Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4ICA3_LEIIN

TriTrypDb:

LINF_360076100

Length:

469

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4ICA3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ICA3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	253	257	PF00656	0.637
CLV_C14_Caspase3-7	348	352	PF00656	0.645
CLV_C14_Caspase3-7	356	360	PF00656	0.528
CLV_C14_Caspase3-7	98	102	PF00656	0.545
CLV_NRD_NRD_1	134	136	PF00675	0.478
CLV_NRD_NRD_1	201	203	PF00675	0.617
CLV_NRD_NRD_1	216	218	PF00675	0.586
CLV_NRD_NRD_1	242	244	PF00675	0.615
CLV_NRD_NRD_1	297	299	PF00675	0.688
CLV_NRD_NRD_1	402	404	PF00675	0.715
CLV_NRD_NRD_1	408	410	PF00675	0.653
CLV_NRD_NRD_1	70	72	PF00675	0.521
CLV_NRD_NRD_1	86	88	PF00675	0.456
CLV_PCSK_FUR_1	400	404	PF00082	0.621
CLV_PCSK_KEX2_1	134	136	PF00082	0.478
CLV_PCSK_KEX2_1	201	203	PF00082	0.605
CLV_PCSK_KEX2_1	242	244	PF00082	0.615
CLV_PCSK_KEX2_1	296	298	PF00082	0.686
CLV_PCSK_KEX2_1	400	402	PF00082	0.715
CLV_PCSK_KEX2_1	408	410	PF00082	0.640
CLV_PCSK_KEX2_1	85	87	PF00082	0.586
CLV_PCSK_PC1ET2_1	85	87	PF00082	0.586
CLV_PCSK_SKI1_1	217	221	PF00082	0.657
CLV_PCSK_SKI1_1	233	237	PF00082	0.563
CLV_PCSK_SKI1_1	243	247	PF00082	0.605
CLV_PCSK_SKI1_1	380	384	PF00082	0.607
CLV_PCSK_SKI1_1	463	467	PF00082	0.564
DEG_SPOP_SBC_1	169	173	PF00917	0.620
DEG_SPOP_SBC_1	305	309	PF00917	0.603
DOC_CKS1_1	154	159	PF01111	0.644
DOC_CKS1_1	187	192	PF01111	0.577
DOC_PP2B_LxvP_1	235	238	PF13499	0.699
DOC_USP7_MATH_1	170	174	PF00917	0.640
DOC_USP7_MATH_1	197	201	PF00917	0.692
DOC_USP7_MATH_1	223	227	PF00917	0.679
DOC_USP7_MATH_1	273	277	PF00917	0.686
DOC_USP7_MATH_1	280	284	PF00917	0.621
DOC_USP7_MATH_1	285	289	PF00917	0.574
DOC_USP7_MATH_1	305	309	PF00917	0.508
DOC_USP7_MATH_1	338	342	PF00917	0.589
DOC_USP7_MATH_1	376	380	PF00917	0.609
DOC_USP7_MATH_1	427	431	PF00917	0.603
DOC_USP7_UBL2_3	218	222	PF12436	0.608
DOC_WW_Pin1_4	153	158	PF00397	0.605
DOC_WW_Pin1_4	172	177	PF00397	0.518
DOC_WW_Pin1_4	186	191	PF00397	0.573
DOC_WW_Pin1_4	192	197	PF00397	0.528
DOC_WW_Pin1_4	274	279	PF00397	0.691
DOC_WW_Pin1_4	323	328	PF00397	0.658
DOC_WW_Pin1_4	437	442	PF00397	0.653
DOC_WW_Pin1_4	5	10	PF00397	0.636
LIG_14-3-3_CanoR_1	168	178	PF00244	0.616
LIG_14-3-3_CanoR_1	296	302	PF00244	0.658
LIG_14-3-3_CanoR_1	319	324	PF00244	0.641
LIG_14-3-3_CanoR_1	380	388	PF00244	0.616
LIG_14-3-3_CanoR_1	400	410	PF00244	0.574
LIG_14-3-3_CanoR_1	74	78	PF00244	0.494
LIG_BIR_II_1	1	5	PF00653	0.639
LIG_BRCT_BRCA1_1	285	289	PF00533	0.666
LIG_BRCT_BRCA1_1	373	377	PF00533	0.625
LIG_CtBP_PxDLS_1	146	150	PF00389	0.569
LIG_FHA_1	154	160	PF00498	0.628
LIG_FHA_1	234	240	PF00498	0.696
LIG_FHA_1	290	296	PF00498	0.645
LIG_FHA_1	87	93	PF00498	0.558
LIG_FHA_2	20	26	PF00498	0.615
LIG_FHA_2	263	269	PF00498	0.643
LIG_FHA_2	346	352	PF00498	0.650
LIG_FHA_2	74	80	PF00498	0.530
LIG_PCNA_yPIPBox_3	30	40	PF02747	0.498
LIG_Pex14_2	289	293	PF04695	0.609
LIG_SH2_GRB2like	460	463	PF00017	0.576
LIG_SH2_STAT3	66	69	PF00017	0.508
LIG_SH2_STAT5	460	463	PF00017	0.615
LIG_SH3_3	184	190	PF00018	0.634
LIG_SH3_3	327	333	PF00018	0.694
LIG_SH3_3	359	365	PF00018	0.625
LIG_SH3_3	370	376	PF00018	0.562
LIG_SH3_3	4	10	PF00018	0.624
LIG_SUMO_SIM_par_1	145	151	PF11976	0.565
LIG_TRAF2_1	266	269	PF00917	0.585
LIG_TRAF2_1	352	355	PF00917	0.598
LIG_TRAF2_1	404	407	PF00917	0.659
LIG_WRC_WIRS_1	33	38	PF05994	0.499
MOD_CDC14_SPxK_1	440	443	PF00782	0.651
MOD_CDK_SPK_2	172	177	PF00069	0.580
MOD_CDK_SPK_2	323	328	PF00069	0.658
MOD_CDK_SPxK_1	437	443	PF00069	0.653
MOD_CDK_SPxxK_3	437	444	PF00069	0.652
MOD_CK1_1	148	154	PF00069	0.614
MOD_CK1_1	20	26	PF00069	0.662
MOD_CK1_1	252	258	PF00069	0.654
MOD_CK1_1	276	282	PF00069	0.665
MOD_CK1_1	283	289	PF00069	0.621
MOD_CK1_1	306	312	PF00069	0.652
MOD_CK1_1	322	328	PF00069	0.556
MOD_CK1_1	345	351	PF00069	0.615
MOD_CK1_1	366	372	PF00069	0.665
MOD_CK1_1	389	395	PF00069	0.637
MOD_CK1_1	413	419	PF00069	0.696
MOD_CK1_1	452	458	PF00069	0.627
MOD_CK2_1	262	268	PF00069	0.647
MOD_CK2_1	401	407	PF00069	0.704
MOD_CK2_1	73	79	PF00069	0.522
MOD_GlcNHglycan	160	163	PF01048	0.629
MOD_GlcNHglycan	19	22	PF01048	0.576
MOD_GlcNHglycan	2	5	PF01048	0.635
MOD_GlcNHglycan	203	206	PF01048	0.679
MOD_GlcNHglycan	247	250	PF01048	0.673
MOD_GlcNHglycan	271	274	PF01048	0.677
MOD_GlcNHglycan	289	292	PF01048	0.498
MOD_GlcNHglycan	396	399	PF01048	0.630
MOD_GlcNHglycan	429	432	PF01048	0.618
MOD_GlcNHglycan	455	458	PF01048	0.659
MOD_GlcNHglycan	88	92	PF01048	0.565
MOD_GSK3_1	168	175	PF00069	0.662
MOD_GSK3_1	17	24	PF00069	0.691
MOD_GSK3_1	192	199	PF00069	0.684
MOD_GSK3_1	245	252	PF00069	0.657
MOD_GSK3_1	257	264	PF00069	0.586
MOD_GSK3_1	269	276	PF00069	0.561
MOD_GSK3_1	279	286	PF00069	0.597
MOD_GSK3_1	303	310	PF00069	0.665
MOD_GSK3_1	313	320	PF00069	0.638
MOD_GSK3_1	322	329	PF00069	0.574
MOD_GSK3_1	338	345	PF00069	0.557
MOD_GSK3_1	346	353	PF00069	0.593
MOD_GSK3_1	363	370	PF00069	0.701
MOD_GSK3_1	376	383	PF00069	0.526
MOD_GSK3_1	389	396	PF00069	0.564
MOD_GSK3_1	429	436	PF00069	0.602
MOD_GSK3_1	449	456	PF00069	0.514
MOD_GSK3_1	61	68	PF00069	0.526
MOD_GSK3_1	73	80	PF00069	0.423
MOD_LATS_1	378	384	PF00433	0.608
MOD_NEK2_1	12	17	PF00069	0.663
MOD_NEK2_1	245	250	PF00069	0.676
MOD_NEK2_1	261	266	PF00069	0.568
MOD_NEK2_1	289	294	PF00069	0.647
MOD_NEK2_1	313	318	PF00069	0.700
MOD_NEK2_1	386	391	PF00069	0.610
MOD_NEK2_1	410	415	PF00069	0.640
MOD_NEK2_1	77	82	PF00069	0.491
MOD_PIKK_1	115	121	PF00454	0.488
MOD_PIKK_1	150	156	PF00454	0.619
MOD_PIKK_1	280	286	PF00454	0.639
MOD_PIKK_1	350	356	PF00454	0.609
MOD_PIKK_1	402	408	PF00454	0.664
MOD_PIKK_1	433	439	PF00454	0.633
MOD_PIKK_1	65	71	PF00454	0.514
MOD_PK_1	297	303	PF00069	0.623
MOD_PKA_1	201	207	PF00069	0.599
MOD_PKA_1	297	303	PF00069	0.661
MOD_PKA_1	401	407	PF00069	0.704
MOD_PKA_1	443	449	PF00069	0.675
MOD_PKA_1	86	92	PF00069	0.505
MOD_PKA_2	176	182	PF00069	0.590
MOD_PKA_2	201	207	PF00069	0.599
MOD_PKA_2	223	229	PF00069	0.637
MOD_PKA_2	297	303	PF00069	0.682
MOD_PKA_2	343	349	PF00069	0.644
MOD_PKA_2	401	407	PF00069	0.704
MOD_PKA_2	73	79	PF00069	0.521
MOD_PKA_2	86	92	PF00069	0.493
MOD_PKB_1	391	399	PF00069	0.602
MOD_PKB_1	400	408	PF00069	0.582
MOD_Plk_1	243	249	PF00069	0.637
MOD_Plk_1	410	416	PF00069	0.572
MOD_Plk_1	449	455	PF00069	0.574
MOD_Plk_1	87	93	PF00069	0.545
MOD_Plk_4	257	263	PF00069	0.637
MOD_Plk_4	289	295	PF00069	0.637
MOD_Plk_4	32	38	PF00069	0.534
MOD_Plk_4	456	462	PF00069	0.663
MOD_ProDKin_1	153	159	PF00069	0.607
MOD_ProDKin_1	172	178	PF00069	0.518
MOD_ProDKin_1	186	192	PF00069	0.571
MOD_ProDKin_1	274	280	PF00069	0.691
MOD_ProDKin_1	323	329	PF00069	0.659
MOD_ProDKin_1	437	443	PF00069	0.653
MOD_ProDKin_1	5	11	PF00069	0.636
MOD_SUMO_rev_2	355	362	PF00179	0.651
MOD_SUMO_rev_2	96	100	PF00179	0.522
TRG_ER_diArg_1	133	135	PF00400	0.471
TRG_ER_diArg_1	295	298	PF00400	0.677
TRG_ER_diArg_1	399	402	PF00400	0.705
TRG_ER_diArg_1	408	410	PF00400	0.631
TRG_NLS_Bipartite_1	201	221	PF00514	0.596
TRG_NLS_MonoExtN_4	214	221	PF00514	0.649
TRG_Pf-PMV_PEXEL_1	131	136	PF00026	0.553

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8ILD3	Leishmania donovani	99%	100%
A4HQG7	Leishmania braziliensis	54%	97%
Q4Q0B1	Leishmania major	85%	100%