WD domain, G-beta repeat-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4IC79_LEIIN

TriTrypDb:

LINF_360063200

Length:

545

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4IC79

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IC79

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	251	255	PF00656	0.396
CLV_C14_Caspase3-7	394	398	PF00656	0.648
CLV_C14_Caspase3-7	466	470	PF00656	0.549
CLV_NRD_NRD_1	14	16	PF00675	0.617
CLV_NRD_NRD_1	297	299	PF00675	0.651
CLV_NRD_NRD_1	33	35	PF00675	0.734
CLV_NRD_NRD_1	333	335	PF00675	0.474
CLV_NRD_NRD_1	399	401	PF00675	0.505
CLV_NRD_NRD_1	75	77	PF00675	0.685
CLV_PCSK_KEX2_1	14	16	PF00082	0.678
CLV_PCSK_KEX2_1	297	299	PF00082	0.646
CLV_PCSK_KEX2_1	31	33	PF00082	0.675
CLV_PCSK_KEX2_1	335	337	PF00082	0.607
CLV_PCSK_KEX2_1	399	401	PF00082	0.505
CLV_PCSK_KEX2_1	453	455	PF00082	0.683
CLV_PCSK_KEX2_1	75	77	PF00082	0.632
CLV_PCSK_PC1ET2_1	31	33	PF00082	0.714
CLV_PCSK_PC1ET2_1	335	337	PF00082	0.607
CLV_PCSK_PC1ET2_1	453	455	PF00082	0.620
CLV_PCSK_SKI1_1	161	165	PF00082	0.614
CLV_PCSK_SKI1_1	167	171	PF00082	0.503
CLV_PCSK_SKI1_1	454	458	PF00082	0.807
CLV_PCSK_SKI1_1	475	479	PF00082	0.610
CLV_Separin_Metazoa	221	225	PF03568	0.494
DEG_Nend_UBRbox_3	1	3	PF02207	0.674
DOC_ANK_TNKS_1	101	108	PF00023	0.550
DOC_CYCLIN_RxL_1	472	482	PF00134	0.607
DOC_CYCLIN_yClb1_LxF_4	428	434	PF00134	0.511
DOC_MAPK_gen_1	334	342	PF00069	0.496
DOC_MAPK_MEF2A_6	362	370	PF00069	0.504
DOC_MAPK_MEF2A_6	496	505	PF00069	0.632
DOC_PP1_RVXF_1	178	184	PF00149	0.542
DOC_PP1_RVXF_1	227	234	PF00149	0.616
DOC_PP2B_LxvP_1	407	410	PF13499	0.507
DOC_PP4_FxxP_1	505	508	PF00568	0.518
DOC_USP7_MATH_1	101	105	PF00917	0.746
DOC_USP7_MATH_1	136	140	PF00917	0.440
DOC_USP7_MATH_1	238	242	PF00917	0.481
DOC_USP7_MATH_1	311	315	PF00917	0.636
DOC_USP7_MATH_1	341	345	PF00917	0.547
DOC_USP7_MATH_1	357	361	PF00917	0.457
DOC_USP7_MATH_1	424	428	PF00917	0.446
DOC_USP7_MATH_1	43	47	PF00917	0.642
DOC_USP7_MATH_1	442	446	PF00917	0.712
DOC_USP7_UBL2_3	27	31	PF12436	0.758
DOC_WW_Pin1_4	109	114	PF00397	0.667
DOC_WW_Pin1_4	234	239	PF00397	0.484
DOC_WW_Pin1_4	272	277	PF00397	0.621
DOC_WW_Pin1_4	405	410	PF00397	0.632
DOC_WW_Pin1_4	497	502	PF00397	0.518
LIG_14-3-3_CanoR_1	180	184	PF00244	0.519
LIG_14-3-3_CanoR_1	399	407	PF00244	0.562
LIG_14-3-3_CanoR_1	47	53	PF00244	0.696
LIG_14-3-3_CanoR_1	92	100	PF00244	0.617
LIG_AP2alpha_1	467	471	PF02296	0.544
LIG_BRCT_BRCA1_1	429	433	PF00533	0.480
LIG_BRCT_BRCA1_1	501	505	PF00533	0.506
LIG_BRCT_BRCA1_1	64	68	PF00533	0.742
LIG_CSL_BTD_1	498	501	PF09270	0.557
LIG_FHA_1	186	192	PF00498	0.509
LIG_FHA_1	223	229	PF00498	0.604
LIG_FHA_1	244	250	PF00498	0.418
LIG_FHA_1	264	270	PF00498	0.393
LIG_FHA_1	294	300	PF00498	0.722
LIG_FHA_1	446	452	PF00498	0.733
LIG_FHA_2	122	128	PF00498	0.570
LIG_FHA_2	18	24	PF00498	0.636
LIG_FHA_2	249	255	PF00498	0.440
LIG_FHA_2	304	310	PF00498	0.472
LIG_LIR_Apic_2	502	508	PF02991	0.528
LIG_LIR_Gen_1	116	125	PF02991	0.381
LIG_LIR_Gen_1	139	146	PF02991	0.445
LIG_LIR_Gen_1	385	393	PF02991	0.610
LIG_LIR_Nem_3	116	122	PF02991	0.389
LIG_LIR_Nem_3	139	144	PF02991	0.437
LIG_LIR_Nem_3	182	186	PF02991	0.577
LIG_LIR_Nem_3	385	390	PF02991	0.515
LIG_LIR_Nem_3	430	436	PF02991	0.441
LIG_LYPXL_S_1	422	426	PF13949	0.432
LIG_LYPXL_yS_3	423	426	PF13949	0.433
LIG_MLH1_MIPbox_1	64	68	PF16413	0.742
LIG_PCNA_yPIPBox_3	2	15	PF02747	0.724
LIG_Pex14_2	467	471	PF04695	0.675
LIG_Pex14_2	505	509	PF04695	0.513
LIG_SH2_CRK	119	123	PF00017	0.378
LIG_SH2_GRB2like	38	41	PF00017	0.608
LIG_SH2_SRC	132	135	PF00017	0.452
LIG_SH2_SRC	38	41	PF00017	0.739
LIG_SH2_SRC	434	437	PF00017	0.587
LIG_SH2_STAP1	38	42	PF00017	0.707
LIG_SH2_STAT5	132	135	PF00017	0.551
LIG_SH3_3	13	19	PF00018	0.713
LIG_SH3_3	280	286	PF00018	0.657
LIG_SH3_3	351	357	PF00018	0.523
LIG_SH3_3	473	479	PF00018	0.656
LIG_SUMO_SIM_par_1	162	168	PF11976	0.593
LIG_SUMO_SIM_par_1	246	254	PF11976	0.476
LIG_SUMO_SIM_par_1	266	273	PF11976	0.530
LIG_SUMO_SIM_par_1	325	332	PF11976	0.470
LIG_SUMO_SIM_par_1	338	344	PF11976	0.498
LIG_TRAF2_1	386	389	PF00917	0.507
LIG_TYR_ITIM	421	426	PF00017	0.432
LIG_UBA3_1	327	335	PF00899	0.586
LIG_WRC_WIRS_1	114	119	PF05994	0.512
MOD_CDC14_SPxK_1	408	411	PF00782	0.604
MOD_CDK_SPxK_1	405	411	PF00069	0.627
MOD_CK1_1	120	126	PF00069	0.490
MOD_CK1_1	194	200	PF00069	0.483
MOD_CK1_1	241	247	PF00069	0.567
MOD_CK1_1	398	404	PF00069	0.607
MOD_CK1_1	427	433	PF00069	0.434
MOD_CK1_1	445	451	PF00069	0.701
MOD_CK1_1	497	503	PF00069	0.589
MOD_CK1_1	510	516	PF00069	0.434
MOD_CK2_1	17	23	PF00069	0.630
MOD_CK2_1	303	309	PF00069	0.544
MOD_CK2_1	382	388	PF00069	0.463
MOD_Cter_Amidation	73	76	PF01082	0.683
MOD_GlcNHglycan	10	13	PF01048	0.618
MOD_GlcNHglycan	103	106	PF01048	0.550
MOD_GlcNHglycan	138	141	PF01048	0.558
MOD_GlcNHglycan	167	170	PF01048	0.566
MOD_GlcNHglycan	201	204	PF01048	0.465
MOD_GlcNHglycan	243	246	PF01048	0.502
MOD_GlcNHglycan	289	292	PF01048	0.566
MOD_GlcNHglycan	373	376	PF01048	0.571
MOD_GlcNHglycan	403	406	PF01048	0.559
MOD_GlcNHglycan	5	8	PF01048	0.588
MOD_GlcNHglycan	519	522	PF01048	0.457
MOD_GlcNHglycan	525	528	PF01048	0.488
MOD_GlcNHglycan	542	545	PF01048	0.462
MOD_GlcNHglycan	64	67	PF01048	0.640
MOD_GSK3_1	109	116	PF00069	0.499
MOD_GSK3_1	117	124	PF00069	0.439
MOD_GSK3_1	17	24	PF00069	0.682
MOD_GSK3_1	190	197	PF00069	0.515
MOD_GSK3_1	234	241	PF00069	0.497
MOD_GSK3_1	244	251	PF00069	0.420
MOD_GSK3_1	259	266	PF00069	0.449
MOD_GSK3_1	378	385	PF00069	0.474
MOD_GSK3_1	388	395	PF00069	0.394
MOD_GSK3_1	401	408	PF00069	0.444
MOD_GSK3_1	440	447	PF00069	0.761
MOD_GSK3_1	452	459	PF00069	0.698
MOD_GSK3_1	495	502	PF00069	0.677
MOD_GSK3_1	503	510	PF00069	0.451
MOD_GSK3_1	515	522	PF00069	0.402
MOD_GSK3_1	538	545	PF00069	0.548
MOD_GSK3_1	90	97	PF00069	0.526
MOD_N-GLC_1	405	410	PF02516	0.507
MOD_N-GLC_2	263	265	PF02516	0.454
MOD_NEK2_1	1	6	PF00069	0.702
MOD_NEK2_1	117	122	PF00069	0.488
MOD_NEK2_1	144	149	PF00069	0.480
MOD_NEK2_1	185	190	PF00069	0.450
MOD_NEK2_1	191	196	PF00069	0.486
MOD_NEK2_1	239	244	PF00069	0.588
MOD_NEK2_1	452	457	PF00069	0.686
MOD_NEK2_1	494	499	PF00069	0.672
MOD_NEK2_1	503	508	PF00069	0.373
MOD_NEK2_1	540	545	PF00069	0.583
MOD_NEK2_1	68	73	PF00069	0.707
MOD_NEK2_1	8	13	PF00069	0.662
MOD_NEK2_2	113	118	PF00069	0.619
MOD_NEK2_2	357	362	PF00069	0.666
MOD_PIKK_1	185	191	PF00454	0.506
MOD_PIKK_1	398	404	PF00454	0.564
MOD_PIKK_1	442	448	PF00454	0.587
MOD_PIKK_1	456	462	PF00454	0.749
MOD_PIKK_1	51	57	PF00454	0.648
MOD_PKA_1	495	501	PF00069	0.605
MOD_PKA_2	101	107	PF00069	0.682
MOD_PKA_2	117	123	PF00069	0.521
MOD_PKA_2	179	185	PF00069	0.520
MOD_PKA_2	391	397	PF00069	0.575
MOD_PKA_2	398	404	PF00069	0.492
MOD_Plk_1	388	394	PF00069	0.469
MOD_Plk_2-3	480	486	PF00069	0.780
MOD_Plk_4	117	123	PF00069	0.535
MOD_Plk_4	145	151	PF00069	0.610
MOD_Plk_4	410	416	PF00069	0.454
MOD_Plk_4	427	433	PF00069	0.439
MOD_Plk_4	463	469	PF00069	0.753
MOD_Plk_4	499	505	PF00069	0.499
MOD_ProDKin_1	109	115	PF00069	0.659
MOD_ProDKin_1	234	240	PF00069	0.478
MOD_ProDKin_1	272	278	PF00069	0.615
MOD_ProDKin_1	405	411	PF00069	0.627
MOD_ProDKin_1	497	503	PF00069	0.515
MOD_SUMO_rev_2	147	156	PF00179	0.526
MOD_SUMO_rev_2	160	169	PF00179	0.513
MOD_SUMO_rev_2	23	29	PF00179	0.677
MOD_SUMO_rev_2	492	497	PF00179	0.683
TRG_DiLeu_BaLyEn_6	413	418	PF01217	0.514
TRG_ENDOCYTIC_2	119	122	PF00928	0.377
TRG_ENDOCYTIC_2	423	426	PF00928	0.433
TRG_ER_diArg_1	14	16	PF00400	0.622
TRG_ER_diArg_1	297	299	PF00400	0.729
TRG_ER_diArg_1	32	34	PF00400	0.701
TRG_ER_diArg_1	333	336	PF00400	0.529
TRG_ER_diArg_1	75	77	PF00400	0.576
TRG_Pf-PMV_PEXEL_1	229	234	PF00026	0.625
TRG_Pf-PMV_PEXEL_1	475	480	PF00026	0.613

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC59	Leptomonas seymouri	43%	84%
A0A3Q8IGL8	Leishmania donovani	100%	100%
A4HQ51	Leishmania braziliensis	75%	100%
E9ATX1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q0M5	Leishmania major	90%	100%