LeishMANIAdb
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Glucose transporter, lmgt1

Quick info Annotations Function or PPIs Localization Phosphorylation Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Glucose transporter, lmgt1
Gene product:
glucose transporter 2
Species:
Leishmania infantum
UniProt:
A4IC83_LEIIN
TriTrypDb:
LINF_360073600
Length:
653

Annotations

LeishMANIAdb annotations

Publication identifier(s): 30068561 23766511
These proteins are related to other Eukaryotic proton-coupled hexose transporters, but the family has extremely expanded in parazitic species.. Subcellular localization depends on the actual paralogue. In L. mexicana, the GT2 protein (E9AU63) is found on the cell membrane, GT3 (E9AU62) is largely located at the ER while GT1 (E9AU64) is flagellar.. Localization: ER (experimental) / Cell surface (experimental) / Flagellar (experimental)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) yes yes: 2
Forrest at al. (procyclic) yes yes: 2
Silverman et al. no yes: 0
Pissara et al. no yes: 3
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 5
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 39
NetGPI no yes: 0, no: 39
Cellular components
Term Name Level Count
GO:0016020 membrane 2 40
GO:0110165 cellular anatomical entity 1 40
GO:0005886 plasma membrane 3 3
GO:0051286 cell tip 3 3
GO:0060187 cell pole 2 3

Phosphorylation

Promastigote: 648
Promastigote/Amastigote: 644, 646

Expansion

Sequence features

A4IC83
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IC83

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 16
GO:0008643 carbohydrate transport 5 16
GO:0051179 localization 1 16
GO:0051234 establishment of localization 2 16
GO:0071702 organic substance transport 4 16
GO:0009987 cellular process 1 1
GO:0015749 monosaccharide transmembrane transport 4 1
GO:0034219 carbohydrate transmembrane transport 3 1
GO:0055085 transmembrane transport 2 1
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 40
GO:0015144 carbohydrate transmembrane transporter activity 3 15
GO:0022857 transmembrane transporter activity 2 40
GO:0015145 monosaccharide transmembrane transporter activity 5 2
GO:0015149 hexose transmembrane transporter activity 6 2
GO:0051119 sugar transmembrane transporter activity 4 2
GO:0005353 fructose transmembrane transporter activity 7 1
GO:0005354 galactose transmembrane transporter activity 7 1
GO:0015578 mannose transmembrane transporter activity 7 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 625 629 PF00656 0.698
CLV_NRD_NRD_1 199 201 PF00675 0.611
CLV_NRD_NRD_1 56 58 PF00675 0.435
CLV_PCSK_KEX2_1 199 201 PF00082 0.534
CLV_PCSK_KEX2_1 331 333 PF00082 0.377
CLV_PCSK_KEX2_1 626 628 PF00082 0.407
CLV_PCSK_KEX2_1 631 633 PF00082 0.586
CLV_PCSK_PC1ET2_1 331 333 PF00082 0.389
CLV_PCSK_PC1ET2_1 626 628 PF00082 0.407
CLV_PCSK_PC1ET2_1 631 633 PF00082 0.586
CLV_PCSK_PC7_1 627 633 PF00082 0.441
CLV_PCSK_SKI1_1 488 492 PF00082 0.318
CLV_PCSK_SKI1_1 57 61 PF00082 0.439
DEG_ODPH_VHL_1 458 469 PF01847 0.397
DEG_SCF_FBW7_1 96 102 PF00400 0.605
DOC_CKS1_1 44 49 PF01111 0.638
DOC_CKS1_1 96 101 PF01111 0.622
DOC_CYCLIN_RxL_1 485 495 PF00134 0.585
DOC_MAPK_gen_1 329 338 PF00069 0.528
DOC_MAPK_HePTP_8 301 313 PF00069 0.485
DOC_MAPK_MEF2A_6 271 279 PF00069 0.536
DOC_MAPK_MEF2A_6 304 313 PF00069 0.368
DOC_MAPK_MEF2A_6 329 338 PF00069 0.537
DOC_MAPK_NFAT4_5 304 312 PF00069 0.438
DOC_PP1_RVXF_1 269 275 PF00149 0.532
DOC_PP2B_LxvP_1 59 62 PF13499 0.635
DOC_PP2B_LxvP_1 81 84 PF13499 0.621
DOC_PP4_FxxP_1 260 263 PF00568 0.505
DOC_PP4_FxxP_1 619 622 PF00568 0.406
DOC_SPAK_OSR1_1 304 308 PF12202 0.467
DOC_USP7_MATH_1 119 123 PF00917 0.664
DOC_USP7_MATH_1 263 267 PF00917 0.523
DOC_USP7_MATH_1 512 516 PF00917 0.399
DOC_USP7_UBL2_3 517 521 PF12436 0.349
DOC_USP7_UBL2_3 626 630 PF12436 0.694
DOC_WW_Pin1_4 117 122 PF00397 0.681
DOC_WW_Pin1_4 35 40 PF00397 0.834
DOC_WW_Pin1_4 43 48 PF00397 0.786
DOC_WW_Pin1_4 69 74 PF00397 0.650
DOC_WW_Pin1_4 95 100 PF00397 0.826
LIG_14-3-3_CanoR_1 169 175 PF00244 0.413
LIG_14-3-3_CanoR_1 199 205 PF00244 0.404
LIG_14-3-3_CanoR_1 222 228 PF00244 0.365
LIG_14-3-3_CanoR_1 271 275 PF00244 0.543
LIG_14-3-3_CanoR_1 559 564 PF00244 0.525
LIG_BIR_II_1 1 5 PF00653 0.652
LIG_BIR_III_2 36 40 PF00653 0.645
LIG_BIR_III_2 67 71 PF00653 0.622
LIG_BRCT_BRCA1_1 119 123 PF00533 0.623
LIG_BRCT_BRCA1_1 144 148 PF00533 0.398
LIG_BRCT_BRCA1_1 152 156 PF00533 0.337
LIG_BRCT_BRCA1_1 242 246 PF00533 0.334
LIG_BRCT_BRCA1_1 358 362 PF00533 0.363
LIG_BRCT_BRCA1_1 380 384 PF00533 0.505
LIG_BRCT_BRCA1_1 481 485 PF00533 0.470
LIG_deltaCOP1_diTrp_1 296 305 PF00928 0.376
LIG_FHA_1 331 337 PF00498 0.537
LIG_FHA_1 341 347 PF00498 0.302
LIG_FHA_1 386 392 PF00498 0.473
LIG_FHA_1 434 440 PF00498 0.409
LIG_FHA_1 525 531 PF00498 0.419
LIG_FHA_1 565 571 PF00498 0.426
LIG_FHA_1 581 587 PF00498 0.328
LIG_FHA_1 96 102 PF00498 0.710
LIG_FHA_2 213 219 PF00498 0.394
LIG_FHA_2 23 29 PF00498 0.784
LIG_FHA_2 62 68 PF00498 0.806
LIG_GBD_Chelix_1 264 272 PF00786 0.496
LIG_LIR_Apic_2 258 263 PF02991 0.505
LIG_LIR_Gen_1 120 131 PF02991 0.595
LIG_LIR_Gen_1 273 282 PF02991 0.397
LIG_LIR_Gen_1 296 306 PF02991 0.363
LIG_LIR_Gen_1 381 391 PF02991 0.439
LIG_LIR_Gen_1 417 428 PF02991 0.542
LIG_LIR_Gen_1 562 571 PF02991 0.326
LIG_LIR_Nem_3 120 126 PF02991 0.558
LIG_LIR_Nem_3 145 151 PF02991 0.376
LIG_LIR_Nem_3 273 277 PF02991 0.399
LIG_LIR_Nem_3 294 300 PF02991 0.309
LIG_LIR_Nem_3 381 387 PF02991 0.414
LIG_LIR_Nem_3 417 421 PF02991 0.615
LIG_LIR_Nem_3 562 566 PF02991 0.441
LIG_LYPXL_S_1 510 514 PF13949 0.386
LIG_LYPXL_yS_3 511 514 PF13949 0.322
LIG_NRBOX 271 277 PF00104 0.612
LIG_NRBOX 382 388 PF00104 0.489
LIG_Pex14_2 380 384 PF04695 0.495
LIG_Pex14_2 493 497 PF04695 0.481
LIG_Pex14_2 532 536 PF04695 0.338
LIG_Pex14_2 552 556 PF04695 0.530
LIG_Pex14_2 619 623 PF04695 0.431
LIG_PTB_Apo_2 573 580 PF02174 0.374
LIG_PTB_Phospho_1 573 579 PF10480 0.416
LIG_SH2_CRK 152 156 PF00017 0.336
LIG_SH2_NCK_1 204 208 PF00017 0.327
LIG_SH2_SRC 448 451 PF00017 0.354
LIG_SH2_STAP1 152 156 PF00017 0.358
LIG_SH2_STAT3 321 324 PF00017 0.554
LIG_SH2_STAT5 190 193 PF00017 0.374
LIG_SH2_STAT5 202 205 PF00017 0.376
LIG_SH2_STAT5 321 324 PF00017 0.500
LIG_SH2_STAT5 420 423 PF00017 0.654
LIG_SH2_STAT5 483 486 PF00017 0.592
LIG_SH2_STAT5 5 8 PF00017 0.641
LIG_SH2_STAT5 545 548 PF00017 0.421
LIG_SH2_STAT5 88 91 PF00017 0.645
LIG_SH3_2 53 58 PF14604 0.636
LIG_SH3_3 313 319 PF00018 0.362
LIG_SH3_3 50 56 PF00018 0.804
LIG_SH3_3 506 512 PF00018 0.363
LIG_SH3_3 574 580 PF00018 0.376
LIG_SH3_3 67 73 PF00018 0.619
LIG_SH3_3 90 96 PF00018 0.827
LIG_SUMO_SIM_anti_2 385 391 PF11976 0.369
LIG_TRFH_1 618 622 PF08558 0.406
MOD_CDK_SPxxK_3 69 76 PF00069 0.632
MOD_CK1_1 122 128 PF00069 0.596
MOD_CK1_1 205 211 PF00069 0.361
MOD_CK1_1 236 242 PF00069 0.363
MOD_CK1_1 385 391 PF00069 0.447
MOD_CK1_1 495 501 PF00069 0.445
MOD_CK1_1 515 521 PF00069 0.385
MOD_CK1_1 645 651 PF00069 0.823
MOD_CK1_1 86 92 PF00069 0.818
MOD_CK2_1 111 117 PF00069 0.752
MOD_CK2_1 203 209 PF00069 0.380
MOD_CK2_1 212 218 PF00069 0.388
MOD_CK2_1 22 28 PF00069 0.748
MOD_CK2_1 225 231 PF00069 0.373
MOD_CK2_1 236 242 PF00069 0.335
MOD_CK2_1 288 294 PF00069 0.486
MOD_Cter_Amidation 628 631 PF01082 0.508
MOD_Cter_Amidation 638 641 PF01082 0.606
MOD_GlcNHglycan 1 4 PF01048 0.580
MOD_GlcNHglycan 10 13 PF01048 0.611
MOD_GlcNHglycan 205 208 PF01048 0.543
MOD_GlcNHglycan 227 230 PF01048 0.549
MOD_GlcNHglycan 235 238 PF01048 0.510
MOD_GlcNHglycan 242 245 PF01048 0.480
MOD_GlcNHglycan 586 589 PF01048 0.501
MOD_GlcNHglycan 590 593 PF01048 0.499
MOD_GlcNHglycan 647 650 PF01048 0.596
MOD_GSK3_1 18 25 PF00069 0.817
MOD_GSK3_1 194 201 PF00069 0.344
MOD_GSK3_1 233 240 PF00069 0.328
MOD_GSK3_1 3 10 PF00069 0.802
MOD_GSK3_1 378 385 PF00069 0.406
MOD_GSK3_1 433 440 PF00069 0.383
MOD_GSK3_1 471 478 PF00069 0.391
MOD_GSK3_1 479 486 PF00069 0.365
MOD_GSK3_1 492 499 PF00069 0.296
MOD_GSK3_1 580 587 PF00069 0.375
MOD_GSK3_1 641 648 PF00069 0.821
MOD_GSK3_1 95 102 PF00069 0.793
MOD_N-GLC_1 183 188 PF02516 0.563
MOD_N-GLC_2 576 578 PF02516 0.434
MOD_NEK2_1 156 161 PF00069 0.331
MOD_NEK2_1 246 251 PF00069 0.379
MOD_NEK2_1 255 260 PF00069 0.319
MOD_NEK2_1 264 269 PF00069 0.246
MOD_NEK2_1 356 361 PF00069 0.322
MOD_NEK2_1 395 400 PF00069 0.515
MOD_NEK2_1 433 438 PF00069 0.375
MOD_NEK2_1 472 477 PF00069 0.402
MOD_NEK2_1 492 497 PF00069 0.178
MOD_NEK2_1 643 648 PF00069 0.693
MOD_NEK2_2 194 199 PF00069 0.368
MOD_NEK2_2 379 384 PF00069 0.467
MOD_NEK2_2 483 488 PF00069 0.558
MOD_OFUCOSY 191 198 PF10250 0.536
MOD_PIKK_1 111 117 PF00454 0.638
MOD_PIKK_1 18 24 PF00454 0.821
MOD_PIKK_1 212 218 PF00454 0.381
MOD_PIKK_1 545 551 PF00454 0.413
MOD_PIKK_1 561 567 PF00454 0.360
MOD_PIKK_1 71 77 PF00454 0.641
MOD_PKA_2 198 204 PF00069 0.408
MOD_PKA_2 223 229 PF00069 0.390
MOD_PKA_2 270 276 PF00069 0.558
MOD_PKB_1 557 565 PF00069 0.525
MOD_Plk_4 151 157 PF00069 0.380
MOD_Plk_4 246 252 PF00069 0.396
MOD_Plk_4 255 261 PF00069 0.345
MOD_Plk_4 270 276 PF00069 0.503
MOD_Plk_4 282 288 PF00069 0.336
MOD_Plk_4 356 362 PF00069 0.375
MOD_Plk_4 379 385 PF00069 0.376
MOD_Plk_4 479 485 PF00069 0.379
MOD_Plk_4 492 498 PF00069 0.341
MOD_ProDKin_1 117 123 PF00069 0.672
MOD_ProDKin_1 35 41 PF00069 0.833
MOD_ProDKin_1 43 49 PF00069 0.786
MOD_ProDKin_1 69 75 PF00069 0.651
MOD_ProDKin_1 95 101 PF00069 0.827
TRG_AP2beta_CARGO_1 294 304 PF09066 0.397
TRG_DiLeu_BaEn_1 296 301 PF01217 0.385
TRG_DiLeu_BaLyEn_6 423 428 PF01217 0.563
TRG_ENDOCYTIC_2 152 155 PF00928 0.315
TRG_ENDOCYTIC_2 418 421 PF00928 0.594
TRG_ENDOCYTIC_2 511 514 PF00928 0.322
TRG_ENDOCYTIC_2 544 547 PF00928 0.446
TRG_ER_diArg_1 221 224 PF00400 0.347
TRG_ER_diArg_1 556 559 PF00400 0.532
TRG_NLS_MonoExtC_3 56 61 PF00514 0.629
TRG_NLS_MonoExtN_4 56 61 PF00514 0.636
TRG_NLS_MonoExtN_4 627 634 PF00514 0.673

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P2E1 Leptomonas seymouri 53% 100%
A0A0N0P3Z7 Leptomonas seymouri 44% 85%
A0A0N0P4D8 Leptomonas seymouri 50% 88%
A0A0N1IG16 Leptomonas seymouri 71% 100%
A0A0N1P9H5 Leptomonas seymouri 46% 100%
A0A0S4J363 Bodo saltans 28% 100%
A0A0S4JDF9 Bodo saltans 39% 100%
A0A0S4JEY7 Bodo saltans 40% 100%
A0A0S4JH90 Bodo saltans 36% 100%
A0A0S4JS00 Bodo saltans 33% 100%
A0A1X0NLE0 Trypanosomatidae 57% 100%
A0A1X0NM05 Trypanosomatidae 56% 100%
A0A1X0NN62 Trypanosomatidae 52% 100%
A0A1X0P9L7 Trypanosomatidae 38% 100%
A0A381N054 Leishmania infantum 97% 100%
A0A3Q8IDK1 Leishmania donovani 43% 100%
A0A3Q8IK60 Leishmania donovani 97% 100%
A0A3Q8IWJ4 Leishmania donovani 99% 100%
A0A3R7KPU3 Trypanosoma rangeli 36% 100%
A0A3S7WY58 Leishmania donovani 22% 100%
A0A3S7XC27 Leishmania donovani 95% 100%
A0A422MNQ4 Trypanosoma rangeli 55% 100%
A4HL65 Leishmania braziliensis 40% 100%
A4HQD6 Leishmania braziliensis 85% 100%
A4HQD7 Leishmania braziliensis 86% 100%
A4HQE7 Leishmania braziliensis 90% 100%
A4I0Q6 Leishmania infantum 22% 100%
A4I8N6 Leishmania infantum 43% 100%
C9ZMM0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 35% 100%
D0A3U1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 47% 100%
D0A3U2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 47% 100%
D0A3U3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 47% 100%
E9AU62 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%
E9AU63 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 100%
E9AU64 Leishmania mexicana (strain MHOM/GT/2001/U1103) 90% 100%
E9AWQ8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 22% 100%
E9B3K8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 43% 100%
K0E3U9 Aspergillus rugulosus 22% 100%
O34718 Bacillus subtilis (strain 168) 21% 100%
O74849 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 22% 100%
P12336 Rattus norvegicus 22% 100%
P13865 Leishmania enriettii 83% 100%
P20303 Sus scrofa 23% 100%
P39003 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 20% 100%
P39004 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 20% 100%
P39924 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 23% 100%
P47185 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 23% 100%
P53631 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 23% 100%
P54854 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 23% 100%
Q01441 Leishmania donovani 43% 100%
Q06221 Trypanosoma brucei brucei 46% 100%
Q06222 Trypanosoma brucei brucei 47% 100%
Q09037 Trypanosoma brucei brucei 45% 100%
Q10PW9 Oryza sativa subsp. japonica 21% 100%
Q27115 Trypanosoma vivax 46% 100%
Q4Q0D0 Leishmania major 89% 100%
Q4Q0D1 Leishmania major 93% 100%
Q4Q0D2 Leishmania major 91% 100%
Q4Q4J1 Leishmania major 43% 100%
Q4QAR5 Leishmania major 22% 100%
Q8TFG1 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 23% 100%
Q9P3U6 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 23% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS