GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

alpha-1 -2-mannosyltransferase - putative

Species:

Leishmania infantum

UniProt:

A4IC43_LEIIN

TriTrypDb:

LINF_350058100

Length:

466

Annotations

Annotations by Jardim et al.

Glycosylation, alpha-1,2-mannosyltransferase

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12
GO:0005789	endoplasmic reticulum membrane	4	5
GO:0031090	organelle membrane	3	5

Expansion

Sequence features

A4IC43

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IC43

Function

Biological processes
Term	Name	Level	Count
GO:0006486	protein glycosylation	4	5
GO:0006487	protein N-linked glycosylation	5	1
GO:0006490	oligosaccharide-lipid intermediate biosynthetic process	4	1
GO:0006629	lipid metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	5
GO:0008152	metabolic process	1	5
GO:0009058	biosynthetic process	2	1
GO:0009987	cellular process	1	1
GO:0019538	protein metabolic process	3	5
GO:0036211	protein modification process	4	5
GO:0043170	macromolecule metabolic process	3	5
GO:0043412	macromolecule modification	4	5
GO:0043413	macromolecule glycosylation	3	5
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	5
GO:0044255	cellular lipid metabolic process	3	1
GO:0070085	glycosylation	2	5
GO:0071704	organic substance metabolic process	2	5
GO:1901135	carbohydrate derivative metabolic process	3	1
GO:1901137	carbohydrate derivative biosynthetic process	4	1
GO:1901564	organonitrogen compound metabolic process	3	5
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000026	alpha-1,2-mannosyltransferase activity	6	12
GO:0000030	mannosyltransferase activity	5	12
GO:0003824	catalytic activity	1	12
GO:0004376	glycolipid mannosyltransferase activity	6	12
GO:0004377	GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity	7	12
GO:0016740	transferase activity	2	12
GO:0016757	glycosyltransferase activity	3	12
GO:0016758	hexosyltransferase activity	4	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	18	20	PF00675	0.396
CLV_NRD_NRD_1	322	324	PF00675	0.339
CLV_PCSK_KEX2_1	20	22	PF00082	0.384
CLV_PCSK_KEX2_1	324	326	PF00082	0.279
CLV_PCSK_KEX2_1	437	439	PF00082	0.299
CLV_PCSK_KEX2_1	62	64	PF00082	0.286
CLV_PCSK_PC1ET2_1	20	22	PF00082	0.500
CLV_PCSK_PC1ET2_1	324	326	PF00082	0.279
CLV_PCSK_PC1ET2_1	437	439	PF00082	0.306
CLV_PCSK_PC1ET2_1	62	64	PF00082	0.364
CLV_PCSK_SKI1_1	209	213	PF00082	0.346
CLV_PCSK_SKI1_1	59	63	PF00082	0.307
DEG_Nend_Nbox_1	1	3	PF02207	0.442
DOC_CYCLIN_yCln2_LP_2	99	105	PF00134	0.270
DOC_MAPK_FxFP_2	159	162	PF00069	0.329
DOC_MAPK_gen_1	286	295	PF00069	0.263
DOC_MAPK_gen_1	59	68	PF00069	0.273
DOC_MAPK_gen_1	98	108	PF00069	0.302
DOC_MAPK_MEF2A_6	390	398	PF00069	0.339
DOC_PP1_RVXF_1	41	47	PF00149	0.245
DOC_PP1_RVXF_1	429	436	PF00149	0.321
DOC_PP1_RVXF_1	99	106	PF00149	0.388
DOC_PP2B_LxvP_1	256	259	PF13499	0.360
DOC_PP4_FxxP_1	159	162	PF00568	0.368
DOC_USP7_MATH_1	179	183	PF00917	0.273
DOC_USP7_MATH_1	266	270	PF00917	0.484
DOC_USP7_MATH_1	80	84	PF00917	0.420
DOC_WW_Pin1_4	145	150	PF00397	0.299
DOC_WW_Pin1_4	398	403	PF00397	0.305
LIG_14-3-3_CanoR_1	123	127	PF00244	0.374
LIG_14-3-3_CanoR_1	25	29	PF00244	0.415
LIG_14-3-3_CanoR_1	278	283	PF00244	0.398
LIG_Actin_WH2_2	93	111	PF00022	0.378
LIG_BIR_III_2	119	123	PF00653	0.321
LIG_eIF4E_1	121	127	PF01652	0.245
LIG_eIF4E_1	161	167	PF01652	0.260
LIG_eIF4E_1	216	222	PF01652	0.339
LIG_FHA_1	1	7	PF00498	0.426
LIG_FHA_1	111	117	PF00498	0.259
LIG_FHA_1	123	129	PF00498	0.214
LIG_FHA_1	146	152	PF00498	0.267
LIG_FHA_1	184	190	PF00498	0.317
LIG_FHA_1	451	457	PF00498	0.446
LIG_FHA_1	9	15	PF00498	0.431
LIG_FHA_2	347	353	PF00498	0.339
LIG_FHA_2	364	370	PF00498	0.196
LIG_FHA_2	408	414	PF00498	0.281
LIG_LIR_Gen_1	217	226	PF02991	0.236
LIG_LIR_Gen_1	3	12	PF02991	0.442
LIG_LIR_Gen_1	403	414	PF02991	0.388
LIG_LIR_Gen_1	453	463	PF02991	0.366
LIG_LIR_Nem_3	119	124	PF02991	0.302
LIG_LIR_Nem_3	174	178	PF02991	0.279
LIG_LIR_Nem_3	217	222	PF02991	0.390
LIG_LIR_Nem_3	3	7	PF02991	0.454
LIG_LIR_Nem_3	369	375	PF02991	0.241
LIG_LIR_Nem_3	403	409	PF02991	0.341
LIG_LIR_Nem_3	430	435	PF02991	0.339
LIG_LIR_Nem_3	453	458	PF02991	0.446
LIG_LYPXL_S_1	160	164	PF13949	0.218
LIG_LYPXL_yS_3	121	124	PF13949	0.279
LIG_LYPXL_yS_3	161	164	PF13949	0.245
LIG_LYPXL_yS_3	178	181	PF13949	0.245
LIG_NRBOX	123	129	PF00104	0.329
LIG_PDZ_Class_2	461	466	PF00595	0.417
LIG_Pex14_2	451	455	PF04695	0.307
LIG_SH2_SRC	462	465	PF00017	0.374
LIG_SH2_STAP1	139	143	PF00017	0.279
LIG_SH2_STAP1	414	418	PF00017	0.279
LIG_SH2_STAT5	107	110	PF00017	0.317
LIG_SH2_STAT5	175	178	PF00017	0.245
LIG_SH2_STAT5	379	382	PF00017	0.305
LIG_SH2_STAT5	432	435	PF00017	0.278
LIG_SH2_STAT5	462	465	PF00017	0.374
LIG_SH2_STAT5	65	68	PF00017	0.269
LIG_SH3_3	152	158	PF00018	0.245
LIG_SH3_3	300	306	PF00018	0.260
LIG_SH3_3	396	402	PF00018	0.164
LIG_SUMO_SIM_anti_2	395	401	PF11976	0.321
LIG_SUMO_SIM_anti_2	5	11	PF11976	0.438
LIG_SUMO_SIM_par_1	124	130	PF11976	0.294
LIG_SUMO_SIM_par_1	148	154	PF11976	0.305
LIG_SUMO_SIM_par_1	373	378	PF11976	0.260
LIG_SUMO_SIM_par_1	417	423	PF11976	0.333
LIG_SUMO_SIM_par_1	5	11	PF11976	0.388
LIG_SUMO_SIM_par_1	86	92	PF11976	0.321
LIG_TRAF2_1	410	413	PF00917	0.282
LIG_TYR_ITIM	213	218	PF00017	0.238
LIG_TYR_ITSM	174	181	PF00017	0.260
LIG_UBA3_1	87	93	PF00899	0.371
LIG_Vh1_VBS_1	207	225	PF01044	0.321
LIG_WRC_WIRS_1	1	6	PF05994	0.390
LIG_WRC_WIRS_1	128	133	PF05994	0.381
LIG_WRC_WIRS_1	443	448	PF05994	0.410
MOD_CK1_1	183	189	PF00069	0.341
MOD_CK1_1	237	243	PF00069	0.245
MOD_CK1_1	450	456	PF00069	0.299
MOD_CK1_1	79	85	PF00069	0.319
MOD_CK2_1	346	352	PF00069	0.371
MOD_CK2_1	407	413	PF00069	0.261
MOD_CK2_1	86	92	PF00069	0.346
MOD_GlcNHglycan	116	119	PF01048	0.331
MOD_GlcNHglycan	182	185	PF01048	0.388
MOD_GlcNHglycan	390	393	PF01048	0.251
MOD_GlcNHglycan	78	81	PF01048	0.407
MOD_GSK3_1	110	117	PF00069	0.353
MOD_GSK3_1	179	186	PF00069	0.323
MOD_GSK3_1	194	201	PF00069	0.365
MOD_GSK3_1	442	449	PF00069	0.480
MOD_GSK3_1	76	83	PF00069	0.360
MOD_N-GLC_1	235	240	PF02516	0.305
MOD_N-GLC_1	346	351	PF02516	0.371
MOD_NEK2_1	127	132	PF00069	0.300
MOD_NEK2_1	2	7	PF00069	0.401
MOD_NEK2_1	234	239	PF00069	0.249
MOD_NEK2_1	346	351	PF00069	0.254
MOD_NEK2_1	446	451	PF00069	0.439
MOD_NEK2_2	363	368	PF00069	0.321
MOD_PIKK_1	183	189	PF00454	0.368
MOD_PIKK_1	237	243	PF00454	0.317
MOD_PIKK_1	266	272	PF00454	0.365
MOD_PK_1	278	284	PF00069	0.321
MOD_PK_1	93	99	PF00069	0.273
MOD_PKA_1	437	443	PF00069	0.411
MOD_PKA_2	122	128	PF00069	0.356
MOD_PKA_2	24	30	PF00069	0.339
MOD_PKA_2	437	443	PF00069	0.317
MOD_PKA_2	76	82	PF00069	0.321
MOD_Plk_1	235	241	PF00069	0.305
MOD_Plk_1	346	352	PF00069	0.371
MOD_Plk_1	446	452	PF00069	0.296
MOD_Plk_4	122	128	PF00069	0.260
MOD_Plk_4	168	174	PF00069	0.250
MOD_Plk_4	243	249	PF00069	0.415
MOD_Plk_4	86	92	PF00069	0.395
MOD_ProDKin_1	145	151	PF00069	0.299
MOD_ProDKin_1	398	404	PF00069	0.305
MOD_SUMO_rev_2	321	326	PF00179	0.283
TRG_DiLeu_BaEn_1	217	222	PF01217	0.236
TRG_DiLeu_BaLyEn_6	159	164	PF01217	0.245
TRG_DiLeu_BaLyEn_6	95	100	PF01217	0.455
TRG_ENDOCYTIC_2	121	124	PF00928	0.245
TRG_ENDOCYTIC_2	161	164	PF00928	0.251
TRG_ENDOCYTIC_2	178	181	PF00928	0.249
TRG_ENDOCYTIC_2	215	218	PF00928	0.253
TRG_ENDOCYTIC_2	223	226	PF00928	0.258
TRG_ENDOCYTIC_2	432	435	PF00928	0.260
TRG_ENDOCYTIC_2	65	68	PF00928	0.393
TRG_ER_diArg_1	188	191	PF00400	0.314
TRG_ER_diArg_1	323	326	PF00400	0.261
TRG_ER_diArg_1	424	427	PF00400	0.416
TRG_ER_diArg_1	451	454	PF00400	0.404
TRG_Pf-PMV_PEXEL_1	114	119	PF00026	0.305

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6F7	Leptomonas seymouri	66%	100%
A0A0S4INF7	Bodo saltans	24%	92%
A0A0S4JLQ0	Bodo saltans	42%	99%
A0A1X0P5V7	Trypanosomatidae	50%	98%
A0A3R7K7Z3	Trypanosoma rangeli	49%	98%
A0A3S7XA76	Leishmania donovani	100%	100%
A4HNI6	Leishmania braziliensis	87%	100%
C9ZYD9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	99%
E9AFZ8	Leishmania major	94%	100%
E9B751	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
O74878	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	34%	99%
P53954	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	31%	85%
P53993	Caenorhabditis elegans	33%	99%
Q08B22	Xenopus laevis	38%	96%
Q2TAA5	Homo sapiens	38%	95%
Q3TZM9	Mus musculus	38%	95%
Q54DM9	Dictyostelium discoideum	36%	92%
Q59S72	Candida albicans (strain SC5314 / ATCC MYA-2876)	31%	77%
Q5R7Z6	Pongo abelii	38%	95%
Q6BVB2	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	32%	76%
Q6C9T3	Yarrowia lipolytica (strain CLIB 122 / E 150)	36%	73%
Q6CLD6	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	29%	82%
Q6FWD1	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	34%	92%
Q6P312	Xenopus tropicalis	38%	96%
Q75B12	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	33%	80%
Q7ZW24	Danio rerio	37%	93%
Q8X092	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	32%	84%
Q9XEE9	Arabidopsis thaliana	38%	100%
V5BPD4	Trypanosoma cruzi	50%	98%