LeishMANIAdb
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Poly(A)-specific ribonuclease PARN

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Poly(A)-specific ribonuclease PARN
Gene product:
poly(A)-specific ribonuclease PARN - putative
Species:
Leishmania infantum
UniProt:
A4IC91_LEIIN
TriTrypDb:
LINF_360074400
Length:
510

Annotations

Annotations by Jardim et al.

RNA Processing, poly(A)-specific ribonuclease PARN Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 21
NetGPI no yes: 0, no: 21
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 1
GO:0005737 cytoplasm 2 2
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 2

Expansion

Sequence features

A4IC91
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IC91

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 22
GO:0005488 binding 1 22
GO:0097159 organic cyclic compound binding 2 22
GO:1901363 heterocyclic compound binding 2 22
GO:0000175 3'-5'-RNA exonuclease activity 7 3
GO:0003824 catalytic activity 1 3
GO:0004518 nuclease activity 4 3
GO:0004527 exonuclease activity 5 3
GO:0004532 RNA exonuclease activity 5 3
GO:0004535 poly(A)-specific ribonuclease activity 8 1
GO:0004540 RNA nuclease activity 4 3
GO:0008408 3'-5' exonuclease activity 6 3
GO:0016787 hydrolase activity 2 3
GO:0016788 hydrolase activity, acting on ester bonds 3 3
GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 6 3
GO:0016896 RNA exonuclease activity, producing 5'-phosphomonoesters 6 3
GO:0140098 catalytic activity, acting on RNA 3 3
GO:0140640 catalytic activity, acting on a nucleic acid 2 3
GO:0003723 RNA binding 4 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 178 180 PF00675 0.281
CLV_NRD_NRD_1 186 188 PF00675 0.260
CLV_NRD_NRD_1 225 227 PF00675 0.329
CLV_NRD_NRD_1 249 251 PF00675 0.346
CLV_NRD_NRD_1 321 323 PF00675 0.330
CLV_NRD_NRD_1 481 483 PF00675 0.533
CLV_PCSK_KEX2_1 178 180 PF00082 0.296
CLV_PCSK_KEX2_1 186 188 PF00082 0.296
CLV_PCSK_KEX2_1 224 226 PF00082 0.308
CLV_PCSK_KEX2_1 320 322 PF00082 0.330
CLV_PCSK_KEX2_1 481 483 PF00082 0.445
CLV_PCSK_KEX2_1 54 56 PF00082 0.280
CLV_PCSK_PC1ET2_1 224 226 PF00082 0.322
CLV_PCSK_PC1ET2_1 54 56 PF00082 0.287
CLV_PCSK_SKI1_1 281 285 PF00082 0.335
DEG_APCC_DBOX_1 95 103 PF00400 0.537
DEG_MDM2_SWIB_1 239 247 PF02201 0.446
DEG_Nend_UBRbox_2 1 3 PF02207 0.363
DOC_MAPK_gen_1 186 194 PF00069 0.459
DOC_MAPK_gen_1 231 239 PF00069 0.537
DOC_MAPK_gen_1 469 476 PF00069 0.442
DOC_MAPK_gen_1 54 60 PF00069 0.401
DOC_MIT_MIM_1 477 487 PF04212 0.397
DOC_PP1_RVXF_1 238 244 PF00149 0.460
DOC_PP2B_LxvP_1 135 138 PF13499 0.366
DOC_PP4_FxxP_1 43 46 PF00568 0.443
DOC_USP7_MATH_1 388 392 PF00917 0.475
DOC_USP7_MATH_1 416 420 PF00917 0.319
DOC_USP7_UBL2_3 349 353 PF12436 0.537
DOC_USP7_UBL2_3 441 445 PF12436 0.530
DOC_WW_Pin1_4 268 273 PF00397 0.408
DOC_WW_Pin1_4 489 494 PF00397 0.648
LIG_14-3-3_CanoR_1 178 184 PF00244 0.470
LIG_14-3-3_CanoR_1 322 330 PF00244 0.539
LIG_14-3-3_CanoR_1 481 487 PF00244 0.458
LIG_14-3-3_CanoR_1 96 102 PF00244 0.542
LIG_BIR_III_2 305 309 PF00653 0.415
LIG_BRCT_BRCA1_1 326 330 PF00533 0.468
LIG_BRCT_BRCA1_1 39 43 PF00533 0.530
LIG_BRCT_BRCA1_1 390 394 PF00533 0.503
LIG_FHA_1 115 121 PF00498 0.534
LIG_FHA_1 406 412 PF00498 0.389
LIG_FHA_1 427 433 PF00498 0.550
LIG_FHA_1 76 82 PF00498 0.515
LIG_FHA_2 209 215 PF00498 0.401
LIG_FHA_2 30 36 PF00498 0.470
LIG_FHA_2 300 306 PF00498 0.500
LIG_FHA_2 308 314 PF00498 0.539
LIG_FHA_2 70 76 PF00498 0.476
LIG_GBD_Chelix_1 176 184 PF00786 0.243
LIG_GBD_Chelix_1 366 374 PF00786 0.309
LIG_IRF3_LxIS_1 451 457 PF10401 0.328
LIG_LIR_Apic_2 331 337 PF02991 0.459
LIG_LIR_Apic_2 40 46 PF02991 0.441
LIG_LIR_Gen_1 23 31 PF02991 0.428
LIG_LIR_Gen_1 274 284 PF02991 0.518
LIG_LIR_Gen_1 4 13 PF02991 0.516
LIG_LIR_Nem_3 182 188 PF02991 0.497
LIG_LIR_Nem_3 23 27 PF02991 0.397
LIG_LIR_Nem_3 274 280 PF02991 0.465
LIG_LIR_Nem_3 356 362 PF02991 0.455
LIG_LIR_Nem_3 391 397 PF02991 0.359
LIG_LIR_Nem_3 4 9 PF02991 0.462
LIG_MAD2 244 252 PF02301 0.537
LIG_MLH1_MIPbox_1 390 394 PF16413 0.291
LIG_PCNA_yPIPBox_3 96 105 PF02747 0.415
LIG_Pex14_2 239 243 PF04695 0.451
LIG_RPA_C_Fungi 182 194 PF08784 0.183
LIG_SH2_CRK 334 338 PF00017 0.394
LIG_SH2_STAP1 131 135 PF00017 0.431
LIG_SH2_STAP1 188 192 PF00017 0.290
LIG_SH2_STAP1 359 363 PF00017 0.306
LIG_SH2_STAT3 201 204 PF00017 0.394
LIG_SH2_STAT5 201 204 PF00017 0.364
LIG_SH2_STAT5 277 280 PF00017 0.433
LIG_SH2_STAT5 393 396 PF00017 0.436
LIG_SH2_STAT5 87 90 PF00017 0.308
LIG_SH3_3 36 42 PF00018 0.351
LIG_SH3_3 7 13 PF00018 0.405
LIG_SUMO_SIM_par_1 498 503 PF11976 0.356
LIG_SUMO_SIM_par_1 8 14 PF11976 0.356
LIG_TRAF2_1 130 133 PF00917 0.334
LIG_TRFH_1 334 338 PF08558 0.422
LIG_WRC_WIRS_1 101 106 PF05994 0.251
LIG_WRC_WIRS_1 180 185 PF05994 0.251
LIG_WRC_WIRS_1 463 468 PF05994 0.432
MOD_CK1_1 100 106 PF00069 0.331
MOD_CK1_1 492 498 PF00069 0.562
MOD_CK2_1 217 223 PF00069 0.407
MOD_CK2_1 307 313 PF00069 0.422
MOD_CK2_1 69 75 PF00069 0.350
MOD_GlcNHglycan 117 120 PF01048 0.339
MOD_GlcNHglycan 345 348 PF01048 0.342
MOD_GlcNHglycan 386 389 PF01048 0.443
MOD_GlcNHglycan 39 42 PF01048 0.422
MOD_GlcNHglycan 390 393 PF01048 0.451
MOD_GlcNHglycan 91 94 PF01048 0.414
MOD_GSK3_1 111 118 PF00069 0.399
MOD_GSK3_1 208 215 PF00069 0.291
MOD_GSK3_1 287 294 PF00069 0.343
MOD_GSK3_1 324 331 PF00069 0.435
MOD_GSK3_1 384 391 PF00069 0.384
MOD_GSK3_1 426 433 PF00069 0.469
MOD_GSK3_1 71 78 PF00069 0.311
MOD_LATS_1 480 486 PF00433 0.340
MOD_N-GLC_1 343 348 PF02516 0.399
MOD_N-GLC_1 461 466 PF02516 0.502
MOD_N-GLC_1 75 80 PF02516 0.251
MOD_N-GLC_1 89 94 PF02516 0.385
MOD_N-GLC_1 97 102 PF02516 0.367
MOD_NEK2_1 1 6 PF00069 0.422
MOD_NEK2_1 208 213 PF00069 0.361
MOD_NEK2_1 246 251 PF00069 0.306
MOD_NEK2_1 284 289 PF00069 0.405
MOD_NEK2_1 97 102 PF00069 0.467
MOD_PIKK_1 271 277 PF00454 0.202
MOD_PIKK_1 328 334 PF00454 0.470
MOD_PIKK_1 431 437 PF00454 0.400
MOD_PKA_1 445 451 PF00069 0.385
MOD_Plk_1 1 7 PF00069 0.366
MOD_Plk_1 343 349 PF00069 0.260
MOD_Plk_1 461 467 PF00069 0.433
MOD_Plk_1 75 81 PF00069 0.412
MOD_Plk_1 97 103 PF00069 0.448
MOD_Plk_2-3 217 223 PF00069 0.290
MOD_Plk_2-3 75 81 PF00069 0.409
MOD_Plk_4 111 117 PF00069 0.221
MOD_Plk_4 179 185 PF00069 0.426
MOD_Plk_4 287 293 PF00069 0.382
MOD_Plk_4 405 411 PF00069 0.395
MOD_Plk_4 97 103 PF00069 0.399
MOD_ProDKin_1 268 274 PF00069 0.241
MOD_ProDKin_1 489 495 PF00069 0.641
MOD_SUMO_rev_2 127 135 PF00179 0.353
MOD_SUMO_rev_2 274 283 PF00179 0.378
MOD_SUMO_rev_2 290 297 PF00179 0.285
MOD_SUMO_rev_2 438 447 PF00179 0.541
TRG_DiLeu_BaLyEn_6 496 501 PF01217 0.565
TRG_ENDOCYTIC_2 277 280 PF00928 0.313
TRG_ENDOCYTIC_2 463 466 PF00928 0.456
TRG_ENDOCYTIC_2 61 64 PF00928 0.310
TRG_ER_diArg_1 178 180 PF00400 0.412
TRG_ER_diArg_1 185 187 PF00400 0.413
TRG_ER_diArg_1 225 227 PF00400 0.370
TRG_ER_diArg_1 320 322 PF00400 0.407
TRG_ER_diArg_1 481 483 PF00400 0.533
TRG_NES_CRM1_1 2 14 PF08389 0.290
TRG_Pf-PMV_PEXEL_1 225 230 PF00026 0.366

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P603 Leptomonas seymouri 55% 99%
A0A0N1ILJ1 Leptomonas seymouri 26% 84%
A0A0S4IJ60 Bodo saltans 23% 100%
A0A0S4IMW3 Bodo saltans 23% 100%
A0A0S4IR41 Bodo saltans 22% 80%
A0A0S4J225 Bodo saltans 34% 70%
A0A1X0NLC6 Trypanosomatidae 33% 99%
A0A1X0NXI3 Trypanosomatidae 26% 84%
A0A3Q8ICI3 Leishmania donovani 26% 85%
A0A3R7K5K5 Trypanosoma rangeli 35% 98%
A0A3S7XC77 Leishmania donovani 99% 100%
A0A422N5N5 Trypanosoma rangeli 28% 86%
A4HCS6 Leishmania braziliensis 27% 100%
A4HQF5 Leishmania braziliensis 75% 100%
A4I0A0 Leishmania infantum 26% 100%
B2RXZ1 Mus musculus 22% 96%
C9ZV58 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 29% 87%
C9ZZC3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 23% 82%
D0A3T2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 33% 100%
E9AU71 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%
E9AW65 Leishmania mexicana (strain MHOM/GT/2001/U1103) 27% 100%
H9JAQ7 Bombyx mori 24% 96%
O95453 Homo sapiens 25% 80%
P69341 Bos taurus 24% 80%
Q21412 Caenorhabditis elegans 24% 90%
Q4Q0C3 Leishmania major 91% 100%
Q4QBB3 Leishmania major 26% 100%
Q5R6R6 Pongo abelii 24% 98%
Q5RC51 Pongo abelii 25% 80%
Q7ZU92 Danio rerio 25% 77%
Q8NA58 Homo sapiens 23% 98%
Q8VDG3 Mus musculus 25% 82%
Q90ZA1 Xenopus laevis 25% 81%
V5ASU9 Trypanosoma cruzi 35% 99%
V5BCG2 Trypanosoma cruzi 26% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS