Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4IC58_LEIIN

TriTrypDb:

LINF_350056000

Length:

529

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4IC58

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IC58

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	24	28	PF00656	0.722
CLV_C14_Caspase3-7	74	78	PF00656	0.585
CLV_NRD_NRD_1	33	35	PF00675	0.776
CLV_NRD_NRD_1	387	389	PF00675	0.769
CLV_NRD_NRD_1	391	393	PF00675	0.720
CLV_PCSK_FUR_1	388	392	PF00082	0.702
CLV_PCSK_KEX2_1	33	35	PF00082	0.776
CLV_PCSK_KEX2_1	387	389	PF00082	0.769
CLV_PCSK_KEX2_1	390	392	PF00082	0.735
CLV_PCSK_PC7_1	387	393	PF00082	0.700
CLV_PCSK_SKI1_1	204	208	PF00082	0.671
CLV_PCSK_SKI1_1	257	261	PF00082	0.673
CLV_PCSK_SKI1_1	50	54	PF00082	0.704
CLV_PCSK_SKI1_1	86	90	PF00082	0.636
DEG_SPOP_SBC_1	228	232	PF00917	0.761
DEG_SPOP_SBC_1	303	307	PF00917	0.743
DEG_SPOP_SBC_1	431	435	PF00917	0.635
DEG_SPOP_SBC_1	59	63	PF00917	0.799
DOC_CKS1_1	97	102	PF01111	0.835
DOC_CYCLIN_RxL_1	83	92	PF00134	0.634
DOC_CYCLIN_yCln2_LP_2	194	197	PF00134	0.766
DOC_MAPK_RevD_3	373	388	PF00069	0.746
DOC_PP2B_LxvP_1	194	197	PF13499	0.766
DOC_PP2B_LxvP_1	238	241	PF13499	0.839
DOC_PP2B_LxvP_1	279	282	PF13499	0.841
DOC_PP2B_LxvP_1	469	472	PF13499	0.755
DOC_SPAK_OSR1_1	371	375	PF12202	0.757
DOC_USP7_MATH_1	141	145	PF00917	0.786
DOC_USP7_MATH_1	166	170	PF00917	0.761
DOC_USP7_MATH_1	206	210	PF00917	0.817
DOC_USP7_MATH_1	214	218	PF00917	0.734
DOC_USP7_MATH_1	228	232	PF00917	0.634
DOC_USP7_MATH_1	241	245	PF00917	0.588
DOC_USP7_MATH_1	289	293	PF00917	0.788
DOC_USP7_MATH_1	318	322	PF00917	0.593
DOC_USP7_MATH_1	327	331	PF00917	0.609
DOC_USP7_MATH_1	407	411	PF00917	0.775
DOC_USP7_MATH_1	432	436	PF00917	0.736
DOC_USP7_MATH_1	478	482	PF00917	0.820
DOC_USP7_MATH_1	59	63	PF00917	0.747
DOC_USP7_MATH_2	459	465	PF00917	0.650
DOC_WW_Pin1_4	216	221	PF00397	0.834
DOC_WW_Pin1_4	233	238	PF00397	0.567
DOC_WW_Pin1_4	323	328	PF00397	0.729
DOC_WW_Pin1_4	349	354	PF00397	0.773
DOC_WW_Pin1_4	402	407	PF00397	0.752
DOC_WW_Pin1_4	455	460	PF00397	0.765
DOC_WW_Pin1_4	473	478	PF00397	0.555
DOC_WW_Pin1_4	72	77	PF00397	0.756
DOC_WW_Pin1_4	96	101	PF00397	0.835
LIG_14-3-3_CanoR_1	117	121	PF00244	0.770
LIG_14-3-3_CanoR_1	227	237	PF00244	0.727
LIG_14-3-3_CanoR_1	397	401	PF00244	0.705
LIG_14-3-3_CanoR_1	422	431	PF00244	0.742
LIG_BRCT_BRCA1_1	351	355	PF00533	0.688
LIG_CtBP_PxDLS_1	220	224	PF00389	0.765
LIG_EVH1_1	279	283	PF00568	0.842
LIG_FHA_1	297	303	PF00498	0.744
LIG_FHA_1	40	46	PF00498	0.581
LIG_FHA_1	416	422	PF00498	0.635
LIG_FHA_2	412	418	PF00498	0.719
LIG_IBAR_NPY_1	4	6	PF08397	0.569
LIG_LIR_Gen_1	369	378	PF02991	0.753
LIG_LIR_Nem_3	232	238	PF02991	0.667
LIG_LIR_Nem_3	369	375	PF02991	0.758
LIG_MYND_1	110	114	PF01753	0.817
LIG_MYND_1	490	494	PF01753	0.725
LIG_SH2_SRC	336	339	PF00017	0.582
LIG_SH2_STAT3	6	9	PF00017	0.555
LIG_SH2_STAT5	6	9	PF00017	0.555
LIG_SH3_1	277	283	PF00018	0.841
LIG_SH3_1	33	39	PF00018	0.767
LIG_SH3_2	283	288	PF14604	0.635
LIG_SH3_3	108	114	PF00018	0.486
LIG_SH3_3	135	141	PF00018	0.719
LIG_SH3_3	277	283	PF00018	0.739
LIG_SH3_3	33	39	PF00018	0.692
LIG_SH3_3	342	348	PF00018	0.747
LIG_SH3_3	361	367	PF00018	0.787
LIG_SH3_3	375	381	PF00018	0.510
LIG_SH3_3	42	48	PF00018	0.607
LIG_SH3_3	440	446	PF00018	0.699
LIG_SH3_3	91	97	PF00018	0.823
LIG_SUMO_SIM_anti_2	169	174	PF11976	0.731
MOD_CK1_1	105	111	PF00069	0.773
MOD_CK1_1	119	125	PF00069	0.680
MOD_CK1_1	144	150	PF00069	0.844
MOD_CK1_1	181	187	PF00069	0.766
MOD_CK1_1	189	195	PF00069	0.681
MOD_CK1_1	219	225	PF00069	0.843
MOD_CK1_1	231	237	PF00069	0.644
MOD_CK1_1	245	251	PF00069	0.519
MOD_CK1_1	270	276	PF00069	0.791
MOD_CK1_1	304	310	PF00069	0.725
MOD_CK1_1	439	445	PF00069	0.784
MOD_CK1_1	509	515	PF00069	0.704
MOD_CK2_1	10	16	PF00069	0.586
MOD_CK2_1	171	177	PF00069	0.691
MOD_CK2_1	308	314	PF00069	0.762
MOD_CK2_1	336	342	PF00069	0.724
MOD_CK2_1	411	417	PF00069	0.720
MOD_CK2_1	455	461	PF00069	0.699
MOD_DYRK1A_RPxSP_1	455	459	PF00069	0.864
MOD_DYRK1A_RPxSP_1	96	100	PF00069	0.832
MOD_GlcNHglycan	104	107	PF01048	0.673
MOD_GlcNHglycan	173	176	PF01048	0.756
MOD_GlcNHglycan	191	194	PF01048	0.579
MOD_GlcNHglycan	291	294	PF01048	0.788
MOD_GlcNHglycan	311	314	PF01048	0.681
MOD_GlcNHglycan	331	334	PF01048	0.567
MOD_GlcNHglycan	381	384	PF01048	0.728
MOD_GlcNHglycan	434	437	PF01048	0.775
MOD_GlcNHglycan	438	441	PF01048	0.706
MOD_GlcNHglycan	511	514	PF01048	0.630
MOD_GlcNHglycan	55	58	PF01048	0.814
MOD_GlcNHglycan	62	65	PF01048	0.718
MOD_GSK3_1	116	123	PF00069	0.845
MOD_GSK3_1	139	146	PF00069	0.839
MOD_GSK3_1	202	209	PF00069	0.776
MOD_GSK3_1	212	219	PF00069	0.711
MOD_GSK3_1	227	234	PF00069	0.623
MOD_GSK3_1	241	248	PF00069	0.594
MOD_GSK3_1	301	308	PF00069	0.767
MOD_GSK3_1	323	330	PF00069	0.588
MOD_GSK3_1	407	414	PF00069	0.721
MOD_GSK3_1	432	439	PF00069	0.810
MOD_GSK3_1	46	53	PF00069	0.741
MOD_GSK3_1	461	468	PF00069	0.777
MOD_GSK3_1	55	62	PF00069	0.642
MOD_GSK3_1	67	74	PF00069	0.621
MOD_GSK3_1	92	99	PF00069	0.826
MOD_N-GLC_1	142	147	PF02516	0.773
MOD_N-GLC_1	50	55	PF02516	0.727
MOD_NEK2_1	178	183	PF00069	0.735
MOD_NEK2_1	267	272	PF00069	0.734
MOD_NEK2_1	328	333	PF00069	0.785
MOD_NEK2_1	41	46	PF00069	0.660
MOD_NEK2_1	411	416	PF00069	0.690
MOD_NEK2_1	453	458	PF00069	0.797
MOD_NEK2_1	52	57	PF00069	0.598
MOD_NEK2_2	407	412	PF00069	0.742
MOD_PIKK_1	336	342	PF00454	0.627
MOD_PKA_2	116	122	PF00069	0.846
MOD_PKA_2	128	134	PF00069	0.617
MOD_PKA_2	181	187	PF00069	0.813
MOD_PKA_2	270	276	PF00069	0.654
MOD_PKA_2	396	402	PF00069	0.702
MOD_PKA_2	421	427	PF00069	0.744
MOD_PKA_2	46	52	PF00069	0.789
MOD_Plk_1	267	273	PF00069	0.647
MOD_Plk_1	318	324	PF00069	0.819
MOD_Plk_1	367	373	PF00069	0.756
MOD_Plk_1	478	484	PF00069	0.712
MOD_Plk_4	407	413	PF00069	0.818
MOD_Plk_4	41	47	PF00069	0.596
MOD_Plk_4	488	494	PF00069	0.652
MOD_ProDKin_1	216	222	PF00069	0.833
MOD_ProDKin_1	233	239	PF00069	0.568
MOD_ProDKin_1	323	329	PF00069	0.726
MOD_ProDKin_1	349	355	PF00069	0.774
MOD_ProDKin_1	402	408	PF00069	0.747
MOD_ProDKin_1	455	461	PF00069	0.767
MOD_ProDKin_1	473	479	PF00069	0.554
MOD_ProDKin_1	72	78	PF00069	0.753
MOD_ProDKin_1	96	102	PF00069	0.834
TRG_DiLeu_BaEn_1	221	226	PF01217	0.726
TRG_DiLeu_BaEn_1	488	493	PF01217	0.692
TRG_DiLeu_BaLyEn_6	108	113	PF01217	0.817
TRG_ER_diArg_1	32	34	PF00400	0.798
TRG_ER_diArg_1	387	390	PF00400	0.770
TRG_Pf-PMV_PEXEL_1	484	488	PF00026	0.729

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H810	Leishmania donovani	99%	82%
A4HNG7	Leishmania braziliensis	57%	100%
E9AFX8	Leishmania major	85%	100%
E9B731	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%