Putative carboxypeptidase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

carboxypeptidase - putative

Species:

Leishmania infantum

UniProt:

A4IC85_LEIIN

TriTrypDb:

LINF_360072600

Length:

371

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 1
Forrest at al. (metacyclic)	no	yes: 3
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 2
Pissara et al.	yes	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 9

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 24
NetGPI	no	yes: 0, no: 24

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005829	cytosol	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4IC85

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IC85

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	25
GO:0006807	nitrogen compound metabolic process	2	25
GO:0008152	metabolic process	1	25
GO:0019538	protein metabolic process	3	25
GO:0043170	macromolecule metabolic process	3	25
GO:0044238	primary metabolic process	2	25
GO:0071704	organic substance metabolic process	2	25
GO:1901564	organonitrogen compound metabolic process	3	25
GO:0006518	peptide metabolic process	4	1
GO:0043603	amide metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	25
GO:0004180	carboxypeptidase activity	5	25
GO:0004181	metallocarboxypeptidase activity	6	25
GO:0008233	peptidase activity	3	25
GO:0008235	metalloexopeptidase activity	5	25
GO:0008237	metallopeptidase activity	4	25
GO:0008238	exopeptidase activity	4	25
GO:0016787	hydrolase activity	2	25
GO:0140096	catalytic activity, acting on a protein	2	25
GO:0016853	isomerase activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	17	19	PF00675	0.354
CLV_NRD_NRD_1	252	254	PF00675	0.432
CLV_NRD_NRD_1	264	266	PF00675	0.399
CLV_NRD_NRD_1	357	359	PF00675	0.501
CLV_PCSK_KEX2_1	17	19	PF00082	0.433
CLV_PCSK_KEX2_1	357	359	PF00082	0.472
CLV_PCSK_PC7_1	353	359	PF00082	0.421
CLV_PCSK_SKI1_1	101	105	PF00082	0.440
CLV_PCSK_SKI1_1	175	179	PF00082	0.392
CLV_PCSK_SKI1_1	196	200	PF00082	0.438
CLV_PCSK_SKI1_1	21	25	PF00082	0.242
CLV_Separin_Metazoa	14	18	PF03568	0.230
DEG_APCC_DBOX_1	317	325	PF00400	0.283
DOC_CKS1_1	117	122	PF01111	0.283
DOC_CYCLIN_RxL_1	172	180	PF00134	0.385
DOC_CYCLIN_yCln2_LP_2	349	352	PF00134	0.395
DOC_MAPK_gen_1	306	313	PF00069	0.349
DOC_PP1_RVXF_1	323	330	PF00149	0.188
DOC_PP2B_LxvP_1	349	352	PF13499	0.395
DOC_USP7_MATH_1	61	65	PF00917	0.319
DOC_USP7_UBL2_3	250	254	PF12436	0.188
DOC_WW_Pin1_4	116	121	PF00397	0.283
DOC_WW_Pin1_4	166	171	PF00397	0.468
DOC_WW_Pin1_4	64	69	PF00397	0.474
LIG_14-3-3_CanoR_1	163	167	PF00244	0.474
LIG_14-3-3_CanoR_1	21	26	PF00244	0.433
LIG_14-3-3_CanoR_1	366	371	PF00244	0.659
LIG_Actin_WH2_2	309	327	PF00022	0.315
LIG_Actin_WH2_2	45	62	PF00022	0.315
LIG_BRCT_BRCA1_1	225	229	PF00533	0.308
LIG_Clathr_ClatBox_1	49	53	PF01394	0.283
LIG_CSL_BTD_1	41	44	PF09270	0.375
LIG_FHA_1	172	178	PF00498	0.463
LIG_FHA_1	212	218	PF00498	0.441
LIG_FHA_2	178	184	PF00498	0.421
LIG_FHA_2	43	49	PF00498	0.385
LIG_LIR_Apic_2	165	170	PF02991	0.466
LIG_LIR_Apic_2	231	235	PF02991	0.349
LIG_LIR_Gen_1	160	167	PF02991	0.194
LIG_LIR_Gen_1	86	97	PF02991	0.238
LIG_LIR_Nem_3	226	232	PF02991	0.333
LIG_LIR_Nem_3	309	313	PF02991	0.323
LIG_LIR_Nem_3	67	72	PF02991	0.463
LIG_LIR_Nem_3	86	92	PF02991	0.194
LIG_PDZ_Class_1	366	371	PF00595	0.399
LIG_Pex14_1	329	333	PF04695	0.427
LIG_SH2_CRK	69	73	PF00017	0.501
LIG_SH2_NCK_1	147	151	PF00017	0.283
LIG_SH2_SRC	147	150	PF00017	0.283
LIG_SH2_SRC	89	92	PF00017	0.412
LIG_SH2_STAP1	173	177	PF00017	0.491
LIG_SH2_STAP1	273	277	PF00017	0.384
LIG_SH2_STAT5	161	164	PF00017	0.448
LIG_SH2_STAT5	173	176	PF00017	0.457
LIG_SH2_STAT5	232	235	PF00017	0.397
LIG_SH2_STAT5	340	343	PF00017	0.348
LIG_SH3_3	348	354	PF00018	0.499
LIG_SUMO_SIM_par_1	48	53	PF11976	0.283
LIG_TRAF2_1	45	48	PF00917	0.345
LIG_WW_3	350	354	PF00397	0.410
MOD_CDK_SPxxK_3	116	123	PF00069	0.283
MOD_CK1_1	365	371	PF00069	0.429
MOD_CK1_1	64	70	PF00069	0.370
MOD_CK2_1	110	116	PF00069	0.358
MOD_CK2_1	177	183	PF00069	0.479
MOD_CK2_1	42	48	PF00069	0.378
MOD_GlcNHglycan	225	228	PF01048	0.270
MOD_GlcNHglycan	63	66	PF01048	0.312
MOD_GSK3_1	112	119	PF00069	0.283
MOD_GSK3_1	162	169	PF00069	0.451
MOD_GSK3_1	17	24	PF00069	0.337
MOD_GSK3_1	177	184	PF00069	0.467
MOD_GSK3_1	362	369	PF00069	0.418
MOD_GSK3_1	60	67	PF00069	0.441
MOD_N-GLC_1	171	176	PF02516	0.464
MOD_NEK2_1	177	182	PF00069	0.359
MOD_NEK2_2	245	250	PF00069	0.301
MOD_NEK2_2	273	278	PF00069	0.188
MOD_PIKK_1	211	217	PF00454	0.425
MOD_PIKK_1	6	12	PF00454	0.502
MOD_PKA_1	17	23	PF00069	0.371
MOD_PKA_2	162	168	PF00069	0.339
MOD_PKA_2	17	23	PF00069	0.408
MOD_PKA_2	365	371	PF00069	0.422
MOD_Plk_4	162	168	PF00069	0.440
MOD_Plk_4	213	219	PF00069	0.320
MOD_Plk_4	91	97	PF00069	0.351
MOD_ProDKin_1	116	122	PF00069	0.283
MOD_ProDKin_1	166	172	PF00069	0.468
MOD_ProDKin_1	64	70	PF00069	0.474
MOD_SUMO_for_1	187	190	PF00179	0.270
MOD_SUMO_rev_2	86	94	PF00179	0.392
TRG_DiLeu_BaEn_1	213	218	PF01217	0.283
TRG_DiLeu_BaLyEn_6	232	237	PF01217	0.385
TRG_ENDOCYTIC_2	100	103	PF00928	0.430
TRG_ENDOCYTIC_2	161	164	PF00928	0.194
TRG_ENDOCYTIC_2	310	313	PF00928	0.344
TRG_ENDOCYTIC_2	69	72	PF00928	0.341
TRG_ENDOCYTIC_2	89	92	PF00928	0.477
TRG_ER_diArg_1	16	18	PF00400	0.432
TRG_NES_CRM1_1	231	244	PF08389	0.283
TRG_NLS_MonoExtN_4	17	22	PF00514	0.239
TRG_Pf-PMV_PEXEL_1	196	201	PF00026	0.309
TRG_Pf-PMV_PEXEL_1	253	257	PF00026	0.444
TRG_Pf-PMV_PEXEL_1	265	269	PF00026	0.434
TRG_Pf-PMV_PEXEL_1	287	291	PF00026	0.334
TRG_PTS2	1	29	PF00400	0.207

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4IZ28	Bodo saltans	43%	82%
A0A1X0NY67	Trypanosomatidae	47%	73%
A0A1X0P441	Trypanosomatidae	51%	74%
A0A1X0P598	Trypanosomatidae	52%	74%
A0A3Q8IBW2	Leishmania donovani	87%	74%
A0A3Q8IJY8	Leishmania donovani	98%	82%
A0A3Q8IU74	Leishmania donovani	46%	74%
A0A3S7WSA3	Leishmania donovani	49%	74%
A0A422P042	Trypanosoma rangeli	48%	74%
A0A422P4R1	Trypanosoma rangeli	49%	74%
A4H716	Leishmania braziliensis	49%	100%
A4HLW4	Leishmania braziliensis	46%	100%
A4HVE5	Leishmania infantum	49%	100%
A4HVW0	Leishmania infantum	87%	100%
A4I993	Leishmania infantum	46%	100%
D0A656	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	74%
E9AP43	Leishmania mexicana (strain MHOM/GT/2001/U1103)	49%	100%
E9B493	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	100%
P42663	Thermus aquaticus	31%	73%
P50848	Bacillus subtilis (strain 168)	32%	74%
Q4Q0D4	Leishmania major	88%	100%
Q4Q3T3	Leishmania major	46%	100%
Q4QFW7	Leishmania major	86%	100%
Q4QGE5	Leishmania major	47%	100%
Q5SLM3	Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8)	31%	73%
Q8U3L0	Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)	29%	74%
V5DQA0	Trypanosoma cruzi	51%	74%