BTB domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF2946), putative

Species:

Leishmania infantum

UniProt:

A4IC89_LEIIN

TriTrypDb:

Length:

194

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4IC89

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IC89

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	3	7	PF00656	0.588
CLV_PCSK_KEX2_1	110	112	PF00082	0.389
CLV_PCSK_PC1ET2_1	110	112	PF00082	0.389
CLV_PCSK_PC7_1	106	112	PF00082	0.389
CLV_PCSK_SKI1_1	111	115	PF00082	0.345
CLV_PCSK_SKI1_1	183	187	PF00082	0.494
DEG_APCC_DBOX_1	105	113	PF00400	0.436
DEG_Nend_UBRbox_4	1	3	PF02207	0.608
DOC_CKS1_1	174	179	PF01111	0.401
DOC_CKS1_1	186	191	PF01111	0.330
DOC_CYCLIN_RxL_1	110	124	PF00134	0.491
DOC_CYCLIN_yCln2_LP_2	114	120	PF00134	0.380
DOC_MAPK_gen_1	38	45	PF00069	0.475
DOC_MAPK_MEF2A_6	38	45	PF00069	0.424
DOC_MAPK_RevD_3	96	111	PF00069	0.399
DOC_PP4_FxxP_1	174	177	PF00568	0.413
DOC_PP4_FxxP_1	186	189	PF00568	0.443
DOC_PP4_FxxP_1	93	96	PF00568	0.449
DOC_USP7_UBL2_3	40	44	PF12436	0.407
DOC_WW_Pin1_4	173	178	PF00397	0.473
DOC_WW_Pin1_4	185	190	PF00397	0.505
LIG_14-3-3_CanoR_1	12	16	PF00244	0.516
LIG_14-3-3_CanoR_1	160	164	PF00244	0.378
LIG_14-3-3_CanoR_1	183	189	PF00244	0.434
LIG_14-3-3_CanoR_1	63	71	PF00244	0.480
LIG_BRCT_BRCA1_1	13	17	PF00533	0.593
LIG_FHA_1	174	180	PF00498	0.458
LIG_FHA_1	79	85	PF00498	0.476
LIG_FHA_2	167	173	PF00498	0.438
LIG_GBD_Chelix_1	129	137	PF00786	0.428
LIG_IRF3_LxIS_1	55	62	PF10401	0.386
LIG_LIR_Apic_2	172	177	PF02991	0.429
LIG_LIR_Apic_2	92	96	PF02991	0.509
LIG_LIR_Nem_3	14	20	PF02991	0.459
LIG_Pex14_2	89	93	PF04695	0.263
LIG_SH2_STAP1	138	142	PF00017	0.375
LIG_SH2_STAP1	57	61	PF00017	0.468
LIG_SH2_STAT5	142	145	PF00017	0.372
LIG_SUMO_SIM_par_1	80	87	PF11976	0.515
LIG_SUMO_SIM_par_1	97	102	PF11976	0.261
LIG_TRFH_1	142	146	PF08558	0.369
MOD_CK1_1	62	68	PF00069	0.502
MOD_CK1_1	78	84	PF00069	0.255
MOD_CK2_1	184	190	PF00069	0.600
MOD_CK2_1	5	11	PF00069	0.602
MOD_GlcNHglycan	166	169	PF01048	0.532
MOD_GlcNHglycan	51	54	PF01048	0.447
MOD_GlcNHglycan	64	67	PF01048	0.396
MOD_GSK3_1	173	180	PF00069	0.383
MOD_GSK3_1	49	56	PF00069	0.393
MOD_N-GLC_1	59	64	PF02516	0.398
MOD_N-GLC_1	78	83	PF02516	0.405
MOD_N-GLC_2	156	158	PF02516	0.345
MOD_NEK2_1	133	138	PF00069	0.379
MOD_NEK2_1	20	25	PF00069	0.529
MOD_NEK2_1	51	56	PF00069	0.428
MOD_NEK2_1	59	64	PF00069	0.471
MOD_NEK2_2	22	27	PF00069	0.539
MOD_PKA_2	11	17	PF00069	0.679
MOD_PKA_2	159	165	PF00069	0.510
MOD_PKA_2	62	68	PF00069	0.477
MOD_Plk_1	5	11	PF00069	0.545
MOD_Plk_1	59	65	PF00069	0.407
MOD_Plk_2-3	159	165	PF00069	0.399
MOD_Plk_2-3	166	172	PF00069	0.391
MOD_Plk_4	133	139	PF00069	0.439
MOD_ProDKin_1	173	179	PF00069	0.464
MOD_ProDKin_1	185	191	PF00069	0.517
MOD_SUMO_rev_2	102	112	PF00179	0.384
TRG_DiLeu_BaEn_1	108	113	PF01217	0.467
TRG_ENDOCYTIC_2	142	145	PF00928	0.372
TRG_ER_diArg_1	26	29	PF00400	0.380

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBK6	Leptomonas seymouri	53%	100%
A0A1X0NLE1	Trypanosomatidae	29%	100%
A0A3S5IQS5	Trypanosoma rangeli	33%	100%
A0A3S7XC31	Leishmania donovani	99%	100%
A4HQF2	Leishmania braziliensis	91%	100%
D0A3T4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	91%
E9AU69	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
Q4Q0C5	Leishmania major	98%	100%