Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4IC42_LEIIN

TriTrypDb:

LINF_350058000

Length:

270

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 6, no: 0
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4IC42

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IC42

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	113	117	PF00656	0.426
CLV_NRD_NRD_1	146	148	PF00675	0.590
CLV_NRD_NRD_1	26	28	PF00675	0.542
CLV_PCSK_SKI1_1	137	141	PF00082	0.544
CLV_PCSK_SKI1_1	244	248	PF00082	0.647
DOC_CKS1_1	169	174	PF01111	0.378
DOC_CYCLIN_yCln2_LP_2	119	122	PF00134	0.422
DOC_MAPK_HePTP_8	199	211	PF00069	0.383
DOC_MAPK_MEF2A_6	202	211	PF00069	0.384
DOC_PP2B_LxvP_1	119	122	PF13499	0.422
DOC_PP2B_LxvP_1	19	22	PF13499	0.566
DOC_PP2B_LxvP_1	194	197	PF13499	0.371
DOC_PP2B_LxvP_1	94	97	PF13499	0.331
DOC_PP4_FxxP_1	181	184	PF00568	0.390
DOC_USP7_MATH_1	184	188	PF00917	0.403
DOC_USP7_MATH_1	249	253	PF00917	0.275
DOC_WW_Pin1_4	168	173	PF00397	0.334
DOC_WW_Pin1_4	180	185	PF00397	0.366
DOC_WW_Pin1_4	201	206	PF00397	0.390
DOC_WW_Pin1_4	236	241	PF00397	0.347
LIG_14-3-3_CanoR_1	134	140	PF00244	0.312
LIG_14-3-3_CanoR_1	82	88	PF00244	0.337
LIG_BIR_III_2	33	37	PF00653	0.358
LIG_BRCT_BRCA1_1	197	201	PF00533	0.371
LIG_deltaCOP1_diTrp_1	130	139	PF00928	0.312
LIG_FHA_1	122	128	PF00498	0.417
LIG_FHA_1	130	136	PF00498	0.287
LIG_FHA_1	214	220	PF00498	0.390
LIG_FHA_1	245	251	PF00498	0.300
LIG_FHA_1	50	56	PF00498	0.266
LIG_GBD_Chelix_1	262	270	PF00786	0.308
LIG_LIR_Apic_2	180	184	PF02991	0.394
LIG_LIR_Gen_1	221	227	PF02991	0.361
LIG_LIR_Gen_1	64	71	PF02991	0.487
LIG_LIR_Nem_3	221	225	PF02991	0.362
LIG_LIR_Nem_3	64	69	PF02991	0.491
LIG_NRBOX	2	8	PF00104	0.409
LIG_NRBOX	263	269	PF00104	0.379
LIG_PDZ_Class_2	265	270	PF00595	0.524
LIG_PDZ_Wminus1_1	268	270	PF00595	0.621
LIG_SH2_CRK	66	70	PF00017	0.378
LIG_SH2_CRK	84	88	PF00017	0.379
LIG_SH2_STAP1	66	70	PF00017	0.375
LIG_SH2_STAP1	84	88	PF00017	0.371
LIG_SH2_STAT5	84	87	PF00017	0.405
LIG_SH2_STAT5	93	96	PF00017	0.314
LIG_SH3_3	33	39	PF00018	0.334
LIG_SH3_3	94	100	PF00018	0.293
LIG_SH3_5	232	236	PF00018	0.402
LIG_SUMO_SIM_anti_2	260	266	PF11976	0.275
LIG_SUMO_SIM_par_1	223	231	PF11976	0.368
LIG_SUMO_SIM_par_1	6	12	PF11976	0.419
MOD_CK1_1	123	129	PF00069	0.411
MOD_CK1_1	167	173	PF00069	0.397
MOD_CK1_1	180	186	PF00069	0.342
MOD_CK1_1	213	219	PF00069	0.402
MOD_CK1_1	49	55	PF00069	0.271
MOD_GlcNHglycan	251	254	PF01048	0.414
MOD_GlcNHglycan	255	258	PF01048	0.400
MOD_GlcNHglycan	259	262	PF01048	0.391
MOD_GlcNHglycan	66	69	PF01048	0.605
MOD_GSK3_1	163	170	PF00069	0.338
MOD_GSK3_1	180	187	PF00069	0.310
MOD_GSK3_1	197	204	PF00069	0.291
MOD_GSK3_1	249	256	PF00069	0.500
MOD_N-GLC_1	174	179	PF02516	0.593
MOD_N-GLC_1	227	232	PF02516	0.589
MOD_N-GLC_2	51	53	PF02516	0.550
MOD_NEK2_1	174	179	PF00069	0.407
MOD_NEK2_1	9	14	PF00069	0.526
MOD_NEK2_2	197	202	PF00069	0.445
MOD_OFUCOSY	161	168	PF10250	0.549
MOD_PIKK_1	213	219	PF00454	0.368
MOD_PIKK_1	77	83	PF00454	0.429
MOD_PK_1	106	112	PF00069	0.377
MOD_Plk_1	129	135	PF00069	0.316
MOD_Plk_4	210	216	PF00069	0.366
MOD_Plk_4	83	89	PF00069	0.380
MOD_Plk_4	9	15	PF00069	0.564
MOD_ProDKin_1	168	174	PF00069	0.335
MOD_ProDKin_1	180	186	PF00069	0.372
MOD_ProDKin_1	201	207	PF00069	0.386
MOD_ProDKin_1	236	242	PF00069	0.342
TRG_ENDOCYTIC_2	66	69	PF00928	0.380
TRG_ENDOCYTIC_2	84	87	PF00928	0.348
TRG_ENDOCYTIC_2	93	96	PF00928	0.265
TRG_NES_CRM1_1	217	231	PF08389	0.332

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBL7	Leptomonas seymouri	70%	100%
A0A0S4JP52	Bodo saltans	41%	97%
A0A3S7XA33	Leishmania donovani	99%	100%
E9AFZ7	Leishmania major	95%	100%
E9B750	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%