C-myc binding protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Homeobox associated leucine zipper - putative

Species:

Leishmania infantum

UniProt:

A4IC44_LEIIN

TriTrypDb:

LINF_350058200

Length:

Annotations

Annotations by Jardim et al.

Transcription, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 4
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

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Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	9
GO:0005815	microtubule organizing center	2	1
GO:0005930	axoneme	2	1
GO:0036064	ciliary basal body	3	1
GO:0043226	organelle	2	9
GO:0043227	membrane-bounded organelle	3	9
GO:0043229	intracellular organelle	3	9
GO:0043231	intracellular membrane-bounded organelle	4	9
GO:0110165	cellular anatomical entity	1	9

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Expansion

Sequence features

A4IC44

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IC44

Function

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Biological processes
Term	Name	Level	Count
GO:0006355	regulation of DNA-templated transcription	6	1
GO:0009889	regulation of biosynthetic process	4	1
GO:0010468	regulation of gene expression	5	1
GO:0010556	regulation of macromolecule biosynthetic process	5	1
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	1
GO:0019222	regulation of metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031326	regulation of cellular biosynthetic process	5	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1

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Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003677	DNA binding	4	1
GO:0003712	transcription coregulator activity	2	9
GO:0003713	transcription coactivator activity	3	9
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:0140110	transcription regulator activity	1	9
GO:1901363	heterocyclic compound binding	2	1

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	13	15	PF00675	0.421
CLV_PCSK_KEX2_1	48	50	PF00082	0.535
CLV_PCSK_PC1ET2_1	48	50	PF00082	0.535
CLV_PCSK_SKI1_1	48	52	PF00082	0.475
LIG_APCC_ABBA_1	31	36	PF00400	0.448
LIG_BIR_II_1	1	5	PF00653	0.533
LIG_FHA_1	18	24	PF00498	0.487
LIG_FHA_1	25	31	PF00498	0.338
LIG_GBD_Chelix_1	22	30	PF00786	0.507
LIG_LIR_Gen_1	56	67	PF02991	0.464

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P616	Leptomonas seymouri	96%	100%
A0A0S4JQH9	Bodo saltans	73%	97%
A0A3S5H811	Leishmania donovani	100%	100%
A4HNI7	Leishmania braziliensis	96%	100%
C9ZYD0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	80%	100%
E9AFZ9	Leishmania major	99%	100%
E9B752	Leishmania mexicana (strain MHOM/GT/2001/U1103)	99%	100%
Q2TBP7	Bos taurus	38%	83%
Q54I57	Dictyostelium discoideum	53%	94%
Q5R7A8	Pongo abelii	39%	83%

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