Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4IC56_LEIIN

TriTrypDb:

LINF_350055800

Length:

531

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4IC56

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IC56

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	505	509	PF00656	0.341
CLV_NRD_NRD_1	149	151	PF00675	0.478
CLV_NRD_NRD_1	159	161	PF00675	0.426
CLV_NRD_NRD_1	305	307	PF00675	0.418
CLV_NRD_NRD_1	416	418	PF00675	0.321
CLV_NRD_NRD_1	42	44	PF00675	0.497
CLV_NRD_NRD_1	457	459	PF00675	0.569
CLV_NRD_NRD_1	64	66	PF00675	0.549
CLV_NRD_NRD_1	73	75	PF00675	0.484
CLV_PCSK_FUR_1	303	307	PF00082	0.397
CLV_PCSK_KEX2_1	149	151	PF00082	0.478
CLV_PCSK_KEX2_1	158	160	PF00082	0.439
CLV_PCSK_KEX2_1	215	217	PF00082	0.442
CLV_PCSK_KEX2_1	305	307	PF00082	0.418
CLV_PCSK_KEX2_1	457	459	PF00082	0.581
CLV_PCSK_KEX2_1	64	66	PF00082	0.474
CLV_PCSK_KEX2_1	73	75	PF00082	0.477
CLV_PCSK_PC1ET2_1	215	217	PF00082	0.442
CLV_PCSK_PC7_1	154	160	PF00082	0.483
CLV_PCSK_SKI1_1	202	206	PF00082	0.485
CLV_PCSK_SKI1_1	278	282	PF00082	0.542
CLV_PCSK_SKI1_1	338	342	PF00082	0.522
CLV_PCSK_SKI1_1	97	101	PF00082	0.446
DEG_APCC_DBOX_1	305	313	PF00400	0.586
DEG_Nend_Nbox_1	1	3	PF02207	0.660
DOC_CKS1_1	363	368	PF01111	0.701
DOC_CKS1_1	374	379	PF01111	0.568
DOC_CKS1_1	526	531	PF01111	0.347
DOC_CYCLIN_RxL_1	199	206	PF00134	0.668
DOC_CYCLIN_yCln2_LP_2	50	56	PF00134	0.622
DOC_MAPK_gen_1	164	172	PF00069	0.615
DOC_MAPK_gen_1	93	101	PF00069	0.671
DOC_MAPK_MEF2A_6	164	172	PF00069	0.678
DOC_PP1_RVXF_1	328	334	PF00149	0.651
DOC_PP1_RVXF_1	42	49	PF00149	0.690
DOC_PP2B_LxvP_1	205	208	PF13499	0.707
DOC_PP2B_LxvP_1	50	53	PF13499	0.637
DOC_USP7_MATH_1	128	132	PF00917	0.754
DOC_USP7_MATH_1	192	196	PF00917	0.601
DOC_USP7_MATH_1	290	294	PF00917	0.722
DOC_USP7_MATH_1	386	390	PF00917	0.669
DOC_USP7_MATH_1	489	493	PF00917	0.398
DOC_USP7_MATH_1	509	513	PF00917	0.340
DOC_USP7_MATH_1	514	518	PF00917	0.305
DOC_USP7_UBL2_3	177	181	PF12436	0.659
DOC_WW_Pin1_4	122	127	PF00397	0.728
DOC_WW_Pin1_4	283	288	PF00397	0.664
DOC_WW_Pin1_4	355	360	PF00397	0.738
DOC_WW_Pin1_4	362	367	PF00397	0.686
DOC_WW_Pin1_4	373	378	PF00397	0.530
DOC_WW_Pin1_4	396	401	PF00397	0.666
DOC_WW_Pin1_4	525	530	PF00397	0.363
LIG_14-3-3_CanoR_1	136	141	PF00244	0.740
LIG_14-3-3_CanoR_1	158	164	PF00244	0.752
LIG_14-3-3_CanoR_1	235	243	PF00244	0.726
LIG_14-3-3_CanoR_1	79	87	PF00244	0.660
LIG_Actin_WH2_2	267	283	PF00022	0.601
LIG_APCC_ABBA_1	472	477	PF00400	0.313
LIG_BIR_III_2	508	512	PF00653	0.343
LIG_CSL_BTD_1	459	462	PF09270	0.365
LIG_DLG_GKlike_1	136	144	PF00625	0.651
LIG_FHA_1	215	221	PF00498	0.634
LIG_FHA_1	374	380	PF00498	0.627
LIG_FHA_1	446	452	PF00498	0.434
LIG_FHA_1	489	495	PF00498	0.506
LIG_FHA_1	75	81	PF00498	0.714
LIG_FHA_2	100	106	PF00498	0.663
LIG_FHA_2	180	186	PF00498	0.620
LIG_FHA_2	33	39	PF00498	0.690
LIG_LIR_Gen_1	102	110	PF02991	0.635
LIG_LIR_Gen_1	477	487	PF02991	0.346
LIG_LIR_Nem_3	102	107	PF02991	0.654
LIG_LIR_Nem_3	232	237	PF02991	0.669
LIG_LIR_Nem_3	276	280	PF02991	0.637
LIG_LIR_Nem_3	40	45	PF02991	0.648
LIG_LIR_Nem_3	477	482	PF02991	0.345
LIG_LIR_Nem_3	515	521	PF02991	0.334
LIG_NRBOX	426	432	PF00104	0.315
LIG_REV1ctd_RIR_1	1	10	PF16727	0.666
LIG_SH2_CRK	104	108	PF00017	0.588
LIG_SH2_CRK	277	281	PF00017	0.679
LIG_SH2_CRK	42	46	PF00017	0.682
LIG_SH2_STAP1	403	407	PF00017	0.637
LIG_SH2_STAP1	521	525	PF00017	0.326
LIG_SH2_STAT5	106	109	PF00017	0.713
LIG_SH3_3	145	151	PF00018	0.697
LIG_SH3_3	240	246	PF00018	0.695
LIG_SH3_3	281	287	PF00018	0.716
LIG_SH3_3	353	359	PF00018	0.692
LIG_SH3_3	360	366	PF00018	0.666
LIG_SH3_3	394	400	PF00018	0.698
LIG_SH3_3	456	462	PF00018	0.367
LIG_SUMO_SIM_par_1	502	508	PF11976	0.449
LIG_TRAF2_1	182	185	PF00917	0.573
LIG_TRAF2_1	447	450	PF00917	0.325
LIG_WRC_WIRS_1	431	436	PF05994	0.395
MOD_CDC14_SPxK_1	286	289	PF00782	0.681
MOD_CDK_SPxK_1	283	289	PF00069	0.683
MOD_CK1_1	122	128	PF00069	0.736
MOD_CK1_1	14	20	PF00069	0.688
MOD_CK1_1	162	168	PF00069	0.818
MOD_CK1_1	203	209	PF00069	0.698
MOD_CK1_1	221	227	PF00069	0.621
MOD_CK1_1	238	244	PF00069	0.686
MOD_CK1_1	273	279	PF00069	0.618
MOD_CK1_1	409	415	PF00069	0.719
MOD_CK2_1	179	185	PF00069	0.621
MOD_CK2_1	509	515	PF00069	0.329
MOD_Cter_Amidation	156	159	PF01082	0.486
MOD_GlcNHglycan	155	158	PF01048	0.579
MOD_GlcNHglycan	237	240	PF01048	0.540
MOD_GlcNHglycan	300	303	PF01048	0.470
MOD_GlcNHglycan	338	341	PF01048	0.439
MOD_GlcNHglycan	345	348	PF01048	0.405
MOD_GlcNHglycan	438	441	PF01048	0.491
MOD_GlcNHglycan	491	494	PF01048	0.570
MOD_GSK3_1	105	112	PF00069	0.709
MOD_GSK3_1	159	166	PF00069	0.799
MOD_GSK3_1	214	221	PF00069	0.664
MOD_GSK3_1	357	364	PF00069	0.740
MOD_GSK3_1	386	393	PF00069	0.598
MOD_GSK3_1	430	437	PF00069	0.454
MOD_GSK3_1	441	448	PF00069	0.303
MOD_GSK3_1	60	67	PF00069	0.707
MOD_GSK3_1	74	81	PF00069	0.753
MOD_GSK3_1	93	100	PF00069	0.640
MOD_LATS_1	134	140	PF00433	0.713
MOD_N-GLC_2	115	117	PF02516	0.425
MOD_N-GLC_2	335	337	PF02516	0.447
MOD_NEK2_1	11	16	PF00069	0.655
MOD_NEK2_1	170	175	PF00069	0.647
MOD_NEK2_1	2	7	PF00069	0.703
MOD_NEK2_1	200	205	PF00069	0.689
MOD_NEK2_1	229	234	PF00069	0.675
MOD_NEK2_1	270	275	PF00069	0.591
MOD_NEK2_1	32	37	PF00069	0.658
MOD_NEK2_1	430	435	PF00069	0.395
MOD_NEK2_1	60	65	PF00069	0.668
MOD_NEK2_2	497	502	PF00069	0.427
MOD_PIKK_1	409	415	PF00454	0.606
MOD_PIKK_1	509	515	PF00454	0.387
MOD_PIKK_1	80	86	PF00454	0.701
MOD_PK_1	159	165	PF00069	0.711
MOD_PKA_1	159	165	PF00069	0.690
MOD_PKA_1	64	70	PF00069	0.721
MOD_PKA_1	73	79	PF00069	0.666
MOD_PKA_2	153	159	PF00069	0.687
MOD_PKA_2	163	169	PF00069	0.701
MOD_PKA_2	229	235	PF00069	0.637
MOD_PKA_2	64	70	PF00069	0.682
MOD_PKA_2	73	79	PF00069	0.694
MOD_PKB_1	334	342	PF00069	0.653
MOD_PKB_1	95	103	PF00069	0.721
MOD_Plk_1	200	206	PF00069	0.704
MOD_Plk_1	422	428	PF00069	0.538
MOD_Plk_1	514	520	PF00069	0.368
MOD_Plk_1	97	103	PF00069	0.697
MOD_Plk_4	200	206	PF00069	0.722
MOD_Plk_4	291	297	PF00069	0.728
MOD_Plk_4	406	412	PF00069	0.655
MOD_Plk_4	430	436	PF00069	0.384
MOD_ProDKin_1	122	128	PF00069	0.731
MOD_ProDKin_1	283	289	PF00069	0.664
MOD_ProDKin_1	355	361	PF00069	0.740
MOD_ProDKin_1	362	368	PF00069	0.684
MOD_ProDKin_1	373	379	PF00069	0.530
MOD_ProDKin_1	396	402	PF00069	0.663
MOD_ProDKin_1	525	531	PF00069	0.379
MOD_SUMO_rev_2	178	188	PF00179	0.658
MOD_SUMO_rev_2	326	331	PF00179	0.653
TRG_AP2beta_CARGO_1	477	486	PF09066	0.327
TRG_DiLeu_BaEn_1	423	428	PF01217	0.567
TRG_DiLeu_BaLyEn_6	265	270	PF01217	0.625
TRG_DiLeu_BaLyEn_6	275	280	PF01217	0.651
TRG_DiLeu_BaLyEn_6	374	379	PF01217	0.644
TRG_ENDOCYTIC_2	104	107	PF00928	0.633
TRG_ENDOCYTIC_2	277	280	PF00928	0.640
TRG_ENDOCYTIC_2	42	45	PF00928	0.684
TRG_ENDOCYTIC_2	523	526	PF00928	0.352
TRG_ER_diArg_1	148	150	PF00400	0.742
TRG_ER_diArg_1	158	160	PF00400	0.639
TRG_ER_diArg_1	303	306	PF00400	0.611
TRG_ER_diArg_1	333	336	PF00400	0.698
TRG_ER_diArg_1	456	458	PF00400	0.382
TRG_ER_diArg_1	68	71	PF00400	0.678
TRG_ER_diArg_1	72	74	PF00400	0.667
TRG_ER_diArg_1	92	95	PF00400	0.768
TRG_Pf-PMV_PEXEL_1	268	272	PF00026	0.408
TRG_Pf-PMV_PEXEL_1	278	282	PF00026	0.446
TRG_Pf-PMV_PEXEL_1	394	398	PF00026	0.414
TRG_Pf-PMV_PEXEL_1	70	75	PF00026	0.537

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3L4	Leptomonas seymouri	34%	92%
A0A3S7XA13	Leishmania donovani	99%	100%
A4HNG5	Leishmania braziliensis	58%	100%
E9AFX6	Leishmania major	85%	100%
E9B729	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%