Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

PSP1 C-terminal conserved region containing protein - putative

Species:

Leishmania infantum

UniProt:

A4IC69_LEIIN

TriTrypDb:

LINF_350055500

Length:

280

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 21
NetGPI	no	yes: 0, no: 21

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4IC69

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IC69

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	64	68	PF00656	0.575
CLV_NRD_NRD_1	108	110	PF00675	0.468
CLV_NRD_NRD_1	154	156	PF00675	0.359
CLV_NRD_NRD_1	166	168	PF00675	0.262
CLV_NRD_NRD_1	218	220	PF00675	0.361
CLV_NRD_NRD_1	253	255	PF00675	0.615
CLV_NRD_NRD_1	257	259	PF00675	0.599
CLV_PCSK_KEX2_1	154	156	PF00082	0.359
CLV_PCSK_KEX2_1	16	18	PF00082	0.584
CLV_PCSK_KEX2_1	166	168	PF00082	0.284
CLV_PCSK_KEX2_1	218	220	PF00082	0.305
CLV_PCSK_KEX2_1	253	255	PF00082	0.626
CLV_PCSK_KEX2_1	257	259	PF00082	0.609
CLV_PCSK_PC1ET2_1	16	18	PF00082	0.664
CLV_PCSK_PC7_1	253	259	PF00082	0.725
CLV_PCSK_SKI1_1	148	152	PF00082	0.440
CLV_PCSK_SKI1_1	154	158	PF00082	0.332
CLV_PCSK_SKI1_1	16	20	PF00082	0.613
CLV_PCSK_SKI1_1	167	171	PF00082	0.298
CLV_PCSK_SKI1_1	201	205	PF00082	0.341
CLV_PCSK_SKI1_1	222	226	PF00082	0.294
CLV_PCSK_SKI1_1	268	272	PF00082	0.477
CLV_PCSK_SKI1_1	63	67	PF00082	0.712
DOC_CKS1_1	30	35	PF01111	0.637
DOC_CYCLIN_RxL_1	218	226	PF00134	0.415
DOC_CYCLIN_yCln2_LP_2	30	36	PF00134	0.696
DOC_CYCLIN_yCln2_LP_2	87	93	PF00134	0.616
DOC_MAPK_gen_1	201	207	PF00069	0.297
DOC_MAPK_gen_1	209	217	PF00069	0.313
DOC_PP1_RVXF_1	146	152	PF00149	0.500
DOC_PP1_RVXF_1	229	235	PF00149	0.370
DOC_PP2B_LxvP_1	87	90	PF13499	0.678
DOC_USP7_MATH_1	210	214	PF00917	0.284
DOC_USP7_MATH_1	272	276	PF00917	0.431
DOC_USP7_MATH_1	4	8	PF00917	0.655
DOC_USP7_MATH_1	52	56	PF00917	0.642
DOC_USP7_MATH_1	61	65	PF00917	0.533
DOC_USP7_MATH_1	69	73	PF00917	0.622
DOC_USP7_MATH_1	77	81	PF00917	0.618
DOC_USP7_MATH_1	83	87	PF00917	0.641
DOC_USP7_UBL2_3	106	110	PF12436	0.377
DOC_USP7_UBL2_3	15	19	PF12436	0.641
DOC_WW_Pin1_4	140	145	PF00397	0.555
DOC_WW_Pin1_4	29	34	PF00397	0.579
DOC_WW_Pin1_4	45	50	PF00397	0.633
DOC_WW_Pin1_4	57	62	PF00397	0.557
LIG_14-3-3_CanoR_1	154	161	PF00244	0.378
LIG_14-3-3_CanoR_1	166	170	PF00244	0.365
LIG_14-3-3_CanoR_1	179	188	PF00244	0.285
LIG_14-3-3_CanoR_1	209	215	PF00244	0.334
LIG_14-3-3_CanoR_1	219	225	PF00244	0.280
LIG_Actin_WH2_2	237	255	PF00022	0.445
LIG_BRCT_BRCA1_1	210	214	PF00533	0.377
LIG_FHA_1	140	146	PF00498	0.479
LIG_FHA_1	202	208	PF00498	0.291
LIG_FHA_1	247	253	PF00498	0.704
LIG_FHA_2	155	161	PF00498	0.291
LIG_FHA_2	166	172	PF00498	0.293
LIG_FHA_2	187	193	PF00498	0.468
LIG_LIR_Gen_1	211	220	PF02991	0.351
LIG_LIR_Gen_1	99	107	PF02991	0.454
LIG_LIR_Nem_3	211	217	PF02991	0.331
LIG_LIR_Nem_3	223	228	PF02991	0.324
LIG_LIR_Nem_3	99	105	PF02991	0.395
LIG_PALB2_WD40_1	229	237	PF16756	0.364
LIG_PCNA_yPIPBox_3	110	124	PF02747	0.291
LIG_PCNA_yPIPBox_3	218	228	PF02747	0.395
LIG_Pex14_2	112	116	PF04695	0.345
LIG_SH2_STAP1	26	30	PF00017	0.562
LIG_SH2_STAT5	236	239	PF00017	0.337
LIG_SH3_3	182	188	PF00018	0.305
LIG_SH3_3	245	251	PF00018	0.685
LIG_SH3_3	30	36	PF00018	0.545
LIG_SH3_3	46	52	PF00018	0.731
LIG_SUMO_SIM_par_1	122	127	PF11976	0.520
LIG_SUMO_SIM_par_1	203	208	PF11976	0.411
LIG_UBA3_1	195	202	PF00899	0.367
MOD_CDC14_SPxK_1	60	63	PF00782	0.646
MOD_CDK_SPK_2	45	50	PF00069	0.654
MOD_CDK_SPxK_1	57	63	PF00069	0.652
MOD_CK1_1	180	186	PF00069	0.430
MOD_CK1_1	208	214	PF00069	0.373
MOD_CK1_1	29	35	PF00069	0.604
MOD_CK1_1	3	9	PF00069	0.608
MOD_CK1_1	48	54	PF00069	0.633
MOD_CK1_1	55	61	PF00069	0.587
MOD_CK2_1	165	171	PF00069	0.364
MOD_CK2_1	186	192	PF00069	0.468
MOD_CK2_1	258	264	PF00069	0.691
MOD_CK2_1	32	38	PF00069	0.417
MOD_Cter_Amidation	107	110	PF01082	0.493
MOD_Cter_Amidation	199	202	PF01082	0.319
MOD_GlcNHglycan	2	5	PF01048	0.616
MOD_GlcNHglycan	71	74	PF01048	0.564
MOD_GSK3_1	201	208	PF00069	0.278
MOD_GSK3_1	242	249	PF00069	0.553
MOD_GSK3_1	270	277	PF00069	0.468
MOD_GSK3_1	3	10	PF00069	0.573
MOD_GSK3_1	48	55	PF00069	0.604
MOD_GSK3_1	57	64	PF00069	0.557
MOD_NEK2_1	2	7	PF00069	0.643
MOD_NEK2_1	220	225	PF00069	0.376
MOD_NEK2_1	9	14	PF00069	0.660
MOD_NEK2_2	174	179	PF00069	0.378
MOD_PIKK_1	159	165	PF00454	0.381
MOD_PIKK_1	180	186	PF00454	0.220
MOD_PIKK_1	4	10	PF00454	0.480
MOD_PKA_1	154	160	PF00069	0.364
MOD_PKA_1	201	207	PF00069	0.341
MOD_PKA_1	257	263	PF00069	0.609
MOD_PKA_2	154	160	PF00069	0.401
MOD_PKA_2	165	171	PF00069	0.326
MOD_PKA_2	208	214	PF00069	0.348
MOD_PKA_2	257	263	PF00069	0.586
MOD_Plk_4	26	32	PF00069	0.576
MOD_ProDKin_1	140	146	PF00069	0.556
MOD_ProDKin_1	29	35	PF00069	0.574
MOD_ProDKin_1	45	51	PF00069	0.630
MOD_ProDKin_1	57	63	PF00069	0.558
MOD_SUMO_rev_2	193	203	PF00179	0.353
MOD_SUMO_rev_2	261	271	PF00179	0.462
TRG_DiLeu_BaEn_2	146	152	PF01217	0.395
TRG_ER_diArg_1	153	155	PF00400	0.369
TRG_ER_diArg_1	217	219	PF00400	0.338
TRG_ER_diArg_1	228	231	PF00400	0.294
TRG_ER_diArg_1	252	254	PF00400	0.654
TRG_NLS_MonoExtC_3	14	19	PF00514	0.454
TRG_NLS_MonoExtN_4	15	20	PF00514	0.454
TRG_Pf-PMV_PEXEL_1	179	184	PF00026	0.356
TRG_Pf-PMV_PEXEL_1	222	226	PF00026	0.398
TRG_Pf-PMV_PEXEL_1	63	67	PF00026	0.644

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYT9	Leptomonas seymouri	25%	73%
A0A0N1I362	Leptomonas seymouri	26%	69%
A0A0N1PC14	Leptomonas seymouri	65%	97%
A0A0S4J5L8	Bodo saltans	33%	95%
A0A0S4JEW1	Bodo saltans	27%	80%
A0A1X0NLP9	Trypanosomatidae	28%	100%
A0A1X0P536	Trypanosomatidae	43%	100%
A0A3Q8IC14	Leishmania donovani	25%	77%
A0A3Q8IJZ1	Leishmania donovani	99%	100%
A0A3Q8ILM8	Leishmania donovani	29%	100%
A0A3R7NIU7	Trypanosoma rangeli	41%	100%
A4HMC6	Leishmania braziliensis	24%	68%
A4HNG2	Leishmania braziliensis	82%	100%
A4HUB9	Leishmania infantum	25%	100%
A4ICE2	Leishmania infantum	29%	100%
C9ZYF4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
D0A3S8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9AFX3	Leishmania major	95%	100%
E9B726	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5BJK0	Trypanosoma cruzi	27%	77%