LeishMANIAdb
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IQ calmodulin-binding motif protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
IQ calmodulin-binding motif protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4IC31_LEIIN
TriTrypDb:
LINF_350056800
Length:
370

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4IC31
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IC31

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 170 172 PF00675 0.466
CLV_NRD_NRD_1 245 247 PF00675 0.575
CLV_NRD_NRD_1 46 48 PF00675 0.642
CLV_PCSK_FUR_1 243 247 PF00082 0.589
CLV_PCSK_KEX2_1 170 172 PF00082 0.498
CLV_PCSK_KEX2_1 245 247 PF00082 0.583
CLV_PCSK_KEX2_1 46 48 PF00082 0.617
CLV_PCSK_SKI1_1 170 174 PF00082 0.457
CLV_PCSK_SKI1_1 180 184 PF00082 0.425
CLV_PCSK_SKI1_1 20 24 PF00082 0.623
DEG_Nend_UBRbox_2 1 3 PF02207 0.703
DEG_SPOP_SBC_1 205 209 PF00917 0.644
DEG_SPOP_SBC_1 339 343 PF00917 0.577
DOC_CYCLIN_RxL_1 167 177 PF00134 0.388
DOC_CYCLIN_RxL_1 308 319 PF00134 0.499
DOC_CYCLIN_yCln2_LP_2 123 129 PF00134 0.702
DOC_MAPK_gen_1 185 193 PF00069 0.532
DOC_MAPK_MEF2A_6 188 195 PF00069 0.474
DOC_PP1_RVXF_1 171 177 PF00149 0.543
DOC_PP1_RVXF_1 18 25 PF00149 0.585
DOC_PP1_RVXF_1 309 316 PF00149 0.491
DOC_USP7_MATH_1 119 123 PF00917 0.722
DOC_USP7_MATH_1 222 226 PF00917 0.623
DOC_USP7_MATH_1 241 245 PF00917 0.342
DOC_USP7_MATH_1 283 287 PF00917 0.702
DOC_USP7_MATH_1 294 298 PF00917 0.717
DOC_USP7_MATH_1 328 332 PF00917 0.630
DOC_WW_Pin1_4 127 132 PF00397 0.710
DOC_WW_Pin1_4 290 295 PF00397 0.705
DOC_WW_Pin1_4 348 353 PF00397 0.762
LIG_14-3-3_CanoR_1 206 211 PF00244 0.673
LIG_14-3-3_CanoR_1 223 227 PF00244 0.492
LIG_BRCT_BRCA1_1 267 271 PF00533 0.675
LIG_CaM_IQ_9 232 248 PF13499 0.480
LIG_FHA_1 10 16 PF00498 0.738
LIG_FHA_1 122 128 PF00498 0.714
LIG_FHA_1 135 141 PF00498 0.681
LIG_FHA_1 216 222 PF00498 0.510
LIG_FHA_1 226 232 PF00498 0.440
LIG_FHA_1 270 276 PF00498 0.673
LIG_FHA_1 341 347 PF00498 0.583
LIG_FHA_1 74 80 PF00498 0.736
LIG_LIR_Apic_2 289 294 PF02991 0.701
LIG_LIR_Gen_1 21 31 PF02991 0.623
LIG_LIR_Nem_3 21 27 PF02991 0.624
LIG_MYND_1 257 261 PF01753 0.653
LIG_PCNA_yPIPBox_3 295 309 PF02747 0.613
LIG_Pex14_2 194 198 PF04695 0.556
LIG_Pex14_2 238 242 PF04695 0.581
LIG_SH2_NCK_1 276 280 PF00017 0.696
LIG_SH2_PTP2 291 294 PF00017 0.625
LIG_SH2_STAP1 56 60 PF00017 0.682
LIG_SH2_STAT5 291 294 PF00017 0.703
LIG_SH2_STAT5 301 304 PF00017 0.604
LIG_SH2_STAT5 314 317 PF00017 0.417
LIG_SH3_3 2 8 PF00018 0.709
LIG_SH3_3 251 257 PF00018 0.669
LIG_SH3_3 346 352 PF00018 0.668
LIG_TRAF2_1 264 267 PF00917 0.650
LIG_WRC_WIRS_1 195 200 PF05994 0.568
MOD_CDK_SPxxK_3 348 355 PF00069 0.707
MOD_CK1_1 121 127 PF00069 0.760
MOD_CK1_1 133 139 PF00069 0.660
MOD_CK1_1 225 231 PF00069 0.572
MOD_CK1_1 274 280 PF00069 0.626
MOD_CK1_1 290 296 PF00069 0.553
MOD_CK1_1 324 330 PF00069 0.629
MOD_CK1_1 333 339 PF00069 0.597
MOD_CK1_1 341 347 PF00069 0.558
MOD_CK1_1 351 357 PF00069 0.570
MOD_CK1_1 360 366 PF00069 0.509
MOD_CK1_1 40 46 PF00069 0.678
MOD_CK2_1 283 289 PF00069 0.672
MOD_CK2_1 38 44 PF00069 0.771
MOD_DYRK1A_RPxSP_1 348 352 PF00069 0.687
MOD_GlcNHglycan 155 158 PF01048 0.590
MOD_GlcNHglycan 254 257 PF01048 0.654
MOD_GlcNHglycan 277 280 PF01048 0.673
MOD_GlcNHglycan 326 329 PF01048 0.675
MOD_GlcNHglycan 330 333 PF01048 0.640
MOD_GSK3_1 129 136 PF00069 0.715
MOD_GSK3_1 153 160 PF00069 0.589
MOD_GSK3_1 200 207 PF00069 0.658
MOD_GSK3_1 227 234 PF00069 0.483
MOD_GSK3_1 265 272 PF00069 0.632
MOD_GSK3_1 283 290 PF00069 0.533
MOD_GSK3_1 324 331 PF00069 0.606
MOD_GSK3_1 338 345 PF00069 0.572
MOD_GSK3_1 347 354 PF00069 0.642
MOD_GSK3_1 360 367 PF00069 0.558
MOD_GSK3_1 60 67 PF00069 0.718
MOD_N-GLC_1 287 292 PF02516 0.673
MOD_N-GLC_1 294 299 PF02516 0.566
MOD_NEK2_1 194 199 PF00069 0.568
MOD_NEK2_1 204 209 PF00069 0.681
MOD_NEK2_1 215 220 PF00069 0.546
MOD_NEK2_1 231 236 PF00069 0.404
MOD_NEK2_1 271 276 PF00069 0.684
MOD_NEK2_1 338 343 PF00069 0.603
MOD_NEK2_1 75 80 PF00069 0.682
MOD_NEK2_1 9 14 PF00069 0.714
MOD_PK_1 206 212 PF00069 0.637
MOD_PKA_2 200 206 PF00069 0.668
MOD_PKA_2 222 228 PF00069 0.633
MOD_PKA_2 347 353 PF00069 0.775
MOD_PKB_1 62 70 PF00069 0.781
MOD_Plk_1 20 26 PF00069 0.752
MOD_Plk_1 283 289 PF00069 0.699
MOD_Plk_1 294 300 PF00069 0.610
MOD_Plk_1 305 311 PF00069 0.460
MOD_Plk_1 333 339 PF00069 0.672
MOD_Plk_1 357 363 PF00069 0.705
MOD_Plk_4 143 149 PF00069 0.699
MOD_Plk_4 194 200 PF00069 0.543
MOD_Plk_4 222 228 PF00069 0.518
MOD_Plk_4 271 277 PF00069 0.752
MOD_Plk_4 287 293 PF00069 0.593
MOD_Plk_4 333 339 PF00069 0.732
MOD_ProDKin_1 127 133 PF00069 0.709
MOD_ProDKin_1 290 296 PF00069 0.703
MOD_ProDKin_1 348 354 PF00069 0.761
MOD_SUMO_for_1 172 175 PF00179 0.467
MOD_SUMO_rev_2 84 92 PF00179 0.772
TRG_ER_diArg_1 170 172 PF00400 0.499
TRG_ER_diArg_1 242 245 PF00400 0.551
TRG_ER_diArg_1 97 100 PF00400 0.676
TRG_Pf-PMV_PEXEL_1 138 143 PF00026 0.660
TRG_Pf-PMV_PEXEL_1 170 175 PF00026 0.462

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I004 Leptomonas seymouri 42% 96%
A0A1X0P4S3 Trypanosomatidae 32% 100%
A0A3S7XA50 Leishmania donovani 99% 100%
A4HNH5 Leishmania braziliensis 60% 98%
C9ZYD7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 29% 100%
E9AFY6 Leishmania major 94% 100%
E9B739 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%
V5BTY5 Trypanosoma cruzi 28% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS