Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitogen-activated protein kinase - putative

Species:

Leishmania infantum

UniProt:

A4IC54_LEIIN

TriTrypDb:

LINF_350055600

Length:

392

Annotations

LeishMANIAdb annotations

A large and apprently artificial collection of diverse kinetoplastid protein kinases. None of them appear to be TM.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Show entries

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

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Expansion

Sequence features

A4IC54

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IC54

Function

Show entries

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	11
GO:0006793	phosphorus metabolic process	3	11
GO:0006796	phosphate-containing compound metabolic process	4	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0007165	signal transduction	2	1
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0016310	phosphorylation	5	11
GO:0019538	protein metabolic process	3	11
GO:0035556	intracellular signal transduction	3	1

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003824	catalytic activity	1	11
GO:0004672	protein kinase activity	3	11
GO:0004674	protein serine/threonine kinase activity	4	1
GO:0005488	binding	1	11
GO:0005524	ATP binding	5	11
GO:0016301	kinase activity	4	11
GO:0016740	transferase activity	2	11
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	11
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	11

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	326	328	PF00675	0.698
CLV_NRD_NRD_1	343	345	PF00675	0.719
CLV_NRD_NRD_1	55	57	PF00675	0.325
CLV_NRD_NRD_1	95	97	PF00675	0.309
CLV_PCSK_KEX2_1	55	57	PF00082	0.324
CLV_PCSK_SKI1_1	127	131	PF00082	0.325
CLV_PCSK_SKI1_1	265	269	PF00082	0.328
CLV_PCSK_SKI1_1	279	283	PF00082	0.267
CLV_PCSK_SKI1_1	33	37	PF00082	0.348
CLV_PCSK_SKI1_1	77	81	PF00082	0.306

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2E2	Leptomonas seymouri	32%	100%
A0A0N0P2X9	Leptomonas seymouri	34%	100%
A0A0N0P3Z9	Leptomonas seymouri	32%	100%
A0A0N0P407	Leptomonas seymouri	33%	100%
A0A0N0P7D2	Leptomonas seymouri	37%	100%
A0A0N1HS61	Leptomonas seymouri	35%	100%
A0A0N1I0C1	Leptomonas seymouri	35%	88%
A0A0N1I0G1	Leptomonas seymouri	33%	100%
A0A0N1I304	Leptomonas seymouri	31%	67%
A0A0N1I3G0	Leptomonas seymouri	31%	97%

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