Peroxin-12

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Peroxin-12

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4IC87_LEIIN

TriTrypDb:

LINF_360073900

Length:

278

Annotations

LeishMANIAdb annotations

Appears to be a transporter for some unknown substrate

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005777	peroxisome	6	1
GO:0016020	membrane	2	1
GO:0020015	glycosome	7	1
GO:0042579	microbody	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	2

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Expansion

Sequence features

A4IC87

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IC87

Function

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Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0016559	peroxisome fission	6	1
GO:0048285	organelle fission	5	1
GO:0071840	cellular component organization or biogenesis	2	1

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Could not find GO molecular_function term for this entry.

Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	263	267	PF00656	0.717
CLV_MEL_PAP_1	178	184	PF00089	0.624
CLV_NRD_NRD_1	156	158	PF00675	0.582
CLV_NRD_NRD_1	55	57	PF00675	0.428
CLV_PCSK_FUR_1	53	57	PF00082	0.285
CLV_PCSK_KEX2_1	156	158	PF00082	0.580
CLV_PCSK_KEX2_1	255	257	PF00082	0.424
CLV_PCSK_KEX2_1	55	57	PF00082	0.428
CLV_PCSK_PC1ET2_1	255	257	PF00082	0.424
CLV_PCSK_SKI1_1	123	127	PF00082	0.591

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDG3	Leptomonas seymouri	62%	100%
A0A0S4JRR1	Bodo saltans	32%	100%
A0A1X0NLN6	Trypanosomatidae	38%	100%
A0A3Q8ILX5	Leishmania donovani	100%	100%
A0A422N9F2	Trypanosoma rangeli	39%	100%
A4HQF0	Leishmania braziliensis	77%	100%
D0A3T7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9AU67	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4Q0C7	Leishmania major	92%	100%
V5D8S7	Trypanosoma cruzi	36%	100%

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