Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4ICA0_LEIIN

TriTrypDb:

LINF_360075800

Length:

308

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4ICA0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4ICA0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	136	140	PF00656	0.506
CLV_C14_Caspase3-7	49	53	PF00656	0.546
CLV_NRD_NRD_1	215	217	PF00675	0.574
CLV_NRD_NRD_1	221	223	PF00675	0.508
CLV_NRD_NRD_1	8	10	PF00675	0.453
CLV_PCSK_KEX2_1	215	217	PF00082	0.598
CLV_PCSK_KEX2_1	79	81	PF00082	0.282
CLV_PCSK_KEX2_1	8	10	PF00082	0.453
CLV_PCSK_PC1ET2_1	79	81	PF00082	0.282
CLV_PCSK_SKI1_1	175	179	PF00082	0.622
CLV_PCSK_SKI1_1	80	84	PF00082	0.266
DEG_APCC_DBOX_1	214	222	PF00400	0.501
DEG_APCC_DBOX_1	54	62	PF00400	0.482
DEG_APCC_DBOX_1	79	87	PF00400	0.496
DEG_Nend_UBRbox_3	1	3	PF02207	0.502
DOC_MAPK_gen_1	215	221	PF00069	0.582
DOC_PP1_SILK_1	80	85	PF00149	0.530
DOC_PP2B_LxvP_1	88	91	PF13499	0.564
DOC_USP7_MATH_1	203	207	PF00917	0.610
DOC_USP7_MATH_1	224	228	PF00917	0.550
DOC_USP7_MATH_1	78	82	PF00917	0.547
DOC_USP7_UBL2_3	44	48	PF12436	0.558
DOC_WW_Pin1_4	193	198	PF00397	0.605
DOC_WW_Pin1_4	264	269	PF00397	0.783
LIG_14-3-3_CanoR_1	147	151	PF00244	0.717
LIG_14-3-3_CanoR_1	249	259	PF00244	0.769
LIG_14-3-3_CanoR_1	55	59	PF00244	0.523
LIG_14-3-3_CanoR_1	99	109	PF00244	0.591
LIG_deltaCOP1_diTrp_1	117	125	PF00928	0.586
LIG_EH1_1	59	67	PF00400	0.562
LIG_eIF4E_1	60	66	PF01652	0.534
LIG_FHA_1	104	110	PF00498	0.589
LIG_FHA_1	15	21	PF00498	0.480
LIG_FHA_1	69	75	PF00498	0.586
LIG_FHA_2	134	140	PF00498	0.585
LIG_GBD_Chelix_1	58	66	PF00786	0.386
LIG_LIR_Gen_1	116	127	PF02991	0.452
LIG_LIR_Gen_1	25	34	PF02991	0.534
LIG_LIR_Nem_3	116	122	PF02991	0.507
LIG_LIR_Nem_3	25	29	PF02991	0.534
LIG_Pex14_2	125	129	PF04695	0.482
LIG_SH2_SRC	164	167	PF00017	0.582
LIG_SH2_SRC	60	63	PF00017	0.586
LIG_SH2_STAT5	40	43	PF00017	0.583
LIG_SH2_STAT5	60	63	PF00017	0.533
LIG_SH3_3	265	271	PF00018	0.747
LIG_UBA3_1	109	114	PF00899	0.586
LIG_UBA3_1	218	223	PF00899	0.582
LIG_WRC_WIRS_1	303	308	PF05994	0.698
MOD_CK1_1	103	109	PF00069	0.586
MOD_CK1_1	149	155	PF00069	0.566
MOD_CK1_1	254	260	PF00069	0.720
MOD_CK1_1	276	282	PF00069	0.775
MOD_CK1_1	68	74	PF00069	0.581
MOD_CK2_1	224	230	PF00069	0.585
MOD_GlcNHglycan	142	145	PF01048	0.604
MOD_GlcNHglycan	151	154	PF01048	0.572
MOD_GlcNHglycan	183	186	PF01048	0.698
MOD_GlcNHglycan	189	192	PF01048	0.732
MOD_GlcNHglycan	206	209	PF01048	0.489
MOD_GlcNHglycan	253	256	PF01048	0.736
MOD_GlcNHglycan	275	278	PF01048	0.685
MOD_GlcNHglycan	292	295	PF01048	0.726
MOD_GlcNHglycan	91	94	PF01048	0.386
MOD_GSK3_1	113	120	PF00069	0.494
MOD_GSK3_1	145	152	PF00069	0.624
MOD_GSK3_1	183	190	PF00069	0.722
MOD_GSK3_1	247	254	PF00069	0.637
MOD_GSK3_1	269	276	PF00069	0.803
MOD_GSK3_1	68	75	PF00069	0.591
MOD_NEK2_1	133	138	PF00069	0.536
MOD_NEK2_1	65	70	PF00069	0.480
MOD_PIKK_1	288	294	PF00454	0.715
MOD_PKA_2	100	106	PF00069	0.565
MOD_PKA_2	146	152	PF00069	0.671
MOD_PKA_2	248	254	PF00069	0.740
MOD_PKA_2	54	60	PF00069	0.561
MOD_Plk_1	103	109	PF00069	0.586
MOD_Plk_4	302	308	PF00069	0.698
MOD_Plk_4	54	60	PF00069	0.557
MOD_ProDKin_1	193	199	PF00069	0.606
MOD_ProDKin_1	264	270	PF00069	0.779
MOD_SUMO_for_1	177	180	PF00179	0.591
MOD_SUMO_for_1	282	285	PF00179	0.774
TRG_ER_diArg_1	8	10	PF00400	0.453
TRG_ER_diArg_1	98	101	PF00400	0.565

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4IY70	Bodo saltans	28%	100%
A0A1X0NLM3	Trypanosomatidae	33%	100%
A0A3Q8IGT5	Leishmania donovani	99%	100%
A0A3R7NPS1	Trypanosoma rangeli	37%	100%
A4HQG4	Leishmania braziliensis	86%	100%
D0A3L5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9AU80	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q0B4	Leishmania major	94%	100%
V5D8U2	Trypanosoma cruzi	34%	100%