LeishMANIAdb
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Anaphase-promoting complex subunit 1

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Anaphase-promoting complex subunit 1
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4IC75_LEIIN
TriTrypDb:
LINF_360062800
Length:
1073

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 7
NetGPI no yes: 0, no: 7
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4IC75
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IC75

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 1058 1062 PF00656 0.513
CLV_C14_Caspase3-7 330 334 PF00656 0.584
CLV_C14_Caspase3-7 861 865 PF00656 0.558
CLV_MEL_PAP_1 114 120 PF00089 0.512
CLV_NRD_NRD_1 177 179 PF00675 0.604
CLV_NRD_NRD_1 205 207 PF00675 0.581
CLV_NRD_NRD_1 208 210 PF00675 0.563
CLV_NRD_NRD_1 388 390 PF00675 0.503
CLV_NRD_NRD_1 493 495 PF00675 0.563
CLV_NRD_NRD_1 515 517 PF00675 0.582
CLV_NRD_NRD_1 590 592 PF00675 0.604
CLV_NRD_NRD_1 636 638 PF00675 0.591
CLV_NRD_NRD_1 725 727 PF00675 0.632
CLV_NRD_NRD_1 748 750 PF00675 0.579
CLV_NRD_NRD_1 886 888 PF00675 0.529
CLV_NRD_NRD_1 923 925 PF00675 0.706
CLV_NRD_NRD_1 961 963 PF00675 0.623
CLV_PCSK_FUR_1 205 209 PF00082 0.622
CLV_PCSK_FUR_1 386 390 PF00082 0.516
CLV_PCSK_KEX2_1 1016 1018 PF00082 0.669
CLV_PCSK_KEX2_1 175 177 PF00082 0.661
CLV_PCSK_KEX2_1 205 207 PF00082 0.603
CLV_PCSK_KEX2_1 208 210 PF00082 0.614
CLV_PCSK_KEX2_1 388 390 PF00082 0.503
CLV_PCSK_KEX2_1 493 495 PF00082 0.563
CLV_PCSK_KEX2_1 515 517 PF00082 0.582
CLV_PCSK_KEX2_1 590 592 PF00082 0.639
CLV_PCSK_KEX2_1 636 638 PF00082 0.591
CLV_PCSK_KEX2_1 725 727 PF00082 0.567
CLV_PCSK_KEX2_1 747 749 PF00082 0.607
CLV_PCSK_KEX2_1 831 833 PF00082 0.459
CLV_PCSK_KEX2_1 961 963 PF00082 0.623
CLV_PCSK_PC1ET2_1 1016 1018 PF00082 0.669
CLV_PCSK_PC1ET2_1 175 177 PF00082 0.784
CLV_PCSK_PC1ET2_1 207 209 PF00082 0.611
CLV_PCSK_PC1ET2_1 831 833 PF00082 0.499
CLV_PCSK_PC7_1 827 833 PF00082 0.409
CLV_PCSK_SKI1_1 194 198 PF00082 0.649
CLV_PCSK_SKI1_1 474 478 PF00082 0.542
CLV_PCSK_SKI1_1 494 498 PF00082 0.648
CLV_PCSK_SKI1_1 674 678 PF00082 0.539
CLV_PCSK_SKI1_1 768 772 PF00082 0.482
CLV_PCSK_SKI1_1 814 818 PF00082 0.500
CLV_PCSK_SKI1_1 902 906 PF00082 0.580
DEG_APCC_DBOX_1 473 481 PF00400 0.565
DEG_APCC_DBOX_1 763 771 PF00400 0.446
DEG_APCC_DBOX_1 813 821 PF00400 0.561
DEG_SCF_FBW7_1 364 371 PF00400 0.445
DEG_SPOP_SBC_1 107 111 PF00917 0.546
DEG_SPOP_SBC_1 216 220 PF00917 0.600
DEG_SPOP_SBC_1 225 229 PF00917 0.604
DEG_SPOP_SBC_1 231 235 PF00917 0.605
DEG_SPOP_SBC_1 479 483 PF00917 0.590
DOC_CKS1_1 58 63 PF01111 0.618
DOC_CYCLIN_RxL_1 746 755 PF00134 0.429
DOC_CYCLIN_yCln2_LP_2 576 582 PF00134 0.660
DOC_CYCLIN_yCln2_LP_2 763 769 PF00134 0.506
DOC_MAPK_gen_1 386 393 PF00069 0.498
DOC_MAPK_gen_1 515 522 PF00069 0.585
DOC_MAPK_gen_1 747 753 PF00069 0.555
DOC_MAPK_gen_1 831 840 PF00069 0.493
DOC_MAPK_HePTP_8 751 763 PF00069 0.423
DOC_MAPK_JIP1_4 862 868 PF00069 0.520
DOC_MAPK_MEF2A_6 515 522 PF00069 0.585
DOC_MAPK_MEF2A_6 754 763 PF00069 0.434
DOC_MAPK_MEF2A_6 990 998 PF00069 0.586
DOC_PP1_RVXF_1 491 498 PF00149 0.560
DOC_PP2B_LxvP_1 340 343 PF13499 0.480
DOC_PP4_FxxP_1 358 361 PF00568 0.560
DOC_USP7_MATH_1 155 159 PF00917 0.686
DOC_USP7_MATH_1 180 184 PF00917 0.720
DOC_USP7_MATH_1 216 220 PF00917 0.765
DOC_USP7_MATH_1 225 229 PF00917 0.600
DOC_USP7_MATH_1 232 236 PF00917 0.501
DOC_USP7_MATH_1 240 244 PF00917 0.578
DOC_USP7_MATH_1 28 32 PF00917 0.760
DOC_USP7_MATH_1 479 483 PF00917 0.608
DOC_USP7_MATH_1 531 535 PF00917 0.606
DOC_USP7_MATH_1 582 586 PF00917 0.629
DOC_USP7_MATH_1 665 669 PF00917 0.630
DOC_USP7_MATH_1 681 685 PF00917 0.557
DOC_USP7_MATH_1 697 701 PF00917 0.434
DOC_USP7_MATH_1 853 857 PF00917 0.602
DOC_USP7_MATH_1 889 893 PF00917 0.585
DOC_USP7_MATH_1 964 968 PF00917 0.636
DOC_USP7_MATH_2 285 291 PF00917 0.674
DOC_USP7_UBL2_3 182 186 PF12436 0.675
DOC_USP7_UBL2_3 190 194 PF12436 0.621
DOC_WW_Pin1_4 1034 1039 PF00397 0.705
DOC_WW_Pin1_4 153 158 PF00397 0.657
DOC_WW_Pin1_4 364 369 PF00397 0.479
DOC_WW_Pin1_4 392 397 PF00397 0.382
DOC_WW_Pin1_4 405 410 PF00397 0.478
DOC_WW_Pin1_4 487 492 PF00397 0.581
DOC_WW_Pin1_4 57 62 PF00397 0.580
DOC_WW_Pin1_4 784 789 PF00397 0.586
DOC_WW_Pin1_4 939 944 PF00397 0.558
DOC_WW_Pin1_4 976 981 PF00397 0.616
LIG_14-3-3_CanoR_1 125 134 PF00244 0.535
LIG_14-3-3_CanoR_1 48 54 PF00244 0.548
LIG_14-3-3_CanoR_1 725 729 PF00244 0.625
LIG_14-3-3_CanoR_1 814 822 PF00244 0.559
LIG_14-3-3_CanoR_1 858 866 PF00244 0.593
LIG_14-3-3_CanoR_1 88 97 PF00244 0.435
LIG_Actin_WH2_2 384 402 PF00022 0.458
LIG_BIR_II_1 1 5 PF00653 0.623
LIG_BRCT_BRCA1_1 681 685 PF00533 0.642
LIG_BRCT_BRCA1_1 780 784 PF00533 0.618
LIG_eIF4E_1 503 509 PF01652 0.526
LIG_FHA_1 100 106 PF00498 0.415
LIG_FHA_1 1047 1053 PF00498 0.537
LIG_FHA_1 108 114 PF00498 0.352
LIG_FHA_1 281 287 PF00498 0.829
LIG_FHA_1 335 341 PF00498 0.622
LIG_FHA_1 369 375 PF00498 0.683
LIG_FHA_1 411 417 PF00498 0.500
LIG_FHA_1 419 425 PF00498 0.532
LIG_FHA_1 571 577 PF00498 0.492
LIG_FHA_1 603 609 PF00498 0.566
LIG_FHA_1 716 722 PF00498 0.562
LIG_FHA_1 89 95 PF00498 0.586
LIG_FHA_2 149 155 PF00498 0.559
LIG_FHA_2 291 297 PF00498 0.720
LIG_FHA_2 303 309 PF00498 0.454
LIG_FHA_2 543 549 PF00498 0.646
LIG_FHA_2 559 565 PF00498 0.408
LIG_FHA_2 850 856 PF00498 0.627
LIG_FHA_2 859 865 PF00498 0.551
LIG_FHA_2 903 909 PF00498 0.619
LIG_LIR_Apic_2 809 815 PF02991 0.450
LIG_LIR_Gen_1 303 312 PF02991 0.486
LIG_LIR_Gen_1 561 570 PF02991 0.561
LIG_LIR_Gen_1 897 906 PF02991 0.495
LIG_LIR_LC3C_4 110 115 PF02991 0.517
LIG_LIR_Nem_3 303 307 PF02991 0.480
LIG_LIR_Nem_3 561 566 PF02991 0.588
LIG_LIR_Nem_3 682 688 PF02991 0.562
LIG_LIR_Nem_3 796 802 PF02991 0.490
LIG_LIR_Nem_3 897 901 PF02991 0.517
LIG_MYND_1 980 984 PF01753 0.513
LIG_NRBOX 54 60 PF00104 0.572
LIG_SH2_GRB2like 835 838 PF00017 0.541
LIG_SH2_NCK_1 222 226 PF00017 0.493
LIG_SH2_STAP1 420 424 PF00017 0.572
LIG_SH2_STAP1 563 567 PF00017 0.557
LIG_SH2_STAP1 688 692 PF00017 0.597
LIG_SH2_STAT5 1046 1049 PF00017 0.524
LIG_SH2_STAT5 304 307 PF00017 0.452
LIG_SH2_STAT5 420 423 PF00017 0.577
LIG_SH2_STAT5 54 57 PF00017 0.561
LIG_SH2_STAT5 750 753 PF00017 0.432
LIG_SH2_STAT5 878 881 PF00017 0.471
LIG_SH3_3 1018 1024 PF00018 0.604
LIG_SH3_3 419 425 PF00018 0.473
LIG_SH3_3 450 456 PF00018 0.692
LIG_SH3_3 461 467 PF00018 0.403
LIG_SH3_3 763 769 PF00018 0.459
LIG_SH3_3 909 915 PF00018 0.677
LIG_SH3_3 94 100 PF00018 0.555
LIG_SH3_4 190 197 PF00018 0.643
LIG_Sin3_3 412 419 PF02671 0.411
LIG_SUMO_SIM_anti_2 310 317 PF11976 0.400
LIG_SUMO_SIM_anti_2 457 462 PF11976 0.539
LIG_SUMO_SIM_anti_2 79 85 PF11976 0.624
LIG_SUMO_SIM_par_1 310 317 PF11976 0.400
LIG_SUMO_SIM_par_1 389 395 PF11976 0.436
LIG_SUMO_SIM_par_1 420 426 PF11976 0.569
LIG_SUMO_SIM_par_1 624 630 PF11976 0.647
LIG_SUMO_SIM_par_1 994 999 PF11976 0.575
LIG_TYR_ITIM 302 307 PF00017 0.529
LIG_WW_1 342 345 PF00397 0.475
LIG_WW_3 587 591 PF00397 0.596
LIG_WW_3 921 925 PF00397 0.621
MOD_CDC14_SPxK_1 490 493 PF00782 0.570
MOD_CDK_SPxK_1 487 493 PF00069 0.577
MOD_CDK_SPxxK_3 153 160 PF00069 0.650
MOD_CDK_SPxxK_3 487 494 PF00069 0.572
MOD_CK1_1 1026 1032 PF00069 0.521
MOD_CK1_1 1034 1040 PF00069 0.578
MOD_CK1_1 145 151 PF00069 0.663
MOD_CK1_1 181 187 PF00069 0.597
MOD_CK1_1 212 218 PF00069 0.678
MOD_CK1_1 224 230 PF00069 0.669
MOD_CK1_1 233 239 PF00069 0.720
MOD_CK1_1 249 255 PF00069 0.682
MOD_CK1_1 265 271 PF00069 0.685
MOD_CK1_1 290 296 PF00069 0.679
MOD_CK1_1 377 383 PF00069 0.672
MOD_CK1_1 426 432 PF00069 0.564
MOD_CK1_1 481 487 PF00069 0.620
MOD_CK1_1 542 548 PF00069 0.660
MOD_CK1_1 627 633 PF00069 0.603
MOD_CK1_1 668 674 PF00069 0.691
MOD_CK1_1 778 784 PF00069 0.661
MOD_CK1_1 786 792 PF00069 0.569
MOD_CK1_1 897 903 PF00069 0.618
MOD_CK1_1 975 981 PF00069 0.679
MOD_CK1_1 999 1005 PF00069 0.533
MOD_CK2_1 148 154 PF00069 0.686
MOD_CK2_1 217 223 PF00069 0.582
MOD_CK2_1 451 457 PF00069 0.570
MOD_CK2_1 479 485 PF00069 0.601
MOD_CK2_1 540 546 PF00069 0.682
MOD_CK2_1 558 564 PF00069 0.613
MOD_CK2_1 73 79 PF00069 0.644
MOD_CK2_1 849 855 PF00069 0.696
MOD_CK2_1 9 15 PF00069 0.678
MOD_CMANNOS 797 800 PF00535 0.485
MOD_Cter_Amidation 173 176 PF01082 0.671
MOD_GlcNHglycan 1 4 PF01048 0.639
MOD_GlcNHglycan 1031 1034 PF01048 0.533
MOD_GlcNHglycan 11 14 PF01048 0.612
MOD_GlcNHglycan 144 147 PF01048 0.647
MOD_GlcNHglycan 200 203 PF01048 0.658
MOD_GlcNHglycan 223 226 PF01048 0.669
MOD_GlcNHglycan 235 238 PF01048 0.732
MOD_GlcNHglycan 251 254 PF01048 0.695
MOD_GlcNHglycan 264 267 PF01048 0.715
MOD_GlcNHglycan 271 274 PF01048 0.543
MOD_GlcNHglycan 289 292 PF01048 0.696
MOD_GlcNHglycan 30 33 PF01048 0.443
MOD_GlcNHglycan 453 456 PF01048 0.644
MOD_GlcNHglycan 464 467 PF01048 0.525
MOD_GlcNHglycan 485 488 PF01048 0.576
MOD_GlcNHglycan 529 532 PF01048 0.598
MOD_GlcNHglycan 602 605 PF01048 0.609
MOD_GlcNHglycan 655 659 PF01048 0.754
MOD_GlcNHglycan 681 684 PF01048 0.559
MOD_GlcNHglycan 777 780 PF01048 0.693
MOD_GlcNHglycan 855 858 PF01048 0.619
MOD_GlcNHglycan 962 965 PF01048 0.605
MOD_GlcNHglycan 967 970 PF01048 0.677
MOD_GSK3_1 1019 1026 PF00069 0.590
MOD_GSK3_1 181 188 PF00069 0.736
MOD_GSK3_1 190 197 PF00069 0.599
MOD_GSK3_1 211 218 PF00069 0.814
MOD_GSK3_1 221 228 PF00069 0.683
MOD_GSK3_1 231 238 PF00069 0.683
MOD_GSK3_1 258 265 PF00069 0.742
MOD_GSK3_1 364 371 PF00069 0.544
MOD_GSK3_1 425 432 PF00069 0.639
MOD_GSK3_1 479 486 PF00069 0.626
MOD_GSK3_1 523 530 PF00069 0.552
MOD_GSK3_1 668 675 PF00069 0.573
MOD_GSK3_1 692 699 PF00069 0.549
MOD_GSK3_1 73 80 PF00069 0.643
MOD_GSK3_1 733 740 PF00069 0.604
MOD_GSK3_1 775 782 PF00069 0.696
MOD_GSK3_1 836 843 PF00069 0.632
MOD_GSK3_1 849 856 PF00069 0.728
MOD_GSK3_1 890 897 PF00069 0.634
MOD_GSK3_1 941 948 PF00069 0.525
MOD_GSK3_1 956 963 PF00069 0.490
MOD_GSK3_1 972 979 PF00069 0.673
MOD_GSK3_1 996 1003 PF00069 0.705
MOD_N-GLC_1 216 221 PF02516 0.660
MOD_N-GLC_1 327 332 PF02516 0.614
MOD_N-GLC_1 410 415 PF02516 0.512
MOD_N-GLC_1 540 545 PF02516 0.666
MOD_N-GLC_1 836 841 PF02516 0.563
MOD_N-GLC_1 889 894 PF02516 0.594
MOD_N-GLC_1 972 977 PF02516 0.651
MOD_NEK2_1 1031 1036 PF00069 0.586
MOD_NEK2_1 313 318 PF00069 0.598
MOD_NEK2_1 374 379 PF00069 0.709
MOD_NEK2_1 793 798 PF00069 0.544
MOD_NEK2_1 820 825 PF00069 0.456
MOD_NEK2_1 953 958 PF00069 0.480
MOD_NEK2_1 996 1001 PF00069 0.550
MOD_NEK2_2 49 54 PF00069 0.541
MOD_NEK2_2 558 563 PF00069 0.574
MOD_NEK2_2 63 68 PF00069 0.610
MOD_NEK2_2 681 686 PF00069 0.536
MOD_NEK2_2 779 784 PF00069 0.615
MOD_NEK2_2 842 847 PF00069 0.622
MOD_OFUCOSY 988 993 PF10250 0.510
MOD_PIKK_1 235 241 PF00454 0.635
MOD_PIKK_1 314 320 PF00454 0.380
MOD_PIKK_1 752 758 PF00454 0.466
MOD_PIKK_1 890 896 PF00454 0.656
MOD_PIKK_1 932 938 PF00454 0.723
MOD_PK_1 1017 1023 PF00069 0.617
MOD_PKA_1 198 204 PF00069 0.607
MOD_PKA_2 116 122 PF00069 0.477
MOD_PKA_2 142 148 PF00069 0.613
MOD_PKA_2 249 255 PF00069 0.718
MOD_PKA_2 724 730 PF00069 0.628
MOD_PKA_2 857 863 PF00069 0.612
MOD_PKA_2 87 93 PF00069 0.439
MOD_PKA_2 960 966 PF00069 0.602
MOD_PKA_2 989 995 PF00069 0.558
MOD_PKB_1 176 184 PF00069 0.572
MOD_Plk_1 1017 1023 PF00069 0.642
MOD_Plk_1 302 308 PF00069 0.520
MOD_Plk_1 410 416 PF00069 0.517
MOD_Plk_1 558 564 PF00069 0.573
MOD_Plk_1 654 660 PF00069 0.663
MOD_Plk_1 836 842 PF00069 0.574
MOD_Plk_1 953 959 PF00069 0.523
MOD_Plk_2-3 297 303 PF00069 0.535
MOD_Plk_2-3 77 83 PF00069 0.628
MOD_Plk_4 1026 1032 PF00069 0.550
MOD_Plk_4 1037 1043 PF00069 0.511
MOD_Plk_4 266 272 PF00069 0.724
MOD_Plk_4 297 303 PF00069 0.632
MOD_Plk_4 49 55 PF00069 0.581
MOD_Plk_4 558 564 PF00069 0.637
MOD_Plk_4 570 576 PF00069 0.479
MOD_Plk_4 681 687 PF00069 0.452
MOD_Plk_4 779 785 PF00069 0.717
MOD_Plk_4 941 947 PF00069 0.527
MOD_ProDKin_1 1034 1040 PF00069 0.697
MOD_ProDKin_1 153 159 PF00069 0.660
MOD_ProDKin_1 364 370 PF00069 0.485
MOD_ProDKin_1 392 398 PF00069 0.383
MOD_ProDKin_1 405 411 PF00069 0.480
MOD_ProDKin_1 487 493 PF00069 0.577
MOD_ProDKin_1 57 63 PF00069 0.584
MOD_ProDKin_1 784 790 PF00069 0.584
MOD_ProDKin_1 939 945 PF00069 0.548
MOD_ProDKin_1 976 982 PF00069 0.611
MOD_SUMO_rev_2 277 286 PF00179 0.591
TRG_DiLeu_BaEn_1 640 645 PF01217 0.635
TRG_DiLeu_BaLyEn_6 798 803 PF01217 0.595
TRG_DiLeu_BaLyEn_6 899 904 PF01217 0.606
TRG_DiLeu_BaLyEn_6 992 997 PF01217 0.592
TRG_ENDOCYTIC_2 304 307 PF00928 0.435
TRG_ENDOCYTIC_2 563 566 PF00928 0.609
TRG_ENDOCYTIC_2 688 691 PF00928 0.603
TRG_ENDOCYTIC_2 750 753 PF00928 0.427
TRG_ENDOCYTIC_2 835 838 PF00928 0.492
TRG_ER_diArg_1 1063 1066 PF00400 0.556
TRG_ER_diArg_1 176 178 PF00400 0.608
TRG_ER_diArg_1 205 208 PF00400 0.577
TRG_ER_diArg_1 247 250 PF00400 0.602
TRG_ER_diArg_1 386 389 PF00400 0.523
TRG_ER_diArg_1 471 474 PF00400 0.454
TRG_ER_diArg_1 493 495 PF00400 0.563
TRG_ER_diArg_1 514 516 PF00400 0.574
TRG_ER_diArg_1 589 591 PF00400 0.648
TRG_ER_diArg_1 635 637 PF00400 0.571
TRG_ER_diArg_1 724 726 PF00400 0.571
TRG_ER_diArg_1 747 749 PF00400 0.606
TRG_NLS_MonoCore_2 174 179 PF00514 0.567
TRG_NLS_MonoCore_2 205 210 PF00514 0.634
TRG_NLS_MonoExtN_4 172 179 PF00514 0.641
TRG_NLS_MonoExtN_4 205 211 PF00514 0.664
TRG_Pf-PMV_PEXEL_1 636 640 PF00026 0.552

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P433 Leptomonas seymouri 44% 95%
A0A3Q8IJY6 Leishmania donovani 99% 100%
A4HQ47 Leishmania braziliensis 76% 100%
D0A8R3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 25% 100%
E9ATW7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 90% 100%
Q4Q0M9 Leishmania major 92% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS