Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4IC90_LEIIN

TriTrypDb:

LINF_360074300

Length:

190

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4IC90

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IC90

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	150	152	PF00675	0.510
CLV_NRD_NRD_1	2	4	PF00675	0.475
CLV_NRD_NRD_1	45	47	PF00675	0.478
CLV_PCSK_KEX2_1	150	152	PF00082	0.445
CLV_PCSK_KEX2_1	156	158	PF00082	0.385
CLV_PCSK_KEX2_1	2	4	PF00082	0.496
CLV_PCSK_KEX2_1	22	24	PF00082	0.347
CLV_PCSK_KEX2_1	45	47	PF00082	0.362
CLV_PCSK_KEX2_1	58	60	PF00082	0.395
CLV_PCSK_PC1ET2_1	156	158	PF00082	0.485
CLV_PCSK_PC1ET2_1	22	24	PF00082	0.504
CLV_PCSK_PC1ET2_1	58	60	PF00082	0.395
CLV_PCSK_SKI1_1	151	155	PF00082	0.565
CLV_PCSK_SKI1_1	182	186	PF00082	0.458
CLV_PCSK_SKI1_1	22	26	PF00082	0.653
CLV_PCSK_SKI1_1	74	78	PF00082	0.481
DEG_Nend_UBRbox_1	1	4	PF02207	0.529
DOC_CDC14_PxL_1	128	136	PF14671	0.518
DOC_CYCLIN_RxL_1	148	159	PF00134	0.486
DOC_MAPK_gen_1	2	9	PF00069	0.441
DOC_MAPK_gen_1	45	52	PF00069	0.447
DOC_MAPK_MEF2A_6	2	11	PF00069	0.475
LIG_14-3-3_CanoR_1	173	181	PF00244	0.422
LIG_14-3-3_CanoR_1	23	29	PF00244	0.480
LIG_14-3-3_CanoR_1	8	14	PF00244	0.501
LIG_BIR_III_4	142	146	PF00653	0.414
LIG_BRCT_BRCA1_1	31	35	PF00533	0.580
LIG_FAT_LD_1	106	114	PF03623	0.380
LIG_FHA_1	13	19	PF00498	0.547
LIG_FHA_1	75	81	PF00498	0.517
LIG_FHA_2	46	52	PF00498	0.453
LIG_GBD_Chelix_1	105	113	PF00786	0.518
LIG_LIR_Gen_1	164	169	PF02991	0.463
LIG_LIR_Nem_3	159	165	PF02991	0.424
LIG_MYND_3	131	135	PF01753	0.494
LIG_NRBOX	109	115	PF00104	0.567
LIG_Pex14_1	176	180	PF04695	0.378
LIG_Pex14_1	37	41	PF04695	0.508
LIG_RPA_C_Fungi	98	110	PF08784	0.462
LIG_SH2_CRK	165	169	PF00017	0.415
LIG_SH2_NCK_1	165	169	PF00017	0.439
LIG_SH2_STAT5	180	183	PF00017	0.372
LIG_SH2_STAT5	41	44	PF00017	0.496
LIG_SUMO_SIM_par_1	9	15	PF11976	0.483
LIG_TRAF2_1	144	147	PF00917	0.462
LIG_WRC_WIRS_1	25	30	PF05994	0.494
MOD_CK1_1	164	170	PF00069	0.453
MOD_CK1_1	174	180	PF00069	0.427
MOD_CK1_1	26	32	PF00069	0.508
MOD_CK2_1	164	170	PF00069	0.506
MOD_CK2_1	24	30	PF00069	0.540
MOD_CK2_1	45	51	PF00069	0.443
MOD_CMANNOS	176	179	PF00535	0.384
MOD_GlcNHglycan	176	179	PF01048	0.385
MOD_GlcNHglycan	74	77	PF01048	0.565
MOD_GSK3_1	12	19	PF00069	0.610
MOD_N-GLC_1	72	77	PF02516	0.535
MOD_NEK2_1	9	14	PF00069	0.581
MOD_NEK2_1	99	104	PF00069	0.643
MOD_NEK2_2	145	150	PF00069	0.455
MOD_PKA_1	156	162	PF00069	0.448
MOD_PKA_1	2	8	PF00069	0.604
MOD_PKA_1	45	51	PF00069	0.443
MOD_PKA_2	156	162	PF00069	0.448
MOD_PKA_2	172	178	PF00069	0.447
MOD_PKA_2	2	8	PF00069	0.550
MOD_PKA_2	45	51	PF00069	0.451
MOD_Plk_1	145	151	PF00069	0.511
MOD_Plk_1	171	177	PF00069	0.419
MOD_Plk_1	87	93	PF00069	0.549
MOD_Plk_2-3	101	107	PF00069	0.400
MOD_Plk_2-3	88	94	PF00069	0.518
MOD_Plk_4	9	15	PF00069	0.434
TRG_DiLeu_BaLyEn_6	129	134	PF01217	0.532
TRG_DiLeu_BaLyEn_6	5	10	PF01217	0.447
TRG_ENDOCYTIC_2	165	168	PF00928	0.418
TRG_ER_diArg_1	1	3	PF00400	0.496
TRG_ER_diArg_1	149	151	PF00400	0.501
TRG_ER_diArg_1	66	69	PF00400	0.517
TRG_ER_diLys_1	185	190	PF00400	0.519
TRG_NES_CRM1_1	51	64	PF08389	0.418
TRG_NLS_Bipartite_1	45	61	PF00514	0.500
TRG_NLS_MonoExtC_3	56	61	PF00514	0.519
TRG_Pf-PMV_PEXEL_1	40	44	PF00026	0.387

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5I8	Leptomonas seymouri	59%	69%
A0A1X0NM61	Trypanosomatidae	40%	100%
A0A3Q8II22	Leishmania donovani	99%	100%
A0A3R7LRR3	Trypanosoma rangeli	38%	100%
A4HQF3	Leishmania braziliensis	86%	100%
D0A3T3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
E9AU70	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4Q0C4	Leishmania major	93%	96%