LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
GTPase activating protein - putative
Species:
Leishmania infantum
UniProt:
A4IC93_LEIIN
TriTrypDb:
LINF_360075000
Length:
557

Annotations

Annotations by Jardim et al.

Intracellular protein trafficking, GTPase activating Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4IC93
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IC93

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 1
GO:0015931 nucleobase-containing compound transport 5 1
GO:0050657 nucleic acid transport 6 1
GO:0050658 RNA transport 4 1
GO:0051028 mRNA transport 5 1
GO:0051179 localization 1 1
GO:0051234 establishment of localization 2 1
GO:0051236 establishment of RNA localization 3 1
GO:0071702 organic substance transport 4 1
GO:0071705 nitrogen compound transport 4 1
Could not find GO molecular_function term for this entry.

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 420 424 PF00656 0.357
CLV_C14_Caspase3-7 490 494 PF00656 0.383
CLV_NRD_NRD_1 274 276 PF00675 0.463
CLV_NRD_NRD_1 308 310 PF00675 0.341
CLV_NRD_NRD_1 68 70 PF00675 0.467
CLV_PCSK_KEX2_1 308 310 PF00082 0.374
CLV_PCSK_KEX2_1 505 507 PF00082 0.526
CLV_PCSK_KEX2_1 529 531 PF00082 0.480
CLV_PCSK_PC1ET2_1 505 507 PF00082 0.526
CLV_PCSK_PC1ET2_1 529 531 PF00082 0.472
CLV_PCSK_SKI1_1 153 157 PF00082 0.644
CLV_PCSK_SKI1_1 214 218 PF00082 0.459
CLV_PCSK_SKI1_1 270 274 PF00082 0.440
CLV_PCSK_SKI1_1 300 304 PF00082 0.277
CLV_PCSK_SKI1_1 403 407 PF00082 0.312
CLV_PCSK_SKI1_1 72 76 PF00082 0.417
CLV_Separin_Metazoa 462 466 PF03568 0.344
DEG_APCC_DBOX_1 241 249 PF00400 0.362
DEG_APCC_DBOX_1 434 442 PF00400 0.337
DEG_APCC_DBOX_1 444 452 PF00400 0.246
DEG_SPOP_SBC_1 125 129 PF00917 0.742
DEG_SPOP_SBC_1 184 188 PF00917 0.510
DOC_MAPK_gen_1 275 283 PF00069 0.511
DOC_MAPK_gen_1 308 314 PF00069 0.339
DOC_MAPK_MEF2A_6 403 412 PF00069 0.277
DOC_MAPK_MEF2A_6 546 554 PF00069 0.474
DOC_PP1_RVXF_1 308 315 PF00149 0.292
DOC_PP1_RVXF_1 390 396 PF00149 0.419
DOC_PP4_FxxP_1 224 227 PF00568 0.344
DOC_PP4_FxxP_1 229 232 PF00568 0.345
DOC_PP4_FxxP_1 302 305 PF00568 0.312
DOC_SPAK_OSR1_1 431 435 PF12202 0.357
DOC_USP7_MATH_1 104 108 PF00917 0.573
DOC_USP7_MATH_1 117 121 PF00917 0.591
DOC_USP7_MATH_1 124 128 PF00917 0.561
DOC_USP7_MATH_1 131 135 PF00917 0.589
DOC_USP7_MATH_1 194 198 PF00917 0.626
DOC_USP7_MATH_1 24 28 PF00917 0.398
DOC_USP7_MATH_1 31 35 PF00917 0.281
DOC_USP7_MATH_1 450 454 PF00917 0.491
DOC_USP7_UBL2_3 213 217 PF12436 0.577
DOC_USP7_UBL2_3 266 270 PF12436 0.449
DOC_USP7_UBL2_3 388 392 PF12436 0.357
DOC_USP7_UBL2_3 528 532 PF12436 0.449
DOC_USP7_UBL2_3 55 59 PF12436 0.528
DOC_WW_Pin1_4 162 167 PF00397 0.768
LIG_14-3-3_CanoR_1 513 522 PF00244 0.470
LIG_14-3-3_CanoR_1 87 96 PF00244 0.505
LIG_AP2alpha_1 421 425 PF02296 0.291
LIG_BIR_II_1 1 5 PF00653 0.584
LIG_BIR_III_3 1 5 PF00653 0.419
LIG_BIR_III_4 23 27 PF00653 0.506
LIG_BRCT_BRCA1_1 176 180 PF00533 0.613
LIG_BRCT_BRCA1_2 176 182 PF00533 0.575
LIG_Clathr_ClatBox_1 463 467 PF01394 0.473
LIG_deltaCOP1_diTrp_1 265 273 PF00928 0.347
LIG_eIF4E_1 228 234 PF01652 0.414
LIG_FHA_1 343 349 PF00498 0.286
LIG_FHA_1 352 358 PF00498 0.277
LIG_FHA_1 444 450 PF00498 0.342
LIG_FHA_2 339 345 PF00498 0.419
LIG_LIR_Apic_2 222 227 PF02991 0.425
LIG_LIR_Apic_2 299 305 PF02991 0.312
LIG_LIR_Gen_1 20 30 PF02991 0.449
LIG_LIR_Gen_1 38 47 PF02991 0.258
LIG_LIR_Gen_1 417 426 PF02991 0.278
LIG_LIR_Gen_1 459 468 PF02991 0.335
LIG_LIR_Nem_3 20 25 PF02991 0.440
LIG_LIR_Nem_3 321 325 PF02991 0.287
LIG_LIR_Nem_3 38 42 PF02991 0.314
LIG_LIR_Nem_3 417 422 PF02991 0.287
LIG_LIR_Nem_3 45 50 PF02991 0.386
LIG_LIR_Nem_3 553 557 PF02991 0.426
LIG_LIR_Nem_3 84 89 PF02991 0.454
LIG_LYPXL_SIV_4 324 332 PF13949 0.292
LIG_PCNA_PIPBox_1 383 392 PF02747 0.419
LIG_Pex14_1 373 377 PF04695 0.357
LIG_Pex14_1 396 400 PF04695 0.277
LIG_Pex14_2 35 39 PF04695 0.419
LIG_Pex14_2 415 419 PF04695 0.277
LIG_Pex14_2 421 425 PF04695 0.277
LIG_Pex14_2 432 436 PF04695 0.277
LIG_PTB_Apo_2 313 320 PF02174 0.371
LIG_PTB_Phospho_1 313 319 PF10480 0.419
LIG_SH2_CRK 218 222 PF00017 0.532
LIG_SH2_CRK 274 278 PF00017 0.442
LIG_SH2_PTP2 280 283 PF00017 0.378
LIG_SH2_PTP2 485 488 PF00017 0.286
LIG_SH2_SRC 280 283 PF00017 0.277
LIG_SH2_STAP1 503 507 PF00017 0.433
LIG_SH2_STAT3 377 380 PF00017 0.357
LIG_SH2_STAT5 218 221 PF00017 0.438
LIG_SH2_STAT5 228 231 PF00017 0.357
LIG_SH2_STAT5 280 283 PF00017 0.349
LIG_SH2_STAT5 331 334 PF00017 0.322
LIG_SH2_STAT5 356 359 PF00017 0.312
LIG_SH2_STAT5 377 380 PF00017 0.357
LIG_SH2_STAT5 400 403 PF00017 0.277
LIG_SH2_STAT5 485 488 PF00017 0.536
LIG_SH3_3 120 126 PF00018 0.655
LIG_SUMO_SIM_anti_2 474 481 PF11976 0.477
LIG_SUMO_SIM_anti_2 493 500 PF11976 0.374
LIG_SUMO_SIM_par_1 336 342 PF11976 0.277
LIG_SUMO_SIM_par_1 446 456 PF11976 0.504
LIG_TYR_ITIM 278 283 PF00017 0.363
LIG_UBA3_1 448 452 PF00899 0.410
LIG_ULM_U2AF65_1 528 534 PF00076 0.444
LIG_WRC_WIRS_1 196 201 PF05994 0.629
LIG_WRC_WIRS_1 32 37 PF05994 0.331
LIG_WRC_WIRS_1 418 423 PF05994 0.438
MOD_CDK_SPK_2 162 167 PF00069 0.603
MOD_CK1_1 127 133 PF00069 0.609
MOD_CK1_1 195 201 PF00069 0.762
MOD_CK1_1 78 84 PF00069 0.565
MOD_CK1_1 97 103 PF00069 0.653
MOD_CK2_1 338 344 PF00069 0.337
MOD_CK2_1 450 456 PF00069 0.445
MOD_CK2_1 78 84 PF00069 0.492
MOD_GlcNHglycan 119 122 PF01048 0.773
MOD_GlcNHglycan 129 132 PF01048 0.469
MOD_GlcNHglycan 133 136 PF01048 0.592
MOD_GlcNHglycan 370 373 PF01048 0.337
MOD_GlcNHglycan 39 42 PF01048 0.308
MOD_GlcNHglycan 77 80 PF01048 0.437
MOD_GlcNHglycan 89 92 PF01048 0.376
MOD_GSK3_1 100 107 PF00069 0.641
MOD_GSK3_1 127 134 PF00069 0.654
MOD_GSK3_1 140 147 PF00069 0.540
MOD_GSK3_1 158 165 PF00069 0.707
MOD_GSK3_1 180 187 PF00069 0.674
MOD_GSK3_1 31 38 PF00069 0.329
MOD_GSK3_1 338 345 PF00069 0.319
MOD_N-GLC_1 117 122 PF02516 0.777
MOD_N-GLC_1 131 136 PF02516 0.618
MOD_NEK2_1 158 163 PF00069 0.722
MOD_NEK2_1 180 185 PF00069 0.666
MOD_NEK2_1 35 40 PF00069 0.350
MOD_NEK2_1 368 373 PF00069 0.277
MOD_NEK2_1 497 502 PF00069 0.450
MOD_NEK2_2 298 303 PF00069 0.277
MOD_PIKK_1 112 118 PF00454 0.675
MOD_PIKK_1 141 147 PF00454 0.752
MOD_PIKK_1 497 503 PF00454 0.496
MOD_PKA_2 209 215 PF00069 0.464
MOD_Plk_1 131 137 PF00069 0.503
MOD_Plk_1 298 304 PF00069 0.330
MOD_Plk_1 48 54 PF00069 0.511
MOD_Plk_2-3 417 423 PF00069 0.357
MOD_Plk_2-3 491 497 PF00069 0.419
MOD_Plk_4 104 110 PF00069 0.746
MOD_Plk_4 327 333 PF00069 0.291
MOD_Plk_4 396 402 PF00069 0.277
MOD_ProDKin_1 162 168 PF00069 0.766
MOD_SUMO_for_1 515 518 PF00179 0.493
MOD_SUMO_rev_2 521 531 PF00179 0.468
MOD_SUMO_rev_2 543 548 PF00179 0.498
MOD_SUMO_rev_2 90 96 PF00179 0.391
TRG_DiLeu_BaEn_1 459 464 PF01217 0.470
TRG_DiLeu_BaEn_2 416 422 PF01217 0.337
TRG_DiLeu_LyEn_5 241 246 PF01217 0.433
TRG_ENDOCYTIC_2 228 231 PF00928 0.465
TRG_ENDOCYTIC_2 280 283 PF00928 0.344
TRG_ENDOCYTIC_2 319 322 PF00928 0.386
TRG_ENDOCYTIC_2 461 464 PF00928 0.326
TRG_ENDOCYTIC_2 485 488 PF00928 0.286
TRG_ER_diArg_1 260 263 PF00400 0.368
TRG_NES_CRM1_1 230 241 PF08389 0.426
TRG_NLS_MonoCore_2 528 533 PF00514 0.477
TRG_NLS_MonoExtN_4 528 533 PF00514 0.477
TRG_Pf-PMV_PEXEL_1 94 98 PF00026 0.394

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IL31 Leptomonas seymouri 65% 90%
A0A0S4IUJ5 Bodo saltans 51% 98%
A0A1X0NLM8 Trypanosomatidae 54% 100%
A0A3Q8IRX0 Leishmania donovani 99% 100%
A0A3R7LIA2 Trypanosoma rangeli 53% 100%
A4HQF7 Leishmania braziliensis 78% 100%
D0A3K6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 55% 100%
E9AU73 Leishmania mexicana (strain MHOM/GT/2001/U1103) 96% 100%
Q4Q0C1 Leishmania major 96% 100%
V5B8C0 Trypanosoma cruzi 55% 98%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS