G domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4IC35_LEIIN

TriTrypDb:

LINF_350057200

Length:

312

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4IC35

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IC35

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	2
GO:0005488	binding	1	2
GO:0005525	GTP binding	5	2
GO:0017076	purine nucleotide binding	4	2
GO:0019001	guanyl nucleotide binding	5	2
GO:0032553	ribonucleotide binding	3	2
GO:0032555	purine ribonucleotide binding	4	2
GO:0032561	guanyl ribonucleotide binding	5	2
GO:0035639	purine ribonucleoside triphosphate binding	4	2
GO:0036094	small molecule binding	2	2
GO:0043167	ion binding	2	2
GO:0043168	anion binding	3	2
GO:0097159	organic cyclic compound binding	2	2
GO:0097367	carbohydrate derivative binding	2	2
GO:1901265	nucleoside phosphate binding	3	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	307	311	PF00656	0.392
CLV_NRD_NRD_1	26	28	PF00675	0.664
CLV_PCSK_KEX2_1	26	28	PF00082	0.664
CLV_PCSK_SKI1_1	273	277	PF00082	0.562
CLV_PCSK_SKI1_1	74	78	PF00082	0.460
DOC_CKS1_1	122	127	PF01111	0.343
DOC_CKS1_1	33	38	PF01111	0.708
DOC_CYCLIN_RxL_1	71	80	PF00134	0.483
DOC_MAPK_gen_1	149	158	PF00069	0.552
DOC_MAPK_MEF2A_6	294	303	PF00069	0.408
DOC_MAPK_MEF2A_6	58	66	PF00069	0.466
DOC_PP1_RVXF_1	261	267	PF00149	0.324
DOC_PP2B_LxvP_1	156	159	PF13499	0.549
DOC_PP2B_LxvP_1	67	70	PF13499	0.483
DOC_USP7_MATH_1	242	246	PF00917	0.423
DOC_USP7_UBL2_3	147	151	PF12436	0.446
DOC_WW_Pin1_4	121	126	PF00397	0.348
DOC_WW_Pin1_4	162	167	PF00397	0.446
DOC_WW_Pin1_4	2	7	PF00397	0.710
DOC_WW_Pin1_4	225	230	PF00397	0.390
DOC_WW_Pin1_4	32	37	PF00397	0.725
LIG_14-3-3_CanoR_1	16	25	PF00244	0.720
LIG_14-3-3_CanoR_1	37	42	PF00244	0.629
LIG_APCC_ABBA_1	293	298	PF00400	0.371
LIG_BIR_III_2	226	230	PF00653	0.404
LIG_BRCT_BRCA1_1	47	51	PF00533	0.669
LIG_deltaCOP1_diTrp_1	186	196	PF00928	0.393
LIG_FHA_1	102	108	PF00498	0.410
LIG_FHA_1	180	186	PF00498	0.366
LIG_FHA_1	265	271	PF00498	0.450
LIG_FHA_1	279	285	PF00498	0.453
LIG_FHA_1	33	39	PF00498	0.533
LIG_FHA_1	59	65	PF00498	0.414
LIG_FHA_2	103	109	PF00498	0.380
LIG_FHA_2	232	238	PF00498	0.397
LIG_LIR_Gen_1	118	125	PF02991	0.377
LIG_LIR_Gen_1	228	236	PF02991	0.312
LIG_LIR_Gen_1	57	67	PF02991	0.480
LIG_LIR_Nem_3	118	122	PF02991	0.386
LIG_LIR_Nem_3	228	233	PF02991	0.330
LIG_Pex14_1	190	194	PF04695	0.443
LIG_Pex14_1	196	200	PF04695	0.461
LIG_SH2_STAT5	129	132	PF00017	0.535
LIG_SH2_STAT5	212	215	PF00017	0.418
LIG_SH2_STAT5	265	268	PF00017	0.328
LIG_SH3_3	30	36	PF00018	0.704
LIG_SH3_3	89	95	PF00018	0.474
LIG_SUMO_SIM_par_1	37	44	PF11976	0.520
LIG_TRAF2_1	19	22	PF00917	0.659
LIG_WRC_WIRS_1	191	196	PF05994	0.370
MOD_CDK_SPK_2	32	37	PF00069	0.708
MOD_CK1_1	127	133	PF00069	0.515
MOD_CK1_1	215	221	PF00069	0.419
MOD_CK1_1	40	46	PF00069	0.713
MOD_CK2_1	102	108	PF00069	0.525
MOD_CK2_1	16	22	PF00069	0.722
MOD_DYRK1A_RPxSP_1	2	6	PF00069	0.641
MOD_GlcNHglycan	18	21	PF01048	0.669
MOD_GlcNHglycan	244	247	PF01048	0.467
MOD_GlcNHglycan	30	33	PF01048	0.761
MOD_GlcNHglycan	98	101	PF01048	0.614
MOD_GSK3_1	2	9	PF00069	0.719
MOD_GSK3_1	212	219	PF00069	0.525
MOD_GSK3_1	28	35	PF00069	0.748
MOD_GSK3_1	37	44	PF00069	0.597
MOD_LATS_1	113	119	PF00433	0.510
MOD_LATS_1	14	20	PF00433	0.687
MOD_N-GLC_1	86	91	PF02516	0.559
MOD_NEK2_1	101	106	PF00069	0.474
MOD_NEK2_1	216	221	PF00069	0.341
MOD_NEK2_1	275	280	PF00069	0.600
MOD_NEK2_1	284	289	PF00069	0.459
MOD_NEK2_1	77	82	PF00069	0.410
MOD_PIKK_1	304	310	PF00454	0.333
MOD_PK_1	37	43	PF00069	0.634
MOD_PKA_2	1	7	PF00069	0.704
MOD_PKA_2	41	47	PF00069	0.650
MOD_Plk_1	86	92	PF00069	0.604
MOD_Plk_4	115	121	PF00069	0.414
MOD_Plk_4	124	130	PF00069	0.386
MOD_Plk_4	190	196	PF00069	0.534
MOD_Plk_4	212	218	PF00069	0.484
MOD_Plk_4	250	256	PF00069	0.388
MOD_Plk_4	72	78	PF00069	0.356
MOD_ProDKin_1	121	127	PF00069	0.347
MOD_ProDKin_1	162	168	PF00069	0.448
MOD_ProDKin_1	2	8	PF00069	0.707
MOD_ProDKin_1	225	231	PF00069	0.385
MOD_ProDKin_1	32	38	PF00069	0.725
TRG_DiLeu_BaEn_1	271	276	PF01217	0.534
TRG_ENDOCYTIC_2	59	62	PF00928	0.564
TRG_ER_diArg_1	196	199	PF00400	0.566
TRG_ER_diArg_1	25	27	PF00400	0.724
TRG_Pf-PMV_PEXEL_1	221	225	PF00026	0.462

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5M5	Leptomonas seymouri	70%	76%
A0A0S4JLN7	Bodo saltans	35%	78%
A0A1X0P4S5	Trypanosomatidae	57%	78%
A0A3Q8IFN6	Leishmania donovani	100%	75%
A0A422NCK5	Trypanosoma rangeli	52%	99%
A4HNH9	Leishmania braziliensis	81%	100%
C9ZYD6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	82%
E9AFZ0	Leishmania major	94%	100%
E9B743	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5B8T8	Trypanosoma cruzi	53%	80%