LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4IC36_LEIIN
TriTrypDb:
LINF_350057300
Length:
604

Annotations

LeishMANIAdb annotations

Putative transporter, with little homology outside Kinetoplastida

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0016020 membrane 2 7
GO:0110165 cellular anatomical entity 1 7

Expansion

Sequence features

A4IC36
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IC36

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 235 239 PF00656 0.601
CLV_MEL_PAP_1 215 221 PF00089 0.391
CLV_NRD_NRD_1 128 130 PF00675 0.271
CLV_NRD_NRD_1 27 29 PF00675 0.387
CLV_NRD_NRD_1 33 35 PF00675 0.369
CLV_NRD_NRD_1 406 408 PF00675 0.306
CLV_NRD_NRD_1 473 475 PF00675 0.377
CLV_NRD_NRD_1 557 559 PF00675 0.300
CLV_NRD_NRD_1 65 67 PF00675 0.443
CLV_PCSK_FUR_1 63 67 PF00082 0.318
CLV_PCSK_KEX2_1 35 37 PF00082 0.391
CLV_PCSK_KEX2_1 406 408 PF00082 0.393
CLV_PCSK_KEX2_1 473 475 PF00082 0.412
CLV_PCSK_KEX2_1 557 559 PF00082 0.301
CLV_PCSK_KEX2_1 65 67 PF00082 0.453
CLV_PCSK_PC1ET2_1 35 37 PF00082 0.391
CLV_PCSK_SKI1_1 279 283 PF00082 0.493
CLV_PCSK_SKI1_1 53 57 PF00082 0.398
DEG_COP1_1 500 510 PF00400 0.384
DEG_Nend_Nbox_1 1 3 PF02207 0.567
DEG_SPOP_SBC_1 300 304 PF00917 0.559
DOC_CKS1_1 100 105 PF01111 0.646
DOC_CKS1_1 267 272 PF01111 0.658
DOC_CYCLIN_yCln2_LP_2 466 472 PF00134 0.627
DOC_CYCLIN_yCln2_LP_2 547 553 PF00134 0.233
DOC_MAPK_DCC_7 333 342 PF00069 0.595
DOC_MAPK_gen_1 129 136 PF00069 0.474
DOC_MAPK_gen_1 473 482 PF00069 0.520
DOC_MAPK_gen_1 581 590 PF00069 0.537
DOC_MAPK_HePTP_8 126 138 PF00069 0.463
DOC_MAPK_MEF2A_6 129 138 PF00069 0.599
DOC_MAPK_MEF2A_6 333 342 PF00069 0.595
DOC_PP1_RVXF_1 291 297 PF00149 0.542
DOC_PP1_RVXF_1 387 394 PF00149 0.360
DOC_PP4_FxxP_1 244 247 PF00568 0.647
DOC_PP4_FxxP_1 505 508 PF00568 0.423
DOC_USP7_MATH_1 227 231 PF00917 0.488
DOC_USP7_MATH_1 270 274 PF00917 0.634
DOC_USP7_MATH_1 308 312 PF00917 0.596
DOC_USP7_MATH_1 315 319 PF00917 0.443
DOC_USP7_MATH_1 321 325 PF00917 0.550
DOC_WW_Pin1_4 114 119 PF00397 0.480
DOC_WW_Pin1_4 178 183 PF00397 0.622
DOC_WW_Pin1_4 243 248 PF00397 0.665
DOC_WW_Pin1_4 266 271 PF00397 0.651
DOC_WW_Pin1_4 38 43 PF00397 0.534
DOC_WW_Pin1_4 448 453 PF00397 0.502
DOC_WW_Pin1_4 480 485 PF00397 0.486
DOC_WW_Pin1_4 99 104 PF00397 0.613
LIG_14-3-3_CanoR_1 129 135 PF00244 0.479
LIG_14-3-3_CanoR_1 163 169 PF00244 0.538
LIG_14-3-3_CanoR_1 218 224 PF00244 0.585
LIG_14-3-3_CanoR_1 343 351 PF00244 0.420
LIG_14-3-3_CanoR_1 389 394 PF00244 0.483
LIG_14-3-3_CanoR_1 53 58 PF00244 0.541
LIG_14-3-3_CanoR_1 557 566 PF00244 0.547
LIG_14-3-3_CanoR_1 63 73 PF00244 0.508
LIG_Actin_WH2_2 363 378 PF00022 0.324
LIG_Actin_WH2_2 438 456 PF00022 0.554
LIG_BRCT_BRCA1_1 170 174 PF00533 0.582
LIG_BRCT_BRCA1_1 458 462 PF00533 0.561
LIG_CtBP_PxDLS_1 469 473 PF00389 0.621
LIG_DLG_GKlike_1 568 576 PF00625 0.601
LIG_eIF4E_1 439 445 PF01652 0.556
LIG_eIF4E_1 529 535 PF01652 0.359
LIG_FHA_1 131 137 PF00498 0.594
LIG_FHA_1 181 187 PF00498 0.596
LIG_FHA_1 381 387 PF00498 0.292
LIG_FHA_1 43 49 PF00498 0.530
LIG_FHA_1 433 439 PF00498 0.536
LIG_FHA_1 448 454 PF00498 0.452
LIG_FHA_1 483 489 PF00498 0.439
LIG_FHA_1 542 548 PF00498 0.302
LIG_FHA_1 593 599 PF00498 0.316
LIG_FHA_2 100 106 PF00498 0.559
LIG_FHA_2 330 336 PF00498 0.588
LIG_FHA_2 66 72 PF00498 0.661
LIG_GBD_Chelix_1 539 547 PF00786 0.396
LIG_IRF3_LxIS_1 16 23 PF10401 0.546
LIG_LIR_Apic_2 504 508 PF02991 0.393
LIG_LIR_Apic_2 97 103 PF02991 0.604
LIG_LIR_Gen_1 10 20 PF02991 0.526
LIG_LIR_Gen_1 107 115 PF02991 0.580
LIG_LIR_Gen_1 240 248 PF02991 0.600
LIG_LIR_Gen_1 392 401 PF02991 0.450
LIG_LIR_Nem_3 10 16 PF02991 0.532
LIG_LIR_Nem_3 107 112 PF02991 0.603
LIG_LIR_Nem_3 153 158 PF02991 0.629
LIG_LIR_Nem_3 171 177 PF02991 0.410
LIG_LIR_Nem_3 240 245 PF02991 0.614
LIG_LIR_Nem_3 260 266 PF02991 0.631
LIG_LIR_Nem_3 392 396 PF02991 0.450
LIG_LIR_Nem_3 459 465 PF02991 0.562
LIG_LIR_Nem_3 525 529 PF02991 0.351
LIG_LIR_Nem_3 545 551 PF02991 0.150
LIG_LIR_Nem_3 575 580 PF02991 0.553
LIG_MLH1_MIPbox_1 170 174 PF16413 0.579
LIG_Pex14_1 341 345 PF04695 0.554
LIG_Pex14_1 495 499 PF04695 0.349
LIG_Pex14_2 491 495 PF04695 0.370
LIG_PTB_Apo_2 103 110 PF02174 0.560
LIG_PTB_Apo_2 236 243 PF02174 0.636
LIG_PTB_Apo_2 295 302 PF02174 0.537
LIG_PTB_Apo_2 336 343 PF02174 0.591
LIG_SH2_CRK 100 104 PF00017 0.605
LIG_SH2_CRK 155 159 PF00017 0.594
LIG_SH2_CRK 433 437 PF00017 0.587
LIG_SH2_CRK 582 586 PF00017 0.507
LIG_SH2_GRB2like 104 107 PF00017 0.547
LIG_SH2_NCK_1 100 104 PF00017 0.605
LIG_SH2_NCK_1 297 301 PF00017 0.529
LIG_SH2_NCK_1 499 503 PF00017 0.330
LIG_SH2_SRC 225 228 PF00017 0.553
LIG_SH2_SRC 597 600 PF00017 0.402
LIG_SH2_STAP1 104 108 PF00017 0.553
LIG_SH2_STAP1 263 267 PF00017 0.614
LIG_SH2_STAT3 564 567 PF00017 0.581
LIG_SH2_STAT5 173 176 PF00017 0.509
LIG_SH2_STAT5 225 228 PF00017 0.553
LIG_SH2_STAT5 433 436 PF00017 0.503
LIG_SH2_STAT5 46 49 PF00017 0.490
LIG_SH2_STAT5 597 600 PF00017 0.374
LIG_SH3_3 354 360 PF00018 0.335
LIG_SH3_3 461 467 PF00018 0.523
LIG_SH3_3 484 490 PF00018 0.420
LIG_SH3_3 510 516 PF00018 0.370
LIG_SH3_3 521 527 PF00018 0.412
LIG_SH3_3 563 569 PF00018 0.608
LIG_SUMO_SIM_anti_2 586 595 PF11976 0.412
LIG_SUMO_SIM_par_1 586 595 PF11976 0.412
LIG_TRFH_1 109 113 PF08558 0.564
LIG_UBA3_1 2 8 PF00899 0.576
MOD_CDK_SPxK_1 448 454 PF00069 0.558
MOD_CDK_SPxxK_3 114 121 PF00069 0.538
MOD_CK1_1 114 120 PF00069 0.519
MOD_CK1_1 246 252 PF00069 0.685
MOD_CK1_1 378 384 PF00069 0.331
MOD_CK1_1 592 598 PF00069 0.320
MOD_CK2_1 147 153 PF00069 0.622
MOD_CK2_1 20 26 PF00069 0.560
MOD_CK2_1 4 10 PF00069 0.612
MOD_CK2_1 408 414 PF00069 0.598
MOD_CK2_1 494 500 PF00069 0.368
MOD_CK2_1 65 71 PF00069 0.620
MOD_CK2_1 99 105 PF00069 0.648
MOD_CMANNOS 495 498 PF00535 0.349
MOD_GlcNHglycan 270 273 PF01048 0.535
MOD_GlcNHglycan 279 282 PF01048 0.576
MOD_GlcNHglycan 303 306 PF01048 0.391
MOD_GlcNHglycan 346 349 PF01048 0.420
MOD_GlcNHglycan 410 413 PF01048 0.407
MOD_GlcNHglycan 42 45 PF01048 0.333
MOD_GlcNHglycan 441 444 PF01048 0.356
MOD_GSK3_1 164 171 PF00069 0.622
MOD_GSK3_1 176 183 PF00069 0.506
MOD_GSK3_1 266 273 PF00069 0.659
MOD_GSK3_1 327 334 PF00069 0.574
MOD_GSK3_1 38 45 PF00069 0.551
MOD_GSK3_1 416 423 PF00069 0.674
MOD_GSK3_1 494 501 PF00069 0.362
MOD_GSK3_1 568 575 PF00069 0.664
MOD_GSK3_1 95 102 PF00069 0.625
MOD_N-GLC_1 188 193 PF02516 0.402
MOD_N-GLC_1 389 394 PF02516 0.388
MOD_N-GLC_1 456 461 PF02516 0.365
MOD_NEK2_1 144 149 PF00069 0.617
MOD_NEK2_1 168 173 PF00069 0.511
MOD_NEK2_1 177 182 PF00069 0.548
MOD_NEK2_1 301 306 PF00069 0.552
MOD_NEK2_1 375 380 PF00069 0.344
MOD_NEK2_1 425 430 PF00069 0.529
MOD_NEK2_1 538 543 PF00069 0.308
MOD_NEK2_1 572 577 PF00069 0.586
MOD_NEK2_1 591 596 PF00069 0.166
MOD_NEK2_2 227 232 PF00069 0.504
MOD_NEK2_2 308 313 PF00069 0.600
MOD_PIKK_1 147 153 PF00454 0.586
MOD_PKA_1 65 71 PF00069 0.527
MOD_PKA_2 257 263 PF00069 0.555
MOD_PKA_2 375 381 PF00069 0.333
MOD_PKA_2 64 70 PF00069 0.549
MOD_PKB_1 581 589 PF00069 0.543
MOD_PKB_1 63 71 PF00069 0.521
MOD_Plk_1 389 395 PF00069 0.388
MOD_Plk_1 456 462 PF00069 0.553
MOD_Plk_4 164 170 PF00069 0.517
MOD_Plk_4 375 381 PF00069 0.352
MOD_Plk_4 42 48 PF00069 0.524
MOD_Plk_4 494 500 PF00069 0.490
MOD_Plk_4 501 507 PF00069 0.355
MOD_Plk_4 509 515 PF00069 0.236
MOD_Plk_4 538 544 PF00069 0.344
MOD_Plk_4 95 101 PF00069 0.581
MOD_ProDKin_1 114 120 PF00069 0.476
MOD_ProDKin_1 178 184 PF00069 0.622
MOD_ProDKin_1 243 249 PF00069 0.661
MOD_ProDKin_1 266 272 PF00069 0.658
MOD_ProDKin_1 38 44 PF00069 0.529
MOD_ProDKin_1 448 454 PF00069 0.501
MOD_ProDKin_1 480 486 PF00069 0.486
MOD_ProDKin_1 99 105 PF00069 0.610
TRG_DiLeu_BaEn_1 107 112 PF01217 0.572
TRG_DiLeu_BaEn_2 239 245 PF01217 0.624
TRG_DiLeu_BaLyEn_6 580 585 PF01217 0.543
TRG_ENDOCYTIC_2 155 158 PF00928 0.595
TRG_ENDOCYTIC_2 297 300 PF00928 0.542
TRG_ENDOCYTIC_2 433 436 PF00928 0.522
TRG_ENDOCYTIC_2 582 585 PF00928 0.544
TRG_ER_diArg_1 34 37 PF00400 0.578
TRG_ER_diArg_1 472 474 PF00400 0.651
TRG_ER_diArg_1 514 517 PF00400 0.314
TRG_ER_diArg_1 557 559 PF00400 0.524
TRG_ER_diArg_1 63 66 PF00400 0.524
TRG_NLS_MonoExtC_3 33 39 PF00514 0.507
TRG_NLS_MonoExtN_4 31 38 PF00514 0.555

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I7A6 Leptomonas seymouri 68% 94%
A0A0S4JQH1 Bodo saltans 27% 93%
A0A1X0P4Y6 Trypanosomatidae 37% 93%
A0A3Q8IK04 Leishmania donovani 100% 100%
A0A3R7MCC1 Trypanosoma rangeli 42% 95%
A4HNI0 Leishmania braziliensis 80% 100%
C9ZYD5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 37% 98%
E9AFZ1 Leishmania major 95% 100%
E9B744 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS