Putative tartrate-sensitive acid phosphatase acp-3.2

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

tartrate-sensitive acid phosphatase acp-3.2 - putative

Species:

Leishmania infantum

UniProt:

A4ICA2_LEIIN

TriTrypDb:

LINF_360076000

Length:

315

Annotations

LeishMANIAdb annotations

An extensively expanded family of exophosphatase enzymes presumed to be active at acidic pH

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 1
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 5, no: 3
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4ICA2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ICA2

Function

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Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	2
GO:0006796	phosphate-containing compound metabolic process	4	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0016311	dephosphorylation	5	2
GO:0044237	cellular metabolic process	2	2

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0016787	hydrolase activity	2	2
GO:0016788	hydrolase activity, acting on ester bonds	3	2
GO:0016791	phosphatase activity	5	2
GO:0042578	phosphoric ester hydrolase activity	4	2

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	154	158	PF00656	0.606
CLV_NRD_NRD_1	304	306	PF00675	0.541
CLV_PCSK_KEX2_1	303	305	PF00082	0.573
CLV_PCSK_PC7_1	299	305	PF00082	0.494
CLV_PCSK_SKI1_1	119	123	PF00082	0.405
CLV_PCSK_SKI1_1	239	243	PF00082	0.526
CLV_PCSK_SKI1_1	39	43	PF00082	0.581
CLV_Separin_Metazoa	66	70	PF03568	0.352
DEG_COP1_1	143	150	PF00400	0.578
DOC_CYCLIN_RxL_1	116	125	PF00134	0.331

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9G2	Leptomonas seymouri	37%	100%
A0A0N1PEH4	Leptomonas seymouri	60%	69%
A0A3Q8ILZ1	Leishmania donovani	100%	100%
A4HQG6	Leishmania braziliensis	80%	71%
Q4Q0A9	Leishmania major	63%	75%
Q4Q0B2	Leishmania major	61%	78%
V5BL75	Trypanosoma cruzi	28%	67%

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