bVLRF1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4IC59_LEIIN

TriTrypDb:

LINF_350056100

Length:

513

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

A4IC59

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IC59

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006511	ubiquitin-dependent protein catabolic process	7	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006950	response to stress	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009987	cellular process	1	1
GO:0010033	response to organic substance	3	1
GO:0010243	response to organonitrogen compound	4	1
GO:0010498	proteasomal protein catabolic process	5	1
GO:0019538	protein metabolic process	3	1
GO:0019941	modification-dependent protein catabolic process	6	1
GO:0030163	protein catabolic process	4	1
GO:0030433	ubiquitin-dependent ERAD pathway	6	1
GO:0033554	cellular response to stress	3	1
GO:0034976	response to endoplasmic reticulum stress	4	1
GO:0036503	ERAD pathway	5	1
GO:0042221	response to chemical	2	1
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043632	modification-dependent macromolecule catabolic process	5	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0050896	response to stimulus	1	1
GO:0051603	proteolysis involved in protein catabolic process	5	1
GO:0051716	cellular response to stimulus	2	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901565	organonitrogen compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1
GO:1901698	response to nitrogen compound	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	286	290	PF00656	0.668
CLV_NRD_NRD_1	114	116	PF00675	0.640
CLV_NRD_NRD_1	384	386	PF00675	0.260
CLV_NRD_NRD_1	465	467	PF00675	0.275
CLV_PCSK_KEX2_1	114	116	PF00082	0.686
CLV_PCSK_KEX2_1	138	140	PF00082	0.666
CLV_PCSK_KEX2_1	70	72	PF00082	0.510
CLV_PCSK_PC1ET2_1	138	140	PF00082	0.666
CLV_PCSK_PC1ET2_1	70	72	PF00082	0.510
CLV_PCSK_SKI1_1	15	19	PF00082	0.501
CLV_PCSK_SKI1_1	209	213	PF00082	0.474
CLV_PCSK_SKI1_1	274	278	PF00082	0.528
CLV_PCSK_SKI1_1	346	350	PF00082	0.337
CLV_PCSK_SKI1_1	42	46	PF00082	0.521
CLV_PCSK_SKI1_1	422	426	PF00082	0.240
CLV_PCSK_SKI1_1	448	452	PF00082	0.240
CLV_Separin_Metazoa	215	219	PF03568	0.337
CLV_Separin_Metazoa	493	497	PF03568	0.403
DEG_APCC_DBOX_1	41	49	PF00400	0.524
DEG_APCC_DBOX_1	502	510	PF00400	0.553
DEG_Nend_Nbox_1	1	3	PF02207	0.542
DEG_SCF_FBW7_1	17	24	PF00400	0.449
DEG_SPOP_SBC_1	190	194	PF00917	0.605
DEG_SPOP_SBC_1	284	288	PF00917	0.735
DOC_CKS1_1	18	23	PF01111	0.544
DOC_CKS1_1	203	208	PF01111	0.384
DOC_CYCLIN_RxL_1	9	20	PF00134	0.386
DOC_MAPK_DCC_7	466	474	PF00069	0.448
DOC_MAPK_gen_1	466	474	PF00069	0.557
DOC_MAPK_gen_1	475	484	PF00069	0.508
DOC_MAPK_RevD_3	454	467	PF00069	0.475
DOC_PP1_RVXF_1	207	213	PF00149	0.366
DOC_PP2B_LxvP_1	331	334	PF13499	0.574
DOC_USP7_MATH_1	110	114	PF00917	0.727
DOC_USP7_MATH_1	116	120	PF00917	0.774
DOC_USP7_MATH_1	152	156	PF00917	0.619
DOC_USP7_MATH_1	258	262	PF00917	0.567
DOC_USP7_MATH_1	284	288	PF00917	0.732
DOC_USP7_MATH_1	298	302	PF00917	0.538
DOC_USP7_MATH_1	459	463	PF00917	0.503
DOC_USP7_MATH_1	46	50	PF00917	0.538
DOC_USP7_MATH_1	477	481	PF00917	0.546
DOC_USP7_UBL2_3	118	122	PF12436	0.640
DOC_USP7_UBL2_3	387	391	PF12436	0.440
DOC_WW_Pin1_4	165	170	PF00397	0.737
DOC_WW_Pin1_4	17	22	PF00397	0.507
DOC_WW_Pin1_4	202	207	PF00397	0.381
DOC_WW_Pin1_4	280	285	PF00397	0.667
DOC_WW_Pin1_4	467	472	PF00397	0.465
LIG_14-3-3_CanoR_1	209	217	PF00244	0.563
LIG_14-3-3_CanoR_1	22	26	PF00244	0.492
LIG_14-3-3_CanoR_1	346	355	PF00244	0.298
LIG_14-3-3_CanoR_1	448	458	PF00244	0.440
LIG_14-3-3_CanoR_1	481	491	PF00244	0.494
LIG_14-3-3_CanoR_1	503	507	PF00244	0.464
LIG_BRCT_BRCA1_1	298	302	PF00533	0.514
LIG_BRCT_BRCA1_1	337	341	PF00533	0.549
LIG_BRCT_BRCA1_1	85	89	PF00533	0.666
LIG_FHA_1	169	175	PF00498	0.576
LIG_FHA_1	211	217	PF00498	0.427
LIG_FHA_1	22	28	PF00498	0.538
LIG_FHA_1	328	334	PF00498	0.488
LIG_FHA_1	347	353	PF00498	0.520
LIG_FHA_1	9	15	PF00498	0.509
LIG_FHA_2	118	124	PF00498	0.718
LIG_FHA_2	138	144	PF00498	0.772
LIG_FHA_2	21	27	PF00498	0.477
LIG_FHA_2	236	242	PF00498	0.446
LIG_FHA_2	263	269	PF00498	0.570
LIG_FHA_2	284	290	PF00498	0.640
LIG_FHA_2	305	311	PF00498	0.534
LIG_FHA_2	488	494	PF00498	0.471
LIG_LIR_Apic_2	238	242	PF02991	0.327
LIG_LIR_Gen_1	170	180	PF02991	0.495
LIG_LIR_Gen_1	350	357	PF02991	0.346
LIG_LIR_Gen_1	401	409	PF02991	0.534
LIG_LIR_Gen_1	452	461	PF02991	0.472
LIG_LIR_Gen_1	490	498	PF02991	0.453
LIG_LIR_Nem_3	170	176	PF02991	0.512
LIG_LIR_Nem_3	228	233	PF02991	0.362
LIG_LIR_Nem_3	350	356	PF02991	0.363
LIG_LIR_Nem_3	401	405	PF02991	0.441
LIG_LIR_Nem_3	427	431	PF02991	0.471
LIG_LIR_Nem_3	436	440	PF02991	0.458
LIG_LIR_Nem_3	452	457	PF02991	0.377
LIG_LIR_Nem_3	490	494	PF02991	0.453
LIG_NRBOX	13	19	PF00104	0.391
LIG_PCNA_yPIPBox_3	198	211	PF02747	0.503
LIG_Pex14_2	85	89	PF04695	0.666
LIG_SH2_CRK	230	234	PF00017	0.360
LIG_SH2_CRK	402	406	PF00017	0.440
LIG_SH2_CRK	440	444	PF00017	0.535
LIG_SH2_NCK_1	316	320	PF00017	0.494
LIG_SH2_NCK_1	402	406	PF00017	0.535
LIG_SH2_NCK_1	440	444	PF00017	0.535
LIG_SH2_SRC	316	319	PF00017	0.435
LIG_SH2_STAP1	272	276	PF00017	0.602
LIG_SH2_STAT3	508	511	PF00017	0.461
LIG_SH2_STAT3	52	55	PF00017	0.517
LIG_SH2_STAT5	362	365	PF00017	0.440
LIG_SH2_STAT5	382	385	PF00017	0.440
LIG_SH2_STAT5	431	434	PF00017	0.440
LIG_SH2_STAT5	508	511	PF00017	0.361
LIG_SH2_STAT5	52	55	PF00017	0.400
LIG_SH3_3	143	149	PF00018	0.656
LIG_SH3_3	200	206	PF00018	0.441
LIG_TRAF2_1	322	325	PF00917	0.585
LIG_TRAF2_1	411	414	PF00917	0.535
LIG_TRAF2_1	490	493	PF00917	0.453
LIG_TRAF2_2	471	476	PF00917	0.492
LIG_TRFH_1	454	458	PF08558	0.535
MOD_CDK_SPK_2	17	22	PF00069	0.546
MOD_CDK_SPK_2	280	285	PF00069	0.599
MOD_CDK_SPxxK_3	165	172	PF00069	0.534
MOD_CDK_SPxxK_3	202	209	PF00069	0.377
MOD_CK1_1	167	173	PF00069	0.706
MOD_CK1_1	283	289	PF00069	0.740
MOD_CK1_1	401	407	PF00069	0.446
MOD_CK1_1	502	508	PF00069	0.489
MOD_CK2_1	1	7	PF00069	0.460
MOD_CK2_1	117	123	PF00069	0.747
MOD_CK2_1	152	158	PF00069	0.589
MOD_CK2_1	20	26	PF00069	0.360
MOD_CK2_1	235	241	PF00069	0.501
MOD_CK2_1	242	248	PF00069	0.396
MOD_CK2_1	298	304	PF00069	0.711
MOD_CK2_1	487	493	PF00069	0.453
MOD_Cter_Amidation	133	136	PF01082	0.721
MOD_Cter_Amidation	464	467	PF01082	0.275
MOD_GlcNHglycan	103	106	PF01048	0.721
MOD_GlcNHglycan	193	196	PF01048	0.530
MOD_GlcNHglycan	274	277	PF01048	0.718
MOD_GlcNHglycan	296	301	PF01048	0.780
MOD_GlcNHglycan	47	51	PF01048	0.445
MOD_GSK3_1	13	20	PF00069	0.523
MOD_GSK3_1	163	170	PF00069	0.681
MOD_GSK3_1	258	265	PF00069	0.503
MOD_GSK3_1	280	287	PF00069	0.706
MOD_GSK3_1	292	299	PF00069	0.674
MOD_GSK3_1	483	490	PF00069	0.453
MOD_NEK2_1	191	196	PF00069	0.558
MOD_PIKK_1	404	410	PF00454	0.455
MOD_PKA_1	117	123	PF00069	0.696
MOD_PKA_1	137	143	PF00069	0.712
MOD_PKA_2	21	27	PF00069	0.484
MOD_PKA_2	369	375	PF00069	0.538
MOD_PKA_2	477	483	PF00069	0.552
MOD_PKA_2	487	493	PF00069	0.375
MOD_PKA_2	502	508	PF00069	0.551
MOD_PKB_1	344	352	PF00069	0.443
MOD_Plk_1	304	310	PF00069	0.542
MOD_Plk_1	452	458	PF00069	0.479
MOD_Plk_2-3	304	310	PF00069	0.520
MOD_Plk_4	13	19	PF00069	0.467
MOD_Plk_4	298	304	PF00069	0.677
MOD_Plk_4	433	439	PF00069	0.497
MOD_Plk_4	502	508	PF00069	0.567
MOD_ProDKin_1	165	171	PF00069	0.723
MOD_ProDKin_1	17	23	PF00069	0.504
MOD_ProDKin_1	202	208	PF00069	0.372
MOD_ProDKin_1	280	286	PF00069	0.671
MOD_ProDKin_1	467	473	PF00069	0.465
MOD_SUMO_rev_2	4	11	PF00179	0.427
TRG_ENDOCYTIC_2	230	233	PF00928	0.382
TRG_ENDOCYTIC_2	402	405	PF00928	0.440
TRG_ER_diArg_1	114	116	PF00400	0.667
TRG_NLS_Bipartite_1	117	139	PF00514	0.706
TRG_NLS_MonoCore_2	134	139	PF00514	0.540
TRG_NLS_MonoExtC_3	134	139	PF00514	0.577
TRG_NLS_MonoExtN_4	133	140	PF00514	0.723
TRG_Pf-PMV_PEXEL_1	139	143	PF00026	0.626

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IGL8	Leptomonas seymouri	63%	99%
A0A1X0P4S2	Trypanosomatidae	41%	100%
A0A3Q8IQ93	Leishmania donovani	99%	100%
A0A3S5IQY8	Trypanosoma rangeli	39%	99%
A4HNG8	Leishmania braziliensis	74%	99%
C9ZYE4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9AFX9	Leishmania major	92%	100%
E9B732	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5DQH4	Trypanosoma cruzi	42%	100%