Putative biopterin transporter

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

pteridine transporter (truncated) - putative

Species:

Leishmania infantum

UniProt:

A4IC33_LEIIN

TriTrypDb:

LINF_350057000

Length:

632

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 9
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 52

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 71
NetGPI	no	yes: 0, no: 71

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	72
GO:0110165	cellular anatomical entity	1	72
GO:0005737	cytoplasm	2	6
GO:0005886	plasma membrane	3	1

Expansion

Sequence features

A4IC33

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IC33

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0015877	biopterin transport	5	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	1
GO:0015224	biopterin transmembrane transporter activity	3	1
GO:0022857	transmembrane transporter activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	243	245	PF00675	0.303
CLV_NRD_NRD_1	604	606	PF00675	0.280
CLV_NRD_NRD_1	629	631	PF00675	0.473
CLV_PCSK_KEX2_1	122	124	PF00082	0.292
CLV_PCSK_KEX2_1	243	245	PF00082	0.252
CLV_PCSK_KEX2_1	479	481	PF00082	0.521
CLV_PCSK_KEX2_1	629	631	PF00082	0.506
CLV_PCSK_PC1ET2_1	122	124	PF00082	0.292
CLV_PCSK_PC1ET2_1	479	481	PF00082	0.521
CLV_PCSK_SKI1_1	327	331	PF00082	0.253
CLV_PCSK_SKI1_1	335	339	PF00082	0.266
CLV_PCSK_SKI1_1	52	56	PF00082	0.252
DEG_APCC_DBOX_1	334	342	PF00400	0.398
DEG_ODPH_VHL_1	519	531	PF01847	0.520
DEG_SPOP_SBC_1	623	627	PF00917	0.622
DOC_CDC14_PxL_1	30	38	PF14671	0.529
DOC_CDC14_PxL_1	565	573	PF14671	0.331
DOC_CYCLIN_yClb5_NLxxxL_5	397	406	PF00134	0.264
DOC_CYCLIN_yCln2_LP_2	466	472	PF00134	0.206
DOC_CYCLIN_yCln2_LP_2	508	514	PF00134	0.397
DOC_MAPK_gen_1	479	487	PF00069	0.323
DOC_MAPK_MEF2A_6	359	367	PF00069	0.184
DOC_MAPK_MEF2A_6	47	55	PF00069	0.549
DOC_MAPK_MEF2A_6	479	487	PF00069	0.357
DOC_PP1_RVXF_1	385	392	PF00149	0.477
DOC_PP2B_LxvP_1	400	403	PF13499	0.374
DOC_PP2B_LxvP_1	508	511	PF13499	0.337
DOC_PP4_FxxP_1	310	313	PF00568	0.458
DOC_PP4_FxxP_1	379	382	PF00568	0.316
DOC_PP4_FxxP_1	582	585	PF00568	0.257
DOC_USP7_MATH_1	145	149	PF00917	0.264
DOC_USP7_MATH_1	188	192	PF00917	0.323
DOC_USP7_MATH_1	45	49	PF00917	0.564
DOC_USP7_MATH_1	452	456	PF00917	0.524
DOC_USP7_MATH_1	468	472	PF00917	0.322
DOC_USP7_MATH_1	521	525	PF00917	0.486
DOC_USP7_MATH_1	6	10	PF00917	0.644
DOC_WW_Pin1_4	10	15	PF00397	0.777
DOC_WW_Pin1_4	269	274	PF00397	0.488
LIG_14-3-3_CanoR_1	93	98	PF00244	0.491
LIG_Actin_WH2_2	15	33	PF00022	0.490
LIG_APCC_ABBA_1	172	177	PF00400	0.520
LIG_APCC_ABBA_1	237	242	PF00400	0.406
LIG_BIR_III_4	306	310	PF00653	0.545
LIG_BRCT_BRCA1_1	375	379	PF00533	0.257
LIG_BRCT_BRCA1_1	42	46	PF00533	0.527
LIG_BRCT_BRCA1_1	423	427	PF00533	0.317
LIG_BRCT_BRCA1_1	454	458	PF00533	0.460
LIG_BRCT_BRCA1_1	525	529	PF00533	0.492
LIG_EH1_1	500	508	PF00400	0.369
LIG_FHA_1	112	118	PF00498	0.548
LIG_FHA_1	194	200	PF00498	0.334
LIG_FHA_1	222	228	PF00498	0.427
LIG_FHA_1	342	348	PF00498	0.349
LIG_FHA_1	378	384	PF00498	0.354
LIG_FHA_1	406	412	PF00498	0.378
LIG_FHA_1	572	578	PF00498	0.416
LIG_FHA_2	356	362	PF00498	0.208
LIG_FHA_2	613	619	PF00498	0.681
LIG_GBD_Chelix_1	348	356	PF00786	0.315
LIG_LIR_Apic_2	376	382	PF02991	0.401
LIG_LIR_Gen_1	113	120	PF02991	0.522
LIG_LIR_Gen_1	358	368	PF02991	0.295
LIG_LIR_Gen_1	426	435	PF02991	0.323
LIG_LIR_Gen_1	444	452	PF02991	0.384
LIG_LIR_Gen_1	471	478	PF02991	0.334
LIG_LIR_Gen_1	526	537	PF02991	0.511
LIG_LIR_Nem_3	113	118	PF02991	0.497
LIG_LIR_Nem_3	121	127	PF02991	0.501
LIG_LIR_Nem_3	361	367	PF02991	0.285
LIG_LIR_Nem_3	376	381	PF02991	0.367
LIG_LIR_Nem_3	424	430	PF02991	0.300
LIG_LIR_Nem_3	43	49	PF02991	0.506
LIG_LIR_Nem_3	444	450	PF02991	0.344
LIG_LIR_Nem_3	455	459	PF02991	0.466
LIG_LIR_Nem_3	471	476	PF02991	0.335
LIG_LIR_Nem_3	526	532	PF02991	0.472
LIG_LIR_Nem_3	552	558	PF02991	0.291
LIG_MLH1_MIPbox_1	375	379	PF16413	0.399
LIG_NRBOX	229	235	PF00104	0.378
LIG_PCNA_TLS_4	312	319	PF02747	0.392
LIG_Pex14_1	360	364	PF04695	0.285
LIG_Pex14_2	42	46	PF04695	0.488
LIG_Pex14_2	423	427	PF04695	0.306
LIG_Pex14_2	447	451	PF04695	0.365
LIG_PTAP_UEV_1	7	12	PF05743	0.603
LIG_PTB_Apo_2	404	411	PF02174	0.391
LIG_PTB_Phospho_1	404	410	PF10480	0.402
LIG_SH2_CRK	125	129	PF00017	0.367
LIG_SH2_CRK	140	144	PF00017	0.321
LIG_SH2_CRK	456	460	PF00017	0.495
LIG_SH2_CRK	91	95	PF00017	0.512
LIG_SH2_GRB2like	393	396	PF00017	0.381
LIG_SH2_GRB2like	399	402	PF00017	0.405
LIG_SH2_GRB2like	565	568	PF00017	0.351
LIG_SH2_NCK_1	565	569	PF00017	0.295
LIG_SH2_PTP2	21	24	PF00017	0.612
LIG_SH2_PTP2	364	367	PF00017	0.197
LIG_SH2_PTP2	588	591	PF00017	0.206
LIG_SH2_SRC	21	24	PF00017	0.618
LIG_SH2_STAP1	120	124	PF00017	0.501
LIG_SH2_STAP1	175	179	PF00017	0.486
LIG_SH2_STAT3	297	300	PF00017	0.382
LIG_SH2_STAT5	120	123	PF00017	0.498
LIG_SH2_STAT5	125	128	PF00017	0.340
LIG_SH2_STAT5	21	24	PF00017	0.610
LIG_SH2_STAT5	222	225	PF00017	0.349
LIG_SH2_STAT5	318	321	PF00017	0.548
LIG_SH2_STAT5	364	367	PF00017	0.224
LIG_SH2_STAT5	393	396	PF00017	0.350
LIG_SH2_STAT5	399	402	PF00017	0.340
LIG_SH2_STAT5	410	413	PF00017	0.279
LIG_SH2_STAT5	425	428	PF00017	0.261
LIG_SH2_STAT5	493	496	PF00017	0.294
LIG_SH2_STAT5	537	540	PF00017	0.297
LIG_SH2_STAT5	548	551	PF00017	0.257
LIG_SH2_STAT5	588	591	PF00017	0.505
LIG_SH2_STAT5	98	101	PF00017	0.545
LIG_SH3_1	5	11	PF00018	0.610
LIG_SH3_2	273	278	PF14604	0.394
LIG_SH3_3	270	276	PF00018	0.534
LIG_SH3_3	408	414	PF00018	0.329
LIG_SH3_3	415	421	PF00018	0.280
LIG_SH3_3	462	468	PF00018	0.206
LIG_SH3_3	5	11	PF00018	0.695
LIG_SH3_3	586	592	PF00018	0.390
LIG_SUMO_SIM_anti_2	344	349	PF11976	0.253
LIG_SUMO_SIM_anti_2	474	479	PF11976	0.315
LIG_SUMO_SIM_par_1	226	231	PF11976	0.206
LIG_SUMO_SIM_par_1	341	346	PF11976	0.299
LIG_TRAF2_1	619	622	PF00917	0.626
LIG_TRFH_1	140	144	PF08558	0.361
LIG_TRFH_1	588	592	PF08558	0.291
LIG_TYR_ITIM	138	143	PF00017	0.377
LIG_TYR_ITIM	362	367	PF00017	0.374
LIG_TYR_ITIM	397	402	PF00017	0.333
LIG_TYR_ITIM	586	591	PF00017	0.505
LIG_UBA3_1	138	146	PF00899	0.348
LIG_UBA3_1	472	479	PF00899	0.323
LIG_WRC_WIRS_1	375	380	PF05994	0.287
LIG_WRC_WIRS_1	406	411	PF05994	0.335
LIG_WRC_WIRS_1	46	51	PF05994	0.556
MOD_CDC14_SPxK_1	275	278	PF00782	0.398
MOD_CDK_SPxK_1	272	278	PF00069	0.398
MOD_CK1_1	129	135	PF00069	0.224
MOD_CK1_1	263	269	PF00069	0.392
MOD_CK1_1	272	278	PF00069	0.546
MOD_CK1_1	377	383	PF00069	0.206
MOD_CK1_1	541	547	PF00069	0.361
MOD_CK2_1	284	290	PF00069	0.526
MOD_CK2_1	6	12	PF00069	0.659
MOD_CK2_1	612	618	PF00069	0.701
MOD_Cter_Amidation	603	606	PF01082	0.320
MOD_GlcNHglycan	128	131	PF01048	0.390
MOD_GlcNHglycan	147	151	PF01048	0.502
MOD_GlcNHglycan	230	233	PF01048	0.387
MOD_GlcNHglycan	25	28	PF01048	0.280
MOD_GlcNHglycan	262	265	PF01048	0.356
MOD_GlcNHglycan	462	465	PF01048	0.378
MOD_GlcNHglycan	543	546	PF01048	0.391
MOD_GlcNHglycan	592	595	PF01048	0.400
MOD_GlcNHglycan	8	11	PF01048	0.482
MOD_GSK3_1	258	265	PF00069	0.472
MOD_GSK3_1	373	380	PF00069	0.293
MOD_GSK3_1	441	448	PF00069	0.308
MOD_GSK3_1	537	544	PF00069	0.376
MOD_GSK3_1	559	566	PF00069	0.405
MOD_GSK3_1	590	597	PF00069	0.518
MOD_GSK3_1	6	13	PF00069	0.631
MOD_GSK3_1	92	99	PF00069	0.541
MOD_NEK2_1	111	116	PF00069	0.495
MOD_NEK2_1	118	123	PF00069	0.453
MOD_NEK2_1	157	162	PF00069	0.342
MOD_NEK2_1	193	198	PF00069	0.310
MOD_NEK2_1	202	207	PF00069	0.326
MOD_NEK2_1	228	233	PF00069	0.286
MOD_NEK2_1	258	263	PF00069	0.558
MOD_NEK2_1	341	346	PF00069	0.353
MOD_NEK2_1	423	428	PF00069	0.304
MOD_NEK2_1	445	450	PF00069	0.387
MOD_NEK2_1	460	465	PF00069	0.363
MOD_NEK2_1	531	536	PF00069	0.346
MOD_NEK2_1	538	543	PF00069	0.355
MOD_NEK2_1	550	555	PF00069	0.312
MOD_NEK2_1	571	576	PF00069	0.457
MOD_NEK2_1	72	77	PF00069	0.479
MOD_NEK2_2	374	379	PF00069	0.462
MOD_NEK2_2	45	50	PF00069	0.422
MOD_NEK2_2	468	473	PF00069	0.369
MOD_PIKK_1	556	562	PF00454	0.410
MOD_PKA_2	521	527	PF00069	0.490
MOD_PKA_2	594	600	PF00069	0.400
MOD_PKA_2	92	98	PF00069	0.519
MOD_PKB_1	312	320	PF00069	0.394
MOD_Plk_4	188	194	PF00069	0.338
MOD_Plk_4	202	208	PF00069	0.325
MOD_Plk_4	314	320	PF00069	0.500
MOD_Plk_4	343	349	PF00069	0.334
MOD_Plk_4	374	380	PF00069	0.391
MOD_Plk_4	405	411	PF00069	0.343
MOD_Plk_4	423	429	PF00069	0.370
MOD_Plk_4	441	447	PF00069	0.235
MOD_Plk_4	468	474	PF00069	0.320
MOD_Plk_4	523	529	PF00069	0.517
MOD_Plk_4	531	537	PF00069	0.360
MOD_Plk_4	550	556	PF00069	0.300
MOD_Plk_4	93	99	PF00069	0.444
MOD_ProDKin_1	10	16	PF00069	0.776
MOD_ProDKin_1	269	275	PF00069	0.488
MOD_SUMO_rev_2	293	303	PF00179	0.384
TRG_ENDOCYTIC_2	125	128	PF00928	0.346
TRG_ENDOCYTIC_2	140	143	PF00928	0.336
TRG_ENDOCYTIC_2	364	367	PF00928	0.358
TRG_ENDOCYTIC_2	399	402	PF00928	0.352
TRG_ENDOCYTIC_2	428	431	PF00928	0.304
TRG_ENDOCYTIC_2	456	459	PF00928	0.495
TRG_ENDOCYTIC_2	548	551	PF00928	0.323
TRG_ENDOCYTIC_2	588	591	PF00928	0.495
TRG_ENDOCYTIC_2	91	94	PF00928	0.480
TRG_ER_diArg_1	179	182	PF00400	0.437
TRG_ER_diArg_1	311	314	PF00400	0.539
TRG_ER_diArg_1	628	630	PF00400	0.632

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2U2	Leptomonas seymouri	42%	90%
A0A0N1HY49	Leptomonas seymouri	41%	94%
A0A0N1HZ06	Leptomonas seymouri	58%	100%
A0A0N1IHL1	Leptomonas seymouri	39%	89%
A0A0N1PAY4	Leptomonas seymouri	39%	72%
A0A0N1PB77	Leptomonas seymouri	69%	98%
A0A0N1PBZ2	Leptomonas seymouri	38%	94%
A0A0N1PCC1	Leptomonas seymouri	37%	95%
A0A0S4INN8	Bodo saltans	28%	98%
A0A381MBI0	Leishmania infantum	39%	100%
A0A3Q8I8X7	Leishmania donovani	39%	96%
A0A3Q8IAZ0	Leishmania donovani	36%	90%
A0A3Q8IH50	Leishmania donovani	39%	88%
A0A3Q8IVN0	Leishmania donovani	97%	100%
A0A3R7M4J1	Trypanosoma rangeli	37%	99%
A0A3S5H5P4	Leishmania donovani	40%	93%
A0A3S5H5V2	Leishmania donovani	45%	97%
A0A3S5H6F6	Leishmania donovani	37%	91%
A0A3S5H763	Leishmania donovani	43%	94%
A0A3S7WR10	Leishmania donovani	39%	85%
A0A3S7WR14	Leishmania donovani	36%	92%
A0A3S7WR15	Leishmania donovani	37%	74%
A0A3S7WR24	Leishmania donovani	38%	90%
A4H4T8	Leishmania braziliensis	45%	100%
A4H5Y4	Leishmania braziliensis	39%	100%
A4H617	Leishmania braziliensis	37%	100%
A4H618	Leishmania braziliensis	37%	100%
A4H619	Leishmania braziliensis	38%	100%
A4H620	Leishmania braziliensis	40%	100%
A4H6C3	Leishmania braziliensis	39%	100%
A4HNH7	Leishmania braziliensis	84%	99%
A4HSS2	Leishmania infantum	40%	100%
A4HUE4	Leishmania infantum	40%	100%
A4HUE5	Leishmania infantum	37%	100%
A4HUE6	Leishmania infantum	36%	100%
A4HUE7	Leishmania infantum	35%	100%
A4HUE8	Leishmania infantum	37%	100%
A4HUF4	Leishmania infantum	36%	100%
A4HUF5	Leishmania infantum	39%	100%
A4HYA9	Leishmania infantum	42%	100%
C9ZIK0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	97%
C9ZIK3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	97%
C9ZVE8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
C9ZVE9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
C9ZVF1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
D0A423	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	99%
E8NHQ5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	100%
E9AG72	Leishmania infantum	45%	97%
E9AI40	Leishmania braziliensis	38%	100%
E9AJY4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	100%
E9AKQ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	100%
E9AL06	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	100%
E9AN44	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	100%
E9AN45	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	100%
E9AN46	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	100%
E9AN47	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	100%
E9ANE5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	100%
E9AS42	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	100%
E9B741	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4QDC4	Leishmania major	42%	100%
Q4QH81	Leishmania major	39%	100%
Q4QHH7	Leishmania major	39%	100%
Q4QHH8	Leishmania major	36%	100%
Q4QHH9	Leishmania major	36%	100%
Q4QHI0	Leishmania major	35%	100%
Q4QHI1	Leishmania major	36%	100%
Q4QHI2	Leishmania major	36%	100%
Q4QIU9	Leishmania major	44%	100%
Q4QJ48	Leishmania major	40%	100%
Q7KIP2	Leishmania major	90%	100%