C3H1-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Zinc finger C-x8-C-x5-C-x3-H type (and similar) - putative

Species:

Leishmania infantum

UniProt:

A4IC38_LEIIN

TriTrypDb:

LINF_350057600

Length:

257

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4IC38

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IC38

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	11	13	PF00675	0.517
CLV_PCSK_KEX2_1	11	13	PF00082	0.517
CLV_PCSK_SKI1_1	27	31	PF00082	0.453
CLV_Separin_Metazoa	17	21	PF03568	0.474
DOC_CDC14_PxL_1	227	235	PF14671	0.632
DOC_CKS1_1	125	130	PF01111	0.597
DOC_CKS1_1	233	238	PF01111	0.675
DOC_CKS1_1	5	10	PF01111	0.511
DOC_MAPK_MEF2A_6	94	103	PF00069	0.432
DOC_USP7_MATH_1	111	115	PF00917	0.491
DOC_USP7_MATH_1	143	147	PF00917	0.628
DOC_USP7_MATH_1	174	178	PF00917	0.598
DOC_USP7_MATH_1	186	190	PF00917	0.604
DOC_USP7_MATH_1	192	196	PF00917	0.530
DOC_USP7_MATH_1	245	249	PF00917	0.709
DOC_WW_Pin1_4	124	129	PF00397	0.551
DOC_WW_Pin1_4	172	177	PF00397	0.623
DOC_WW_Pin1_4	232	237	PF00397	0.619
DOC_WW_Pin1_4	35	40	PF00397	0.350
DOC_WW_Pin1_4	4	9	PF00397	0.520
LIG_BIR_II_1	1	5	PF00653	0.672
LIG_FHA_1	125	131	PF00498	0.554
LIG_FHA_1	49	55	PF00498	0.529
LIG_LIR_Apic_2	107	111	PF02991	0.488
LIG_LIR_Gen_1	40	47	PF02991	0.313
LIG_LIR_Gen_1	97	106	PF02991	0.456
LIG_LIR_Nem_3	177	182	PF02991	0.627
LIG_LIR_Nem_3	248	254	PF02991	0.734
LIG_LIR_Nem_3	40	46	PF02991	0.313
LIG_LIR_Nem_3	97	101	PF02991	0.437
LIG_SH2_CRK	98	102	PF00017	0.428
LIG_SH2_GRB2like	108	111	PF00017	0.492
LIG_SH2_GRB2like	182	185	PF00017	0.685
LIG_SH2_NCK_1	182	186	PF00017	0.619
LIG_SH2_SRC	108	111	PF00017	0.492
LIG_SH2_SRC	182	185	PF00017	0.622
LIG_SH2_STAT3	93	96	PF00017	0.404
LIG_SH2_STAT5	108	111	PF00017	0.492
LIG_SH2_STAT5	251	254	PF00017	0.562
LIG_SH3_3	122	128	PF00018	0.655
LIG_SH3_3	130	136	PF00018	0.596
LIG_SH3_3	149	155	PF00018	0.430
LIG_SH3_3	196	202	PF00018	0.754
LIG_SH3_3	36	42	PF00018	0.349
LIG_SH3_3	89	95	PF00018	0.432
LIG_SH3_3	98	104	PF00018	0.456
LIG_WRC_WIRS_1	58	63	PF05994	0.404
MOD_CDK_SPxxK_3	4	11	PF00069	0.516
MOD_CK1_1	114	120	PF00069	0.518
MOD_CK1_1	195	201	PF00069	0.658
MOD_CK1_1	57	63	PF00069	0.410
MOD_GlcNHglycan	194	197	PF01048	0.691
MOD_GlcNHglycan	87	90	PF01048	0.579
MOD_GSK3_1	160	167	PF00069	0.600
MOD_GSK3_1	168	175	PF00069	0.613
MOD_GSK3_1	186	193	PF00069	0.665
MOD_GSK3_1	29	36	PF00069	0.501
MOD_NEK2_1	164	169	PF00069	0.697
MOD_NEK2_1	29	34	PF00069	0.340
MOD_NEK2_1	75	80	PF00069	0.398
MOD_NEK2_1	85	90	PF00069	0.466
MOD_NEK2_2	143	148	PF00069	0.516
MOD_OFUCOSY	35	41	PF10250	0.313
MOD_PIKK_1	154	160	PF00454	0.623
MOD_PIKK_1	164	170	PF00454	0.723
MOD_PIKK_1	186	192	PF00454	0.617
MOD_PIKK_1	218	224	PF00454	0.562
MOD_PIKK_1	239	245	PF00454	0.730
MOD_PIKK_1	60	66	PF00454	0.421
MOD_PIKK_1	75	81	PF00454	0.409
MOD_PKA_2	33	39	PF00069	0.453
MOD_Plk_4	160	166	PF00069	0.602
MOD_Plk_4	195	201	PF00069	0.592
MOD_Plk_4	57	63	PF00069	0.416
MOD_Plk_4	70	76	PF00069	0.411
MOD_ProDKin_1	124	130	PF00069	0.552
MOD_ProDKin_1	172	178	PF00069	0.623
MOD_ProDKin_1	232	238	PF00069	0.619
MOD_ProDKin_1	35	41	PF00069	0.350
MOD_ProDKin_1	4	10	PF00069	0.517
TRG_ENDOCYTIC_2	251	254	PF00928	0.543
TRG_ENDOCYTIC_2	43	46	PF00928	0.335
TRG_ENDOCYTIC_2	98	101	PF00928	0.438

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IL43	Leptomonas seymouri	55%	90%
A0A3S7XA28	Leishmania donovani	99%	100%
A4HNI2	Leishmania braziliensis	81%	100%
E9AFZ3	Leishmania major	93%	100%
E9B746	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%