LeishMANIAdb
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PRORP domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
PRORP domain-containing protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4IC62_LEIIN
TriTrypDb:
LINF_350056400
Length:
584

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 5
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 15
NetGPI no yes: 0, no: 15
Cellular components
Term Name Level Count
GO:0005739 mitochondrion 5 12
GO:0043226 organelle 2 16
GO:0043227 membrane-bounded organelle 3 16
GO:0043229 intracellular organelle 3 16
GO:0043231 intracellular membrane-bounded organelle 4 16
GO:0110165 cellular anatomical entity 1 16

Expansion

Sequence features

A4IC62
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IC62

Function

Biological processes
Term Name Level Count
GO:0006139 nucleobase-containing compound metabolic process 3 16
GO:0006396 RNA processing 6 16
GO:0006399 tRNA metabolic process 7 16
GO:0006725 cellular aromatic compound metabolic process 3 16
GO:0006807 nitrogen compound metabolic process 2 16
GO:0008033 tRNA processing 8 16
GO:0008152 metabolic process 1 16
GO:0009987 cellular process 1 16
GO:0016070 RNA metabolic process 5 16
GO:0034470 ncRNA processing 7 16
GO:0034641 cellular nitrogen compound metabolic process 3 16
GO:0034660 ncRNA metabolic process 6 16
GO:0043170 macromolecule metabolic process 3 16
GO:0044237 cellular metabolic process 2 16
GO:0044238 primary metabolic process 2 16
GO:0046483 heterocycle metabolic process 3 16
GO:0071704 organic substance metabolic process 2 16
GO:0090304 nucleic acid metabolic process 4 16
GO:1901360 organic cyclic compound metabolic process 3 16
GO:0000966 RNA 5'-end processing 7 1
GO:0001682 tRNA 5'-leader removal 9 1
GO:0099116 tRNA 5'-end processing 8 1
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 16
GO:0016787 hydrolase activity 2 16
GO:0004518 nuclease activity 4 6
GO:0004519 endonuclease activity 5 5
GO:0004521 RNA endonuclease activity 5 5
GO:0004526 ribonuclease P activity 6 5
GO:0004540 RNA nuclease activity 4 5
GO:0004549 tRNA-specific ribonuclease activity 5 5
GO:0016788 hydrolase activity, acting on ester bonds 3 6
GO:0016891 RNA endonuclease activity, producing 5'-phosphomonoesters 6 5
GO:0016893 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 6 5
GO:0140098 catalytic activity, acting on RNA 3 5
GO:0140101 catalytic activity, acting on a tRNA 4 5
GO:0140640 catalytic activity, acting on a nucleic acid 2 5

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 350 354 PF00656 0.416
CLV_C14_Caspase3-7 368 372 PF00656 0.510
CLV_C14_Caspase3-7 467 471 PF00656 0.423
CLV_NRD_NRD_1 164 166 PF00675 0.419
CLV_NRD_NRD_1 177 179 PF00675 0.266
CLV_NRD_NRD_1 21 23 PF00675 0.614
CLV_NRD_NRD_1 581 583 PF00675 0.535
CLV_PCSK_FUR_1 19 23 PF00082 0.686
CLV_PCSK_KEX2_1 164 166 PF00082 0.412
CLV_PCSK_KEX2_1 176 178 PF00082 0.299
CLV_PCSK_KEX2_1 18 20 PF00082 0.631
CLV_PCSK_KEX2_1 21 23 PF00082 0.598
CLV_PCSK_KEX2_1 581 583 PF00082 0.535
CLV_PCSK_PC1ET2_1 176 178 PF00082 0.389
CLV_PCSK_PC1ET2_1 18 20 PF00082 0.703
CLV_PCSK_SKI1_1 164 168 PF00082 0.418
CLV_PCSK_SKI1_1 177 181 PF00082 0.231
CLV_PCSK_SKI1_1 263 267 PF00082 0.435
CLV_PCSK_SKI1_1 296 300 PF00082 0.429
CLV_PCSK_SKI1_1 306 310 PF00082 0.397
CLV_PCSK_SKI1_1 370 374 PF00082 0.362
CLV_PCSK_SKI1_1 512 516 PF00082 0.331
CLV_PCSK_SKI1_1 58 62 PF00082 0.417
CLV_PCSK_SKI1_1 6 10 PF00082 0.635
CLV_Separin_Metazoa 217 221 PF03568 0.327
CLV_Separin_Metazoa 95 99 PF03568 0.488
DEG_APCC_DBOX_1 163 171 PF00400 0.365
DEG_APCC_DBOX_1 516 524 PF00400 0.408
DOC_CKS1_1 109 114 PF01111 0.383
DOC_CYCLIN_RxL_1 260 269 PF00134 0.464
DOC_CYCLIN_yCln2_LP_2 449 455 PF00134 0.275
DOC_MAPK_DCC_7 389 398 PF00069 0.528
DOC_MAPK_gen_1 176 185 PF00069 0.401
DOC_MAPK_gen_1 414 423 PF00069 0.312
DOC_MAPK_gen_1 509 518 PF00069 0.404
DOC_MAPK_HePTP_8 185 197 PF00069 0.313
DOC_MAPK_MEF2A_6 143 151 PF00069 0.324
DOC_MAPK_MEF2A_6 188 197 PF00069 0.391
DOC_MAPK_MEF2A_6 512 520 PF00069 0.429
DOC_MAPK_MEF2A_6 78 85 PF00069 0.487
DOC_PP4_FxxP_1 390 393 PF00568 0.543
DOC_SPAK_OSR1_1 389 393 PF12202 0.538
DOC_SPAK_OSR1_1 490 494 PF12202 0.414
DOC_USP7_MATH_1 30 34 PF00917 0.463
DOC_USP7_MATH_1 344 348 PF00917 0.510
DOC_USP7_MATH_1 412 416 PF00917 0.308
DOC_WW_Pin1_4 108 113 PF00397 0.461
DOC_WW_Pin1_4 429 434 PF00397 0.342
DOC_WW_Pin1_4 448 453 PF00397 0.301
LIG_14-3-3_CanoR_1 389 393 PF00244 0.575
LIG_14-3-3_CanoR_1 498 504 PF00244 0.344
LIG_14-3-3_CanoR_1 512 517 PF00244 0.346
LIG_14-3-3_CanoR_1 522 527 PF00244 0.352
LIG_14-3-3_CanoR_1 54 61 PF00244 0.426
LIG_14-3-3_CanoR_1 98 102 PF00244 0.299
LIG_Actin_WH2_2 137 152 PF00022 0.422
LIG_BIR_III_2 168 172 PF00653 0.450
LIG_BIR_III_4 66 70 PF00653 0.492
LIG_BRCT_BRCA1_1 390 394 PF00533 0.526
LIG_BRCT_BRCA1_1 450 454 PF00533 0.390
LIG_BRCT_BRCA1_1 61 65 PF00533 0.226
LIG_FHA_1 109 115 PF00498 0.521
LIG_FHA_1 238 244 PF00498 0.491
LIG_FHA_1 513 519 PF00498 0.309
LIG_FHA_1 573 579 PF00498 0.521
LIG_FHA_2 230 236 PF00498 0.428
LIG_FHA_2 348 354 PF00498 0.385
LIG_FHA_2 408 414 PF00498 0.431
LIG_FHA_2 465 471 PF00498 0.316
LIG_FHA_2 558 564 PF00498 0.550
LIG_GBD_Chelix_1 299 307 PF00786 0.402
LIG_LIR_Apic_2 388 393 PF02991 0.542
LIG_LIR_Gen_1 212 223 PF02991 0.287
LIG_LIR_Gen_1 335 344 PF02991 0.410
LIG_LIR_Gen_1 347 355 PF02991 0.430
LIG_LIR_Gen_1 457 466 PF02991 0.314
LIG_LIR_Gen_1 481 492 PF02991 0.290
LIG_LIR_Gen_1 62 72 PF02991 0.287
LIG_LIR_Nem_3 212 218 PF02991 0.317
LIG_LIR_Nem_3 335 339 PF02991 0.364
LIG_LIR_Nem_3 347 351 PF02991 0.425
LIG_LIR_Nem_3 457 462 PF02991 0.301
LIG_LIR_Nem_3 481 487 PF02991 0.258
LIG_LIR_Nem_3 502 506 PF02991 0.379
LIG_LIR_Nem_3 62 68 PF02991 0.269
LIG_MAD2 104 112 PF02301 0.366
LIG_PCNA_yPIPBox_3 92 106 PF02747 0.488
LIG_Pex14_1 211 215 PF04695 0.353
LIG_Pex14_1 539 543 PF04695 0.390
LIG_Pex14_2 136 140 PF04695 0.473
LIG_Pex14_2 180 184 PF04695 0.325
LIG_Pex14_2 390 394 PF04695 0.550
LIG_Pex14_2 491 495 PF04695 0.336
LIG_PTB_Apo_2 453 460 PF02174 0.301
LIG_PTB_Phospho_1 453 459 PF10480 0.301
LIG_REV1ctd_RIR_1 489 498 PF16727 0.336
LIG_SH2_CRK 348 352 PF00017 0.356
LIG_SH2_CRK 463 467 PF00017 0.313
LIG_SH2_CRK 503 507 PF00017 0.334
LIG_SH2_NCK_1 507 511 PF00017 0.211
LIG_SH2_STAP1 348 352 PF00017 0.356
LIG_SH2_STAP1 438 442 PF00017 0.301
LIG_SH2_STAP1 524 528 PF00017 0.288
LIG_SH2_STAT5 366 369 PF00017 0.494
LIG_SH2_STAT5 459 462 PF00017 0.276
LIG_SH2_STAT5 483 486 PF00017 0.327
LIG_SH2_STAT5 543 546 PF00017 0.449
LIG_SH3_3 176 182 PF00018 0.438
LIG_SH3_3 389 395 PF00018 0.423
LIG_SH3_3 483 489 PF00018 0.462
LIG_SH3_4 309 316 PF00018 0.463
LIG_SUMO_SIM_anti_2 159 164 PF11976 0.292
LIG_SUMO_SIM_anti_2 546 551 PF11976 0.504
LIG_TYR_ITIM 357 362 PF00017 0.319
LIG_TYR_ITIM 501 506 PF00017 0.334
LIG_WRC_WIRS_1 286 291 PF05994 0.403
MOD_CDK_SPK_2 108 113 PF00069 0.323
MOD_CK1_1 325 331 PF00069 0.530
MOD_CK1_1 347 353 PF00069 0.374
MOD_CK1_1 364 370 PF00069 0.499
MOD_CK1_1 383 389 PF00069 0.589
MOD_CK2_1 229 235 PF00069 0.440
MOD_CK2_1 313 319 PF00069 0.516
MOD_CK2_1 400 406 PF00069 0.445
MOD_CK2_1 407 413 PF00069 0.387
MOD_CK2_1 74 80 PF00069 0.518
MOD_Cter_Amidation 415 418 PF01082 0.370
MOD_GlcNHglycan 116 119 PF01048 0.453
MOD_GlcNHglycan 188 191 PF01048 0.506
MOD_GlcNHglycan 27 31 PF01048 0.544
MOD_GlcNHglycan 290 294 PF01048 0.490
MOD_GlcNHglycan 385 388 PF01048 0.544
MOD_GlcNHglycan 413 417 PF01048 0.211
MOD_GlcNHglycan 560 563 PF01048 0.570
MOD_GSK3_1 121 128 PF00069 0.223
MOD_GSK3_1 26 33 PF00069 0.563
MOD_GSK3_1 285 292 PF00069 0.409
MOD_GSK3_1 379 386 PF00069 0.524
MOD_GSK3_1 464 471 PF00069 0.352
MOD_GSK3_1 554 561 PF00069 0.538
MOD_GSK3_1 577 584 PF00069 0.430
MOD_N-GLC_1 4 9 PF02516 0.481
MOD_N-GLC_1 434 439 PF02516 0.346
MOD_N-GLC_1 554 559 PF02516 0.623
MOD_NEK2_1 114 119 PF00069 0.472
MOD_NEK2_1 121 126 PF00069 0.445
MOD_NEK2_1 266 271 PF00069 0.523
MOD_NEK2_1 312 317 PF00069 0.369
MOD_NEK2_1 373 378 PF00069 0.477
MOD_NEK2_1 4 9 PF00069 0.716
MOD_NEK2_1 53 58 PF00069 0.522
MOD_PIKK_1 53 59 PF00454 0.554
MOD_PIKK_1 532 538 PF00454 0.449
MOD_PK_1 522 528 PF00069 0.360
MOD_PKA_2 388 394 PF00069 0.577
MOD_PKA_2 499 505 PF00069 0.390
MOD_PKA_2 53 59 PF00069 0.419
MOD_PKA_2 97 103 PF00069 0.320
MOD_Plk_1 325 331 PF00069 0.573
MOD_Plk_1 4 10 PF00069 0.481
MOD_Plk_1 434 440 PF00069 0.406
MOD_Plk_1 554 560 PF00069 0.631
MOD_Plk_4 121 127 PF00069 0.382
MOD_Plk_4 347 353 PF00069 0.406
MOD_Plk_4 361 367 PF00069 0.276
MOD_Plk_4 37 43 PF00069 0.509
MOD_Plk_4 522 528 PF00069 0.362
MOD_Plk_4 554 560 PF00069 0.479
MOD_Plk_4 81 87 PF00069 0.384
MOD_Plk_4 97 103 PF00069 0.410
MOD_ProDKin_1 108 114 PF00069 0.454
MOD_ProDKin_1 429 435 PF00069 0.342
MOD_ProDKin_1 448 454 PF00069 0.301
MOD_SUMO_rev_2 335 342 PF00179 0.397
MOD_SUMO_rev_2 364 372 PF00179 0.374
TRG_DiLeu_BaEn_1 238 243 PF01217 0.411
TRG_DiLeu_BaEn_1 37 42 PF01217 0.511
TRG_ENDOCYTIC_2 215 218 PF00928 0.296
TRG_ENDOCYTIC_2 348 351 PF00928 0.331
TRG_ENDOCYTIC_2 359 362 PF00928 0.289
TRG_ENDOCYTIC_2 459 462 PF00928 0.264
TRG_ENDOCYTIC_2 463 466 PF00928 0.250
TRG_ENDOCYTIC_2 483 486 PF00928 0.327
TRG_ENDOCYTIC_2 503 506 PF00928 0.133
TRG_ENDOCYTIC_2 507 510 PF00928 0.317
TRG_ER_diArg_1 163 165 PF00400 0.429
TRG_ER_diArg_1 177 179 PF00400 0.207
TRG_ER_diArg_1 19 22 PF00400 0.593
TRG_ER_diArg_1 374 377 PF00400 0.437
TRG_ER_diArg_1 495 498 PF00400 0.270
TRG_NLS_Bipartite_1 164 180 PF00514 0.481
TRG_NLS_MonoCore_2 17 22 PF00514 0.607
TRG_NLS_MonoExtC_3 17 22 PF00514 0.710
TRG_NLS_MonoExtN_4 15 22 PF00514 0.712
TRG_Pf-PMV_PEXEL_1 164 168 PF00026 0.475

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I198 Leptomonas seymouri 67% 99%
A0A0S4JLM5 Bodo saltans 40% 100%
A0A1X0P3X4 Trypanosomatidae 31% 100%
A0A1X0P680 Trypanosomatidae 41% 100%
A0A3Q8IIJ5 Leishmania donovani 99% 100%
A0A3R7LTW4 Trypanosoma rangeli 45% 100%
A0A422MWI6 Trypanosoma rangeli 30% 100%
A4HNH1 Leishmania braziliensis 81% 100%
C9ZYE1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 42% 100%
D0A6B5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 31% 100%
E9AFY2 Leishmania major 94% 100%
E9B735 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 100%
V5B8T9 Trypanosoma cruzi 44% 100%
V5BPA7 Trypanosoma cruzi 30% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS