LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
Domain of unknown function (DUF4496) - putative
Species:
Leishmania infantum
UniProt:
A4IC97_LEIIN
TriTrypDb:
LINF_360075500
Length:
532

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0005815 microtubule organizing center 2 1
GO:0036064 ciliary basal body 3 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4IC97
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IC97

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 239 243 PF00656 0.798
CLV_C14_Caspase3-7 487 491 PF00656 0.613
CLV_NRD_NRD_1 187 189 PF00675 0.524
CLV_NRD_NRD_1 272 274 PF00675 0.592
CLV_NRD_NRD_1 286 288 PF00675 0.587
CLV_NRD_NRD_1 294 296 PF00675 0.566
CLV_NRD_NRD_1 329 331 PF00675 0.795
CLV_NRD_NRD_1 416 418 PF00675 0.721
CLV_NRD_NRD_1 438 440 PF00675 0.679
CLV_NRD_NRD_1 46 48 PF00675 0.455
CLV_NRD_NRD_1 509 511 PF00675 0.707
CLV_NRD_NRD_1 81 83 PF00675 0.411
CLV_PCSK_KEX2_1 204 206 PF00082 0.570
CLV_PCSK_KEX2_1 271 273 PF00082 0.593
CLV_PCSK_KEX2_1 286 288 PF00082 0.597
CLV_PCSK_KEX2_1 294 296 PF00082 0.570
CLV_PCSK_KEX2_1 329 331 PF00082 0.739
CLV_PCSK_KEX2_1 438 440 PF00082 0.679
CLV_PCSK_KEX2_1 46 48 PF00082 0.455
CLV_PCSK_KEX2_1 511 513 PF00082 0.719
CLV_PCSK_PC1ET2_1 204 206 PF00082 0.601
CLV_PCSK_PC1ET2_1 511 513 PF00082 0.719
CLV_PCSK_PC7_1 434 440 PF00082 0.679
CLV_PCSK_PC7_1 507 513 PF00082 0.725
CLV_PCSK_SKI1_1 137 141 PF00082 0.411
CLV_PCSK_SKI1_1 248 252 PF00082 0.664
CLV_PCSK_SKI1_1 26 30 PF00082 0.461
CLV_PCSK_SKI1_1 46 50 PF00082 0.220
DEG_Nend_Nbox_1 1 3 PF02207 0.589
DEG_SPOP_SBC_1 206 210 PF00917 0.592
DOC_ANK_TNKS_1 106 113 PF00023 0.660
DOC_CYCLIN_RxL_1 148 156 PF00134 0.436
DOC_CYCLIN_RxL_1 43 53 PF00134 0.457
DOC_MAPK_gen_1 149 157 PF00069 0.502
DOC_MAPK_gen_1 166 172 PF00069 0.513
DOC_MAPK_gen_1 80 90 PF00069 0.459
DOC_MAPK_MEF2A_6 149 157 PF00069 0.513
DOC_MAPK_MEF2A_6 166 174 PF00069 0.411
DOC_MAPK_MEF2A_6 36 43 PF00069 0.444
DOC_MAPK_RevD_3 153 167 PF00069 0.513
DOC_PP1_RVXF_1 80 87 PF00149 0.407
DOC_PP2B_LxvP_1 155 158 PF13499 0.411
DOC_PP2B_LxvP_1 333 336 PF13499 0.615
DOC_PP4_FxxP_1 432 435 PF00568 0.691
DOC_USP7_MATH_1 213 217 PF00917 0.690
DOC_USP7_MATH_1 222 226 PF00917 0.637
DOC_USP7_MATH_1 254 258 PF00917 0.649
DOC_USP7_MATH_1 274 278 PF00917 0.356
DOC_USP7_MATH_1 336 340 PF00917 0.704
DOC_USP7_MATH_1 359 363 PF00917 0.747
DOC_USP7_MATH_2 455 461 PF00917 0.804
DOC_WW_Pin1_4 232 237 PF00397 0.578
DOC_WW_Pin1_4 252 257 PF00397 0.651
DOC_WW_Pin1_4 469 474 PF00397 0.839
LIG_14-3-3_CanoR_1 115 119 PF00244 0.393
LIG_14-3-3_CanoR_1 130 139 PF00244 0.279
LIG_14-3-3_CanoR_1 229 233 PF00244 0.730
LIG_14-3-3_CanoR_1 271 280 PF00244 0.569
LIG_14-3-3_CanoR_1 368 377 PF00244 0.799
LIG_14-3-3_CanoR_1 438 442 PF00244 0.664
LIG_14-3-3_CanoR_1 497 506 PF00244 0.742
LIG_14-3-3_CanoR_1 5 14 PF00244 0.495
LIG_BRCT_BRCA1_1 210 214 PF00533 0.687
LIG_FHA_1 222 228 PF00498 0.792
LIG_FHA_1 7 13 PF00498 0.455
LIG_FHA_1 79 85 PF00498 0.452
LIG_FHA_1 98 104 PF00498 0.351
LIG_FHA_2 237 243 PF00498 0.797
LIG_FHA_2 346 352 PF00498 0.648
LIG_FHA_2 438 444 PF00498 0.683
LIG_FHA_2 485 491 PF00498 0.738
LIG_IBAR_NPY_1 77 79 PF08397 0.593
LIG_LIR_Apic_2 429 435 PF02991 0.675
LIG_LIR_Apic_2 449 455 PF02991 0.676
LIG_LIR_Gen_1 111 121 PF02991 0.513
LIG_LIR_Gen_1 138 147 PF02991 0.384
LIG_LIR_Gen_1 197 206 PF02991 0.607
LIG_LIR_Gen_1 341 352 PF02991 0.725
LIG_LIR_Gen_1 35 45 PF02991 0.443
LIG_LIR_Gen_1 65 73 PF02991 0.486
LIG_LIR_Nem_3 111 116 PF02991 0.621
LIG_LIR_Nem_3 138 143 PF02991 0.384
LIG_LIR_Nem_3 197 202 PF02991 0.591
LIG_LIR_Nem_3 341 347 PF02991 0.706
LIG_LIR_Nem_3 35 41 PF02991 0.446
LIG_LIR_Nem_3 65 71 PF02991 0.481
LIG_Pex14_1 64 68 PF04695 0.474
LIG_Pex14_2 60 64 PF04695 0.400
LIG_SH2_CRK 344 348 PF00017 0.645
LIG_SH2_CRK 452 456 PF00017 0.689
LIG_SH2_GRB2like 92 95 PF00017 0.570
LIG_SH2_NCK_1 315 319 PF00017 0.728
LIG_SH2_NCK_1 344 348 PF00017 0.829
LIG_SH2_NCK_1 452 456 PF00017 0.689
LIG_SH2_PTP2 113 116 PF00017 0.411
LIG_SH2_PTP2 68 71 PF00017 0.475
LIG_SH2_SRC 305 308 PF00017 0.601
LIG_SH2_SRC 315 318 PF00017 0.538
LIG_SH2_STAP1 315 319 PF00017 0.682
LIG_SH2_STAP1 92 96 PF00017 0.464
LIG_SH2_STAT5 113 116 PF00017 0.411
LIG_SH2_STAT5 142 145 PF00017 0.411
LIG_SH2_STAT5 68 71 PF00017 0.429
LIG_SH3_3 328 334 PF00018 0.823
LIG_SH3_3 403 409 PF00018 0.774
LIG_SUMO_SIM_anti_2 390 395 PF11976 0.713
LIG_SUMO_SIM_par_1 392 401 PF11976 0.742
LIG_TRAF2_1 265 268 PF00917 0.557
LIG_UBA3_1 30 36 PF00899 0.474
MOD_CDK_SPxxK_3 252 259 PF00069 0.646
MOD_CK1_1 212 218 PF00069 0.687
MOD_CK1_1 220 226 PF00069 0.665
MOD_CK1_1 228 234 PF00069 0.666
MOD_CK1_1 24 30 PF00069 0.507
MOD_CK1_1 339 345 PF00069 0.678
MOD_CK1_1 372 378 PF00069 0.844
MOD_CK1_1 437 443 PF00069 0.670
MOD_CK1_1 465 471 PF00069 0.687
MOD_CK1_1 472 478 PF00069 0.819
MOD_CK1_1 482 488 PF00069 0.742
MOD_CK2_1 29 35 PF00069 0.467
MOD_CK2_1 437 443 PF00069 0.681
MOD_Cter_Amidation 508 511 PF01082 0.724
MOD_GlcNHglycan 132 135 PF01048 0.416
MOD_GlcNHglycan 211 214 PF01048 0.670
MOD_GlcNHglycan 215 218 PF01048 0.688
MOD_GlcNHglycan 256 259 PF01048 0.748
MOD_GlcNHglycan 276 279 PF01048 0.600
MOD_GlcNHglycan 336 339 PF01048 0.665
MOD_GlcNHglycan 371 374 PF01048 0.781
MOD_GlcNHglycan 443 447 PF01048 0.660
MOD_GlcNHglycan 464 467 PF01048 0.746
MOD_GlcNHglycan 479 482 PF01048 0.698
MOD_GlcNHglycan 51 55 PF01048 0.570
MOD_GSK3_1 205 212 PF00069 0.618
MOD_GSK3_1 213 220 PF00069 0.686
MOD_GSK3_1 221 228 PF00069 0.713
MOD_GSK3_1 232 239 PF00069 0.740
MOD_GSK3_1 371 378 PF00069 0.811
MOD_GSK3_1 430 437 PF00069 0.664
MOD_GSK3_1 465 472 PF00069 0.699
MOD_GSK3_1 479 486 PF00069 0.750
MOD_N-GLC_1 21 26 PF02516 0.654
MOD_NEK2_1 1 6 PF00069 0.581
MOD_NEK2_1 153 158 PF00069 0.390
MOD_NEK2_1 450 455 PF00069 0.674
MOD_NEK2_1 50 55 PF00069 0.532
MOD_NEK2_2 161 166 PF00069 0.513
MOD_PIKK_1 450 456 PF00454 0.681
MOD_PKA_1 272 278 PF00069 0.565
MOD_PKA_2 114 120 PF00069 0.408
MOD_PKA_2 220 226 PF00069 0.676
MOD_PKA_2 228 234 PF00069 0.691
MOD_PKA_2 272 278 PF00069 0.514
MOD_PKA_2 352 358 PF00069 0.845
MOD_PKA_2 437 443 PF00069 0.662
MOD_PKB_1 510 518 PF00069 0.735
MOD_Plk_1 24 30 PF00069 0.515
MOD_Plk_4 24 30 PF00069 0.515
MOD_Plk_4 339 345 PF00069 0.723
MOD_Plk_4 522 528 PF00069 0.636
MOD_ProDKin_1 232 238 PF00069 0.580
MOD_ProDKin_1 252 258 PF00069 0.651
MOD_ProDKin_1 469 475 PF00069 0.841
MOD_SUMO_rev_2 242 249 PF00179 0.674
TRG_DiLeu_BaEn_1 66 71 PF01217 0.462
TRG_DiLeu_BaEn_4 66 72 PF01217 0.469
TRG_DiLeu_BaLyEn_6 44 49 PF01217 0.438
TRG_ENDOCYTIC_2 113 116 PF00928 0.411
TRG_ENDOCYTIC_2 199 202 PF00928 0.639
TRG_ENDOCYTIC_2 344 347 PF00928 0.671
TRG_ENDOCYTIC_2 68 71 PF00928 0.475
TRG_ER_diArg_1 149 152 PF00400 0.385
TRG_ER_diArg_1 271 273 PF00400 0.660
TRG_ER_diArg_1 285 287 PF00400 0.514
TRG_ER_diArg_1 294 296 PF00400 0.570
TRG_ER_diArg_1 328 330 PF00400 0.792
TRG_ER_diArg_1 46 48 PF00400 0.455
TRG_ER_diArg_1 510 513 PF00400 0.724
TRG_Pf-PMV_PEXEL_1 286 290 PF00026 0.593
TRG_Pf-PMV_PEXEL_1 424 428 PF00026 0.675
TRG_Pf-PMV_PEXEL_1 46 51 PF00026 0.458

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I476 Leptomonas seymouri 56% 94%
A0A3Q8IPX9 Leishmania donovani 99% 100%
A4HQG1 Leishmania braziliensis 76% 100%
E9AU77 Leishmania mexicana (strain MHOM/GT/2001/U1103) 90% 100%
Q4Q0B7 Leishmania major 92% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS