LeishMANIAdb
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Putative folate/biopterin transporter

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative folate/biopterin transporter
Gene product:
NIMA-related kinase - putative
Species:
Leishmania infantum
UniProt:
A4IC37_LEIIN
TriTrypDb:
LINF_350057500
Length:
477

Annotations

LeishMANIAdb annotations

A large and apprently artificial collection of diverse kinetoplastid protein kinases. None of them appear to be TM.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 6
Forrest at al. (procyclic) no yes: 6
Silverman et al. no yes: 0
Pissara et al. no yes: 42
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 5
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 10
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 77
NetGPI no yes: 0, no: 77
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4IC37
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IC37

Function

Biological processes
Term Name Level Count
GO:0006468 protein phosphorylation 5 78
GO:0006793 phosphorus metabolic process 3 78
GO:0006796 phosphate-containing compound metabolic process 4 78
GO:0006807 nitrogen compound metabolic process 2 78
GO:0008152 metabolic process 1 78
GO:0009987 cellular process 1 78
GO:0016310 phosphorylation 5 78
GO:0019538 protein metabolic process 3 78
GO:0036211 protein modification process 4 78
GO:0043170 macromolecule metabolic process 3 78
GO:0043412 macromolecule modification 4 78
GO:0044237 cellular metabolic process 2 78
GO:0044238 primary metabolic process 2 78
GO:0071704 organic substance metabolic process 2 78
GO:1901564 organonitrogen compound metabolic process 3 78
GO:0007165 signal transduction 2 1
GO:0035556 intracellular signal transduction 3 1
GO:0050789 regulation of biological process 2 1
GO:0050794 regulation of cellular process 3 1
GO:0065007 biological regulation 1 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 78
GO:0003824 catalytic activity 1 78
GO:0004672 protein kinase activity 3 78
GO:0005488 binding 1 78
GO:0005524 ATP binding 5 78
GO:0016301 kinase activity 4 78
GO:0016740 transferase activity 2 78
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 78
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 78
GO:0017076 purine nucleotide binding 4 78
GO:0030554 adenyl nucleotide binding 5 78
GO:0032553 ribonucleotide binding 3 78
GO:0032555 purine ribonucleotide binding 4 78
GO:0032559 adenyl ribonucleotide binding 5 78
GO:0035639 purine ribonucleoside triphosphate binding 4 78
GO:0036094 small molecule binding 2 78
GO:0043167 ion binding 2 78
GO:0043168 anion binding 3 78
GO:0097159 organic cyclic compound binding 2 78
GO:0097367 carbohydrate derivative binding 2 78
GO:0140096 catalytic activity, acting on a protein 2 78
GO:1901265 nucleoside phosphate binding 3 78
GO:1901363 heterocyclic compound binding 2 78
GO:0004674 protein serine/threonine kinase activity 4 50

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 187 189 PF00675 0.301
CLV_NRD_NRD_1 243 245 PF00675 0.266
CLV_PCSK_KEX2_1 187 189 PF00082 0.417
CLV_PCSK_KEX2_1 245 247 PF00082 0.282
CLV_PCSK_KEX2_1 393 395 PF00082 0.294
CLV_PCSK_PC1ET2_1 245 247 PF00082 0.333
CLV_PCSK_PC1ET2_1 393 395 PF00082 0.296
CLV_PCSK_SKI1_1 106 110 PF00082 0.440
CLV_PCSK_SKI1_1 138 142 PF00082 0.315
CLV_PCSK_SKI1_1 153 157 PF00082 0.261
CLV_PCSK_SKI1_1 192 196 PF00082 0.304
CLV_PCSK_SKI1_1 268 272 PF00082 0.305
CLV_Separin_Metazoa 349 353 PF03568 0.452
DEG_APCC_DBOX_1 111 119 PF00400 0.410
DEG_COP1_1 424 435 PF00400 0.333
DEG_SPOP_SBC_1 293 297 PF00917 0.161
DOC_CDC14_PxL_1 235 243 PF14671 0.290
DOC_MAPK_gen_1 156 165 PF00069 0.358
DOC_MAPK_gen_1 192 201 PF00069 0.307
DOC_MAPK_MEF2A_6 134 143 PF00069 0.290
DOC_MAPK_MEF2A_6 21 28 PF00069 0.513
DOC_MAPK_MEF2A_6 439 448 PF00069 0.350
DOC_PP4_FxxP_1 200 203 PF00568 0.295
DOC_PP4_FxxP_1 270 273 PF00568 0.295
DOC_PP4_FxxP_1 290 293 PF00568 0.266
DOC_PP4_FxxP_1 430 433 PF00568 0.260
DOC_USP7_MATH_1 293 297 PF00917 0.361
DOC_USP7_MATH_1 362 366 PF00917 0.531
DOC_USP7_UBL2_3 134 138 PF12436 0.273
DOC_USP7_UBL2_3 156 160 PF12436 0.283
DOC_USP7_UBL2_3 245 249 PF12436 0.241
DOC_USP7_UBL2_3 94 98 PF12436 0.401
DOC_WW_Pin1_4 230 235 PF00397 0.308
DOC_WW_Pin1_4 340 345 PF00397 0.526
LIG_14-3-3_CanoR_1 106 111 PF00244 0.328
LIG_14-3-3_CanoR_1 313 320 PF00244 0.282
LIG_14-3-3_CanoR_1 337 344 PF00244 0.374
LIG_14-3-3_CanoR_1 404 408 PF00244 0.290
LIG_14-3-3_CanoR_1 76 84 PF00244 0.438
LIG_AP2alpha_2 288 290 PF02296 0.263
LIG_APCC_ABBAyCdc20_2 187 193 PF00400 0.311
LIG_Clathr_ClatBox_1 140 144 PF01394 0.252
LIG_deltaCOP1_diTrp_1 388 396 PF00928 0.289
LIG_deltaCOP1_diTrp_1 465 471 PF00928 0.357
LIG_eIF4E_1 168 174 PF01652 0.351
LIG_eIF4E_1 22 28 PF01652 0.404
LIG_eIF4E_1 68 74 PF01652 0.371
LIG_FHA_1 11 17 PF00498 0.470
LIG_FHA_1 202 208 PF00498 0.277
LIG_FHA_1 314 320 PF00498 0.322
LIG_FHA_1 346 352 PF00498 0.509
LIG_FHA_1 371 377 PF00498 0.464
LIG_FHA_1 69 75 PF00498 0.447
LIG_FHA_2 27 33 PF00498 0.359
LIG_FHA_2 423 429 PF00498 0.337
LIG_FHA_2 458 464 PF00498 0.294
LIG_HCF-1_HBM_1 65 68 PF13415 0.499
LIG_LIR_Apic_2 233 239 PF02991 0.307
LIG_LIR_Apic_2 288 293 PF02991 0.298
LIG_LIR_Apic_2 428 433 PF02991 0.332
LIG_LIR_Nem_3 322 327 PF02991 0.389
LIG_NRBOX 259 265 PF00104 0.245
LIG_Pex14_1 391 395 PF04695 0.271
LIG_Pex14_1 467 471 PF04695 0.331
LIG_SH2_CRK 175 179 PF00017 0.333
LIG_SH2_GRB2like 457 460 PF00017 0.155
LIG_SH2_SRC 175 178 PF00017 0.308
LIG_SH2_STAP1 19 23 PF00017 0.364
LIG_SH2_STAP1 218 222 PF00017 0.276
LIG_SH2_STAP1 247 251 PF00017 0.322
LIG_SH2_STAP1 457 461 PF00017 0.323
LIG_SH2_STAT5 22 25 PF00017 0.402
LIG_SH2_STAT5 236 239 PF00017 0.299
LIG_SH2_STAT5 327 330 PF00017 0.394
LIG_SH2_STAT5 381 384 PF00017 0.298
LIG_SH2_STAT5 395 398 PF00017 0.278
LIG_SH2_STAT5 68 71 PF00017 0.368
LIG_SH3_3 47 53 PF00018 0.541
LIG_SUMO_SIM_anti_2 135 144 PF11976 0.247
LIG_SUMO_SIM_par_1 135 144 PF11976 0.309
LIG_SUMO_SIM_par_1 177 183 PF11976 0.239
LIG_TRAF2_1 164 167 PF00917 0.379
LIG_TRFH_1 235 239 PF08558 0.268
LIG_TYR_ITIM 173 178 PF00017 0.300
LIG_TYR_ITIM 259 264 PF00017 0.318
LIG_UBA3_1 263 271 PF00899 0.284
LIG_UBA3_1 301 308 PF00899 0.300
MOD_CDK_SPxxK_3 340 347 PF00069 0.288
MOD_CK1_1 10 16 PF00069 0.436
MOD_CK1_1 345 351 PF00069 0.480
MOD_CK1_1 374 380 PF00069 0.352
MOD_CK1_1 89 95 PF00069 0.300
MOD_CK2_1 26 32 PF00069 0.407
MOD_CK2_1 271 277 PF00069 0.385
MOD_CK2_1 403 409 PF00069 0.296
MOD_GlcNHglycan 146 149 PF01048 0.264
MOD_GlcNHglycan 195 198 PF01048 0.339
MOD_GlcNHglycan 356 359 PF01048 0.346
MOD_GlcNHglycan 9 12 PF01048 0.613
MOD_GSK3_1 106 113 PF00069 0.334
MOD_GSK3_1 212 219 PF00069 0.303
MOD_GSK3_1 226 233 PF00069 0.304
MOD_GSK3_1 336 343 PF00069 0.450
MOD_GSK3_1 370 377 PF00069 0.533
MOD_NEK2_1 212 217 PF00069 0.323
MOD_NEK2_1 403 408 PF00069 0.280
MOD_NEK2_1 466 471 PF00069 0.294
MOD_NEK2_1 83 88 PF00069 0.422
MOD_PIKK_1 271 277 PF00454 0.329
MOD_PIKK_1 313 319 PF00454 0.246
MOD_PIKK_1 371 377 PF00454 0.491
MOD_PIKK_1 434 440 PF00454 0.330
MOD_PKA_1 245 251 PF00069 0.349
MOD_PKA_2 245 251 PF00069 0.311
MOD_PKA_2 312 318 PF00069 0.299
MOD_PKA_2 336 342 PF00069 0.386
MOD_PKA_2 403 409 PF00069 0.339
MOD_PKA_2 86 92 PF00069 0.396
MOD_Plk_2-3 132 138 PF00069 0.273
MOD_Plk_2-3 220 226 PF00069 0.295
MOD_Plk_4 69 75 PF00069 0.466
MOD_ProDKin_1 230 236 PF00069 0.308
MOD_ProDKin_1 340 346 PF00069 0.525
MOD_SUMO_rev_2 131 140 PF00179 0.374
TRG_DiLeu_BaLyEn_6 301 306 PF01217 0.394
TRG_ENDOCYTIC_2 175 178 PF00928 0.297
TRG_ENDOCYTIC_2 261 264 PF00928 0.299
TRG_ENDOCYTIC_2 287 290 PF00928 0.250
TRG_ENDOCYTIC_2 369 372 PF00928 0.484
TRG_ENDOCYTIC_2 395 398 PF00928 0.306
TRG_ER_diArg_1 187 189 PF00400 0.415
TRG_ER_diArg_1 244 247 PF00400 0.285
TRG_NLS_MonoExtN_4 390 396 PF00514 0.297
TRG_Pf-PMV_PEXEL_1 276 280 PF00026 0.286
TRG_Pf-PMV_PEXEL_1 352 356 PF00026 0.474

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P3N5 Leptomonas seymouri 38% 100%
A0A0N0P953 Leptomonas seymouri 88% 100%
A0A0N1I9A0 Leptomonas seymouri 28% 73%
A0A0N1PD05 Leptomonas seymouri 36% 100%
A0A0S4IMB7 Bodo saltans 38% 100%
A0A0S4IQ75 Bodo saltans 30% 95%
A0A0S4IRZ7 Bodo saltans 35% 97%
A0A0S4IVW1 Bodo saltans 29% 76%
A0A0S4IX86 Bodo saltans 38% 100%
A0A0S4J804 Bodo saltans 64% 91%
A0A0S4JIJ6 Bodo saltans 25% 84%
A0A0S4JPZ1 Bodo saltans 35% 100%
A0A1X0NIA0 Trypanosomatidae 39% 100%
A0A1X0NIX2 Trypanosomatidae 34% 100%
A0A1X0NUB2 Trypanosomatidae 32% 82%
A0A1X0P527 Trypanosomatidae 38% 100%
A0A1X0P549 Trypanosomatidae 75% 100%
A0A1X0P863 Trypanosomatidae 36% 96%
A0A1X0P994 Trypanosomatidae 34% 96%
A0A3Q8IAQ1 Leishmania donovani 38% 100%
A0A3Q8IC87 Leishmania donovani 30% 100%
A0A3Q8IFW0 Leishmania donovani 38% 100%
A0A3Q8IJM9 Leishmania donovani 99% 100%
A0A3Q8INQ4 Leishmania donovani 31% 100%
A0A3R7KCZ4 Trypanosoma rangeli 40% 100%
A0A3R7MKG5 Trypanosoma rangeli 37% 100%
A0A3S5H5U5 Leishmania donovani 25% 100%
A0A3S7X5M4 Leishmania donovani 29% 73%
A0A3S7X6T8 Leishmania donovani 35% 100%
A0A3S7XAL3 Leishmania donovani 36% 96%
A0A3S7XAT9 Leishmania donovani 36% 95%
A0A422NCP0 Trypanosoma rangeli 36% 96%
A0A422NH41 Trypanosoma rangeli 33% 83%
A4H4S9 Leishmania braziliensis 25% 100%
A4HED7 Leishmania braziliensis 31% 100%
A4HH03 Leishmania braziliensis 28% 100%
A4HJT5 Leishmania braziliensis 36% 100%
A4HJW2 Leishmania braziliensis 37% 100%
A4HKG9 Leishmania braziliensis 29% 100%
A4HLR0 Leishmania braziliensis 36% 100%
A4HNI1 Leishmania braziliensis 90% 100%
A4HP12 Leishmania braziliensis 35% 100%
A4HP13 Leishmania braziliensis 36% 100%
A4HZV1 Leishmania infantum 30% 100%
A4HZW8 Leishmania infantum 38% 100%
A4I1T4 Leishmania infantum 31% 100%
A4I7C4 Leishmania infantum 38% 100%
A4I7Z6 Leishmania infantum 29% 100%
A4I960 Leishmania infantum 35% 100%
A4IDC1 Leishmania infantum 35% 94%
A4IDC2 Leishmania infantum 36% 95%
C9ZMH9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 35% 100%
C9ZWI1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 39% 100%
C9ZWK2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 38% 100%
D0A2Z1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 35% 97%
D0A2Z6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 35% 97%
D0AA64 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 34% 83%
E9AFZ2 Leishmania major 97% 100%
E9AG71 Leishmania infantum 25% 100%
E9AKZ7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 25% 100%
E9ASS2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 35% 100%
E9ASS3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 36% 100%
E9AVR5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 30% 100%
E9AXW8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 32% 100%
E9B0C2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 100%
E9B296 Leishmania mexicana (strain MHOM/GT/2001/U1103) 43% 100%
E9B2B7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 38% 100%
E9B2V8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 73%
E9B436 Leishmania mexicana (strain MHOM/GT/2001/U1103) 39% 100%
E9B4Z4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 28% 100%
E9B745 Leishmania mexicana (strain MHOM/GT/2001/U1103) 96% 100%
P49071 Drosophila melanogaster 28% 100%
Q00771 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) 27% 100%
Q03428 Trypanosoma brucei brucei 38% 100%
Q08942 Trypanosoma brucei brucei 39% 100%
Q4Q1S3 Leishmania major 38% 100%
Q4Q1S4 Leishmania major 34% 100%
Q4Q3Y9 Leishmania major 35% 100%
Q4Q598 Leishmania major 30% 100%
Q4Q5T9 Leishmania major 38% 100%
Q4Q7W2 Leishmania major 31% 100%
Q4QBQ2 Leishmania major 41% 100%
Q4QBR6 Leishmania major 30% 100%
Q4QCK0 Leishmania major 23% 100%
V5BC28 Trypanosoma cruzi 39% 95%
V5BPJ0 Trypanosoma cruzi 36% 96%
V5D579 Trypanosoma cruzi 39% 100%
V5DFW9 Trypanosoma cruzi 32% 82%
V5DKY9 Trypanosoma cruzi 27% 77%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS