Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF2962) - putative

Species:

Leishmania infantum

UniProt:

A4IC92_LEIIN

TriTrypDb:

LINF_360074900

Length:

264

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4IC92

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IC92

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	129	133	PF00656	0.344
CLV_NRD_NRD_1	184	186	PF00675	0.578
CLV_NRD_NRD_1	2	4	PF00675	0.660
CLV_NRD_NRD_1	255	257	PF00675	0.586
CLV_PCSK_FUR_1	10	14	PF00082	0.744
CLV_PCSK_KEX2_1	12	14	PF00082	0.635
CLV_PCSK_KEX2_1	194	196	PF00082	0.586
CLV_PCSK_KEX2_1	2	4	PF00082	0.670
CLV_PCSK_KEX2_1	242	244	PF00082	0.508
CLV_PCSK_KEX2_1	255	257	PF00082	0.566
CLV_PCSK_KEX2_1	31	33	PF00082	0.172
CLV_PCSK_PC1ET2_1	12	14	PF00082	0.739
CLV_PCSK_PC1ET2_1	194	196	PF00082	0.632
CLV_PCSK_PC1ET2_1	242	244	PF00082	0.503
CLV_PCSK_PC1ET2_1	31	33	PF00082	0.187
CLV_PCSK_SKI1_1	168	172	PF00082	0.560
CLV_PCSK_SKI1_1	195	199	PF00082	0.624
CLV_PCSK_SKI1_1	2	6	PF00082	0.665
DEG_Nend_UBRbox_1	1	4	PF02207	0.677
DOC_MAPK_gen_1	185	192	PF00069	0.663
DOC_MAPK_gen_1	28	36	PF00069	0.444
DOC_MAPK_gen_1	42	51	PF00069	0.444
DOC_PP1_RVXF_1	193	200	PF00149	0.619
DOC_PP2B_LxvP_1	125	128	PF13499	0.444
DOC_USP7_MATH_1	154	158	PF00917	0.362
DOC_USP7_MATH_1	201	205	PF00917	0.707
DOC_USP7_MATH_1	251	255	PF00917	0.535
DOC_USP7_UBL2_3	194	198	PF12436	0.662
DOC_USP7_UBL2_3	215	219	PF12436	0.697
DOC_USP7_UBL2_3	40	44	PF12436	0.375
DOC_WW_Pin1_4	161	166	PF00397	0.606
LIG_APCC_ABBA_1	80	85	PF00400	0.408
LIG_FAT_LD_1	171	179	PF03623	0.620
LIG_FHA_1	147	153	PF00498	0.325
LIG_FHA_1	223	229	PF00498	0.662
LIG_FHA_1	46	52	PF00498	0.408
LIG_FHA_2	129	135	PF00498	0.429
LIG_KLC1_Yacidic_2	81	85	PF13176	0.194
LIG_NRBOX	170	176	PF00104	0.621
LIG_PDZ_Class_3	259	264	PF00595	0.679
LIG_REV1ctd_RIR_1	52	62	PF16727	0.344
LIG_SH2_STAP1	66	70	PF00017	0.444
LIG_SH2_STAT5	66	69	PF00017	0.444
LIG_SH2_STAT5	83	86	PF00017	0.325
LIG_SH3_3	12	18	PF00018	0.401
LIG_SH3_3	187	193	PF00018	0.604
LIG_SUMO_SIM_anti_2	134	141	PF11976	0.347
LIG_SUMO_SIM_anti_2	148	154	PF11976	0.359
LIG_TRAF2_1	234	237	PF00917	0.586
MOD_CDK_SPxxK_3	161	168	PF00069	0.655
MOD_CK2_1	256	262	PF00069	0.640
MOD_CK2_1	5	11	PF00069	0.671
MOD_GlcNHglycan	120	123	PF01048	0.444
MOD_GlcNHglycan	244	247	PF01048	0.598
MOD_GlcNHglycan	258	261	PF01048	0.648
MOD_GlcNHglycan	7	10	PF01048	0.667
MOD_GlcNHglycan	89	94	PF01048	0.388
MOD_GSK3_1	201	208	PF00069	0.637
MOD_GSK3_1	214	221	PF00069	0.649
MOD_LATS_1	17	23	PF00433	0.444
MOD_NEK2_1	108	113	PF00069	0.427
MOD_NEK2_1	214	219	PF00069	0.751
MOD_NEK2_1	45	50	PF00069	0.439
MOD_NEK2_1	5	10	PF00069	0.664
MOD_NEK2_1	64	69	PF00069	0.333
MOD_PIKK_1	201	207	PF00454	0.682
MOD_PK_1	19	25	PF00069	0.444
MOD_PKA_1	242	248	PF00069	0.653
MOD_PKA_2	242	248	PF00069	0.624
MOD_Plk_1	108	114	PF00069	0.444
MOD_Plk_1	19	25	PF00069	0.444
MOD_Plk_1	45	51	PF00069	0.441
MOD_Plk_1	72	78	PF00069	0.446
MOD_Plk_1	89	95	PF00069	0.444
MOD_Plk_4	148	154	PF00069	0.420
MOD_ProDKin_1	161	167	PF00069	0.606
MOD_SUMO_for_1	43	46	PF00179	0.444
TRG_DiLeu_BaEn_4	89	95	PF01217	0.369
TRG_ER_diArg_1	1	3	PF00400	0.685
TRG_ER_diArg_1	177	180	PF00400	0.569
TRG_ER_diArg_1	228	231	PF00400	0.636

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I784	Leptomonas seymouri	68%	100%
A0A1X0NLZ7	Trypanosomatidae	43%	100%
A0A3Q8IJD2	Leishmania donovani	99%	100%
A0A422MX73	Trypanosoma rangeli	42%	100%
A4HQF6	Leishmania braziliensis	81%	100%
D0A3K4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9AU72	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	97%
Q4Q0C2	Leishmania major	93%	100%