Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA pseudouridylate synthase - putative

Species:

Leishmania infantum

UniProt:

A4IC64_LEIIN

TriTrypDb:

LINF_350056600

Length:

741

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4IC64

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IC64

Function

Biological processes
Term	Name	Level	Count
GO:0001522	pseudouridine synthesis	6	12
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009451	RNA modification	5	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043412	macromolecule modification	4	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:0000154	rRNA modification	6	1
GO:0000455	enzyme-directed rRNA pseudouridine synthesis	8	1
GO:0006364	rRNA processing	8	1
GO:0006396	RNA processing	6	1
GO:0016072	rRNA metabolic process	7	1
GO:0031118	rRNA pseudouridine synthesis	7	1
GO:0034470	ncRNA processing	7	1
GO:0034660	ncRNA metabolic process	6	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0003824	catalytic activity	1	12
GO:0005488	binding	1	12
GO:0009982	pseudouridine synthase activity	4	12
GO:0016853	isomerase activity	2	12
GO:0016866	intramolecular transferase activity	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12
GO:0009055	electron transfer activity	3	1
GO:0016491	oxidoreductase activity	2	1
GO:0020037	heme binding	4	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1
GO:0046906	tetrapyrrole binding	3	1
GO:0106029	tRNA pseudouridine synthase activity	5	1
GO:0140098	catalytic activity, acting on RNA	3	1
GO:0140101	catalytic activity, acting on a tRNA	4	1
GO:0140640	catalytic activity, acting on a nucleic acid	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	235	239	PF00656	0.539
CLV_C14_Caspase3-7	443	447	PF00656	0.412
CLV_C14_Caspase3-7	631	635	PF00656	0.441
CLV_NRD_NRD_1	12	14	PF00675	0.438
CLV_NRD_NRD_1	128	130	PF00675	0.381
CLV_NRD_NRD_1	249	251	PF00675	0.545
CLV_NRD_NRD_1	331	333	PF00675	0.415
CLV_NRD_NRD_1	336	338	PF00675	0.431
CLV_NRD_NRD_1	671	673	PF00675	0.231
CLV_NRD_NRD_1	729	731	PF00675	0.388
CLV_PCSK_FUR_1	247	251	PF00082	0.411
CLV_PCSK_FUR_1	329	333	PF00082	0.456
CLV_PCSK_KEX2_1	128	130	PF00082	0.373
CLV_PCSK_KEX2_1	249	251	PF00082	0.432
CLV_PCSK_KEX2_1	331	333	PF00082	0.412
CLV_PCSK_KEX2_1	336	338	PF00082	0.427
CLV_PCSK_KEX2_1	387	389	PF00082	0.351
CLV_PCSK_KEX2_1	671	673	PF00082	0.236
CLV_PCSK_KEX2_1	729	731	PF00082	0.423
CLV_PCSK_PC1ET2_1	387	389	PF00082	0.351
CLV_PCSK_PC7_1	332	338	PF00082	0.433
CLV_PCSK_SKI1_1	101	105	PF00082	0.530
CLV_PCSK_SKI1_1	13	17	PF00082	0.512
CLV_PCSK_SKI1_1	283	287	PF00082	0.424
CLV_PCSK_SKI1_1	357	361	PF00082	0.428
CLV_PCSK_SKI1_1	465	469	PF00082	0.302
CLV_PCSK_SKI1_1	564	568	PF00082	0.236
CLV_PCSK_SKI1_1	60	64	PF00082	0.489
CLV_PCSK_SKI1_1	699	703	PF00082	0.262
DEG_APCC_DBOX_1	12	20	PF00400	0.485
DEG_APCC_DBOX_1	33	41	PF00400	0.448
DEG_APCC_DBOX_1	437	445	PF00400	0.375
DEG_APCC_DBOX_1	464	472	PF00400	0.332
DEG_APCC_DBOX_1	728	736	PF00400	0.458
DEG_SCF_FBW7_1	78	84	PF00400	0.474
DEG_SPOP_SBC_1	82	86	PF00917	0.551
DEG_SPOP_SBC_1	89	93	PF00917	0.553
DOC_CDC14_PxL_1	509	517	PF14671	0.472
DOC_CKS1_1	213	218	PF01111	0.400
DOC_CKS1_1	542	547	PF01111	0.415
DOC_CKS1_1	78	83	PF01111	0.460
DOC_CYCLIN_RxL_1	460	469	PF00134	0.308
DOC_CYCLIN_RxL_1	727	738	PF00134	0.325
DOC_CYCLIN_yCln2_LP_2	213	219	PF00134	0.375
DOC_MAPK_gen_1	641	649	PF00069	0.466
DOC_MAPK_MEF2A_6	610	619	PF00069	0.519
DOC_MAPK_RevD_3	323	337	PF00069	0.530
DOC_PP1_RVXF_1	643	650	PF00149	0.424
DOC_PP1_RVXF_1	652	658	PF00149	0.424
DOC_PP4_FxxP_1	289	292	PF00568	0.249
DOC_PP4_FxxP_1	310	313	PF00568	0.474
DOC_PP4_FxxP_1	709	712	PF00568	0.340
DOC_USP7_MATH_1	201	205	PF00917	0.484
DOC_USP7_MATH_1	206	210	PF00917	0.444
DOC_USP7_MATH_1	236	240	PF00917	0.398
DOC_USP7_MATH_1	262	266	PF00917	0.650
DOC_USP7_MATH_1	339	343	PF00917	0.566
DOC_USP7_MATH_1	359	363	PF00917	0.398
DOC_USP7_MATH_1	459	463	PF00917	0.324
DOC_USP7_MATH_1	577	581	PF00917	0.437
DOC_USP7_MATH_1	591	595	PF00917	0.394
DOC_USP7_MATH_1	89	93	PF00917	0.741
DOC_WW_Pin1_4	157	162	PF00397	0.509
DOC_WW_Pin1_4	212	217	PF00397	0.407
DOC_WW_Pin1_4	309	314	PF00397	0.483
DOC_WW_Pin1_4	406	411	PF00397	0.468
DOC_WW_Pin1_4	541	546	PF00397	0.552
DOC_WW_Pin1_4	60	65	PF00397	0.523
DOC_WW_Pin1_4	77	82	PF00397	0.426
LIG_14-3-3_CanoR_1	140	146	PF00244	0.376
LIG_14-3-3_CanoR_1	22	28	PF00244	0.458
LIG_14-3-3_CanoR_1	261	269	PF00244	0.579
LIG_14-3-3_CanoR_1	394	400	PF00244	0.541
LIG_14-3-3_CanoR_1	438	448	PF00244	0.546
LIG_14-3-3_CanoR_1	44	50	PF00244	0.548
LIG_14-3-3_CanoR_1	477	482	PF00244	0.533
LIG_14-3-3_CanoR_1	534	542	PF00244	0.424
LIG_14-3-3_CanoR_1	729	735	PF00244	0.313
LIG_Actin_RPEL_3	37	56	PF02755	0.380
LIG_Actin_WH2_2	341	359	PF00022	0.499
LIG_Actin_WH2_2	608	626	PF00022	0.462
LIG_APCC_ABBA_1	626	631	PF00400	0.441
LIG_BRCT_BRCA1_1	601	605	PF00533	0.519
LIG_BRCT_BRCA1_1	705	709	PF00533	0.432
LIG_deltaCOP1_diTrp_1	352	358	PF00928	0.512
LIG_EH1_1	1	9	PF00400	0.413
LIG_EH1_1	275	283	PF00400	0.429
LIG_FHA_1	22	28	PF00498	0.454
LIG_FHA_1	544	550	PF00498	0.428
LIG_FHA_1	554	560	PF00498	0.416
LIG_FHA_2	120	126	PF00498	0.395
LIG_FHA_2	345	351	PF00498	0.376
LIG_FHA_2	464	470	PF00498	0.419
LIG_FHA_2	501	507	PF00498	0.413
LIG_FHA_2	91	97	PF00498	0.552
LIG_GBD_Chelix_1	244	252	PF00786	0.353
LIG_Integrin_RGD_1	370	372	PF01839	0.371
LIG_Integrin_RGD_1	405	407	PF01839	0.475
LIG_LIR_Apic_2	286	292	PF02991	0.257
LIG_LIR_Apic_2	706	712	PF02991	0.345
LIG_LIR_Gen_1	352	360	PF02991	0.511
LIG_LIR_Gen_1	609	619	PF02991	0.436
LIG_LIR_LC3C_4	519	524	PF02991	0.369
LIG_LIR_Nem_3	352	358	PF02991	0.512
LIG_LIR_Nem_3	412	418	PF02991	0.309
LIG_LIR_Nem_3	462	467	PF02991	0.294
LIG_LIR_Nem_3	609	615	PF02991	0.428
LIG_LIR_Nem_3	642	647	PF02991	0.416
LIG_Pex14_1	306	310	PF04695	0.355
LIG_Pex14_2	222	226	PF04695	0.356
LIG_SH2_CRK	612	616	PF00017	0.453
LIG_SH2_CRK	644	648	PF00017	0.424
LIG_SH2_STAP1	399	403	PF00017	0.299
LIG_SH2_STAT5	114	117	PF00017	0.526
LIG_SH2_STAT5	374	377	PF00017	0.517
LIG_SH2_STAT5	418	421	PF00017	0.479
LIG_SH3_3	191	197	PF00018	0.479
LIG_SH3_3	291	297	PF00018	0.406
LIG_SH3_3	487	493	PF00018	0.317
LIG_SH3_3	504	510	PF00018	0.346
LIG_SH3_3	521	527	PF00018	0.492
LIG_SH3_3	615	621	PF00018	0.453
LIG_SUMO_SIM_anti_2	517	525	PF11976	0.279
LIG_SUMO_SIM_anti_2	546	554	PF11976	0.439
LIG_SUMO_SIM_par_1	517	525	PF11976	0.400
LIG_TYR_ITSM	640	647	PF00017	0.273
LIG_UBA3_1	55	60	PF00899	0.407
LIG_WRC_WIRS_1	223	228	PF05994	0.427
MOD_CK1_1	195	201	PF00069	0.355
MOD_CK1_1	232	238	PF00069	0.454
MOD_CK1_1	239	245	PF00069	0.386
MOD_CK1_1	257	263	PF00069	0.593
MOD_CK1_1	344	350	PF00069	0.467
MOD_CK1_1	606	612	PF00069	0.268
MOD_CK1_1	695	701	PF00069	0.423
MOD_CK2_1	119	125	PF00069	0.370
MOD_CK2_1	346	352	PF00069	0.358
MOD_CK2_1	500	506	PF00069	0.416
MOD_CK2_1	735	741	PF00069	0.361
MOD_Cter_Amidation	11	14	PF01082	0.525
MOD_Cter_Amidation	664	667	PF01082	0.242
MOD_GlcNHglycan	199	202	PF01048	0.352
MOD_GlcNHglycan	203	206	PF01048	0.333
MOD_GlcNHglycan	230	234	PF01048	0.452
MOD_GlcNHglycan	265	268	PF01048	0.625
MOD_GlcNHglycan	361	365	PF01048	0.509
MOD_GlcNHglycan	375	378	PF01048	0.390
MOD_GlcNHglycan	578	582	PF01048	0.252
MOD_GlcNHglycan	601	604	PF01048	0.242
MOD_GlcNHglycan	85	88	PF01048	0.624
MOD_GSK3_1	175	182	PF00069	0.450
MOD_GSK3_1	197	204	PF00069	0.338
MOD_GSK3_1	232	239	PF00069	0.523
MOD_GSK3_1	428	435	PF00069	0.496
MOD_GSK3_1	459	466	PF00069	0.313
MOD_GSK3_1	477	484	PF00069	0.391
MOD_GSK3_1	537	544	PF00069	0.303
MOD_GSK3_1	599	606	PF00069	0.266
MOD_GSK3_1	77	84	PF00069	0.466
MOD_N-GLC_1	257	262	PF02516	0.643
MOD_NEK2_1	175	180	PF00069	0.412
MOD_NEK2_1	222	227	PF00069	0.437
MOD_NEK2_1	360	365	PF00069	0.535
MOD_NEK2_1	395	400	PF00069	0.333
MOD_NEK2_1	411	416	PF00069	0.470
MOD_NEK2_1	439	444	PF00069	0.356
MOD_NEK2_1	471	476	PF00069	0.362
MOD_NEK2_1	530	535	PF00069	0.256
MOD_NEK2_1	537	542	PF00069	0.226
MOD_NEK2_1	599	604	PF00069	0.233
MOD_NEK2_1	735	740	PF00069	0.431
MOD_NEK2_2	591	596	PF00069	0.242
MOD_PIKK_1	239	245	PF00454	0.350
MOD_PIKK_1	537	543	PF00454	0.242
MOD_PIKK_1	62	68	PF00454	0.296
MOD_PKA_2	21	27	PF00069	0.455
MOD_PKA_2	432	438	PF00069	0.484
MOD_PKA_2	476	482	PF00069	0.582
MOD_PKA_2	735	741	PF00069	0.397
MOD_PKB_1	138	146	PF00069	0.344
MOD_Plk_1	283	289	PF00069	0.390
MOD_Plk_1	411	417	PF00069	0.466
MOD_Plk_4	206	212	PF00069	0.366
MOD_Plk_4	341	347	PF00069	0.469
MOD_Plk_4	370	376	PF00069	0.551
MOD_Plk_4	432	438	PF00069	0.413
MOD_Plk_4	45	51	PF00069	0.502
MOD_Plk_4	459	465	PF00069	0.322
MOD_Plk_4	54	60	PF00069	0.328
MOD_Plk_4	692	698	PF00069	0.422
MOD_Plk_4	705	711	PF00069	0.261
MOD_Plk_4	730	736	PF00069	0.474
MOD_ProDKin_1	157	163	PF00069	0.511
MOD_ProDKin_1	212	218	PF00069	0.403
MOD_ProDKin_1	309	315	PF00069	0.478
MOD_ProDKin_1	406	412	PF00069	0.470
MOD_ProDKin_1	541	547	PF00069	0.435
MOD_ProDKin_1	60	66	PF00069	0.522
MOD_ProDKin_1	77	83	PF00069	0.442
MOD_SUMO_for_1	115	118	PF00179	0.394
MOD_SUMO_for_1	486	489	PF00179	0.346
MOD_SUMO_rev_2	479	488	PF00179	0.523
MOD_SUMO_rev_2	631	640	PF00179	0.268
TRG_DiLeu_BaLyEn_6	391	396	PF01217	0.337
TRG_DiLeu_BaLyEn_6	446	451	PF01217	0.509
TRG_ENDOCYTIC_2	172	175	PF00928	0.311
TRG_ENDOCYTIC_2	612	615	PF00928	0.242
TRG_ENDOCYTIC_2	644	647	PF00928	0.251
TRG_ER_diArg_1	137	140	PF00400	0.392
TRG_ER_diArg_1	246	249	PF00400	0.375
TRG_ER_diArg_1	328	331	PF00400	0.426
TRG_ER_diArg_1	335	337	PF00400	0.426
TRG_ER_diArg_1	640	643	PF00400	0.463
TRG_ER_diArg_1	670	672	PF00400	0.265
TRG_ER_diArg_1	728	730	PF00400	0.440
TRG_Pf-PMV_PEXEL_1	388	392	PF00026	0.339
TRG_Pf-PMV_PEXEL_1	452	456	PF00026	0.416
TRG_Pf-PMV_PEXEL_1	465	469	PF00026	0.281
TRG_Pf-PMV_PEXEL_1	69	73	PF00026	0.370

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1F5	Leptomonas seymouri	62%	100%
A0A0S4JPK1	Bodo saltans	37%	100%
A0A1X0NY31	Trypanosomatidae	44%	97%
A0A3Q8IN41	Leishmania donovani	99%	100%
A0A422P4N9	Trypanosoma rangeli	46%	100%
A4HNH3	Leishmania braziliensis	82%	100%
C9ZKA6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	89%
E9AFY4	Leishmania major	94%	100%
E9B737	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5B2G2	Trypanosoma cruzi	45%	100%