HECT domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4IC55_LEIIN

TriTrypDb:

LINF_350055700

Length:

896

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4IC55

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IC55

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	292	296	PF00656	0.577
CLV_C14_Caspase3-7	574	578	PF00656	0.456
CLV_NRD_NRD_1	148	150	PF00675	0.446
CLV_NRD_NRD_1	369	371	PF00675	0.585
CLV_NRD_NRD_1	384	386	PF00675	0.323
CLV_NRD_NRD_1	69	71	PF00675	0.446
CLV_NRD_NRD_1	75	77	PF00675	0.404
CLV_NRD_NRD_1	795	797	PF00675	0.589
CLV_PCSK_FUR_1	382	386	PF00082	0.492
CLV_PCSK_FUR_1	73	77	PF00082	0.423
CLV_PCSK_KEX2_1	369	371	PF00082	0.585
CLV_PCSK_KEX2_1	384	386	PF00082	0.429
CLV_PCSK_KEX2_1	73	75	PF00082	0.426
CLV_PCSK_KEX2_1	795	797	PF00082	0.589
CLV_PCSK_PC7_1	70	76	PF00082	0.428
CLV_PCSK_SKI1_1	300	304	PF00082	0.499
CLV_PCSK_SKI1_1	335	339	PF00082	0.494
CLV_PCSK_SKI1_1	362	366	PF00082	0.649
CLV_PCSK_SKI1_1	369	373	PF00082	0.461
CLV_PCSK_SKI1_1	377	381	PF00082	0.322
CLV_PCSK_SKI1_1	384	388	PF00082	0.316
CLV_PCSK_SKI1_1	480	484	PF00082	0.567
CLV_PCSK_SKI1_1	518	522	PF00082	0.527
CLV_PCSK_SKI1_1	570	574	PF00082	0.474
CLV_PCSK_SKI1_1	580	584	PF00082	0.406
CLV_PCSK_SKI1_1	691	695	PF00082	0.490
CLV_PCSK_SKI1_1	796	800	PF00082	0.560
CLV_PCSK_SKI1_1	886	890	PF00082	0.569
CLV_PCSK_SKI1_1	89	93	PF00082	0.522
CLV_Separin_Metazoa	287	291	PF03568	0.521
DEG_SPOP_SBC_1	522	526	PF00917	0.482
DEG_SPOP_SBC_1	685	689	PF00917	0.459
DOC_CDC14_PxL_1	254	262	PF14671	0.517
DOC_CKS1_1	755	760	PF01111	0.554
DOC_CYCLIN_RxL_1	381	391	PF00134	0.428
DOC_CYCLIN_RxL_1	688	699	PF00134	0.492
DOC_CYCLIN_RxL_1	792	802	PF00134	0.609
DOC_CYCLIN_yCln2_LP_2	755	761	PF00134	0.530
DOC_MAPK_gen_1	262	269	PF00069	0.486
DOC_MAPK_gen_1	369	380	PF00069	0.519
DOC_MAPK_gen_1	70	81	PF00069	0.409
DOC_MAPK_MEF2A_6	558	567	PF00069	0.456
DOC_MAPK_MEF2A_6	691	698	PF00069	0.556
DOC_MAPK_NFAT4_5	691	699	PF00069	0.554
DOC_PP1_RVXF_1	87	94	PF00149	0.430
DOC_USP7_MATH_1	10	14	PF00917	0.523
DOC_USP7_MATH_1	121	125	PF00917	0.670
DOC_USP7_MATH_1	230	234	PF00917	0.631
DOC_USP7_MATH_1	751	755	PF00917	0.601
DOC_WW_Pin1_4	238	243	PF00397	0.476
DOC_WW_Pin1_4	550	555	PF00397	0.508
DOC_WW_Pin1_4	643	648	PF00397	0.557
DOC_WW_Pin1_4	696	701	PF00397	0.596
DOC_WW_Pin1_4	708	713	PF00397	0.715
DOC_WW_Pin1_4	730	735	PF00397	0.512
DOC_WW_Pin1_4	754	759	PF00397	0.524
LIG_14-3-3_CanoR_1	105	110	PF00244	0.524
LIG_14-3-3_CanoR_1	209	214	PF00244	0.442
LIG_14-3-3_CanoR_1	290	298	PF00244	0.571
LIG_14-3-3_CanoR_1	362	372	PF00244	0.618
LIG_14-3-3_CanoR_1	443	449	PF00244	0.556
LIG_14-3-3_CanoR_1	518	527	PF00244	0.485
LIG_14-3-3_CanoR_1	570	576	PF00244	0.444
LIG_14-3-3_CanoR_1	580	589	PF00244	0.445
LIG_14-3-3_CanoR_1	629	636	PF00244	0.468
LIG_14-3-3_CanoR_1	750	756	PF00244	0.556
LIG_14-3-3_CanoR_1	777	786	PF00244	0.563
LIG_14-3-3_CanoR_1	821	826	PF00244	0.508
LIG_Actin_WH2_2	420	438	PF00022	0.513
LIG_BIR_III_2	748	752	PF00653	0.540
LIG_BIR_III_4	293	297	PF00653	0.520
LIG_BRCT_BRCA1_1	224	228	PF00533	0.431
LIG_CtBP_PxDLS_1	164	168	PF00389	0.520
LIG_DLG_GKlike_1	209	216	PF00625	0.486
LIG_FHA_1	143	149	PF00498	0.354
LIG_FHA_1	374	380	PF00498	0.550
LIG_FHA_1	492	498	PF00498	0.461
LIG_FHA_1	524	530	PF00498	0.527
LIG_FHA_1	581	587	PF00498	0.454
LIG_FHA_1	755	761	PF00498	0.499
LIG_FHA_1	785	791	PF00498	0.394
LIG_FHA_2	110	116	PF00498	0.755
LIG_FHA_2	136	142	PF00498	0.515
LIG_FHA_2	203	209	PF00498	0.460
LIG_FHA_2	232	238	PF00498	0.685
LIG_FHA_2	445	451	PF00498	0.509
LIG_FHA_2	487	493	PF00498	0.452
LIG_FHA_2	572	578	PF00498	0.541
LIG_FHA_2	615	621	PF00498	0.538
LIG_FHA_2	687	693	PF00498	0.562
LIG_Integrin_RGD_1	199	201	PF01839	0.533
LIG_LIR_Gen_1	208	218	PF02991	0.439
LIG_LIR_Gen_1	41	50	PF02991	0.460
LIG_LIR_Gen_1	514	523	PF02991	0.423
LIG_LIR_Gen_1	53	63	PF02991	0.573
LIG_LIR_Gen_1	631	640	PF02991	0.482
LIG_LIR_Gen_1	64	69	PF02991	0.435
LIG_LIR_Nem_3	160	165	PF02991	0.461
LIG_LIR_Nem_3	208	213	PF02991	0.436
LIG_LIR_Nem_3	514	519	PF02991	0.460
LIG_LIR_Nem_3	53	59	PF02991	0.577
LIG_LIR_Nem_3	555	560	PF02991	0.460
LIG_LIR_Nem_3	631	636	PF02991	0.454
LIG_LIR_Nem_3	64	68	PF02991	0.422
LIG_LIR_Nem_3	776	782	PF02991	0.517
LIG_NRBOX	182	188	PF00104	0.503
LIG_NRBOX	329	335	PF00104	0.441
LIG_Pex14_1	778	782	PF04695	0.513
LIG_SH2_CRK	437	441	PF00017	0.560
LIG_SH2_CRK	663	667	PF00017	0.382
LIG_SH2_SRC	413	416	PF00017	0.548
LIG_SH2_SRC	85	88	PF00017	0.547
LIG_SH2_STAP1	516	520	PF00017	0.578
LIG_SH2_STAP1	633	637	PF00017	0.543
LIG_SH2_STAP1	663	667	PF00017	0.382
LIG_SH2_STAT3	811	814	PF00017	0.365
LIG_SH2_STAT5	336	339	PF00017	0.332
LIG_SH2_STAT5	42	45	PF00017	0.403
LIG_SH2_STAT5	552	555	PF00017	0.537
LIG_SH2_STAT5	785	788	PF00017	0.511
LIG_SH2_STAT5	811	814	PF00017	0.516
LIG_SH2_STAT5	877	880	PF00017	0.420
LIG_SH3_3	123	129	PF00018	0.638
LIG_SH3_3	531	537	PF00018	0.578
LIG_SH3_3	585	591	PF00018	0.555
LIG_SH3_3	697	703	PF00018	0.664
LIG_SH3_3	706	712	PF00018	0.595
LIG_SH3_3	731	737	PF00018	0.519
LIG_SUMO_SIM_anti_2	620	626	PF11976	0.476
LIG_SUMO_SIM_anti_2	692	697	PF11976	0.368
LIG_SUMO_SIM_par_1	163	168	PF11976	0.519
LIG_SUMO_SIM_par_1	539	545	PF11976	0.395
LIG_SxIP_EBH_1	250	264	PF03271	0.551
LIG_TRAF2_1	719	722	PF00917	0.516
LIG_TYR_ITIM	435	440	PF00017	0.563
LIG_TYR_ITIM	661	666	PF00017	0.493
LIG_UBA3_1	499	506	PF00899	0.470
LIG_WRC_WIRS_1	633	638	PF05994	0.506
LIG_WRC_WIRS_1	853	858	PF05994	0.623
LIG_WW_3	707	711	PF00397	0.540
MOD_CK1_1	157	163	PF00069	0.510
MOD_CK1_1	231	237	PF00069	0.665
MOD_CK1_1	241	247	PF00069	0.559
MOD_CK1_1	314	320	PF00069	0.569
MOD_CK1_1	354	360	PF00069	0.614
MOD_CK1_1	442	448	PF00069	0.514
MOD_CK1_1	486	492	PF00069	0.502
MOD_CK1_1	614	620	PF00069	0.563
MOD_CK1_1	631	637	PF00069	0.497
MOD_CK1_1	754	760	PF00069	0.475
MOD_CK1_1	890	896	PF00069	0.693
MOD_CK2_1	109	115	PF00069	0.731
MOD_CK2_1	135	141	PF00069	0.447
MOD_CK2_1	355	361	PF00069	0.656
MOD_CK2_1	444	450	PF00069	0.487
MOD_CK2_1	511	517	PF00069	0.515
MOD_CK2_1	686	692	PF00069	0.562
MOD_CK2_1	760	766	PF00069	0.467
MOD_CK2_1	863	869	PF00069	0.575
MOD_Cter_Amidation	367	370	PF01082	0.603
MOD_GlcNHglycan	224	227	PF01048	0.419
MOD_GlcNHglycan	398	401	PF01048	0.588
MOD_GlcNHglycan	456	459	PF01048	0.513
MOD_GlcNHglycan	46	50	PF01048	0.533
MOD_GlcNHglycan	704	707	PF01048	0.665
MOD_GlcNHglycan	779	782	PF01048	0.553
MOD_GlcNHglycan	892	895	PF01048	0.684
MOD_GSK3_1	105	112	PF00069	0.746
MOD_GSK3_1	153	160	PF00069	0.549
MOD_GSK3_1	228	235	PF00069	0.551
MOD_GSK3_1	351	358	PF00069	0.603
MOD_GSK3_1	439	446	PF00069	0.576
MOD_GSK3_1	45	52	PF00069	0.545
MOD_GSK3_1	518	525	PF00069	0.501
MOD_GSK3_1	628	635	PF00069	0.501
MOD_GSK3_1	673	680	PF00069	0.648
MOD_GSK3_1	698	705	PF00069	0.670
MOD_GSK3_1	769	776	PF00069	0.487
MOD_GSK3_1	817	824	PF00069	0.562
MOD_GSK3_1	863	870	PF00069	0.641
MOD_N-GLC_1	157	162	PF02516	0.390
MOD_N-GLC_1	592	597	PF02516	0.477
MOD_NEK2_1	154	159	PF00069	0.375
MOD_NEK2_1	186	191	PF00069	0.471
MOD_NEK2_1	44	49	PF00069	0.443
MOD_NEK2_1	483	488	PF00069	0.547
MOD_NEK2_1	50	55	PF00069	0.473
MOD_NEK2_1	523	528	PF00069	0.505
MOD_NEK2_1	628	633	PF00069	0.496
MOD_NEK2_1	649	654	PF00069	0.595
MOD_NEK2_1	760	765	PF00069	0.451
MOD_NEK2_1	834	839	PF00069	0.489
MOD_PIKK_1	592	598	PF00454	0.456
MOD_PK_1	105	111	PF00069	0.520
MOD_PK_1	821	827	PF00069	0.581
MOD_PKA_2	289	295	PF00069	0.533
MOD_PKA_2	442	448	PF00069	0.534
MOD_PKA_2	628	634	PF00069	0.503
MOD_PKA_2	69	75	PF00069	0.567
MOD_PKA_2	862	868	PF00069	0.597
MOD_Plk_1	121	127	PF00069	0.629
MOD_Plk_1	834	840	PF00069	0.499
MOD_Plk_2-3	135	141	PF00069	0.494
MOD_Plk_2-3	409	415	PF00069	0.515
MOD_Plk_4	135	141	PF00069	0.494
MOD_Plk_4	311	317	PF00069	0.502
MOD_Plk_4	393	399	PF00069	0.593
MOD_Plk_4	50	56	PF00069	0.580
MOD_Plk_4	635	641	PF00069	0.430
MOD_Plk_4	821	827	PF00069	0.526
MOD_ProDKin_1	238	244	PF00069	0.468
MOD_ProDKin_1	550	556	PF00069	0.505
MOD_ProDKin_1	643	649	PF00069	0.554
MOD_ProDKin_1	696	702	PF00069	0.607
MOD_ProDKin_1	708	714	PF00069	0.711
MOD_ProDKin_1	730	736	PF00069	0.507
MOD_ProDKin_1	754	760	PF00069	0.520
MOD_SUMO_rev_2	64	72	PF00179	0.558
MOD_SUMO_rev_2	86	91	PF00179	0.487
TRG_DiLeu_BaEn_1	329	334	PF01217	0.461
TRG_DiLeu_BaEn_2	402	408	PF01217	0.537
TRG_DiLeu_BaLyEn_6	382	387	PF01217	0.490
TRG_DiLeu_BaLyEn_6	495	500	PF01217	0.427
TRG_DiLeu_BaLyEn_6	515	520	PF01217	0.544
TRG_DiLeu_BaLyEn_6	794	799	PF01217	0.608
TRG_DiLeu_BaLyEn_6	870	875	PF01217	0.559
TRG_ENDOCYTIC_2	42	45	PF00928	0.403
TRG_ENDOCYTIC_2	437	440	PF00928	0.558
TRG_ENDOCYTIC_2	516	519	PF00928	0.605
TRG_ENDOCYTIC_2	557	560	PF00928	0.499
TRG_ENDOCYTIC_2	56	59	PF00928	0.475
TRG_ENDOCYTIC_2	633	636	PF00928	0.407
TRG_ENDOCYTIC_2	65	68	PF00928	0.536
TRG_ENDOCYTIC_2	663	666	PF00928	0.383
TRG_ENDOCYTIC_2	85	88	PF00928	0.217
TRG_ER_diArg_1	369	371	PF00400	0.585
TRG_ER_diArg_1	382	385	PF00400	0.336
TRG_ER_diArg_1	73	76	PF00400	0.435
TRG_ER_diArg_1	795	797	PF00400	0.589
TRG_ER_diArg_1	81	84	PF00400	0.429
TRG_NLS_MonoExtC_3	148	153	PF00514	0.551
TRG_Pf-PMV_PEXEL_1	29	33	PF00026	0.508
TRG_Pf-PMV_PEXEL_1	384	389	PF00026	0.435
TRG_Pf-PMV_PEXEL_1	796	800	PF00026	0.593
TRG_Pf-PMV_PEXEL_1	808	813	PF00026	0.421
TRG_Pf-PMV_PEXEL_1	859	864	PF00026	0.655

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJ19	Leptomonas seymouri	52%	85%
A0A1X0P5W4	Trypanosomatidae	29%	90%
A0A3Q8IJL5	Leishmania donovani	100%	100%
A0A3R7KBK5	Trypanosoma rangeli	36%	97%
A4HNG4	Leishmania braziliensis	77%	100%
C9ZYE8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	93%
E9AFX5	Leishmania major	93%	100%
E9B728	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%