394
CLV_C14_Caspase3-7 406 410 PF00656 0.535
CLV_NRD_NRD_1 376 378 PF00675 0.515
CLV_NRD_NRD_1 655 657 PF00675 0.492
CLV_PCSK_KEX2_1 376 378 PF00082 0.500
CLV_PCSK_SKI1_1 119 123 PF00082 0.453
CLV_PCSK_SKI1_1 239 243 PF00082 0.433
CLV_PCSK_SKI1_1 39 43 PF00082 0.298
CLV_Separin_Metazoa 66 70 PF03568 0.242
DEG_COP1_1 143 150 PF00400 0.278
DEG_SPOP_SBC_1 449 453 PF00917 0.502
DOC_CYCLIN_RxL_1 116 125 PF00134 0.433
DOC_CYCLIN_yCln2_LP_2 156 162 PF00134 0.272
DOC_MAPK_gen_1 134 142 PF00069 0.297
DOC_MAPK_gen_1 330 339 PF00069 0.466
DOC_MAPK_gen_1 76 84 PF00069 0.325
DOC_MAPK_MEF2A_6 306 315 PF00069 0.523
DOC_PP4_FxxP_1 618 621 PF00568 0.520
DOC_PP4_MxPP_1 305 308 PF00568 0.516
DOC_USP7_MATH_1 146 150 PF00917 0.304
DOC_USP7_MATH_1 17 21 PF00917 0.578
DOC_USP7_MATH_1 177 181 PF00917 0.303
DOC_USP7_MATH_1 196 200 PF00917 0.304
DOC_USP7_MATH_1 322 326 PF00917 0.578
DOC_USP7_MATH_1 412 416 PF00917 0.409
DOC_USP7_MATH_1 423 427 PF00917 0.519
DOC_USP7_MATH_1 449 453 PF00917 0.693
DOC_USP7_MATH_1 460 464 PF00917 0.712
DOC_USP7_MATH_1 476 480 PF00917 0.547
DOC_USP7_MATH_1 484 488 PF00917 0.531
DOC_USP7_MATH_1 492 496 PF00917 0.530
DOC_USP7_MATH_1 500 504 PF00917 0.538
DOC_USP7_MATH_1 508 512 PF00917 0.533
DOC_USP7_MATH_1 516 520 PF00917 0.526
DOC_USP7_MATH_1 524 528 PF00917 0.522
DOC_USP7_MATH_1 532 536 PF00917 0.530
DOC_USP7_MATH_1 548 552 PF00917 0.515
DOC_USP7_MATH_1 556 560 PF00917 0.529
DOC_USP7_MATH_1 564 568 PF00917 0.534
DOC_USP7_MATH_1 572 576 PF00917 0.525
DOC_USP7_MATH_1 580 584 PF00917 0.522
DOC_USP7_MATH_1 588 592 PF00917 0.536
DOC_USP7_MATH_1 596 600 PF00917 0.527
DOC_USP7_MATH_1 604 608 PF00917 0.521
DOC_WW_Pin1_4 272 277 PF00397 0.414
DOC_WW_Pin1_4 627 632 PF00397 0.512
DOC_WW_Pin1_4 84 89 PF00397 0.406
LIG_14-3-3_CanoR_1 103 111 PF00244 0.450
LIG_14-3-3_CanoR_1 134 142 PF00244 0.588
LIG_14-3-3_CanoR_1 197 205 PF00244 0.406
LIG_14-3-3_CanoR_1 362 372 PF00244 0.477
LIG_APCC_ABBA_1 311 316 PF00400 0.266
LIG_BIR_II_1 1 5 PF00653 0.539
LIG_BIR_III_2 145 149 PF00653 0.368
LIG_BIR_III_4 323 327 PF00653 0.319
LIG_BIR_III_4 357 361 PF00653 0.568
LIG_BRCT_BRCA1_1 86 90 PF00533 0.310
LIG_eIF4E_1 79 85 PF01652 0.325
LIG_FHA_1 113 119 PF00498 0.339
LIG_FHA_1 136 142 PF00498 0.431
LIG_FHA_1 196 202 PF00498 0.457
LIG_FHA_1 245 251 PF00498 0.583
LIG_FHA_1 286 292 PF00498 0.362
LIG_FHA_1 310 316 PF00498 0.418
LIG_FHA_1 430 436 PF00498 0.566
LIG_FHA_1 45 51 PF00498 0.553
LIG_FHA_2 294 300 PF00498 0.497
LIG_FHA_2 347 353 PF00498 0.580
LIG_FHA_2 404 410 PF00498 0.557
LIG_LIR_Apic_2 124 129 PF02991 0.441
LIG_LIR_Apic_2 380 384 PF02991 0.422
LIG_LIR_Apic_2 616 621 PF02991 0.508
LIG_LIR_Gen_1 174 182 PF02991 0.552
LIG_LIR_Gen_1 275 285 PF02991 0.457
LIG_LIR_Gen_1 312 322 PF02991 0.505
LIG_LIR_Gen_1 325 336 PF02991 0.374
LIG_LIR_Gen_1 77 85 PF02991 0.219
LIG_LIR_LC3C_4 22 27 PF02991 0.467
LIG_LIR_Nem_3 124 130 PF02991 0.531
LIG_LIR_Nem_3 174 178 PF02991 0.562
LIG_LIR_Nem_3 275 281 PF02991 0.501
LIG_LIR_Nem_3 312 317 PF02991 0.491
LIG_LIR_Nem_3 325 331 PF02991 0.384
LIG_LIR_Nem_3 77 82 PF02991 0.432
LIG_LYPXL_S_1 127 131 PF13949 0.521
LIG_LYPXL_S_1 226 230 PF13949 0.256
LIG_LYPXL_yS_3 128 131 PF13949 0.509
LIG_LYPXL_yS_3 227 230 PF13949 0.313
LIG_Pex14_1 418 422 PF04695 0.363
LIG_Pex14_2 238 242 PF04695 0.266
LIG_PTB_Apo_2 338 345 PF02174 0.306
LIG_PTB_Phospho_1 338 344 PF10480 0.307
LIG_Rb_pABgroove_1 199 207 PF01858 0.464
LIG_REV1ctd_RIR_1 615 620 PF16727 0.508
LIG_SH2_CRK 162 166 PF00017 0.272
LIG_SH2_CRK 381 385 PF00017 0.464
LIG_SH2_CRK 422 426 PF00017 0.365
LIG_SH2_GRB2like 398 401 PF00017 0.418
LIG_SH2_NCK_1 205 209 PF00017 0.478
LIG_SH2_NCK_1 381 385 PF00017 0.464
LIG_SH2_NCK_1 422 426 PF00017 0.532
LIG_SH2_PTP2 328 331 PF00017 0.523
LIG_SH2_STAP1 205 209 PF00017 0.392
LIG_SH2_STAT5 101 104 PF00017 0.284
LIG_SH2_STAT5 126 129 PF00017 0.462
LIG_SH2_STAT5 240 243 PF00017 0.376
LIG_SH2_STAT5 328 331 PF00017 0.425
LIG_SH2_STAT5 344 347 PF00017 0.472
LIG_SH2_STAT5 433 436 PF00017 0.530
LIG_SH3_3 625 631 PF00018 0.488
LIG_SH3_3 82 88 PF00018 0.477
LIG_Sin3_3 10 17 PF02671 0.483
LIG_SUMO_SIM_anti_2 81 87 PF11976 0.325
LIG_SUMO_SIM_par_1 291 296 PF11976 0.412
MOD_CDC14_SPxK_1 630 633 PF00782 0.534
MOD_CDK_SPK_2 627 632 PF00069 0.498
MOD_CDK_SPxK_1 627 633 PF00069 0.516
MOD_CK1_1 104 110 PF00069 0.431
MOD_CK1_1 451 457 PF00069 0.720
MOD_CK1_1 463 469 PF00069 0.530
MOD_CK1_1 471 477 PF00069 0.523
MOD_CK1_1 479 485 PF00069 0.519
MOD_CK1_1 487 493 PF00069 0.524
MOD_CK1_1 495 501 PF00069 0.524
MOD_CK1_1 503 509 PF00069 0.517
MOD_CK1_1 519 525 PF00069 0.522
MOD_CK1_1 527 533 PF00069 0.543
MOD_CK1_1 535 541 PF00069 0.555
MOD_CK1_1 543 549 PF00069 0.539
MOD_CK1_1 551 557 PF00069 0.523
MOD_CK1_1 559 565 PF00069 0.532
MOD_CK1_1 567 573 PF00069 0.532
MOD_CK1_1 575 581 PF00069 0.517
MOD_CK1_1 583 589 PF00069 0.529
MOD_CK1_1 599 605 PF00069 0.532
MOD_CK1_1 607 613 PF00069 0.521
MOD_CK2_1 346 352 PF00069 0.491
MOD_CK2_1 458 464 PF00069 0.536
MOD_CK2_1 466 472 PF00069 0.679
MOD_CK2_1 482 488 PF00069 0.517
MOD_CK2_1 490 496 PF00069 0.537
MOD_CK2_1 506 512 PF00069 0.524
MOD_CK2_1 514 520 PF00069 0.543
MOD_CK2_1 530 536 PF00069 0.538
MOD_CK2_1 538 544 PF00069 0.548
MOD_CK2_1 554 560 PF00069 0.529
MOD_CK2_1 562 568 PF00069 0.544
MOD_CK2_1 578 584 PF00069 0.524
MOD_CK2_1 586 592 PF00069 0.538
MOD_CK2_1 594 600 PF00069 0.533
MOD_CK2_1 602 608 PF00069 0.528
MOD_CK2_1 80 86 PF00069 0.385
MOD_GlcNHglycan 112 115 PF01048 0.414
MOD_GlcNHglycan 179 182 PF01048 0.333
MOD_GlcNHglycan 255 258 PF01048 0.501
MOD_GlcNHglycan 282 286 PF01048 0.509
MOD_GlcNHglycan 323 327 PF01048 0.532
MOD_GlcNHglycan 365 368 PF01048 0.424
MOD_GlcNHglycan 39 42 PF01048 0.478
MOD_GlcNHglycan 435 438 PF01048 0.412
MOD_GSK3_1 130 137 PF00069 0.505
MOD_GSK3_1 240 247 PF00069 0.301
MOD_GSK3_1 281 288 PF00069 0.426
MOD_GSK3_1 318 325 PF00069 0.496
MOD_GSK3_1 429 436 PF00069 0.418
MOD_GSK3_1 448 455 PF00069 0.743
MOD_GSK3_1 456 463 PF00069 0.745
MOD_GSK3_1 464 471 PF00069 0.652
MOD_GSK3_1 472 479 PF00069 0.595
MOD_GSK3_1 480 487 PF00069 0.641
MOD_GSK3_1 488 495 PF00069 0.820
MOD_GSK3_1 496 503 PF00069 0.532
MOD_GSK3_1 504 511 PF00069 0.520
MOD_GSK3_1 512 519 PF00069 0.526
MOD_GSK3_1 520 527 PF00069 0.530
MOD_GSK3_1 528 535 PF00069 0.546
MOD_GSK3_1 536 543 PF00069 0.548
MOD_GSK3_1 544 551 PF00069 0.527
MOD_GSK3_1 552 559 PF00069 0.522
MOD_GSK3_1 560 567 PF00069 0.534
MOD_GSK3_1 568 575 PF00069 0.530
MOD_GSK3_1 576 583 PF00069 0.520
MOD_GSK3_1 584 591 PF00069 0.528
MOD_GSK3_1 592 599 PF00069 0.534
MOD_GSK3_1 600 607 PF00069 0.530
MOD_GSK3_1 609 616 PF00069 0.515
MOD_GSK3_1 80 87 PF00069 0.395
MOD_GSK3_1 90 97 PF00069 0.296
MOD_N-GLC_1 134 139 PF02516 0.455
MOD_N-GLC_1 218 223 PF02516 0.454
MOD_N-GLC_1 244 249 PF02516 0.483
MOD_N-GLC_1 301 306 PF02516 0.410
MOD_N-GLC_1 340 345 PF02516 0.482
MOD_N-GLC_1 449 454 PF02516 0.582
MOD_N-GLC_1 45 50 PF02516 0.530
MOD_N-GLC_1 95 100 PF02516 0.415
MOD_NEK2_1 151 156 PF00069 0.482
MOD_NEK2_1 250 255 PF00069 0.392
MOD_NEK2_1 261 266 PF00069 0.381
MOD_NEK2_1 281 286 PF00069 0.427
MOD_NEK2_1 293 298 PF00069 0.468
MOD_NEK2_1 309 314 PF00069 0.403
MOD_NEK2_1 346 351 PF00069 0.534
MOD_NEK2_1 74 79 PF00069 0.432
MOD_NEK2_1 99 104 PF00069 0.415
MOD_NEK2_2 301 306 PF00069 0.318
MOD_PIKK_1 104 110 PF00454 0.219
MOD_PIKK_1 250 256 PF00454 0.418
MOD_PIKK_1 391 397 PF00454 0.466
MOD_PIKK_1 90 96 PF00454 0.429
MOD_PKA_2 102 108 PF00069 0.434
MOD_PKA_2 135 141 PF00069 0.567
MOD_PKA_2 196 202 PF00069 0.445
MOD_PKA_2 346 352 PF00069 0.466
MOD_PKA_2 363 369 PF00069 0.597
MOD_Plk_1 286 292 PF00069 0.456
MOD_Plk_1 301 307 PF00069 0.421
MOD_Plk_1 613 619 PF00069 0.519
MOD_Plk_1 80 86 PF00069 0.447
MOD_Plk_1 95 101 PF00069 0.355
MOD_Plk_2-3 171 177 PF00069 0.289
MOD_Plk_4 146 152 PF00069 0.369
MOD_Plk_4 261 267 PF00069 0.455
MOD_Plk_4 286 292 PF00069 0.289
MOD_Plk_4 309 315 PF00069 0.375
MOD_Plk_4 340 346 PF00069 0.458
MOD_Plk_4 429 435 PF00069 0.351
MOD_Plk_4 50 56 PF00069 0.527
MOD_Plk_4 613 619 PF00069 0.517
MOD_Plk_4 620 626 PF00069 0.452
MOD_Plk_4 80 86 PF00069 0.425
MOD_Plk_4 95 101 PF00069 0.405
MOD_ProDKin_1 272 278 PF00069 0.412
MOD_ProDKin_1 627 633 PF00069 0.516
MOD_ProDKin_1 84 90 PF00069 0.406
TRG_DiLeu_BaLyEn_6 327 332 PF01217 0.495
TRG_ENDOCYTIC_2 128 131 PF00928 0.541
TRG_ENDOCYTIC_2 162 165 PF00928 0.508
TRG_ENDOCYTIC_2 227 230 PF00928 0.498
TRG_ENDOCYTIC_2 278 281 PF00928 0.521
TRG_ENDOCYTIC_2 328 331 PF00928 0.463
TRG_ENDOCYTIC_2 398 401 PF00928 0.487
TRG_ENDOCYTIC_2 79 82 PF00928 0.275
TRG_ER_diArg_1 375 377 PF00400 0.511
TRG_ER_diArg_1 76 79 PF00400 0.447
TRG_NLS_MonoExtN_4 631 636 PF00514 0.521
TRG_Pf-PMV_PEXEL_1 119 123 PF00026 0.457
TRG_Pf-PMV_PEXEL_1 405 409 PF00026 0.397
TRG_Pf-PMV_PEXEL_1 69 73 PF00026 0.362

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P5Y5 Leptomonas seymouri 33% 100%
A0A0N1PEH4 Leptomonas seymouri 61% 100%
A0A0S4IV77 Bodo saltans 32% 100%
A0A0S4IXN9 Bodo saltans 27% 100%
A0A0S4JEA9 Bodo saltans 26% 100%
A0A1X0NQL4 Trypanosomatidae 28% 100%
A0A3Q8IR23 Leishmania donovani 36% 100%
A0A3R7MHJ7 Trypanosoma rangeli 27% 100%
A0A3S5H827 Leishmania donovani 36% 100%
A0A3S7WXU0 Leishmania donovani 35% 100%
A0A3S7X1W4 Leishmania donovani 34% 100%
A4HCZ0 Leishmania braziliensis 36% 100%
A4HGW8 Leishmania braziliensis 34% 100%
A4HPC1 Leishmania braziliensis 36% 100%
A4HPC5 Leishmania braziliensis 39% 100%
A4HQG6 Leishmania braziliensis 78% 100%
A4HQG9 Leishmania braziliensis 79% 100%
A4I0H5 Leishmania infantum 36% 100%
A4I3Z8 Leishmania infantum 35% 100%
A4ICG3 Leishmania infantum 36% 100%
A4ICG5 Leishmania infantum 36% 100%
D0A947 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 25% 100%
D0A948 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 25% 100%
E9AT34 Leishmania mexicana (strain MHOM/GT/2001/U1103) 36% 100%
E9AT36 Leishmania mexicana (strain MHOM/GT/2001/U1103) 39% 100%
E9AWD7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 36% 100%
E9B088 Leishmania mexicana (strain MHOM/GT/2001/U1103) 33% 100%
Q4Q1G2 Leishmania major 39% 100%
Q4Q1G4 Leishmania major 37% 100%
Q4Q7Z7 Leishmania major 34% 100%
Q4QB35 Leishmania major 36% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS