LeishMANIAdb
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Putative phosphatidylcholine:ceramide cholinephosphotransferase 2

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative phosphatidylcholine:ceramide cholinephosphotransferase 2
Gene product:
sphingomyelin/ceramide phosphorylethanolamine synthase - bifunctional
Species:
Leishmania infantum
UniProt:
A4IC70_LEIIN
TriTrypDb:
LINF_350055400
Length:
385

Annotations

LeishMANIAdb annotations

Publication identifier(s): 20457606
Bidirectional lipid inositolphosphotransferase (experimentally validated). Homologous to animal phosphatidylcholine:ceramide cholinephosphotransferases. Expanded on the Trypanosoma lineage.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 15
NetGPI no yes: 0, no: 15
Cellular components
Term Name Level Count
GO:0016020 membrane 2 16
GO:0110165 cellular anatomical entity 1 16
GO:0005768 endosome 7 1
GO:0005794 Golgi apparatus 5 1
GO:0005886 plasma membrane 3 1
GO:0020016 ciliary pocket 2 1
GO:0031410 cytoplasmic vesicle 6 1
GO:0031982 vesicle 4 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0097708 intracellular vesicle 5 1

Expansion

Sequence features

A4IC70
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IC70

Function

Biological processes
Term Name Level Count
GO:0006629 lipid metabolic process 3 16
GO:0006643 membrane lipid metabolic process 4 16
GO:0006665 sphingolipid metabolic process 4 16
GO:0006793 phosphorus metabolic process 3 16
GO:0006796 phosphate-containing compound metabolic process 4 16
GO:0006807 nitrogen compound metabolic process 2 16
GO:0008152 metabolic process 1 16
GO:0009987 cellular process 1 16
GO:0016310 phosphorylation 5 16
GO:0044237 cellular metabolic process 2 16
GO:0044238 primary metabolic process 2 16
GO:0044255 cellular lipid metabolic process 3 16
GO:0071704 organic substance metabolic process 2 16
GO:1901564 organonitrogen compound metabolic process 3 16
GO:0006066 alcohol metabolic process 3 1
GO:0006576 biogenic amine metabolic process 5 1
GO:0006580 ethanolamine metabolic process 5 1
GO:0006672 ceramide metabolic process 4 1
GO:0008610 lipid biosynthetic process 4 1
GO:0009058 biosynthetic process 2 1
GO:0009308 amine metabolic process 4 1
GO:0009309 amine biosynthetic process 5 1
GO:0030148 sphingolipid biosynthetic process 5 1
GO:0034308 primary alcohol metabolic process 4 1
GO:0034309 primary alcohol biosynthetic process 5 1
GO:0034641 cellular nitrogen compound metabolic process 3 1
GO:0042401 biogenic amine biosynthetic process 6 1
GO:0042439 ethanolamine-containing compound metabolic process 4 1
GO:0043603 amide metabolic process 3 1
GO:0043604 amide biosynthetic process 4 1
GO:0044249 cellular biosynthetic process 3 1
GO:0044271 cellular nitrogen compound biosynthetic process 4 1
GO:0044281 small molecule metabolic process 2 1
GO:0044283 small molecule biosynthetic process 3 1
GO:0046165 alcohol biosynthetic process 4 1
GO:0046335 ethanolamine biosynthetic process 6 1
GO:0046467 membrane lipid biosynthetic process 4 1
GO:0046513 ceramide biosynthetic process 5 1
GO:1901160 primary amino compound metabolic process 4 1
GO:1901162 primary amino compound biosynthetic process 5 1
GO:1901566 organonitrogen compound biosynthetic process 4 1
GO:1901576 organic substance biosynthetic process 3 1
GO:1901615 organic hydroxy compound metabolic process 3 1
GO:1901617 organic hydroxy compound biosynthetic process 4 1
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 16
GO:0016301 kinase activity 4 16
GO:0016740 transferase activity 2 16
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 16
GO:0016780 phosphotransferase activity, for other substituted phosphate groups 4 16
GO:0033188 sphingomyelin synthase activity 5 6
GO:0047493 ceramide cholinephosphotransferase activity 5 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 328 332 PF00656 0.714
CLV_NRD_NRD_1 142 144 PF00675 0.387
CLV_PCSK_KEX2_1 142 144 PF00082 0.383
CLV_PCSK_SKI1_1 103 107 PF00082 0.333
CLV_PCSK_SKI1_1 132 136 PF00082 0.303
CLV_PCSK_SKI1_1 148 152 PF00082 0.313
CLV_PCSK_SKI1_1 157 161 PF00082 0.259
CLV_PCSK_SKI1_1 36 40 PF00082 0.400
DEG_APCC_DBOX_1 35 43 PF00400 0.323
DOC_CKS1_1 322 327 PF01111 0.704
DOC_MAPK_DCC_7 109 119 PF00069 0.530
DOC_MAPK_DCC_7 63 73 PF00069 0.310
DOC_MAPK_gen_1 63 73 PF00069 0.290
DOC_MAPK_MEF2A_6 36 45 PF00069 0.296
DOC_MAPK_MEF2A_6 64 73 PF00069 0.305
DOC_MAPK_NFAT4_5 36 44 PF00069 0.400
DOC_PP1_RVXF_1 130 136 PF00149 0.589
DOC_PP4_FxxP_1 237 240 PF00568 0.545
DOC_USP7_MATH_1 260 264 PF00917 0.289
DOC_USP7_MATH_1 326 330 PF00917 0.656
DOC_WW_Pin1_4 232 237 PF00397 0.428
DOC_WW_Pin1_4 321 326 PF00397 0.704
DOC_WW_Pin1_4 358 363 PF00397 0.745
DOC_WW_Pin1_4 366 371 PF00397 0.707
LIG_14-3-3_CanoR_1 157 163 PF00244 0.287
LIG_14-3-3_CanoR_1 244 253 PF00244 0.311
LIG_14-3-3_CanoR_1 262 271 PF00244 0.163
LIG_BRCT_BRCA1_1 115 119 PF00533 0.585
LIG_BRCT_BRCA1_1 224 228 PF00533 0.361
LIG_eIF4E_1 265 271 PF01652 0.242
LIG_FHA_1 116 122 PF00498 0.633
LIG_FHA_1 16 22 PF00498 0.619
LIG_FHA_1 168 174 PF00498 0.413
LIG_FHA_1 219 225 PF00498 0.289
LIG_FHA_1 264 270 PF00498 0.236
LIG_FHA_1 277 283 PF00498 0.287
LIG_FHA_1 359 365 PF00498 0.753
LIG_FHA_1 94 100 PF00498 0.403
LIG_FHA_2 322 328 PF00498 0.726
LIG_FHA_2 4 10 PF00498 0.666
LIG_FHA_2 78 84 PF00498 0.389
LIG_IRF3_LxIS_1 247 254 PF10401 0.358
LIG_LIR_Apic_2 235 240 PF02991 0.537
LIG_LIR_Gen_1 160 168 PF02991 0.323
LIG_LIR_Gen_1 170 179 PF02991 0.423
LIG_LIR_Gen_1 254 260 PF02991 0.296
LIG_LIR_Nem_3 160 165 PF02991 0.336
LIG_LIR_Nem_3 233 237 PF02991 0.461
LIG_LIR_Nem_3 254 259 PF02991 0.325
LIG_LIR_Nem_3 279 283 PF02991 0.287
LIG_LIR_Nem_3 44 50 PF02991 0.356
LIG_MYND_1 236 240 PF01753 0.537
LIG_NRBOX 38 44 PF00104 0.432
LIG_Pex14_2 228 232 PF04695 0.402
LIG_Pex14_2 237 241 PF04695 0.518
LIG_SH2_CRK 162 166 PF00017 0.306
LIG_SH2_CRK 24 28 PF00017 0.573
LIG_SH2_CRK 256 260 PF00017 0.306
LIG_SH2_PTP2 274 277 PF00017 0.439
LIG_SH2_STAP1 162 166 PF00017 0.306
LIG_SH2_STAP1 265 269 PF00017 0.236
LIG_SH2_STAT5 256 259 PF00017 0.295
LIG_SH2_STAT5 265 268 PF00017 0.221
LIG_SH2_STAT5 274 277 PF00017 0.228
LIG_SH3_3 118 124 PF00018 0.534
LIG_SH3_3 319 325 PF00018 0.703
LIG_SUMO_SIM_anti_2 316 324 PF11976 0.710
LIG_SUMO_SIM_par_1 198 204 PF11976 0.293
LIG_SUMO_SIM_par_1 316 324 PF11976 0.671
LIG_SUMO_SIM_par_1 38 44 PF11976 0.378
LIG_TRAF2_1 308 311 PF00917 0.673
LIG_TRAF2_1 314 317 PF00917 0.711
LIG_TYR_ITIM 253 258 PF00017 0.361
LIG_TYR_ITSM 158 165 PF00017 0.402
LIG_UBA3_1 72 78 PF00899 0.390
LIG_WRC_WIRS_1 126 131 PF05994 0.599
LIG_WRC_WIRS_1 168 173 PF05994 0.225
MOD_CDK_SPxxK_3 358 365 PF00069 0.606
MOD_CK1_1 218 224 PF00069 0.287
MOD_CK1_1 263 269 PF00069 0.279
MOD_CK1_1 3 9 PF00069 0.665
MOD_CK1_1 356 362 PF00069 0.745
MOD_CK2_1 321 327 PF00069 0.604
MOD_CK2_1 77 83 PF00069 0.284
MOD_CMANNOS 300 303 PF00535 0.417
MOD_Cter_Amidation 140 143 PF01082 0.397
MOD_GlcNHglycan 139 142 PF01048 0.381
MOD_GlcNHglycan 206 209 PF01048 0.549
MOD_GlcNHglycan 217 220 PF01048 0.197
MOD_GlcNHglycan 247 250 PF01048 0.225
MOD_GlcNHglycan 331 335 PF01048 0.538
MOD_GlcNHglycan 358 361 PF01048 0.528
MOD_GlcNHglycan 376 379 PF01048 0.428
MOD_GSK3_1 174 181 PF00069 0.329
MOD_GSK3_1 218 225 PF00069 0.272
MOD_GSK3_1 326 333 PF00069 0.728
MOD_GSK3_1 350 357 PF00069 0.738
MOD_N-GLC_1 83 88 PF02516 0.522
MOD_N-GLC_1 93 98 PF02516 0.395
MOD_N-GLC_2 183 185 PF02516 0.553
MOD_NEK2_1 158 163 PF00069 0.288
MOD_NEK2_1 174 179 PF00069 0.289
MOD_NEK2_1 215 220 PF00069 0.287
MOD_NEK2_1 222 227 PF00069 0.287
MOD_NEK2_1 276 281 PF00069 0.386
MOD_NEK2_1 41 46 PF00069 0.353
MOD_NEK2_1 93 98 PF00069 0.392
MOD_NEK2_2 152 157 PF00069 0.392
MOD_PIKK_1 29 35 PF00454 0.467
MOD_PKA_2 379 385 PF00069 0.639
MOD_Plk_1 93 99 PF00069 0.428
MOD_Plk_2-3 368 374 PF00069 0.569
MOD_Plk_4 115 121 PF00069 0.611
MOD_Plk_4 125 131 PF00069 0.521
MOD_Plk_4 198 204 PF00069 0.299
MOD_Plk_4 218 224 PF00069 0.306
MOD_Plk_4 41 47 PF00069 0.312
MOD_Plk_4 77 83 PF00069 0.377
MOD_Plk_4 94 100 PF00069 0.262
MOD_ProDKin_1 232 238 PF00069 0.428
MOD_ProDKin_1 321 327 PF00069 0.706
MOD_ProDKin_1 358 364 PF00069 0.747
MOD_ProDKin_1 366 372 PF00069 0.708
TRG_DiLeu_BaLyEn_6 359 364 PF01217 0.606
TRG_ENDOCYTIC_2 162 165 PF00928 0.299
TRG_ENDOCYTIC_2 234 237 PF00928 0.436
TRG_ENDOCYTIC_2 255 258 PF00928 0.296
TRG_ENDOCYTIC_2 274 277 PF00928 0.209
TRG_ENDOCYTIC_2 280 283 PF00928 0.296
TRG_ER_diArg_1 142 144 PF00400 0.605
TRG_NLS_MonoExtC_3 62 67 PF00514 0.267
TRG_NLS_MonoExtN_4 60 67 PF00514 0.262
TRG_Pf-PMV_PEXEL_1 66 70 PF00026 0.542

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HRL7 Leptomonas seymouri 68% 100%
A0A0S4J1W3 Bodo saltans 41% 100%
A0A1X0P4U9 Trypanosomatidae 45% 100%
A0A3S7XA07 Leishmania donovani 99% 100%
A0A422NCN9 Trypanosoma rangeli 44% 100%
A4HNG1 Leishmania braziliensis 68% 100%
B3A0L9 Trypanosoma brucei brucei 41% 100%
B3A0M0 Trypanosoma brucei brucei 41% 100%
B3A0M1 Trypanosoma brucei brucei 43% 100%
B3A0M2 Trypanosoma brucei brucei 43% 100%
C9ZYF5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 43% 100%
C9ZYF7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 40% 100%
C9ZYF8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 43% 100%
C9ZYF9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 43% 100%
C9ZYG0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 43% 100%
C9ZYG2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 41% 100%
E9AFX2 Leishmania major 93% 100%
E9B725 Leishmania mexicana (strain MHOM/GT/2001/U1103) 86% 99%
Q38E53 Trypanosoma brucei brucei (strain 927/4 GUTat10.1) 42% 100%
Q38E54 Trypanosoma brucei brucei (strain 927/4 GUTat10.1) 42% 100%
Q38E55 Trypanosoma brucei brucei (strain 927/4 GUTat10.1) 44% 100%
Q38E56 Trypanosoma brucei brucei (strain 927/4 GUTat10.1) 43% 100%
Q4E4I4 Trypanosoma cruzi (strain CL Brener) 52% 100%
Q7T3T4 Gallus gallus 25% 92%
Q96LT4 Homo sapiens 24% 93%
Q9DA37 Mus musculus 24% 81%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS