ABC transmembrane type-1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4IC72_LEIIN

TriTrypDb:

LINF_350055100

Length:

169

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

A4IC72

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IC72

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	105	107	PF00675	0.547
CLV_NRD_NRD_1	147	149	PF00675	0.463
CLV_NRD_NRD_1	80	82	PF00675	0.722
CLV_NRD_NRD_1	85	87	PF00675	0.676
CLV_PCSK_KEX2_1	101	103	PF00082	0.796
CLV_PCSK_KEX2_1	136	138	PF00082	0.517
CLV_PCSK_PC1ET2_1	101	103	PF00082	0.738
CLV_PCSK_PC1ET2_1	136	138	PF00082	0.517
CLV_PCSK_PC7_1	97	103	PF00082	0.790
CLV_PCSK_SKI1_1	148	152	PF00082	0.442
CLV_PCSK_SKI1_1	86	90	PF00082	0.735
DEG_APCC_DBOX_1	85	93	PF00400	0.540
DEG_Nend_Nbox_1	1	3	PF02207	0.598
DOC_USP7_MATH_1	100	104	PF00917	0.497
DOC_USP7_MATH_1	158	162	PF00917	0.671
DOC_WW_Pin1_4	13	18	PF00397	0.757
LIG_14-3-3_CanoR_1	137	142	PF00244	0.680
LIG_deltaCOP1_diTrp_1	34	39	PF00928	0.630
LIG_FHA_1	27	33	PF00498	0.695
LIG_LIR_Nem_3	34	39	PF02991	0.630
LIG_LIR_Nem_3	56	60	PF02991	0.496
LIG_NRBOX	129	135	PF00104	0.334
LIG_PDZ_Class_1	164	169	PF00595	0.706
LIG_Pex14_2	113	117	PF04695	0.521
LIG_SH2_CRK	2	6	PF00017	0.749
LIG_SH2_PTP2	57	60	PF00017	0.496
LIG_SH2_STAT5	132	135	PF00017	0.628
LIG_SH2_STAT5	57	60	PF00017	0.496
LIG_SH2_STAT5	98	101	PF00017	0.542
LIG_SH3_3	102	108	PF00018	0.526
LIG_SxIP_EBH_1	85	94	PF03271	0.544
LIG_WRC_WIRS_1	114	119	PF05994	0.455
MOD_CK2_1	151	157	PF00069	0.771
MOD_Cter_Amidation	146	149	PF01082	0.516
MOD_GlcNHglycan	145	148	PF01048	0.507
MOD_GlcNHglycan	160	163	PF01048	0.506
MOD_GlcNHglycan	48	51	PF01048	0.523
MOD_GSK3_1	109	116	PF00069	0.484
MOD_GSK3_1	158	165	PF00069	0.735
MOD_NEK2_1	113	118	PF00069	0.460
MOD_NEK2_1	143	148	PF00069	0.669
MOD_NEK2_1	150	155	PF00069	0.631
MOD_NEK2_1	26	31	PF00069	0.697
MOD_NEK2_1	43	48	PF00069	0.248
MOD_PIKK_1	37	43	PF00454	0.523
MOD_Plk_4	109	115	PF00069	0.546
MOD_ProDKin_1	13	19	PF00069	0.749
TRG_DiLeu_BaLyEn_6	117	122	PF01217	0.523
TRG_ENDOCYTIC_2	2	5	PF00928	0.691
TRG_ENDOCYTIC_2	57	60	PF00928	0.496
TRG_ER_diArg_1	102	105	PF00400	0.584
TRG_NLS_Bipartite_1	86	105	PF00514	0.512
TRG_NLS_MonoCore_2	105	110	PF00514	0.574
TRG_NLS_MonoExtN_4	100	105	PF00514	0.579
TRG_Pf-PMV_PEXEL_1	148	152	PF00026	0.474
TRG_PTS1	166	169	PF00515	0.712

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IVL9	Leishmania donovani	99%	81%
A4HNF9	Leishmania braziliensis	78%	100%
E9AFX0	Leishmania major	92%	100%
E9B723	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%