AAA domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4IC34_LEIIN

TriTrypDb:

LINF_350057100

Length:

306

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4IC34

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IC34

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	153	157	PF00656	0.540
CLV_C14_Caspase3-7	276	280	PF00656	0.459
CLV_NRD_NRD_1	301	303	PF00675	0.495
CLV_PCSK_KEX2_1	293	295	PF00082	0.379
CLV_PCSK_KEX2_1	300	302	PF00082	0.399
CLV_PCSK_PC1ET2_1	293	295	PF00082	0.379
CLV_PCSK_PC1ET2_1	300	302	PF00082	0.383
CLV_PCSK_SKI1_1	24	28	PF00082	0.345
CLV_Separin_Metazoa	131	135	PF03568	0.436
DEG_APCC_DBOX_1	23	31	PF00400	0.330
DOC_CYCLIN_RxL_1	18	28	PF00134	0.457
DOC_MAPK_DCC_7	261	271	PF00069	0.443
DOC_MAPK_gen_1	177	187	PF00069	0.458
DOC_MAPK_MEF2A_6	4	12	PF00069	0.383
DOC_MAPK_MEF2A_6	96	103	PF00069	0.336
DOC_MAPK_RevD_3	281	294	PF00069	0.346
DOC_PP1_RVXF_1	27	34	PF00149	0.331
DOC_PP4_FxxP_1	200	203	PF00568	0.453
DOC_WW_Pin1_4	151	156	PF00397	0.618
LIG_14-3-3_CanoR_1	108	118	PF00244	0.463
LIG_14-3-3_CanoR_1	248	252	PF00244	0.415
LIG_14-3-3_CanoR_1	273	278	PF00244	0.545
LIG_14-3-3_CanoR_1	43	47	PF00244	0.480
LIG_14-3-3_CanoR_1	57	65	PF00244	0.544
LIG_14-3-3_CanoR_1	70	74	PF00244	0.288
LIG_BIR_II_1	1	5	PF00653	0.431
LIG_BRCT_BRCA1_1	203	207	PF00533	0.388
LIG_FHA_1	207	213	PF00498	0.424
LIG_FHA_1	244	250	PF00498	0.475
LIG_FHA_1	266	272	PF00498	0.453
LIG_FHA_2	274	280	PF00498	0.480
LIG_FHA_2	59	65	PF00498	0.473
LIG_GBD_Chelix_1	291	299	PF00786	0.387
LIG_LIR_Gen_1	2	12	PF02991	0.366
LIG_LIR_Nem_3	16	22	PF02991	0.360
LIG_LIR_Nem_3	193	197	PF02991	0.442
LIG_LIR_Nem_3	2	8	PF02991	0.386
LIG_MYND_1	238	242	PF01753	0.436
LIG_NRBOX	113	119	PF00104	0.429
LIG_PCNA_yPIPBox_3	57	69	PF02747	0.428
LIG_RPA_C_Insects	289	304	PF08784	0.338
LIG_SH2_CRK	5	9	PF00017	0.371
LIG_SH2_STAT5	20	23	PF00017	0.377
LIG_SH2_STAT5	233	236	PF00017	0.603
LIG_SH2_STAT5	270	273	PF00017	0.471
LIG_SH2_STAT5	68	71	PF00017	0.474
LIG_SxIP_EBH_1	259	273	PF03271	0.362
LIG_TYR_ITIM	17	22	PF00017	0.425
LIG_UBA3_1	295	300	PF00899	0.320
LIG_WRC_WIRS_1	144	149	PF05994	0.493
MOD_CK1_1	143	149	PF00069	0.628
MOD_CK1_1	150	156	PF00069	0.621
MOD_CK1_1	157	163	PF00069	0.559
MOD_CK1_1	87	93	PF00069	0.528
MOD_CK2_1	220	226	PF00069	0.523
MOD_CK2_1	58	64	PF00069	0.391
MOD_GlcNHglycan	135	139	PF01048	0.523
MOD_GlcNHglycan	166	170	PF01048	0.450
MOD_GlcNHglycan	263	266	PF01048	0.523
MOD_GSK3_1	136	143	PF00069	0.574
MOD_GSK3_1	147	154	PF00069	0.575
MOD_GSK3_1	201	208	PF00069	0.484
MOD_GSK3_1	220	227	PF00069	0.456
MOD_GSK3_1	243	250	PF00069	0.421
MOD_GSK3_1	261	268	PF00069	0.496
MOD_GSK3_1	52	59	PF00069	0.559
MOD_N-GLC_1	122	127	PF02516	0.457
MOD_N-GLC_1	190	195	PF02516	0.449
MOD_N-GLC_2	280	282	PF02516	0.367
MOD_NEK2_1	25	30	PF00069	0.349
MOD_PIKK_1	58	64	PF00454	0.391
MOD_PIKK_1	87	93	PF00454	0.449
MOD_PKA_2	247	253	PF00069	0.426
MOD_PKA_2	272	278	PF00069	0.511
MOD_PKA_2	42	48	PF00069	0.457
MOD_PKA_2	56	62	PF00069	0.489
MOD_PKA_2	69	75	PF00069	0.285
MOD_Plk_1	122	128	PF00069	0.454
MOD_Plk_1	140	146	PF00069	0.585
MOD_Plk_1	190	196	PF00069	0.505
MOD_Plk_1	37	43	PF00069	0.426
MOD_Plk_1	55	61	PF00069	0.251
MOD_Plk_4	123	129	PF00069	0.417
MOD_Plk_4	157	163	PF00069	0.588
MOD_Plk_4	247	253	PF00069	0.547
MOD_Plk_4	265	271	PF00069	0.458
MOD_Plk_4	281	287	PF00069	0.443
MOD_Plk_4	69	75	PF00069	0.421
MOD_ProDKin_1	151	157	PF00069	0.617
TRG_DiLeu_LyEn_5	95	100	PF01217	0.376
TRG_ENDOCYTIC_2	19	22	PF00928	0.340
TRG_ENDOCYTIC_2	5	8	PF00928	0.396
TRG_ER_diArg_1	301	304	PF00400	0.391
TRG_NLS_MonoExtC_3	299	304	PF00514	0.370
TRG_Pf-PMV_PEXEL_1	294	298	PF00026	0.411

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P619	Leptomonas seymouri	57%	94%
A0A3S7XA31	Leishmania donovani	99%	100%
A0A422P2U5	Trypanosoma rangeli	37%	77%
A4HNH8	Leishmania braziliensis	79%	100%
C9ZZ55	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	74%
E9AFY9	Leishmania major	93%	100%
E9B742	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5BTH5	Trypanosoma cruzi	38%	76%